Taysha Gene TherapiesTSHA
13F holders, Q3 2025 (September 30)155holders +5
27new positions
20sold out
5famous investors
$3.27avg. 13F price*
At the end of Q3 2025, 155 institutions reported holding Taysha Gene Therapies Inc. (TSHA) in their 13F filings, up 5 from Q2 2025. 27 opened new positions and 20 sold out. The largest holders were RTW Investments, LP ($79.6M), Ra Capital Management, L.P. ($77.0M) and Avoro Capital Advisors LLC ($71.0M). 5 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Taysha Gene Therapies Inc.
- CUSIP
- 877619106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $12.9M |
| Exits | 20 | $16.3M |
All 13F filers, Q2 2025 → Q3 2025: 34,537,776 shares bought and 27,609,958 shares sold, net +6,927,818 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 155 holders
| RTW Investments, LP | 0.98% | Reduce -2.7% | 24,354,291 | $79.6M |
| Ra Capital Management, L.P. | 0.95% | No change | 23,555,648 | $77.0M |
| Avoro Capital Advisors LLC | 0.92% | No change | 21,700,000 | $71.0M |
| Morgan Stanley | 0.00% | Add +14.5% | 19,307,603 | $63.1M |
| BlackRock, Inc. | 0.00% | Add +23.0% | 16,364,861 | $53.5M |
| FMR LLC | 0.00% | Reduce -6.6% | 14,593,412 | $47.7M |
| Goldman Sachs Group Inc. | 0.01% | Add +6.3% | 13,383,708 | $43.8M |
| Vanguard Group Inc. | 0.00% | Add +17.9% | 12,849,613 | $42.0M |
| Siren, L.L.C. | 1.41% | No change | 11,014,737 | $36.0M |
| Octagon Capital Advisors LP | 4.63% | Reduce -28.0% | 9,067,500 | $29.7M |
| Point72 Asset Management | 0.06% | Add +0.2% | 7,331,470 | $24.0M |
| State Street Corp. | 0.00% | Add +40.8% | 7,236,465 | $23.7M |
| Vestal Point Capital, LP | 0.82% | Add +83.3% | 5,500,000 | $18.0M |
| Deerfield Management Company, L.P. | 0.29% | No change | 5,386,000 | $17.6M |
| Polar Capital Holdings Plc | 0.08% | Add +5.9% | 5,293,879 | $17.3M |
| Geode Capital Management, LLC | 0.00% | Add +36.4% | 5,174,516 | $16.9M |
| Barclays PLC | 0.01% | Add +1042.8% | 5,148,112 | $16.8M |
| Millennium Management | 0.01% | Add +37.1% | 4,026,122 | $13.2M |
| Baker Bros. Advisors LP | 0.09% | No change | 4,004,756 | $13.1M |
| Tybourne Capital Management (hk) Ltd. | 39.11% | Reduce -9.7% | 3,700,000 | $12.1M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Reduce -31.2% | 3,328,000 | $10.9M |
| Affinity Asset Advisors, LLC | 0.94% | Add +1400.0% | 3,000,000 | $9.8M |
| ADAR1 Capital Management, LLC | 0.92% | Reduce -5.8% | 2,835,680 | $9.3M |
| D. E. Shaw & Co. | 0.01% | Add +574.1% | 2,706,434 | $8.9M |
| Jefferies Financial Group Inc. | 0.07% | Reduce -79.1% | 2,156,642 | $7.1M |
| Toronto Dominion Bank | 0.01% | Reduce -59.3% | 1,923,962 | $6.3M |
| Ally Bridge Group (NY) LLC | 5.20% | New | 1,898,112 | $6.2M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +275.5% | 1,846,510 | $6.0M |
| B Group, Inc. | 5.88% | No change | 1,800,556 | $5.9M |
| Northern Trust Corp. | 0.00% | Add +29.2% | 1,717,178 | $5.6M |
| Great Point Partners LLC | 2.05% | No change | 1,500,000 | $4.9M |
| Bank of America Corp. | 0.00% | Add +78.9% | 1,307,287 | $4.3M |
| Palo Alto Investors LP | 0.75% | No change | 1,246,033 | $4.1M |
| Granahan Investment Management, LLC | 0.15% | Add +16.5% | 1,116,629 | $3.7M |
| Tang Capital Management LLC | 0.11% | No change | 900,000 | $2.9M |
| Stempoint Capital LP | 0.55% | Reduce -30.3% | 839,669 | $2.7M |
| Quantum Private Wealth, LLC | 0.79% | Add +0.8% | 822,076 | $2.7M |
| Sands Capital Alternatives, LLC | 0.52% | No change | 724,873 | $2.4M |
| Alphabet Inc. | 0.09% | No change | 640,882 | $2.1M |
| UBS Group AG | 0.00% | Add +144.7% | 639,356 | $2.1M |
| Bank of New York Mellon Corp | 0.00% | Add +36.2% | 624,839 | $2.0M |
| Anson Funds Management LP | 0.23% | Reduce -24.9% | 603,500 | $2.0M |
| Royal Bank of Canada | 0.00% | Add +17.8% | 583,375 | $1.9M |
