SepternaSEPN
13F holders, Q2 2026 (June 30)153holders +29
45new positions
16sold out
7famous investors
$33.48avg. 13F price*
At the end of Q2 2026, 153 institutions reported holding Septerna Inc. (SEPN) in their 13F filings, up 29 from Q1 2026. 45 opened new positions and 16 sold out. The largest holders were Ra Capital Management, L.P. ($234.3M), TRV GP V, LLC ($208.2M) and Driehaus Capital Management LLC ($148.5M). 7 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Septerna Inc.
- CUSIP
- 81734D104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2026 → Q2 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 45 | $53.7M |
| Exits | 16 | $51.0M |
All 13F filers, Q1 2026 → Q2 2026: 3,778,953 shares bought and 2,673,247 shares sold, net +1,105,706 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 153 holders
| Ra Capital Management, L.P. | 2.04% | No change | 6,995,858 | $234.3M |
| TRV GP V, LLC | 41.78% | No change | 6,215,591 | $208.2M |
| Driehaus Capital Management LLC | 0.86% | Add +0.8% | 4,433,058 | $148.5M |
| TRV GP Vi, LLC | 60.72% | No change | 4,211,659 | $141.0M |
| Samsara Biocapital, LLC | 8.66% | No change | 3,149,128 | $105.5M |
| Goldman Sachs Group Inc. | 0.01% | Add +5.4% | 3,062,766 | $102.6M |
| BlackRock, Inc. | 0.00% | Add +6.0% | 1,932,088 | $64.7M |
| Siren, L.L.C. | 1.29% | Reduce -5.0% | 1,900,000 | $63.6M |
| Avoro Capital Advisors LLC | 0.40% | No change | 1,337,500 | $44.8M |
| Jupiter Topco LLC | 0.02% | — | 1,307,500 | $43.7M |
| Vanguard Capital Management LLC | 0.00% | Add +2.1% | 1,221,673 | $40.9M |
| Primecap Management Co. | 0.02% | Add +11.3% | 1,167,382 | $39.1M |
| First Light Asset Management, LLC | 1.96% | Add +31.4% | 963,260 | $32.3M |
| ADAR1 Capital Management, LLC | 1.49% | Reduce -13.7% | 940,747 | $31.5M |
| Geode Capital Management, LLC | 0.00% | Add +5.3% | 679,163 | $22.8M |
| State Street Corp. | 0.00% | Add +3.4% | 652,630 | $21.9M |
| Loomis Sayles & Co. L P | 0.03% | New | 624,752 | $20.9M |
| Casdin Capital, LLC | 0.93% | No change | 553,268 | $18.5M |
| Catalio Capital Management, LP | 3.37% | Add +82.1% | 536,152 | $18.0M |
| Algert Global LLC | 0.16% | Add +1789.7% | 397,487 | $13.3M |
| Balyasny Asset Management L.P. | 0.02% | Add +48.1% | 350,442 | $11.7M |
| Longaeva Partners L.P. | 0.29% | Add +299.9% | 298,171 | $10.0M |
| Soleus Capital Management, L.P. | 0.32% | No change | 275,000 | $9.2M |
| Vanguard Portfolio Management LLC | 0.00% | Add +18.0% | 230,184 | $7.7M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Reduce -0.6% | 222,702 | $7.5M |
| Two Sigma Investments, LP | 0.01% | Add +193.1% | 220,885 | $7.4M |
| Northern Trust Corp. | 0.00% | Add +22.3% | 201,131 | $6.7M |
| Kalehua Capital Management LLC | 3.75% | No change | 194,544 | $6.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +3.0% | 187,041 | $6.3M |
| Woodline Partners LP | 0.02% | New | 185,535 | $6.2M |
| Vanguard Fiduciary Trust Co. | 0.00% | Add +7.2% | 165,656 | $5.5M |
| Morgan Stanley | 0.00% | Add +21.6% | 134,377 | $4.5M |
| UBS Group AG | 0.00% | Reduce -23.2% | 89,874 | $3.0M |
| JPMorgan Chase & Co. | 0.00% | Add +0.7% | 85,301 | $3.0M |
| Federated Hermes, Inc. | 0.00% | Reduce -2.9% | 86,753 | $2.9M |
| Lazard Asset Management LLC | 0.00% | New | 75,425 | $2.5M |
| Dimensional Fund Advisors LP | 0.00% | New | 75,309 | $2.5M |
| Arrowstreet Capital, Limited Partnership | 0.00% | New | 74,649 | $2.5M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Add +139.8% | 68,180 | $2.3M |
| Hussman Strategic Advisors, Inc. | 0.49% | Reduce -40.0% | 63,000 | $2.1M |
| American Century Companies Inc. | 0.00% | Reduce -0.5% | 60,973 | $2.0M |
