Tyra BiosciencesTYRA
13F holders, Q4 2025 (December 31)133holders +17
23new positions
10sold out
4famous investors
$26.29avg. 13F price*
At the end of Q4 2025, 133 institutions reported holding Tyra Biosciences Inc. (TYRA) in their 13F filings, up 17 from Q3 2025. 23 opened new positions and 10 sold out. The largest holders were Ra Capital Management, L.P. ($320.7M), Nextech Invest Ltd. ($106.6M) and Alta Partners Management Company, L.P. ($100.5M). 4 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Tyra Biosciences Inc.
- CUSIP
- 90240B106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 23 | $33.6M |
| Exits | 10 | $10.5M |
All 13F filers, Q3 2025 → Q4 2025: 4,442,997 shares bought and 4,321,507 shares sold, net +121,490 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 133 holders
| Ra Capital Management, L.P. | 3.29% | No change | 12,198,625 | $320.7M |
| Nextech Invest Ltd. | 10.31% | No change | 4,055,861 | $106.6M |
| Alta Partners Management Company, L.P. | 97.03% | Reduce -6.3% | 3,823,425 | $100.5M |
| Commodore Capital LP | 5.91% | No change | 3,375,000 | $88.7M |
| Canaan Partners XI LLC | 64.85% | Reduce -6.5% | 3,374,329 | $88.7M |
| Janus Henderson Group PLC | 0.03% | Add +2.1% | 2,935,442 | $77.1M |
| TCG Crossover Management, LLC | 2.52% | No change | 2,898,103 | $76.2M |
| Vestal Point Capital, LP | 2.34% | No change | 2,425,000 | $63.8M |
| BVF Inc. | 1.88% | Reduce -41.7% | 2,127,665 | $55.9M |
| BlackRock, Inc. | 0.00% | Add +11.6% | 2,086,423 | $54.9M |
| Farallon Capital Management, L.L.C. | 0.28% | Add +80.7% | 2,066,818 | $54.3M |
| Vanguard Group Inc. | 0.00% | Add +3.5% | 1,572,785 | $41.3M |
| Kynam Capital Management, LP | 2.68% | Reduce -32.9% | 1,564,492 | $41.1M |
| 5AM Venture Management, LLC | 8.51% | Add +9.6% | 1,029,298 | $27.1M |
| Caligan Partners LP | 2.27% | Add +35.5% | 944,257 | $24.8M |
| Point72 Asset Management | 0.04% | Add +210.0% | 874,192 | $23.0M |
| Balyasny Asset Management L.P. | 0.04% | Reduce -3.3% | 818,326 | $21.5M |
| State Street Corp. | 0.00% | Add +74.9% | 749,463 | $19.7M |
| Marshall Wace, LLP | 0.02% | Add +18.3% | 711,891 | $18.7M |
| Trails Edge Capital Partners, LP | 4.55% | — | 700,000 | $18.4M |
| Geode Capital Management, LLC | 0.00% | Add +10.1% | 657,756 | $17.3M |
| Sio Capital Management, LLC | 2.29% | Add +2.1% | 526,002 | $13.8M |
| Boone Capital Management LLC | 3.29% | New | 398,482 | $10.5M |
| Elmind Capital, LP | 2.72% | — | 350,000 | $9.2M |
| Eversept Partners, LP | 0.41% | Add +2.1% | 278,564 | $7.3M |
| Boothbay Fund Management, LLC | 0.16% | Add +18.5% | 221,177 | $5.8M |
| Logos Global Management LP | 0.37% | New | 210,000 | $5.5M |
| Northern Trust Corp. | 0.00% | Reduce -3.6% | 200,956 | $5.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -1.1% | 199,426 | $5.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +82.1% | 182,387 | $4.8M |
| Raymond James Financial Inc. | 0.00% | Add +34.5% | 170,032 | $4.5M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | New | 129,779 | $3.4M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Reduce -48.4% | 129,753 | $3.4M |
| Invesco Ltd. | 0.00% | Add +734.5% | 129,435 | $3.4M |
| Soleus Capital Management, L.P. | 0.14% | New | 125,000 | $3.3M |
