Xenon PharmaceuticalsXENE
13F holders, Q2 2025 (June 30)206holders
42new positions
39sold out
5famous investors
$31.30avg. 13F price*
At the end of Q2 2025, 206 institutions reported holding Xenon Pharmaceuticals Inc. (XENE) in their 13F filings, unchanged from Q1 2025. 42 opened new positions and 39 sold out. The largest holders were FMR LLC ($278.1M), Avoro Capital Advisors LLC ($169.0M) and BlackRock, Inc. ($167.9M). 5 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ron Baron (0.0% of Baron Capital (BAMCO)'s portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Xenon Pharmaceuticals Inc.
- CUSIP
- 98420N105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 42 | $150.7M |
| Exits | 39 | $141.0M |
All 13F filers, Q1 2025 → Q2 2025: 19,022,618 shares bought and 12,528,093 shares sold, net +6,494,525 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 206 holders
| FMR LLC | 0.02% | Add +7.2% | 8,884,363 | $278.1M |
| Avoro Capital Advisors LLC | 2.96% | Reduce -6.0% | 5,400,000 | $169.0M |
| BlackRock, Inc. | 0.00% | Add +163.5% | 5,365,327 | $167.9M |
| Driehaus Capital Management LLC | 1.09% | Reduce -5.4% | 4,335,648 | $135.7M |
| Braidwell LP | 5.40% | Add +33.0% | 3,605,029 | $112.8M |
| Janus Henderson Group PLC | 0.05% | Add +7.6% | 3,577,735 | $112.0M |
| Capital International Investors | 0.02% | Add +3.0% | 3,181,549 | $99.6M |
| Commodore Capital LP | 6.68% | Add +30.1% | 3,025,000 | $94.7M |
| Polar Capital Holdings Plc | 0.45% | Add +3.1% | 2,703,256 | $84.6M |
| Wellington Management Group LLP | 0.01% | Reduce -42.6% | 2,174,761 | $68.1M |
| Vestal Point Capital, LP | 3.30% | Add +53.9% | 2,000,000 | $62.6M |
| Holocene Advisors, LP | 0.14% | New | 1,809,475 | $56.6M |
| Alliancebernstein L.P. | 0.02% | Add +14.2% | 1,518,527 | $47.5M |
| Pictet Asset Management Holding SA | 0.05% | Reduce -0.2% | 1,474,449 | $46.2M |
| State Street Corp. | 0.00% | Add +351.7% | 1,380,460 | $43.2M |
| Deep Track Capital, LP | 1.36% | Add +35.0% | 1,350,000 | $42.3M |
| Adage Capital Partners Gp, L.L.C. | 0.07% | Reduce -32.6% | 1,290,100 | $40.4M |
| JPMorgan Chase & Co. | 0.00% | Reduce -7.4% | 1,256,581 | $39.3M |
| Westfield Capital Management Co. LP | 0.15% | Reduce -17.2% | 1,152,605 | $36.1M |
| Affinity Asset Advisors, LLC | 5.31% | Reduce -17.2% | 1,100,000 | $34.4M |
| Marshall Wace, LLP | 0.04% | Add +34.6% | 1,020,254 | $31.9M |
| Geode Capital Management, LLC | 0.00% | Add +1294.2% | 970,343 | $30.4M |
| Orbimed Advisors LLC | 0.75% | No change | 947,877 | $29.7M |
| Rock Springs Capital Management LP | 1.82% | No change | 931,681 | $29.2M |
| Millennium Management | 0.03% | Add +277.2% | 882,835 | $27.6M |
| Vanguard Group Inc. | 0.00% | Add +159.5% | 873,228 | $27.3M |
| Siren, L.L.C. | 1.32% | Add +10.9% | 812,761 | $25.4M |
| Jennison Associates LLC | 0.01% | Reduce -10.3% | 696,383 | $21.8M |
| American Century Companies Inc. | 0.01% | New | 679,857 | $21.3M |
