Xenon PharmaceuticalsXENE
13F holders, Q1 2026 (March 31)At the end of Q1 2026, 290 institutions reported holding Xenon Pharmaceuticals Inc. (XENE) in their 13F filings, up 45 from Q4 2025. 74 opened new positions and 32 sold out. The largest holders were FMR LLC ($629.1M), Avoro Capital Advisors LLC ($336.0M) and BlackRock, Inc. ($328.0M). 8 famous investors held it, including Stanley Druckenmiller (0.5% of Duquesne Family Office's portfolio), Paul Tudor Jones (0.2% of Tudor Investment Corporation's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Xenon Pharmaceuticals Inc.
- CUSIP
- 98420N105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 74 | $363.1M |
| Exits | 32 | $91.5M |
All 13F filers, Q4 2025 → Q1 2026: 23,174,442 shares bought and 7,003,016 shares sold, net +16,171,426 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 290 holders
| FMR LLC | 0.03% | Add +21.3% | 10,818,491 | $629.1M |
| Avoro Capital Advisors LLC | 3.31% | Add +6.5% | 5,777,777 | $336.0M |
| BlackRock, Inc. | 0.01% | Add +10.6% | 5,640,118 | $328.0M |
| Wellington Management Group LLP | 0.05% | Add +1.4% | 4,829,641 | $280.8M |
| Driehaus Capital Management LLC | 1.92% | Reduce -1.0% | 4,491,653 | $261.2M |
| Polar Capital Holdings Plc | 1.12% | Add +78.7% | 4,405,312 | $256.2M |
| Janus Henderson Group PLC | 0.12% | Add +2.3% | 4,175,982 | $242.9M |
| Capital International Investors | 0.04% | Reduce -21.7% | 2,674,727 | $155.5M |
| Citadel Advisors | 0.11% | Add +100.8% | 2,652,990 | $154.3M |
| JPMorgan Chase & Co. | 0.01% | Add +28.8% | 1,923,610 | $106.9M |
| State Street Corp. | 0.00% | Add +15.3% | 1,720,533 | $100.0M |
| Affinity Asset Advisors, LLC | 5.83% | Add +34.0% | 1,675,000 | $97.4M |
| Deerfield Management Company, L.P. | 1.31% | Add +198.1% | 1,615,696 | $94.0M |
| Holocene Advisors, LP | 0.21% | Add +18.4% | 1,518,686 | $88.3M |
| Westfield Capital Management Co. LP | 0.34% | Add +14.2% | 1,401,483 | $81.5M |
| Caligan Partners LP | 5.73% | Add +153.4% | 1,393,027 | $81.0M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.09% | Add +26.6% | 1,342,028 | $78.0M |
| Braidwell LP | 2.96% | Reduce -26.7% | 1,338,452 | $77.8M |
| T. Rowe Price Associates Inc. | 0.01% | Add +54.2% | 1,329,591 | $77.3M |
| Jennison Associates LLC | 0.05% | Add +2.1% | 1,318,814 | $76.7M |
| Siren, L.L.C. | 2.13% | Add +62.2% | 1,318,564 | $76.7M |
| Alyeska Investment Group, L.P. | 0.21% | New | 1,299,469 | $75.6M |
| Franklin Resources Inc. | 0.02% | Add +68.9% | 1,280,577 | $74.5M |
| Geode Capital Management, LLC | 0.00% | Add +14.7% | 1,092,932 | $63.5M |
| Alliancebernstein L.P. | 0.02% | Reduce -11.9% | 1,403,297 | $62.9M |
| Orbimed Advisors LLC | 1.39% | Add +137.0% | 1,059,971 | $61.6M |
| Federated Hermes, Inc. | 0.09% | Add +44.6% | 972,237 | $56.5M |
| T. Rowe Price Investment Management, Inc. | 0.04% | Add +73.8% | 951,955 | $55.4M |
| Capital World Investors | 0.01% | Add +28.1% | 840,072 | $48.9M |