| BNP Paribas Financial Markets | 0.00% | Reduce -6.7% | 120,278 | $3.2M |
| Morgan Stanley | 0.00% | Reduce -63.1% | 118,898 | $3.1M |
| Millennium Management | 0.00% | Reduce -20.6% | 114,388 | $3.0M |
| Two Sigma Investments, LP | 0.00% | Reduce -46.3% | 107,023 | $2.8M |
| Wellington Management Group LLP | 0.00% | Add +25.9% | 104,305 | $2.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +141.0% | 95,640 | $2.5M |
| Investment Counsel Co. of Nevada | 4.80% | No change | 85,020 | $2.2M |
| Oppenheimer & Co. Inc. | 0.03% | Add +3.0% | 84,726 | $2.2M |
| Seven Fleet Capital Management LP | 1.42% | — | 79,560 | $2.1M |
| Barclays PLC | 0.00% | Add +33.6% | 76,309 | $2.0M |
| Kalehua Capital Management LLC | 1.94% | — | 74,465 | $2.0M |
| JPMorgan Chase & Co. | 0.00% | Reduce -4.1% | 71,175 | $1.9M |
| Bank of New York Mellon Corp | 0.00% | Add +6.5% | 60,901 | $1.6M |
| Two Sigma Advisers, LP | 0.00% | Reduce -48.0% | 58,900 | $1.5M |
| UBS Group AG | 0.00% | Reduce -0.5% | 58,856 | $1.5M |
| Superstring Capital Management LP | 0.83% | New | 58,677 | $1.5M |
| Susquehanna International Group, LLP | 0.00% | New | 55,135 | $1.4M |
| Ameriprise Financial Inc. | 0.00% | Reduce -37.3% | 54,625 | $1.4M |
| Squarepoint Ops LLC | 0.00% | Add +345.6% | 54,424 | $1.4M |
| Susquehanna Portfolio Strategies, LLC | 0.02% | No change | 48,644 | $1.3M |
| Nuveen, LLC | 0.00% | Reduce -41.1% | 47,349 | $1.2M |
| Algert Global LLC | 0.02% | New | 46,870 | $1.2M |
| American Century Companies Inc. | 0.00% | Add +20.4% | 46,227 | $1.2M |
| Y-Intercept (Hong Kong) Ltd | 0.03% | New | 45,942 | $1.2M |
| Alps Advisors Inc. | 0.01% | Add +77.4% | 43,827 | $1.2M |
| ExodusPoint Capital Management, LP | 0.01% | New | 42,791 | $1.1M |
| PDT Partners, LLC | 0.07% | Reduce -2.4% | 42,284 | $1.1M |
| State of Wisconsin Investment Board | 0.00% | Add +31.6% | 39,023 | $1.0M |
| Rhumbline Advisers | 0.00% | Reduce -4.5% | 38,790 | $1.0M |
| Bank of America Corp. | 0.00% | Reduce -71.5% | 38,310 | $1.0M |
| HighVista Strategies LLC | 0.24% | Reduce -46.7% | 35,086 | $922K |
| Alliancebernstein L.P. | 0.00% | Reduce -3.8% | 31,990 | $841K |
| XTX Topco Ltd | 0.02% | Reduce -9.8% | 30,414 | $800K |
| Voya Investment Management LLC | 0.00% | New | 29,887 | $786K |
| Wells Fargo & Company | 0.00% | Add +57.3% | 29,049 | $764K |
| Canada Pension Plan Investment Board | 0.00% | New | 28,900 | $760K |
| Fisher Asset Management | 0.00% | New | 28,800 | $757K |
| AQR Capital Management | 0.00% | Add +2.0% | 28,631 | $753K |
| PSP Research LLC | 0.50% | — | 21,853 | $575K |
| Auour Investments LLC | 0.18% | No change | 21,020 | $553K |
| Creative Planning | 0.00% | New | 19,603 | $515K |
| Victory Capital Management Inc. | 0.00% | No change | 18,790 | $494K |
| Public Employees Retirement System of Ohio | 0.00% | Reduce -25.7% | 18,542 | $487K |
| Deutsche Bank AG | 0.00% | Add +5.8% | 16,377 | $431K |
| Rafferty Asset Management, LLC | 0.00% | New | 15,455 | $406K |
| MetLife Investment Management, LLC | 0.00% | Add +5.0% | 15,356 | $404K |
| T. Rowe Price Associates Inc. | 0.00% | Add +12.7% | 14,432 | $380K |
| Russell Investments Group, Ltd. | 0.00% | Add +2.0% | 12,996 | $342K |