| Bank of New York Mellon Corp | 0.00% | Reduce -4.3% | 56,176 | $1.9M |
| XTX Topco Ltd | 0.02% | Add +48.4% | 54,489 | $1.8M |
| Millennium Management | 0.00% | Reduce -59.3% | 50,562 | $1.7M |
| Barclays PLC | 0.00% | Add +119.3% | 49,821 | $1.7M |
| Elmind Capital, LP | 0.42% | New | 49,444 | $1.7M |
| Nuveen, LLC | 0.00% | Add +65.3% | 48,229 | $1.6M |
| Sofinnova Investments, Inc. | 0.09% | No change | 47,506 | $1.6M |
| D. E. Shaw & Co. | 0.00% | New | 46,483 | $1.6M |
| Jane Street Group, LLC | 0.00% | New | 45,552 | $1.5M |
| Voleon Capital Management LP | 0.03% | New | 44,435 | $1.5M |
| HRT Financial LP | 0.00% | New | 42,022 | $1.4M |
| Renaissance Technologies | 0.00% | Add +9.9% | 41,419 | $1.4M |
| Russell Investments Group, Ltd. | 0.00% | Add +249.2% | 40,209 | $1.3M |
| Caption Management, LLC | 0.05% | New | 38,006 | $1.3M |
| Bank of America Corp. | 0.00% | Add +38.1% | 35,875 | $1.2M |
| T. Rowe Price Associates Inc. | 0.00% | Add +25.8% | 35,323 | $1.2M |
| Alyeska Investment Group, L.P. | 0.00% | No change | 35,000 | $1.2M |
| Brevan Howard Capital Management LP | 0.01% | New | 29,452 | $986K |
| HighVista Strategies LLC | 0.22% | New | 29,337 | $982K |
| Tudor Investment Corporation | 0.00% | New | 28,966 | $970K |
| Rhumbline Advisers | 0.00% | Add +3.9% | 27,636 | $926K |
| Trexquant Investment LP | 0.01% | Reduce -27.4% | 25,645 | $859K |
| Invesco Ltd. | 0.00% | Reduce -70.9% | 24,094 | $807K |
| Logos Global Management LP | 0.03% | No change | 23,548 | $789K |
| FMR LLC | 0.00% | Reduce -0.9% | 23,240 | $778K |
| Fox Run Management, L.L.C. | 0.12% | New | 22,038 | $738K |
| Deutsche Bank AG | 0.00% | Add +29.9% | 21,873 | $733K |
| Alliancebernstein L.P. | 0.00% | Add +52.5% | 29,900 | $718K |
| Squarepoint Ops LLC | 0.00% | Add +17.3% | 21,219 | $711K |
| STRS Ohio | 0.00% | Add +22.1% | 21,000 | $703K |
| Fred Alger Management, LLC | 0.00% | New | 20,958 | $702K |
| Acadian Asset Management LLC | 0.00% | Reduce -32.2% | 20,996 | $701K |
| Jump Financial, LLC | 0.01% | Reduce -61.9% | 20,200 | $676K |
| Swiss National Bank | 0.00% | Reduce -10.4% | 19,800 | $663K |
| Wells Fargo & Company | 0.00% | Add +99.5% | 19,684 | $659K |
| Franklin Resources Inc. | 0.00% | New | 18,607 | $623K |
| Citigroup Inc. | 0.00% | Add +93.7% | 17,808 | $596K |
| Aquatic Capital Management LLC | 0.02% | New | 17,427 | $584K |
| Engineers Gate Manager LP | 0.01% | Add +5.0% | 17,350 | $581K |
| BNP Paribas Financial Markets | 0.00% | Add +216.1% | 16,946 | $568K |
| Los Angeles Capital Management LLC | 0.00% | Add +16.8% | 16,597 | $556K |
| State of Wyoming | 0.06% | New | 16,379 | $549K |
| Vanguard Global Advisers, LLC | 0.00% | No change | 16,247 | $544K |
| AQR Capital Management | 0.00% | Add +0.1% | 15,397 | $516K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | New | 13,300 | $445K |
| Verdad Advisers, LP | 0.42% | New | 12,970 | $434K |
| MetLife Investment Management, LLC | 0.00% | Reduce -5.9% | 12,880 | $431K |
| Osaic Holdings, Inc. | 0.00% | Reduce -0.8% | 12,594 | $422K |
| Man Group plc | 0.00% | Reduce -3.3% | 11,469 | $384K |
| California State Teachers Retirement System | 0.00% | Add +839.1% | 10,866 | $364K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -9.8% | 10,774 | $361K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +1.7% | 10,193 | $341K |
| Legal & General Group Plc | 0.00% | Add +75.5% | 10,062 | $337K |
| Massachusetts Financial Services Co. | 0.00% | Reduce -3.9% | 9,982 | $334K |
| Gotham Asset Management | 0.00% | New | 9,322 | $312K |
| Virtus Investment Advisers, LLC | 0.07% | Reduce -15.1% | 9,102 | $305K |
| Canada Pension Plan Investment Board | 0.00% | New | 8,900 | $298K |
