Rhythm PharmaceuticalsRYTM

13F holders, Q4 2025 (December 31)
281holders +17
48new positions
39sold out
7famous investors
$107.05avg. 13F price*

At the end of Q4 2025, 281 institutions reported holding Rhythm Pharmaceuticals Inc. (RYTM) in their 13F filings, up 17 from Q3 2025. 48 opened new positions and 39 sold out. The largest holders were Ra Capital Management, L.P. ($713.6M), BlackRock, Inc. ($674.1M) and Vanguard Group Inc. ($664.8M). 7 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.1% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).

Company
Rhythm Pharmaceuticals Inc.
CUSIP
76243J105
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400 Q1 2024: 167Q1 2024Q2 2024: 165Q2 2024Q3 2024: 176Q3 2024Q4 2024: 203Q4 2024Q1 2025: 228Q1 2025Q2 2025: 227Q2 2025Q3 2025: 264Q3 2025Q4 2025: 281Q4 2025Q1 2026: 285Q1 2026Q2 2026: 304Q2 2026

Total Exit/New Position Q3 2025 → Q4 2025

InstitutionsTotal Value
New Positions48$127.7M
Exits39$195.0M

All 13F filers, Q3 2025 → Q4 2025: 7,739,927 shares bought and 5,908,810 shares sold, net +1,831,117 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 281 holders

Ra Capital Management, L.P. 7.32% Add +17.4% 6,666,837 $713.6M
BlackRock, Inc. 0.01% Reduce -0.1% 6,297,334 $674.1M
Vanguard Group Inc. 0.01% Add +24.3% 6,210,916 $664.8M
Baker Bros. Advisors LP 3.53% No change 5,604,483 $599.9M
Primecap Management Co. 0.28% Reduce -18.4% 3,478,669 $372.4M
NEA Management Company, LLC 15.88% No change 2,909,956 $311.5M
Perceptive Advisors LLC 5.01% Add +4.4% 2,546,391 $272.6M
State Street Corp. 0.01% Add +8.4% 2,198,615 $235.3M
Goldman Sachs Group Inc. 0.03% Reduce -3.3% 1,830,866 $196.0M
FMR LLC 0.01% Reduce -20.5% 1,706,317 $182.6M
Federated Hermes, Inc. 0.29% Reduce -6.0% 1,623,841 $173.8M
T. Rowe Price Associates Inc. 0.02% Add +11.5% 1,560,847 $167.1M
JPMorgan Chase & Co. 0.01% Add +19.9% 1,423,989 $152.4M
Geode Capital Management, LLC 0.01% Add +0.9% 1,375,729 $147.3M
Driehaus Capital Management LLC 0.93% Reduce -7.1% 1,285,222 $137.6M
Westfield Capital Management Co. LP 0.56% Add +18.5% 1,267,158 $135.6M
Polar Capital Holdings Plc 0.58% Reduce -4.8% 1,185,392 $126.9M
Janus Henderson Group PLC 0.05% Reduce -3.0% 1,126,125 $120.6M
Checkpoint Capital L.P. 33.65% Add +29.9% 992,200 $106.2M
Capital Research Global Investors 0.02% Add +64.7% 985,086 $105.4M
Alliancebernstein L.P. 0.03% Reduce -5.0% 930,233 $99.6M
Jennison Associates LLC 0.06% Add +123.2% 918,567 $98.3M
Franklin Resources Inc. 0.02% Add +22.5% 695,735 $74.5M
Rock Springs Capital Management LP 3.83% Reduce -3.1% 695,010 $74.4M
Woodline Partners LP 0.29% Add +18.7% 688,779 $73.7M
Morgan Stanley 0.00% Add +40.0% 651,402 $69.7M
Adage Capital Partners Gp, L.L.C. 0.10% Add +14.3% 621,585 $66.5M
Lord, Abbett & Co. LLC 0.21% Add +7.6% 619,542 $66.3M