| Commodore Capital LP | 2.78% | Reduce -54.2% | 825,000 | $48.0M |
| First Turn Management, LLC | 5.11% | Reduce -1.6% | 786,844 | $45.8M |
| Goldman Sachs Group Inc. | 0.01% | Add +10.6% | 769,875 | $44.8M |
| Rock Springs Capital Management LP | 2.62% | Reduce -3.1% | 763,020 | $44.4M |
| Fiera Capital Corp | 0.14% | Add +3.4% | 709,529 | $41.3M |
| American Century Companies Inc. | 0.02% | Reduce -0.2% | 679,314 | $39.5M |
| Pictet Asset Management Holding SA | 0.04% | Add +8.6% | 679,709 | $39.2M |
| Vestal Point Capital, LP | 1.04% | Add +6.7% | 639,900 | $37.2M |
| Aberdeen Group plc | 0.06% | Reduce -18.7% | 609,929 | $35.5M |
| Two Sigma Investments, LP | 0.03% | Add +38.8% | 606,085 | $35.2M |
| MPM Bioimpact LLC | 2.64% | Add +21.2% | 588,706 | $34.2M |
| Loomis Sayles & Co. L P | 0.04% | Reduce -7.7% | 564,897 | $32.8M |
| Vanguard Portfolio Management LLC | 0.00% | — | 543,062 | $31.6M |
| Northern Trust Corp. | 0.00% | Add +20.3% | 527,783 | $30.7M |
| Parkman Healthcare Partners LLC | 3.00% | Add +222.4% | 497,035 | $28.9M |
| Tudor Investment Corporation | 0.16% | Add +95.1% | 495,591 | $28.8M |
| Octagon Capital Advisors LP | 3.15% | New | 490,000 | $28.5M |
| Novo Holdings A/S | 2.29% | New | 485,438 | $28.2M |
| Candriam S.C.A. | 0.14% | Add +14.2% | 476,494 | $27.7M |
| Morgan Stanley | 0.00% | Add +61.0% | 473,759 | $27.5M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | Reduce -31.4% | 470,000 | $27.3M |
| Logos Global Management LP | 1.35% | New | 450,000 | $26.2M |
| Trails Edge Capital Partners, LP | 6.02% | Reduce -26.3% | 440,000 | $25.6M |
| Bank of New York Mellon Corp | 0.00% | Add +2.3% | 396,138 | $23.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +158868.6% | 375,166 | $21.8M |
| Baker Bros. Advisors LP | 0.12% | No change | 370,208 | $21.5M |
| TimesSquare Capital Management, LLC | 0.35% | Reduce -32.6% | 359,293 | $20.9M |
| Schonfeld Strategic Advisors LLC | 0.15% | New | 324,722 | $18.9M |
| Sofinnova Investments, Inc. | 0.89% | Add +409.5% | 305,216 | $17.7M |
| Renaissance Technologies | 0.03% | New | 300,500 | $17.5M |
| Soleus Capital Management, L.P. | 0.69% | New | 292,000 | $17.0M |
| Boothbay Fund Management, LLC | 0.38% | Add +657.9% | 270,412 | $15.7M |
| Bank of America Corp. | 0.00% | Add +19.8% | 265,267 | $15.4M |
| Algert Global LLC | 0.23% | Add +114.5% | 264,200 | $15.4M |
| Redmile Group, LLC | 1.01% | Add +96.2% | 262,674 | $15.3M |
| State of Wisconsin Investment Board | 0.03% | Add +23.8% | 254,483 | $14.8M |
| DAFNA Capital Management LLC | 3.36% | Reduce -12.9% | 250,772 | $14.6M |
| Nuveen, LLC | 0.00% | Add +15.6% | 250,036 | $14.5M |
| Nan Fung Trinity (hk) Ltd. | 1.58% | Add +9.2% | 247,765 | $14.4M |
| Nicholas Investment Partners, LP | 1.18% | Add +1.7% | 247,101 | $14.4M |
| Allspring Global Investments Holdings, LLC | 0.02% | New | 246,306 | $14.0M |
| Duquesne Family Office | 0.47% | New | 238,600 | $13.9M |