| Rice Hall James & Associates, LLC | 0.10% | New | 578,118 | $1.9M |
| Wellington Management Group LLP | 0.00% | Reduce -10.7% | 568,006 | $1.9M |
| Jane Street Group, LLC | 0.00% | Add +306.4% | 556,785 | $1.8M |
| Nuveen, LLC | 0.00% | Add +9.0% | 507,210 | $1.7M |
| Woodline Partners LP | 0.01% | Reduce -50.0% | 500,000 | $1.6M |
| Gsa Capital Partners LLP | 0.13% | Add +969.0% | 477,749 | $1.6M |
| Marshall Wace, LLP | 0.00% | Add +499.9% | 476,865 | $1.6M |
| Acuta Capital Partners, LLC | 1.54% | Reduce -6.3% | 454,827 | $1.5M |
| Boothbay Fund Management, LLC | 0.04% | New | 415,607 | $1.4M |
| Sphera Funds Management LTD. | 0.32% | Reduce -2.8% | 408,146 | $1.3M |
| Citadel Advisors | 0.00% | Reduce -30.6% | 367,309 | $1.2M |
| Dimensional Fund Advisors LP | 0.00% | New | 345,163 | $1.1M |
| NorthCoast Asset Management LLC | 0.00% | No change | 298,667 | $977K |
| JPMorgan Chase & Co. | 0.00% | Add +33.0% | 296,244 | $969K |
| Rhumbline Advisers | 0.00% | Add +23.8% | 288,859 | $945K |
| Invesco Ltd. | 0.00% | Add +37.4% | 279,793 | $915K |
| Chicago Partners Investment Group LLC | 0.02% | Add +0.2% | 164,037 | $819K |
| Rafferty Asset Management, LLC | 0.00% | Add +102.0% | 239,785 | $784K |
| Squarepoint Ops LLC | 0.00% | Add +97.9% | 198,352 | $649K |
| Alliancebernstein L.P. | 0.00% | Add +0.0% | 179,640 | $587K |
| Readystate Asset Management LP | 0.05% | New | 161,972 | $530K |
| Palumbo Wealth Management LLC | 0.16% | New | 157,353 | $515K |
| AQR Capital Management | 0.00% | Add +11.2% | 151,000 | $494K |
| Wells Fargo & Company | 0.00% | Add +35.3% | 145,098 | $474K |
| Privium Fund Management B.V. | 0.08% | No change | 134,900 | $441K |
| MetLife Investment Management, LLC | 0.00% | Add +17.6% | 127,044 | $415K |
| Deutsche Bank AG | 0.00% | Add +14.0% | 122,799 | $402K |
| T. Rowe Price Associates Inc. | 0.00% | Add +34.5% | 113,835 | $373K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +15.0% | 111,024 | $362K |
| Franklin Resources Inc. | 0.00% | No change | 108,399 | $354K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Add +0.2% | 80,732 | $264K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +14.5% | 69,857 | $228K |
| Intech Investment Management LLC | 0.00% | Reduce -16.5% | 68,626 | $224K |
| New York State Common Retirement Fund | 0.00% | Add +220.4% | 67,600 | $221K |
| Militia Capital Partners, LP | 0.10% | No change | 66,800 | $218K |
| Two Sigma Investments, LP | 0.00% | Add +102.3% | 66,105 | $216K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -3.0% | 58,257 | $191K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +25.1% | 57,168 | $187K |
| Engineers Gate Manager LP | 0.00% | Reduce -17.2% | 53,483 | $175K |
| Profund Advisors LLC | 0.01% | Add +100.6% | 53,366 | $175K |
| Jain Global LLC | 0.00% | New | 52,608 | $172K |
| Creative Planning | 0.00% | Add +0.5% | 52,226 | $171K |
| Axq Capital, LP | 0.06% | Reduce -12.8% | 49,677 | $162K |
| Virtu Financial LLC | 0.01% | New | 48,123 | $157K |
| China Universal Asset Management Co., Ltd. | 0.01% | Reduce -9.0% | 47,817 | $156K |
| Quadrature Capital Ltd | 0.00% | Reduce -70.8% | 47,328 | $154K |
| Brevan Howard Capital Management LP | 0.00% | New | 46,643 | $153K |
| ProShare Advisors LLC | 0.00% | Add +5.2% | 46,039 | $151K |
| BNP Paribas Financial Markets | 0.00% | Add +147.6% | 46,034 | $151K |
| Williams & Novak, LLC | 0.11% | No change | 45,000 | $147K |
| State of Wisconsin Investment Board | 0.00% | New | 42,949 | $140K |
| Virtus Investment Advisers, LLC | 0.04% | Add +21.0% | 42,938 | $140K |
| American Century Companies Inc. | 0.00% | New | 38,556 | $126K |
| Voya Investment Management LLC | 0.00% | Reduce -22.6% | 36,500 | $119K |
| Citigroup Inc. | 0.00% | Reduce -74.3% | 33,495 | $110K |