Pictet Asset Management Holding SA 0.06% Reduce -10.0% 614,663 $66.2M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% Add +25.5% 549,020 $58.8M
Charles Schwab Investment Management Inc. 0.01% Add +0.9% 532,447 $57.0M
Clearbridge Investments, LLC 0.04% Add +4.4% 506,109 $54.2M
Loomis Sayles & Co. L P 0.07% Reduce -4.5% 503,901 $53.9M
Siren, L.L.C. 1.60% No change 499,975 $53.5M
Northern Trust Corp. 0.01% Reduce -4.4% 488,216 $52.3M
Integral Health Asset Management, LLC 2.58% Add +115.9% 475,000 $50.8M
Point72 Asset Management 0.08% New 429,420 $46.0M
UBS Group AG 0.01% Add +1.6% 427,236 $45.7M
Renaissance Technologies 0.06% Reduce -37.6% 341,193 $36.5M
Opaleye Management Inc. 4.66% Reduce -28.5% 330,000 $35.3M
Qube Research & Technologies Ltd 0.05% Add +30.2% 310,919 $33.3M
Bank of New York Mellon Corp 0.01% Add +65.1% 301,080 $32.2M
First Light Asset Management, LLC 2.42% Add +63.9% 295,844 $31.7M
Invesco Ltd. 0.00% Add +102.8% 291,150 $31.2M
Candriam S.C.A. 0.15% Add +29.8% 287,907 $30.8M
Sofinnova Investments, Inc. 1.25% Add +9.9% 271,394 $29.1M
Artisan Partners Limited Partnership 0.04% Add +11.3% 263,591 $28.2M
Ameriprise Financial Inc. 0.01% Add +89.3% 261,160 $28.0M
Wellington Management Group LLP 0.00% Add +922.0% 250,156 $26.8M
Voya Investment Management LLC 0.03% Add +12.8% 249,874 $26.7M
Orbimed Advisors LLC 0.53% Add +11.5% 239,800 $25.7M
Hood River Capital Management LLC 0.28% Add +0.5% 237,043 $25.4M
Bank of America Corp. 0.00% Reduce -3.7% 224,484 $24.0M
Logos Global Management LP 1.36% Reduce -5.0% 190,000 $20.3M
Millennium Management 0.01% Add +40.2% 186,709 $20.0M
BNP Paribas Financial Markets 0.01% Reduce -26.4% 164,563 $17.6M
Citadel Advisors 0.01% Add +15.6% 153,322 $16.4M
Connor, Clark & Lunn Investment Management Ltd. 0.04% Add +23.2% 149,373 $16.0M
First Turn Management, LLC 1.79% New 146,303 $15.7M
M&G PLC 0.08% New 137,074 $14.7M
Silverarc Capital Management, LLC 2.11% Reduce -63.3% 135,950 $14.6M
Russell Investments Group, Ltd. 0.02% Reduce -14.9% 134,180 $14.4M
Barclays PLC 0.01% Reduce -7.7% 131,436 $14.1M
Deutsche Bank AG 0.00% Add +10.6% 129,123 $13.8M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% Add +21.9% 123,537 $13.2M
Nuveen, LLC 0.00% Reduce -1.7% 115,934 $12.4M
Capital World Investors 0.00% New 115,693 $12.4M
Swiss National Bank 0.01% Add +8.8% 111,300 $11.9M
New York State Common Retirement Fund 0.01% Add +24.7% 93,677 $10.0M
First Trust Advisors LP 0.01% Add +9.4% 88,505 $9.5M
Algert Global LLC 0.15% Reduce -37.1% 88,250 $9.4M
Axiom Investors LLC 0.08% Add +0.6% 83,554 $8.9M
Zweig-DiMenna Associates LLC 0.62% New 81,600 $8.7M
SummitTX Capital, L.P. 0.26% Add +580.2% 80,729 $8.6M
ExodusPoint Capital Management, LP 0.09% New 75,141 $8.0M
Neuberger Berman Group LLC 0.01% Reduce -13.6% 73,572 $7.9M
Wells Fargo & Company 0.00% Add +54.1% 72,617 $7.8M