| Franklin Resources Inc. | 0.00% | New | 12,970 | $341K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +14.1% | 12,908 | $339K |
| FMR LLC | 0.00% | Add +0.3% | 12,563 | $330K |
| Virtus Investment Advisers, LLC | 0.08% | Add +6.7% | 11,756 | $309K |
| Bank of Nova Scotia | 0.00% | New | 11,100 | $292K |
| Baker Bros. Advisors LP | 0.00% | No change | 10,607 | $279K |
| Intech Investment Management LLC | 0.00% | Reduce -14.0% | 9,801 | $258K |
| VARCOV Co. | 0.10% | — | 9,708 | $255K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -6.9% | 8,697 | $229K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 8,357 | $220K |
| New York State Common Retirement Fund | 0.00% | No change | 7,423 | $195K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 6,440 | $169K |
| Citigroup Inc. | 0.00% | Add +123.6% | 3,817 | $100K |
| Bellevue Group AG | 0.00% | New | 3,143 | $83K |
| Caitong International Asset Management Co., Ltd | 0.02% | New | 2,997 | $79K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +25.9% | 2,594 | $68K |
| Legal & General Group Plc | 0.00% | Add +8.0% | 2,367 | $62K |
| AlphaQuest LLC | 0.00% | Reduce -92.9% | 2,139 | $56K |
| Chung Wu Investment Group, LLC | 0.04% | New | 2,000 | $53K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,991 | $52K |
| California State Teachers Retirement System | 0.00% | Add +8.3% | 1,595 | $42K |
| Cwm, LLC | 0.00% | Add +1.1% | 1,546 | $41K |
| Sterling Capital Management LLC | 0.00% | Reduce -10.5% | 1,488 | $39K |
| Federated Hermes, Inc. | 0.00% | Reduce -39.8% | 1,297 | $34K |
| Osaic Holdings, Inc. | 0.00% | Reduce -0.3% | 1,188 | $31K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.6% | 1,048 | $28K |
| Versant Capital Management, Inc | 0.00% | No change | 819 | $22K |
| Amalgamated Bank | 0.00% | Add +16.1% | 814 | $21K |
| Royal Bank of Canada | 0.00% | Reduce -35.8% | 742 | $19K |
| STRS Ohio | 0.00% | No change | 700 | $18K |
| GAMMA Investing LLC | 0.00% | Add +51.8% | 472 | $12K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -62.1% | 331 | $9K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 208 | $5K |
| Daiwa Securities Group Inc. | 0.00% | No change | 173 | $5K |
| Larson Financial Group LLC | 0.00% | Add +5.8% | 146 | $4K |
| True Wealth Design, LLC | 0.00% | No change | 142 | $4K |
| Optiver Holding B.V. | 0.00% | Reduce -65.2% | 128 | $3K |
| Smartleaf Asset Management LLC | 0.00% | New | 127 | $3K |
| Allworth Financial LP | 0.00% | No change | 100 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 86 | $2K |
| Rockefeller Capital Management L.P. | 0.00% | New | 84 | $2K |
| Steward Partners Investment Advisory, LLC | 0.00% | New | 77 | $2K |
| Farther Finance Advisors, LLC | 0.00% | Add +445.4% | 60 | $2K |
| Rothschild Investment LLC | 0.00% | No change | 55 | $1K |
| Signaturefd, LLC | 0.00% | No change | 43 | $1K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -4.5% | 42 | $1K |
| Clearstead Advisors, LLC | 0.00% | Reduce -76.8% | 29 | $759 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -20.0% | 4 | $105 |
| Arax Advisory Partners | 0.00% | Reduce -96.5% | 3 | $79 |
| Covestor Ltd | 0.00% | No change | 6 | $0 |
"% of holder's portfolio" is TYRA's weight in each manager's 13F, not the share of Tyra Biosciences Inc. the manager owns.