| Franklin Resources Inc. | 0.01% | Add +35.7% | 666,466 | $20.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.05% | Reduce -6.1% | 661,082 | $20.7M |
| First Turn Management, LLC | 3.86% | Reduce -3.3% | 660,617 | $20.7M |
| Loomis Sayles & Co. L P | 0.03% | Reduce -2.4% | 657,165 | $20.6M |
| Capital World Investors | 0.00% | Reduce -70.5% | 655,737 | $20.5M |
| TimesSquare Capital Management, LLC | 0.26% | Reduce -23.4% | 571,242 | $17.9M |
| Goldman Sachs Group Inc. | 0.00% | Add +26.9% | 561,800 | $17.6M |
| Deerfield Management Company, L.P. | 0.34% | New | 542,020 | $17.0M |
| Fiera Capital Corp | 0.06% | Add +0.2% | 530,683 | $16.6M |
| Aberdeen Group plc | 0.03% | Add +29.0% | 521,492 | $16.3M |
| Northern Trust Corp. | 0.00% | Add +504.7% | 489,940 | $15.3M |
| Saturn V Capital Management LP | 5.94% | Add +13.2% | 468,364 | $14.7M |
| Assenagon Asset Management S.A. | 0.02% | Add +81.2% | 436,974 | $13.7M |
| Bank of New York Mellon Corp | 0.00% | Add +73.6% | 436,020 | $13.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +536.1% | 404,384 | $12.7M |
| Candriam S.C.A. | 0.07% | Reduce -12.8% | 396,636 | $12.4M |
| Morgan Stanley | 0.00% | Add +199.3% | 387,596 | $12.1M |
| Dimensional Fund Advisors LP | 0.00% | Add +76.8% | 379,988 | $11.9M |
| Baker Bros. Advisors LP | 0.11% | Add +6.6% | 370,208 | $11.6M |
| Bank of America Corp. | 0.00% | Add +162.4% | 358,432 | $11.2M |
| MPM Bioimpact LLC | 1.75% | Add +6.6% | 323,398 | $10.1M |
| DAFNA Capital Management LLC | 2.52% | Add +5.2% | 287,939 | $9.0M |
| ADAR1 Capital Management, LLC | 1.33% | Add +103.5% | 259,503 | $8.1M |
| Granahan Investment Management, LLC | 0.31% | Add +30.6% | 240,038 | $7.5M |
| DNB Asset Management AS | 0.03% | Add +2.0% | 234,157 | $7.3M |
| Federated Hermes, Inc. | 0.01% | No change | 232,500 | $7.3M |
| Nuveen, LLC | 0.00% | New | 228,567 | $7.2M |
| Susquehanna International Group, LLP | 0.01% | New | 222,352 | $7.0M |
| Perceptive Advisors LLC | 0.24% | Reduce -38.3% | 200,791 | $6.3M |
| Great Point Partners LLC | 4.07% | Reduce -18.5% | 200,000 | $6.3M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 192,242 | $6.0M |
| First Light Asset Management, LLC | 0.76% | Reduce -70.0% | 188,367 | $5.9M |
| AXA S.A. | 0.02% | Add +0.2% | 175,632 | $5.5M |
| State of Wisconsin Investment Board | 0.01% | Add +80.0% | 174,850 | $5.5M |
| New York State Common Retirement Fund | 0.01% | Add +16.9% | 166,472 | $5.2M |
| Foresite Capital Management IV, LLC | 4.05% | New | 160,000 | $5.0M |
| Foresite Capital Management VI LLC | 2.82% | New | 160,000 | $5.0M |
| Nan Fung Trinity (hk) Ltd. | 0.59% | New | 158,605 | $5.0M |
| UBS Group AG | 0.00% | Add +45.3% | 153,058 | $4.8M |
| Barclays PLC | 0.00% | Add +692.8% | 152,770 | $4.8M |
| Parkman Healthcare Partners LLC | 0.54% | Reduce -13.9% | 150,373 | $4.7M |
| Neuberger Berman Group LLC | 0.00% | Add +228.7% | 147,411 | $4.6M |
| Royal Bank of Canada | 0.00% | Add +148.0% | 147,226 | $4.6M |
| D. E. Shaw & Co. | 0.00% | Reduce -6.8% | 141,783 | $4.4M |