Balyasny Asset Management L.P. 0.02% Reduce -79.3% 72,282 $7.7M
Rhumbline Advisers 0.01% Reduce -13.2% 71,212 $7.6M
AQR Capital Management 0.00% Reduce -12.2% 70,046 $7.5M
NEXTBio Capital Management LP 4.24% — 67,586 $7.2M
Norges Bank 0.00% — 66,213 $7.1M
Castleark Management LLC 0.20% Add +51.6% 64,479 $6.9M
Voloridge Investment Management, LLC 0.02% Reduce -83.5% 60,575 $6.5M
Manufacturers Life Insurance Company, The 0.01% Reduce -2.1% 59,609 $6.4M
PDT Partners, LLC 0.41% Reduce -31.0% 59,436 $6.4M
Stempoint Capital LP 1.08% Reduce -35.6% 58,915 $6.3M
Informed Momentum Co LLC 0.68% Reduce -2.0% 57,327 $6.1M
Rafferty Asset Management, LLC 0.02% Reduce -0.4% 55,526 $5.9M
Legal & General Group Plc 0.00% Reduce -4.0% 55,075 $5.9M
TD Asset Management Inc 0.00% Reduce -7.6% 55,050 $5.9M
California State Teachers Retirement System 0.01% Add +9.4% 53,537 $5.7M
Granahan Investment Management, LLC 0.24% Add +7.5% 53,452 $5.7M
Prudential Financial Inc. 0.01% Reduce -27.2% 53,145 $5.7M
ADAR1 Capital Management, LLC 0.41% Add +3.6% 51,349 $5.5M
Nan Fung Group Holdings Ltd 4.71% No change 49,120 $5.3M
Victory Capital Management Inc. 0.00% Add +5.8% 45,381 $4.9M
WCM Investment Management, LLC 0.01% Reduce -6.1% 44,805 $4.8M
Harvest Investment Services, LLC 0.89% Reduce -8.7% 43,953 $4.7M
HighVista Strategies LLC 1.18% Add +14.4% 42,867 $4.6M
Hillsdale Investment Management Inc. 0.13% Reduce -0.7% 42,300 $4.5M
Raymond James Financial Inc. 0.00% Reduce -6.8% 41,115 $4.4M
Harbor Capital Advisors, Inc. 0.34% Add +9.9% 40,896 $4.4M
PFM Health Sciences, LP 0.44% Reduce -16.5% 40,210 $4.3M
Kennedy Capital Management LLC 0.09% Add +0.8% 39,887 $4.3M
Sei Investments Co. 0.00% Add +18.2% 37,432 $4.0M
State of Wisconsin Investment Board 0.01% Reduce -11.5% 36,079 $3.9M
Rhenman & Partners Asset Management AB 0.35% No change 35,000 $3.7M
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% Add +28.7% 34,901 $3.7M
Nicholas Investment Partners, LP 0.31% New 34,710 $3.7M
Silvercrest Asset Management Group LLC 0.03% Add +0.1% 34,127 $3.7M
Squarepoint Ops LLC 0.01% New 32,829 $3.5M
Dimensional Fund Advisors LP 0.00% Add +12.8% 32,018 $3.4M
D. E. Shaw & Co. 0.00% Add +774.6% 31,356 $3.4M
Magnetar Financial LLC 0.03% New 29,598 $3.2M
EFG International AG 0.06% — 29,291 $3.1M
MetLife Investment Management, LLC 0.02% Reduce -3.9% 29,174 $3.1M
Lazard Asset Management LLC 0.00% Reduce -15.4% 25,571 $2.7M
Los Angeles Capital Management LLC 0.01% Add +45.5% 24,334 $2.7M
Creative Planning 0.00% Add +1.1% 25,206 $2.7M
Atom Investors LP 0.19% New 22,929 $2.5M
Penserra Capital Management LLC 0.03% Reduce -29.3% 21,514 $2.3M
Intech Investment Management LLC 0.02% Reduce -12.2% 21,350 $2.3M
Profund Advisors LLC 0.07% Add +69.0% 21,046 $2.3M
State of New Jersey Common Pension Fund D 0.01% Reduce -7.9% 19,270 $2.1M