| New York State Common Retirement Fund | 0.00% | Add +51.8% | 8,500 | $285K |
| First Trust Advisors LP | 0.00% | New | 7,739 | $259K |
| Creative Planning | 0.00% | New | 7,636 | $256K |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | No change | 7,420 | $248K |
| Quantinno Capital Management LP | 0.00% | New | 7,330 | $245K |
| CIBC Bancorp USA Inc. | 0.00% | New | 7,222 | $242K |
| Rangeley Capital, LLC | 0.24% | Reduce -81.9% | 7,200 | $241K |
| Occudo Quantitative Strategies LP | 0.01% | New | 7,191 | $241K |
| WINTON GROUP Ltd | 0.01% | Reduce -18.8% | 7,182 | $241K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +26.1% | 6,527 | $219K |
| Citadel Advisors | 0.00% | New | 6,350 | $213K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 6,304 | $211K |
| Captrust Financial Advisors | 0.00% | New | 6,211 | $208K |
| State of Wisconsin Investment Board | 0.00% | New | 6,095 | $204K |
| Chung Wu Investment Group, LLC | 0.11% | New | 4,800 | $161K |
| Vanguard Investments Australia, Ltd. | 0.00% | No change | 3,895 | $130K |
| KLP Kapitalforvaltning As | 0.00% | No change | 2,500 | $84K |
| Covestor Ltd | 0.04% | Reduce -6.1% | 2,123 | $72K |
| Royal Bank of Canada | 0.00% | New | 2,098 | $70K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Reduce -13.7% | 2,016 | $68K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,944 | $65K |
| New York State Teachers Retirement System | 0.00% | New | 1,946 | $65K |
| Steward Partners Investment Advisory, LLC | 0.00% | New | 1,325 | $44K |
| GAMMA Investing LLC | 0.00% | Add +0.8% | 1,119 | $37K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +47.7% | 1,059 | $35K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +91.1% | 971 | $33K |
| Signaturefd, LLC | 0.00% | No change | 966 | $32K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -5.6% | 950 | $32K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -8.7% | 768 | $26K |
| Quantbot Technologies LP | 0.00% | New | 515 | $17K |
| Amova Asset Management Americas, Inc. | 0.00% | New | 507 | $17K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | New | 362 | $12K |
| Pinnacle Wealth Planning Services, Inc. | 0.00% | No change | 322 | $11K |
| Versant Capital Management, Inc | 0.00% | No change | 261 | $9K |
| Arax Advisory Partners | 0.00% | New | 236 | $8K |
| US Bancorp \de | 0.00% | Add +11.7% | 220 | $7K |
| Sterling Capital Management LLC | 0.00% | Reduce -71.9% | 200 | $7K |
| Larson Financial Group LLC | 0.00% | Reduce -3.9% | 196 | $7K |
| N.E.W. Advisory Services LLC | 0.00% | No change | 180 | $6K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | No change | 155 | $5K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Reduce -23.0% | 104 | $3K |
| Aster Capital Management (DIFC) Ltd | 0.00% | New | 102 | $3K |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +102.6% | 77 | $3K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -5.9% | 64 | $2K |
| SBI Securities Co., Ltd. | 0.00% | No change | 55 | $2K |
| Cornerstone Financial Management LLC | 0.00% | No change | 52 | $2K |
| PNC Financial Services Group, Inc. | 0.00% | Add +4.7% | 45 | $2K |
| Rothschild Investment LLC | 0.00% | No change | 30 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 20 | $670 |
| Ameritas Advisory Services, LLC | 0.00% | New | 18 | $603 |
| National Bank of Canada | 0.00% | New | 7 | $234 |
| SJS Investment Consulting Inc. | 0.00% | New | 6 | $201 |
| Global Retirement Partners, LLC | 0.00% | — | 3 | $100 |
| Allworth Financial LP | 0.00% | Reduce -94.1% | 1 | $34 |
| Silver Grove Financial Group, Inc. | 0.00% | New | 1 | $33 |
"% of holder's portfolio" is SEPN's weight in each manager's 13F, not the share of Septerna Inc. the manager owns.