| Schroder Investment Management Group | 0.00% | Reduce -5.9% | 129,103 | $4.0M |
| Swiss National Bank | 0.00% | Reduce -1.0% | 124,300 | $3.9M |
| Ameriprise Financial Inc. | 0.00% | Add +17.8% | 122,026 | $3.8M |
| Citadel Advisors | 0.00% | Reduce -82.5% | 120,045 | $3.8M |
| Wells Fargo & Company | 0.00% | Add +70.8% | 112,562 | $3.5M |
| Rhumbline Advisers | 0.00% | Add +378175.9% | 109,700 | $3.4M |
| Avidity Partners Management LP | 0.68% | Reduce -52.9% | 107,891 | $3.4M |
| Deutsche Bank AG | 0.00% | Add +94.6% | 104,534 | $3.3M |
| Algert Global LLC | 0.07% | Reduce -17.1% | 102,345 | $3.2M |
| Caption Management, LLC | 0.29% | New | 100,940 | $3.2M |
| Mutual of America Capital Management LLC | 0.03% | Add +96.0% | 95,568 | $3.0M |
| Two Sigma Advisers, LP | 0.01% | Reduce -68.1% | 95,300 | $3.0M |
| Moore Capital Management, LP | 0.06% | Add +63.6% | 90,000 | $2.8M |
| J. Safra Sarasin Holding AG | 0.04% | Add +168.4% | 82,048 | $2.6M |
| Legal & General Group Plc | 0.00% | Add +35.4% | 81,792 | $2.6M |
| Soleus Capital Management, L.P. | 0.17% | New | 78,800 | $2.5M |
| T. Rowe Price Investment Management, Inc. | 0.00% | Reduce -90.3% | 76,943 | $2.4M |
| Nicholas Investment Partners, LP | 0.22% | Reduce -20.8% | 68,896 | $2.2M |
| Balyasny Asset Management L.P. | 0.01% | Reduce -74.2% | 68,869 | $2.2M |
| Raymond James Financial Inc. | 0.00% | Add +2.9% | 65,214 | $2.0M |
| Man Group plc | 0.00% | New | 62,348 | $2.0M |
| State of New Jersey Common Pension Fund D | 0.01% | Add +22.5% | 61,772 | $1.9M |
| California State Teachers Retirement System | 0.00% | Add +8.5% | 60,233 | $1.9M |
| Nebula Research & Development LLC | 0.16% | Add +29.3% | 60,223 | $1.9M |
| Invesco Ltd. | 0.00% | Reduce -71.0% | 59,598 | $1.9M |
| Voya Investment Management LLC | 0.00% | Add +23.7% | 59,465 | $1.9M |
| Baron Capital (BAMCO) | 0.00% | Reduce -44.1% | 56,000 | $1.8M |
| Russell Investments Group, Ltd. | 0.00% | Reduce -30.8% | 52,136 | $1.6M |
| Erste Asset Management GmbH | 0.01% | No change | 50,000 | $1.6M |
| Prudential Financial Inc. | 0.00% | Add +22.4% | 47,755 | $1.5M |
| Skandinaviska Enskilda Banken AB (publ) | 0.01% | No change | 47,457 | $1.5M |
| HighVista Strategies LLC | 0.52% | Reduce -31.7% | 45,620 | $1.4M |
| MetLife Investment Management, LLC | 0.01% | New | 45,547 | $1.4M |
| Jane Street Group, LLC | 0.00% | New | 43,676 | $1.4M |
| Woodline Partners LP | 0.01% | New | 43,380 | $1.4M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 41,648 | $1.3M |
| Alps Advisors Inc. | 0.01% | Reduce -25.2% | 41,380 | $1.3M |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 39,000 | $1.3M |
| Artia Global Partners LP | 0.32% | No change | 40,000 | $1.3M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -8.0% | 39,403 | $1.2M |
| T. Rowe Price Associates Inc. | 0.00% | New | 37,935 | $1.2M |
| Citigroup Inc. | 0.00% | Add +416.3% | 36,290 | $1.1M |
| Rhenman & Partners Asset Management AB | 0.14% | No change | 35,000 | $1.1M |