Wedge Capital Management L L P 0.04% Reduce -13.5% 19,247 $2.1M
Advisors Asset Management, Inc. 0.03% Add +30.6% 18,524 $2.0M
Captrust Financial Advisors 0.00% Add +0.4% 18,325 $2.0M
Handelsbanken Fonder AB 0.01% Add +12.9% 17,521 $1.9M
Arizona State Retirement System 0.01% Add +0.9% 15,762 $1.7M
State Board of Administration of Florida Retirement System 0.00% No change 14,650 $1.6M
Police & Firemen's Retirement System of New Jersey 0.01% Reduce -2.9% 14,183 $1.5M
Stifel Financial Corp. 0.00% Reduce -8.4% 13,247 $1.4M
Nisa Investment Advisors, LLC 0.00% Reduce -0.9% 13,139 $1.4M
Citigroup Inc. 0.00% Reduce -2.8% 12,720 $1.4M
ProShare Advisors LLC 0.00% Add +11.7% 12,622 $1.4M
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Add +15.9% 12,435 $1.3M
Guggenheim Capital LLC 0.01% Add +442.7% 12,401 $1.3M
KLP Kapitalforvaltning As 0.01% Add +9.1% 12,000 $1.3M
STRS Ohio 0.00% Reduce -18.9% 12,000 $1.3M
Rockefeller Capital Management L.P. 0.00% Add +32.7% 11,771 $1.3M
SG Americas Securities, LLC 0.00% Reduce -40.0% 11,741 $1.3M
DNB Asset Management AS 0.00% Add +101.9% 11,163 $1.2M
Hennion & Walsh Asset Management, Inc. 0.04% Reduce -75.6% 10,908 $1.2M
China Universal Asset Management Co., Ltd. 0.09% Reduce -6.6% 10,875 $1.2M
XTX Topco Ltd 0.03% New 10,433 $1.1M
Knights of Columbus Asset Advisors LLC 0.06% New 10,314 $1.1M
Cannon Financial Strategists, Inc. 0.15% No change 10,000 $1.1M
Toth Financial Advisory Corp. 0.12% No change 10,000 $1.1M
Man Group plc 0.00% Reduce -92.6% 9,558 $1.0M
Fred Alger Management, LLC 0.00% Reduce -24.6% 9,301 $996K
VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% Add +37.3% 9,200 $985K
Headlands Technologies LLC 0.08% New 8,632 $924K
Teacher Retirement System of Texas 0.00% Reduce -35.5% 8,359 $895K
Allianz Asset Management GmbH 0.00% Reduce -33.9% 8,000 $856K
Bellevue Group AG 0.02% Reduce -17.1% 7,504 $803K
Leo Wealth, LLC 0.05% Reduce -11.6% 6,952 $744K
Jump Financial, LLC 0.01% New 6,759 $723K
E. Ohman J:or Asset Management AB 0.02% Reduce -19.8% 6,589 $705K
Principal Financial Group Inc. 0.00% Reduce -50.8% 6,198 $663K
Acadian Asset Management LLC 0.00% New 6,105 $652K
Exchange Traded Concepts, LLC 0.01% Reduce -4.8% 6,080 $651K
Virtus Investment Advisers, LLC 0.17% Reduce -14.7% 6,017 $644K
CANADA LIFE ASSURANCE Co 0.00% Reduce -59.7% 5,797 $621K
Legato Capital Management LLC 0.05% New 5,723 $613K
Jasper Ridge Partners, L.P. 0.01% No change 5,639 $604K
Quantedge Capital Pte Ltd 0.29% Reduce -68.5% 5,600 $599K
Public Employees Retirement Association of Colorado 0.00% No change 5,463 $585K
LPL Financial LLC 0.00% Add +36.0% 5,427 $581K
AlphaCentric Advisors LLC 0.54% — 5,052 $541K
Voleon Capital Management LP 0.01% Reduce -81.3% 5,025 $538K
Two Sigma Securities, LLC 0.07% New 4,943 $529K