| Barclays PLC | 0.01% | Reduce -60.4% | 238,209 | $13.9M |
| Balyasny Asset Management L.P. | 0.03% | Add +177.3% | 233,905 | $13.6M |
| ADAR1 Capital Management, LLC | 0.81% | Add +12.2% | 228,899 | $13.3M |
| Patient Square Capital LP | 2.34% | Add +66.3% | 227,000 | $13.2M |
| Millennium Management | 0.01% | Reduce -68.2% | 201,785 | $11.7M |
| Integral Health Asset Management, LLC | 0.62% | New | 200,000 | $11.6M |
| Silverarc Capital Management, LLC | 1.36% | New | 197,759 | $11.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.0% | 189,080 | $11.0M |
| New York State Common Retirement Fund | 0.02% | Add +1.0% | 188,505 | $11.0M |
| NEXTBio Capital Management LP | 4.95% | Reduce -0.3% | 183,225 | $10.7M |
| DNB Asset Management AS | 0.04% | Reduce -33.6% | 181,085 | $10.5M |
| Susquehanna International Group, LLP | 0.01% | Add +2029.3% | 177,137 | $10.3M |
| ExodusPoint Capital Management, LP | 0.10% | New | 173,425 | $10.1M |
| Deutsche Bank AG | 0.00% | Reduce -14.5% | 162,682 | $9.5M |
| Foresite Capital Management IV, LLC | 3.92% | No change | 160,000 | $9.3M |
| Swiss National Bank | 0.01% | Add +38.3% | 157,700 | $9.2M |
| Jump Financial, LLC | 0.15% | Add +402.7% | 155,776 | $9.1M |
| Woodline Partners LP | 0.03% | New | 150,302 | $8.7M |
| Peregrine Capital Management LLC | 0.31% | Reduce -18.1% | 143,136 | $8.3M |
| Stempoint Capital LP | 1.57% | Reduce -59.6% | 140,755 | $8.2M |
| Neuberger Berman Group LLC | 0.01% | Reduce -27.0% | 130,438 | $7.6M |
| Eversept Partners, LP | 0.50% | Reduce -44.0% | 129,574 | $7.5M |
| Russell Investments Group, Ltd. | 0.01% | Add +50.1% | 129,399 | $7.5M |
| KBC Group NV | 0.02% | Add +4540.6% | 129,010 | $7.5M |
| Sphera Funds Management LTD. | 1.27% | New | 127,000 | $7.4M |
| HSBC Holdings PLC | 0.00% | New | 121,558 | $7.1M |
| Wells Fargo & Company | 0.00% | Reduce -24.1% | 115,652 | $6.7M |
| Mutual of America Capital Management LLC | 0.08% | Reduce -0.4% | 115,594 | $6.7M |
| Sei Investments Co. | 0.01% | Add +160.8% | 114,381 | $6.7M |
| Granahan Investment Management, LLC | 0.29% | Add +12.6% | 104,478 | $6.1M |
| Rhumbline Advisers | 0.01% | Add +12.9% | 101,785 | $5.9M |
| Burkehill Global Management, LP | 0.30% | New | 100,000 | $5.8M |
| UBS Group AG | 0.00% | Add +89.6% | 99,624 | $5.8M |
| Axiom Investors LLC | 0.06% | New | 99,568 | $5.8M |
| California State Teachers Retirement System | 0.01% | Add +64.0% | 92,747 | $5.4M |
| Royal Bank of Canada | 0.00% | Add +0.7% | 90,387 | $5.3M |
| Raymond James Financial Inc. | 0.00% | Add +6.4% | 88,598 | $5.2M |
| Y-Intercept (Hong Kong) Ltd | 0.09% | Add +17.0% | 85,388 | $5.0M |
| BNP Paribas Financial Markets | 0.00% | Reduce -14.0% | 80,392 | $4.7M |
| Aquatic Capital Management LLC | 0.13% | New | 79,199 | $4.6M |
| Ameriprise Financial Inc. | 0.00% | Reduce -28.0% | 78,905 | $4.6M |
| Schroder Investment Management Group | 0.00% | No change | 81,156 | $4.5M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 75,117 | $4.4M |