| Intech Investment Management LLC | 0.01% | New | 34,312 | $1.1M |
| TLS Advisors LLC | 3.22% | No change | 32,956 | $1.0M |
| Harbor Capital Advisors, Inc. | 0.04% | Reduce -46.9% | 30,036 | $940K |
| HighMark Wealth Management LLC | 0.40% | Add +327.9% | 26,100 | $817K |
| Ensign Peak Advisors, Inc | 0.00% | No change | 26,094 | $817K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 26,079 | $816K |
| Polar Asset Management Partners Inc. | 0.03% | New | 25,300 | $792K |
| NJ State Employees Deferred Compensation Plan | 0.09% | No change | 25,000 | $783K |
| Readystate Asset Management LP | 0.06% | New | 24,814 | $777K |
| CenterBook Partners LP | 0.04% | Add +11.0% | 24,664 | $772K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +25.9% | 23,866 | $747K |
| Rathbones Group PLC | 0.00% | No change | 23,666 | $741K |
| Sei Investments Co. | 0.00% | Add +141.6% | 22,723 | $711K |
| Handelsbanken Fonder AB | 0.00% | No change | 22,700 | $711K |
| Assetmark, Inc. | 0.00% | Add +6.6% | 21,250 | $665K |
| Oxford Asset Management LLP | 0.22% | Add +242.4% | 21,138 | $662K |
| Birchview Capital, LP | 0.65% | No change | 21,000 | $657K |
| Stifel Financial Corp. | 0.00% | Add +0.5% | 20,622 | $645K |
| SG Americas Securities, LLC | 0.00% | Add +121.6% | 19,177 | $600K |
| Arizona State Retirement System | 0.00% | Add +2.0% | 18,956 | $593K |
| ProShare Advisors LLC | 0.00% | New | 18,448 | $577K |
| BNP Paribas Financial Markets | 0.00% | Add +455.9% | 17,844 | $559K |
| Teacher Retirement System of Texas | 0.00% | Add +0.5% | 17,534 | $549K |
| Natixis Advisors, LLC | 0.00% | Reduce -27.4% | 17,424 | $545K |
| Police & Firemen's Retirement System of New Jersey | 0.01% | New | 17,358 | $543K |
| Jump Financial, LLC | 0.01% | New | 16,991 | $532K |
| Cibc World Market Inc. | 0.00% | No change | 16,335 | $511K |
| China Universal Asset Management Co., Ltd. | 0.05% | Add +0.4% | 15,412 | $482K |
| PEAK6 LLC | 0.02% | New | 15,000 | $470K |
| Orion Porfolio Solutions, LLC | 0.00% | Reduce -4.0% | 14,916 | $467K |
| KLP Kapitalforvaltning As | 0.00% | No change | 12,800 | $401K |
| Advisors Asset Management, Inc. | 0.01% | Reduce -14.5% | 12,205 | $382K |
| Supplemental Annuity Collective Trust of NJ | 0.10% | No change | 11,000 | $344K |
| Knott David M Jr | 0.16% | Reduce -30.9% | 10,962 | $343K |
| Elmwood Wealth Management, Inc. | 0.13% | Reduce -1.7% | 10,824 | $339K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 10,633 | $333K |
| Schonfeld Strategic Advisors LLC | 0.00% | Reduce -54.1% | 10,538 | $330K |
| Legato Capital Management LLC | 0.04% | No change | 9,622 | $301K |
| Allianz Asset Management GmbH | 0.00% | No change | 9,400 | $294K |
| Cibc World Markets Corp. | 0.00% | New | 9,363 | $293K |
| Renaissance Technologies | 0.00% | Reduce -94.4% | 8,600 | $269K |
| Ameritas Investment Partners, Inc. | 0.01% | New | 7,758 | $243K |
| CANADA LIFE ASSURANCE Co | 0.00% | No change | 7,024 | $220K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +10614.0% | 5,357 | $168K |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 5,000 | $157K |