Gotham Asset Management 0.00% Reduce -0.1% 4,851 $519K
PSP Research LLC 0.44% — 4,738 $507K
PNC Financial Services Group, Inc. 0.00% Add +10.5% 4,659 $499K
Caption Management, LLC 0.02% New 4,614 $494K
Vestmark Advisory Solutions, Inc. 0.01% New 4,560 $488K
Verition Fund Management LLC 0.00% New 4,504 $482K
Mackenzie Financial Corp. 0.00% No change 4,398 $469K
Ameritas Investment Partners, Inc. 0.01% No change 4,365 $467K
Xponance LLC 0.00% Add +2.6% 4,269 $457K
Empowered Funds, LLC 0.01% Add +94.1% 4,164 $446K
Susquehanna International Group, LLP 0.00% Add +32.0% 4,097 $439K
Comerica Bank 0.00% Reduce -98.1% 4,014 $430K
Ensign Peak Advisors, Inc 0.00% Reduce -96.5% 3,859 $413K
Quantinno Capital Management LP 0.00% Add +49.8% 3,831 $410K
Freestone Capital Holdings, LLC 0.01% No change 3,700 $396K
Cerity Partners LLC 0.00% Add +23.6% 3,664 $392K
O'shaughnessy Asset Management, LLC 0.00% Reduce -26.0% 3,580 $383K
Avior Wealth Management, LLC 0.01% Add +0.9% 3,572 $382K
Cibc World Markets Corp. 0.00% — 3,502 $375K
Tidal Investments LLC 0.00% Add +25.2% 3,336 $357K
Keybank National Association 0.00% New 3,271 $350K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +26.3% 3,243 $347K
Cinctive Capital Management LP 0.02% Reduce -90.8% 3,225 $345K
Yorktown Management & Research Co Inc 0.26% New 3,050 $326K
Cim Investment Management Inc. 0.08% No change 2,993 $320K
Tower Research Capital LLC (TRC) 0.01% Add +69.0% 2,962 $317K
Two Sigma Advisers, LP 0.00% Reduce -12.1% 2,900 $310K
Blueshift Asset Management, LLC 0.09% New 2,881 $308K
JGP Global Gestao de Recursos Ltda. 0.18% Reduce -11.9% 2,866 $307K
CIBC Asset Management Inc 0.00% New 2,848 $305K
Cwm, LLC 0.00% Reduce -4.3% 2,767 $296K
Swiss Life Asset Management Ltd 0.00% Add +7.8% 2,653 $284K
Chicago Partners Investment Group LLC 0.01% Add +11.6% 2,739 $282K
AlphaGrep UK Ltd 0.09% — 2,509 $269K
Entropy Technologies, LP 0.01% Reduce -70.7% 2,492 $267K
State of Wyoming 0.03% Add +155.9% 2,441 $261K
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% Add +385.9% 2,415 $259K
Centaurus Financial, Inc. 0.01% No change 2,389 $256K
Vanguard Personalized Indexing Management, LLC 0.00% Add +15.0% 2,379 $255K
Abel Hall, LLC 0.05% New 2,140 $229K
M&T Bank Corp 0.00% New 2,101 $225K
Cambria Investment Management, L.P. 0.01% New 1,997 $214K
Elevation Wealth Partners, LLC 0.07% No change 1,971 $211K
Jane Street Group, LLC 0.00% Reduce -34.0% 1,960 $210K
KBC Group NV 0.00% No change 1,707 $183K
Whittier Trust Co. 0.00% No change 1,811 $180K
Royal Bank of Canada 0.00% Reduce -98.7% 1,676 $180K
Amalgamated Bank 0.00% Reduce -1.8% 1,663 $178K
AlphaQuest LLC 0.01% Add +8.4% 1,508 $161K
Persistent Asset Partners Ltd 0.07% New 1,446 $155K
GF Fund Management Co. LTD. 0.00% Reduce -8.3% 1,310 $140K
Clearstead Advisors, LLC 0.00% Add +212.3% 1,246 $133K