| Seven Grand Managers, LLC | 0.29% | New | 75,000 | $4.4M |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | — | 74,481 | $4.3M |
| Legal & General Group Plc | 0.00% | Add +4.6% | 73,489 | $4.3M |
| Voya Investment Management LLC | 0.00% | Add +12.3% | 68,363 | $4.0M |
| Alps Advisors Inc. | 0.02% | Add +7.0% | 67,723 | $3.9M |
| Trexquant Investment LP | 0.03% | New | 67,361 | $3.9M |
| Informed Momentum Co LLC | 0.45% | New | 66,550 | $3.9M |
| Vanguard Capital Management LLC | 0.00% | — | 65,961 | $3.8M |
| Artia Global Partners LP | 0.85% | Add +62.5% | 65,000 | $3.8M |
| Castleark Management LLC | 0.12% | New | 64,563 | $3.8M |
| Atika Capital Management LLC | 0.55% | Reduce -35.3% | 59,900 | $3.5M |
| Invesco Ltd. | 0.00% | Add +16.0% | 59,103 | $3.4M |
| LMR Partners LLP | 0.04% | New | 56,200 | $3.3M |
| Quantinno Capital Management LP | 0.01% | Add +125.1% | 55,444 | $3.2M |
| Verition Fund Management LLC | 0.03% | Reduce -41.3% | 55,000 | $3.2M |
| Palo Alto Investors LP | 0.46% | Reduce -46.8% | 51,345 | $3.0M |
| Lazard Asset Management LLC | 0.00% | Reduce -35.5% | 50,755 | $3.0M |
| Victory Capital Management Inc. | 0.00% | New | 49,970 | $2.9M |
| HighVista Strategies LLC | 0.79% | New | 49,050 | $2.9M |
| Erste Asset Management GmbH | 0.03% | No change | 50,000 | $2.8M |
| MetLife Investment Management, LLC | 0.01% | Add +12.7% | 47,343 | $2.8M |
| Nomura Asset Management International Inc. | 0.00% | Reduce -1.9% | 47,041 | $2.7M |
| Qube Research & Technologies Ltd | 0.00% | New | 44,044 | $2.6M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +14.7% | 40,513 | $2.4M |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 39,000 | $2.2M |
| Legato Capital Management LLC | 0.19% | Reduce -1.1% | 36,641 | $2.1M |
| Envestnet Asset Management Inc. | 0.00% | Add +0.8% | 36,068 | $2.1M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +37.6% | 35,204 | $2.0M |
| Act Capital Management, LLC | 1.53% | New | 33,500 | $1.9M |
| TLS Advisors LLC | 4.27% | Add +64.2% | 30,956 | $1.8M |
| Calamos Advisors LLC | 0.01% | New | 30,374 | $1.8M |
| Creative Planning | 0.00% | Add +55.3% | 29,818 | $1.7M |
| Handelsbanken Fonder AB | 0.01% | No change | 29,800 | $1.7M |
| Corient Private Wealth LP | 0.00% | New | 28,302 | $1.6M |
| Rhenman & Partners Asset Management AB | 0.20% | Reduce -79.9% | 28,000 | $1.6M |
| XTX Topco Ltd | 0.03% | Add +30.2% | 28,000 | $1.6M |
| TD Asset Management Inc | 0.00% | Reduce -29.0% | 27,074 | $1.6M |
| Swedbank AB | 0.00% | New | 26,200 | $1.5M |
| SummitTX Capital, L.P. | 0.05% | New | 26,186 | $1.5M |
| Baron Capital (BAMCO) | 0.00% | Reduce -16.7% | 25,000 | $1.5M |
| Vestmark Advisory Solutions, Inc. | 0.02% | Add +9.8% | 24,025 | $1.4M |
| Rathbones Group PLC | 0.01% | No change | 23,666 | $1.4M |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Add +16.3% | 23,405 | $1.4M |