| SG Americas Securities, LLC | 0.00% | Reduce -93.3% | 32,949 | $108K |
| First Manhattan Co. Llc. | 0.00% | No change | 28,500 | $93K |
| Prudential Financial Inc. | 0.00% | Add +24.4% | 28,345 | $93K |
| Leonteq Securities AG | 0.00% | No change | 27,999 | $92K |
| Sender Co & Partners, Inc. | 0.03% | New | 27,121 | $89K |
| Ethic Inc. | 0.00% | Reduce -7.8% | 25,784 | $84K |
| Victory Capital Management Inc. | 0.00% | Add +0.4% | 25,600 | $84K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | No change | 23,690 | $77K |
| Legal & General Group Plc | 0.00% | Add +25.8% | 23,149 | $76K |
| CIBC Bancorp USA Inc. | 0.00% | — | 22,643 | $74K |
| Susquehanna International Group, LLP | 0.00% | Reduce -89.8% | 21,742 | $71K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -8.5% | 21,820 | $71K |
| Lee Financial Co | 0.01% | No change | 20,000 | $65K |
| Russell Investments Group, Ltd. | 0.00% | New | 18,165 | $59K |
| Xponance LLC | 0.00% | Add +29.1% | 16,575 | $54K |
| DRW Securities, LLC | 0.00% | New | 16,389 | $53K |
| Principal Financial Group Inc. | 0.00% | Add +33.6% | 16,251 | $53K |
| Cetera Investment Advisers | 0.00% | New | 16,162 | $53K |
| R Squared Ltd | 0.02% | New | 16,094 | $53K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 15,672 | $51K |
| Allegheny Financial Group | 0.01% | New | 15,000 | $49K |
| Bank of Montreal | 0.00% | New | 13,668 | $45K |
| Cwm, LLC | 0.00% | Reduce -0.5% | 12,885 | $42K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0.06% | New | 12,200 | $40K |
| Mackenzie Financial Corp. | 0.00% | No change | 11,214 | $37K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +4.4% | 10,546 | $34K |
| California State Teachers Retirement System | 0.00% | Reduce -17.9% | 10,373 | $34K |
| Aigen Investment Management, LP | 0.01% | New | 10,367 | $34K |
| Capital Investment Advisors, LLC | 0.00% | No change | 10,000 | $33K |
| St Germain D J Co. Inc. | 0.00% | Add +81.8% | 9,633 | $32K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -62.5% | 6,607 | $22K |
| Nisa Investment Advisors, LLC | 0.00% | Add +56.7% | 5,872 | $19K |
| GF Fund Management Co. LTD. | 0.00% | Add +11.8% | 5,869 | $19K |
| Amalgamated Bank | 0.00% | No change | 5,534 | $18K |
| Rockefeller Capital Management L.P. | 0.00% | New | 5,000 | $16K |
| FNY Investment Advisers, LLC | 0.00% | New | 4,289 | $14K |
| Wexford Capital LP | 0.00% | New | 3,500 | $11K |
| Caitong International Asset Management Co., Ltd | 0.01% | Add +49.2% | 3,204 | $10K |
| Simplex Trading, LLC | 0.00% | Reduce -16.6% | 2,722 | $8K |
| Optiver Holding B.V. | 0.00% | Add +9.9% | 2,269 | $7K |
| Group One Trading LLC | 0.00% | New | 1,754 | $6K |
| PNC Financial Services Group, Inc. | 0.00% | Add +30.8% | 1,308 | $4K |
| Aster Capital Management (DIFC) Ltd | 0.00% | New | 1,280 | $4K |
| US Bancorp \de | 0.00% | Reduce -6.5% | 912 | $3K |
| Clearstead Advisors, LLC | 0.00% | No change | 690 | $2K |
| Sterling Capital Management LLC | 0.00% | Add +26.2% | 515 | $2K |
| Essential Partners LLC | 0.00% | No change | 327 | $1K |
| Parallel Advisors, LLC | 0.00% | No change | 280 | $916 |
| Morton Brown Family Wealth, LLC | 0.00% | No change | 260 | $850 |
| Allworth Financial LP | 0.00% | New | 215 | $704 |
| Osaic Holdings, Inc. | 0.00% | No change | 134 | $426 |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -55.6% | 91 | $298 |
| Farther Finance Advisors, LLC | 0.00% | New | 55 | $180 |
| True Wealth Design, LLC | 0.00% | No change | 30 | $99 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -80.0% | 16 | $52 |
| IFP Advisors, Inc | 0.00% | No change | 14 | $46 |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 79 | $0 |
"% of holder's portfolio" is TSHA's weight in each manager's 13F, not the share of Taysha Gene Therapies Inc. the manager owns.