Danske Bank A/S 0.00% New 1,100 $118K
Osaic Holdings, Inc. 0.00% Add +6.0% 1,039 $111K
US Bancorp \de 0.00% Add +552.7% 953 $102K
Global Retirement Partners, LLC 0.00% Add +114.3% 857 $92K
CFG Wealth Management Services, Inc. 0.08% — 800 $86K
Farther Finance Advisors, LLC 0.00% Add +82.9% 642 $69K
Covestor Ltd 0.03% Add +328.9% 579 $62K
Smartleaf Asset Management LLC 0.00% Add +39.5% 399 $43K
Arax Advisory Partners 0.00% Reduce -51.2% 381 $41K
GAMMA Investing LLC 0.00% Add +48.6% 361 $39K
Sterling Capital Management LLC 0.00% Add +170.9% 344 $37K
SBI Securities Co., Ltd. 0.00% Add +73.2% 343 $37K
EverSource Wealth Advisors, LLC 0.00% Add +303.0% 266 $28K
Signaturefd, LLC 0.00% No change 232 $25K
Jones Financial Companies LLLP 0.00% Reduce -1.3% 231 $25K
Essential Partners LLC 0.01% Add +12.6% 223 $24K
Kemnay Advisory Services Inc. 0.00% New 207 $22K
Daiwa Securities Group Inc. 0.00% Reduce -5.6% 201 $22K
True Wealth Design, LLC 0.00% No change 147 $16K
Truvestments Capital LLC 0.00% No change 138 $15K
AdvisorNet Financial, Inc 0.00% Add +30.5% 137 $15K
Bayforest Capital Ltd 0.01% Reduce -88.6% 134 $14K
Basecamp Wealth Advisors LLC 0.00% — 125 $13K
Allworth Financial LP 0.00% Reduce -16.8% 109 $12K
Optiver Holding B.V. 0.00% Reduce -74.8% 92 $10K
Rothschild Investment LLC 0.00% Add +7.1% 91 $10K
Quarry LP 0.00% New 77 $8K
Larson Financial Group LLC 0.00% Add +175.0% 77 $8K
Bessemer Group Inc. 0.00% No change 66 $7K
WPG Advisers, LLC 0.00% Add +5.3% 60 $6K
Harbour Investments, Inc. 0.00% New 60 $6K
Eastern Bank 0.00% New 59 $6K
Root Financial Partners, LLC 0.00% New 43 $5K
ORG Partners LLC 0.00% Add +15.6% 37 $4K
Versant Capital Management, Inc 0.00% No change 36 $4K
IFP Advisors, Inc 0.00% Add +89.5% 36 $4K
Parkside Financial Bank & Trust 0.00% No change 33 $4K
SageView Advisory Group, LLC 0.00% New 30 $3K
First Horizon Corp. 0.00% New 30 $3K
Parallel Advisors, LLC 0.00% No change 25 $3K
Bare Financial Services, Inc 0.00% Add +22.2% 22 $2K
Physician Wealth Advisors, Inc. 0.00% No change 16 $2K
Rakuten Securities, Inc. 0.00% New 15 $2K
CVA Family Office, LLC 0.00% No change 12 $1K
JFS Wealth Advisors, LLC 0.00% New 10 $1K
Keating Financial Advisory Services, Inc. 0.00% — 9 $963
Fortitude Family Office, LLC 0.00% New 6 $642
Toronto Dominion Bank 0.00% New 6 $642
DiNuzzo Private Wealth, Inc. 0.00% New 3 $322
HFM Investment Advisors, LLC 0.00% New 2 $215
MAI Capital Management 0.00% Reduce -99.9% 2 $215
SJS Investment Consulting Inc. 0.00% New 2 $215
Rialto Wealth Management, LLC 0.00% New 1 $108
TD Private Client Wealth LLC 0.00% New 1 $107
Bay Harbor Wealth Management, LLC 0.00% New 1 $107
Dunhill Financial, LLC 0.00% New 1 $65
Avion Wealth 0.00% New 4 $0

"% of holder's portfolio" is RYTM's weight in each manager's 13F, not the share of Rhythm Pharmaceuticals Inc. the manager owns.