| HighMark Wealth Management LLC | 0.54% | No change | 23,000 | $1.3M |
| Arizona State Retirement System | 0.01% | Add +35.2% | 21,869 | $1.3M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -33.5% | 21,684 | $1.3M |
| Sanders Morris Harris LLC | 0.20% | New | 21,500 | $1.3M |
| Teachers Retirement System of the State of Kentucky | 0.01% | New | 21,133 | $1.2M |
| Birchview Capital, LP | 0.70% | No change | 21,000 | $1.2M |
| Assetmark, Inc. | 0.00% | Reduce -4.7% | 20,272 | $1.2M |
| Vanguard Investments Australia, Ltd. | 0.00% | — | 19,954 | $1.2M |
| State of New Jersey Common Pension Fund D | 0.00% | Add +0.3% | 19,807 | $1.2M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | New | 19,439 | $1.1M |
| State Board of Administration of Florida Retirement System | 0.00% | New | 19,097 | $1.1M |
| Intech Investment Management LLC | 0.01% | Reduce -26.2% | 19,062 | $1.1M |
| Cibc World Market Inc. | 0.00% | Add +40.9% | 18,960 | $1.1M |
| D. E. Shaw & Co. | 0.00% | Reduce -38.6% | 18,940 | $1.1M |
| Martingale Asset Management L P | 0.03% | New | 18,806 | $1.1M |
| Susquehanna Portfolio Strategies, LLC | 0.02% | New | 18,468 | $1.1M |
| Campbell & CO Investment Adviser LLC | 0.06% | Add +12.7% | 18,156 | $1.1M |
| Amundi | 0.00% | Add +290.8% | 18,013 | $1.0M |
| KLP Kapitalforvaltning As | 0.00% | Add +43.1% | 17,600 | $1.0M |
| Stifel Financial Corp. | 0.00% | Reduce -4.7% | 16,718 | $972K |
| ProShare Advisors LLC | 0.00% | Reduce -6.0% | 16,250 | $945K |
| China Universal Asset Management Co., Ltd. | 0.07% | Add +17.2% | 14,763 | $858K |
| Hudson Bay Capital Management LP | 0.01% | New | 14,072 | $818K |
| Orion Porfolio Solutions, LLC | 0.01% | Reduce -4.1% | 13,817 | $803K |
| SBI Okasan Asset Management Co.Ltd. | 0.03% | No change | 14,400 | $800K |
| Neo Ivy Capital Management | 0.21% | Add +83.4% | 13,710 | $797K |
| Prudential Financial Inc. | 0.00% | New | 13,010 | $757K |
| Citigroup Inc. | 0.00% | Add +65.1% | 12,151 | $707K |
| Brevan Howard Capital Management LP | 0.01% | New | 12,041 | $700K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 10,633 | $618K |
| Covalis Capital LLP | 0.04% | New | 10,000 | $582K |
| Elmwood Wealth Management, Inc. | 0.16% | Reduce -8.8% | 9,807 | $570K |
| Engineers Gate Manager LP | 0.01% | New | 9,326 | $542K |
| First Trust Advisors LP | 0.00% | Add +43.6% | 9,133 | $531K |
| Thrivent Financial for Lutherans | 0.00% | Add +63.4% | 9,122 | $531K |
| SG Americas Securities, LLC | 0.00% | Add +28.9% | 9,119 | $530K |
| J. Safra Sarasin Holding AG | 0.01% | Reduce -33.2% | 9,071 | $527K |
| EntryPoint Capital, LLC | 0.15% | Add +75.7% | 8,832 | $514K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Add +93.3% | 8,761 | $509K |
| Xponance LLC | 0.00% | Add +41.7% | 8,465 | $492K |
| PNC Financial Services Group, Inc. | 0.00% | Add +23.2% | 8,097 | $471K |
| Allianz Asset Management GmbH | 0.00% | Reduce -19.1% | 7,600 | $442K |