| Group One Trading LLC | 0.00% | New | 4,653 | $146K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -33.7% | 3,462 | $108K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +15.7% | 2,964 | $93K |
| Virtus Investment Advisers, LLC | 0.03% | Reduce -31.1% | 2,867 | $90K |
| Amalgamated Bank | 0.00% | New | 2,595 | $81K |
| Quarry LP | 0.02% | No change | 2,000 | $63K |
| IFP Advisors, Inc | 0.00% | Reduce -2.9% | 1,865 | $62K |
| GF Fund Management Co. LTD. | 0.00% | No change | 1,952 | $61K |
| KBC Group NV | 0.00% | Reduce -32.2% | 1,871 | $59K |
| L1 Capital Pty Ltd | 0.00% | New | 1,296 | $41K |
| Osaic Holdings, Inc. | 0.00% | Add +541.4% | 1,225 | $40K |
| Elevation Point Wealth Partners, LLC | 0.00% | New | 1,015 | $32K |
| Danske Bank A/S | 0.00% | New | 800 | $25K |
| Farther Finance Advisors, LLC | 0.00% | New | 784 | $25K |
| Nisa Investment Advisors, LLC | 0.00% | New | 689 | $22K |
| Signaturefd, LLC | 0.00% | Add +257.3% | 661 | $21K |
| State of Wyoming | 0.00% | Reduce -5.8% | 541 | $17K |
| Clearstead Advisors, LLC | 0.00% | Add +59.2% | 347 | $11K |
| First Horizon Advisors, Inc. | 0.00% | Reduce -6.8% | 345 | $11K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | No change | 276 | $9K |
| Daiwa Securities Group Inc. | 0.00% | No change | 252 | $8K |
| National Bank of Canada | 0.00% | No change | 235 | $7K |
| Cwm, LLC | 0.00% | Reduce -0.8% | 237 | $7K |
| United Community Bank | 0.00% | New | 200 | $6K |
| Spire Wealth Management | 0.00% | No change | 200 | $6K |
| Sterling Capital Management LLC | 0.00% | New | 184 | $6K |
| US Bancorp \de | 0.00% | Reduce -34.2% | 181 | $6K |
| Parallel Advisors, LLC | 0.00% | Reduce -80.4% | 135 | $4K |
| Rothschild Investment LLC | 0.00% | New | 130 | $4K |
| Caitong International Asset Management Co., Ltd | 0.00% | Reduce -88.5% | 104 | $3K |
| Brooklyn Investment Group | 0.00% | New | 103 | $3K |
| J.Safra Asset Management Corp | 0.00% | Add +3.6% | 87 | $3K |
| Principal Securities, Inc. | 0.00% | Add +17.2% | 68 | $2K |
| Cape Investment Advisory, Inc. | 0.00% | New | 39 | $1K |
| Whittier Trust Co. of Nevada Inc. | 0.00% | No change | 36 | $1K |
| Allworth Financial LP | 0.00% | Add +191.7% | 35 | $1K |
| CVA Family Office, LLC | 0.00% | No change | 33 | $1K |
| Parkside Financial Bank & Trust | 0.00% | New | 30 | $939 |
| Blue Trust, Inc. | 0.00% | Reduce -89.6% | 28 | $876 |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -55.2% | 26 | $814 |
| Park Place Capital Corp | 0.00% | No change | 16 | $513 |
| GAMMA Investing LLC | 0.00% | Add +75.0% | 14 | $438 |
| Bell Investment Advisors, Inc | 0.00% | No change | 11 | $345 |
| American National Bank & Trust | 0.00% | New | 5 | $157 |
| Twin Peaks Wealth Advisors, LLC | 0.00% | New | 1 | $36 |
"% of holder's portfolio" is XENE's weight in each manager's 13F, not the share of Xenon Pharmaceuticals Inc. the manager owns.