| Teacher Retirement System of Texas | 0.00% | Reduce -12.0% | 7,599 | $442K |
| AQR Capital Management | 0.00% | New | 7,279 | $423K |
| Ameritas Investment Partners, Inc. | 0.01% | Add +15.7% | 7,138 | $415K |
| CANADA LIFE ASSURANCE Co | 0.00% | No change | 7,024 | $411K |
| Advisors Asset Management, Inc. | 0.01% | Reduce -13.1% | 6,961 | $405K |
| Oxford Asset Management LLP | 0.16% | Reduce -6.7% | 6,884 | $400K |
| PenderFund Capital Management Ltd. | 0.18% | No change | 6,850 | $398K |
| Bridgefront Capital, LLC | 0.09% | New | 6,564 | $382K |
| Longaeva Partners L.P. | 0.02% | New | 6,250 | $363K |
| Principal Financial Group Inc. | 0.00% | Add +39.1% | 6,244 | $363K |
| Tidal Investments LLC | 0.00% | New | 6,225 | $362K |
| Virtus Investment Advisers, LLC | 0.10% | Add +2.5% | 6,188 | $360K |
| Headlands Technologies LLC | 0.04% | New | 6,120 | $356K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +88.9% | 6,105 | $355K |
| Letson Investment Management, Inc. | 0.13% | No change | 6,000 | $349K |
| STRS Ohio | 0.00% | Add +338.5% | 5,700 | $331K |
| DRW Securities, LLC | 0.02% | New | 5,461 | $318K |
| Caprock Group, LLC | 0.01% | Add +4.4% | 5,291 | $308K |
| Ensign Peak Advisors, Inc | 0.00% | No change | 5,194 | $302K |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 5,000 | $291K |
| LPL Financial LLC | 0.00% | New | 4,964 | $289K |
| Citizens Financial Group Inc. | 0.00% | Reduce -0.7% | 4,963 | $289K |
| Swiss Life Asset Management Ltd | 0.00% | New | 4,847 | $282K |
| CIBC Bancorp USA Inc. | 0.00% | — | 4,349 | $253K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +15.6% | 4,339 | $252K |
| Oppenheimer Asset Management Inc. | 0.00% | New | 4,325 | $251K |
| Snowden Capital Advisors LLC | 0.01% | New | 4,223 | $246K |
| PSP Research LLC | 0.17% | Reduce -64.0% | 4,200 | $244K |
| FNY Investment Advisers, LLC | 0.11% | New | 4,200 | $244K |
| Aigen Investment Management, LP | 0.06% | New | 4,123 | $240K |
| Cetera Investment Advisers | 0.00% | New | 3,624 | $211K |
| Seeds Investor LLC | 0.03% | New | 3,423 | $203K |
| Jane Street Group, LLC | 0.00% | New | 3,468 | $202K |
| Caitong International Asset Management Co., Ltd | 0.04% | Add +171.8% | 3,330 | $194K |
| Eurizon Capital SGR S.p.A. | 0.00% | New | 2,649 | $148K |
| Jones Financial Companies LLLP | 0.00% | Add +1499.3% | 2,399 | $131K |
| IFP Advisors, Inc | 0.00% | Reduce -0.3% | 1,871 | $109K |
| GF Fund Management Co. LTD. | 0.00% | Add +14.4% | 1,735 | $101K |
| State of Wyoming | 0.01% | Reduce -8.0% | 1,381 | $80K |
| Axiom Investment Management LLC | 0.04% | — | 1,000 | $58K |
| SBI Securities Co., Ltd. | 0.00% | Add +98700.0% | 988 | $57K |
| Nisa Investment Advisors, LLC | 0.00% | Add +2.9% | 951 | $55K |
| Kemnay Advisory Services Inc. | 0.01% | Add +521.1% | 764 | $44K |
| Blue Trust, Inc. | 0.00% | No change | 745 | $43K |
| Acadian Asset Management LLC | 0.00% | New | 677 | $39K |
| Sterling Capital Management LLC | 0.00% | Add +14.1% | 560 | $33K |
| Bayforest Capital Ltd | 0.04% | New | 555 | $32K |
| Signaturefd, LLC | 0.00% | Add +16.9% | 553 | $32K |
| Cwm, LLC | 0.00% | Add +39.3% | 510 | $30K |
| Vanguard Global Advisers, LLC | 0.00% | — | 494 | $29K |
| MAI Capital Management | 0.00% | Add +50.2% | 392 | $23K |
| Osaic Holdings, Inc. | 0.00% | Add +21.9% | 389 | $23K |
| GAMMA Investing LLC | 0.00% | Add +41.3% | 373 | $22K |
| Zions Bancorporation, National Association | 0.00% | Add +29.8% | 305 | $18K |
| Huntington National Bank | 0.00% | New | 288 | $17K |
| Basecamp Wealth Advisors LLC | 0.00% | New | 280 | $16K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | No change | 276 | $16K |
| US Bancorp \de | 0.00% | Add +55.4% | 272 | $16K |
| J.Safra Asset Management Corp | 0.00% | Add +208.1% | 268 | $16K |
| National Bank of Canada | 0.00% | Add +23.7% | 235 | $14K |
| Rockefeller Capital Management L.P. | 0.00% | Reduce -81.8% | 200 | $12K |
| Farther Finance Advisors, LLC | 0.00% | Reduce -82.1% | 189 | $11K |
| Rossby Financial, LCC | 0.00% | Add +285.1% | 181 | $10K |
| Quantbot Technologies LP | 0.00% | New | 162 | $9K |
| Parallel Advisors, LLC | 0.00% | Add +3.4% | 152 | $9K |
| SMA Capital LLC | 0.00% | New | 139 | $8K |
| TD Waterhouse Canada Inc. | 0.00% | New | 130 | $7K |
| Rothschild Investment LLC | 0.00% | Add +13.5% | 126 | $7K |
| Bell Investment Advisors, Inc | 0.00% | No change | 100 | $6K |
| Danske Bank A/S | 0.00% | Reduce -87.5% | 100 | $6K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -63.7% | 77 | $4K |
| Larson Financial Group LLC | 0.00% | Add +2500.0% | 52 | $3K |
| Root Financial Partners, LLC | 0.00% | New | 40 | $2K |
| Allworth Financial LP | 0.00% | Reduce -67.2% | 38 | $2K |
| Ascentis Independent Advisors | 0.00% | New | 35 | $2K |
| CVA Family Office, LLC | 0.00% | No change | 33 | $2K |
| Twin Peaks Wealth Advisors, LLC | 0.00% | New | 32 | $2K |
| Parkside Financial Bank & Trust | 0.00% | No change | 30 | $2K |
| First Horizon Corp. | 0.00% | New | 24 | $1K |
| Covestor Ltd | 0.00% | Reduce -96.0% | 10 | $1K |
| Hantz Financial Services, Inc. | 0.00% | No change | 25 | $1K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Add +54.5% | 17 | $989 |
| CoreCap Advisors, LLC | 0.00% | No change | 17 | $989 |
| Park Place Capital Corp | 0.00% | No change | 16 | $930 |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 13 | $756 |
| Smartleaf Asset Management LLC | 0.00% | Reduce -25.0% | 12 | $667 |
| WPG Advisers, LLC | 0.00% | New | 9 | $523 |
| Pinnacle Wealth Planning Services, Inc. | 0.00% | New | 4 | $233 |
| Hughes Financial Services, LLC | 0.00% | New | 4 | $233 |
| Keating Financial Advisory Services, Inc. | 0.00% | New | 2 | $116 |
| TFC Financial Management, Inc. | 0.00% | New | 1 | $59 |
"% of holder's portfolio" is XENE's weight in each manager's 13F, not the share of Xenon Pharmaceuticals Inc. the manager owns.