HighVista Strategies LLC

In its 13F for Q2 2026 (holdings as of June 30, 2026, filed August 14, 2026), HighVista Strategies LLC reported 147 stock positions worth $438.6 million. Its top holding was Invesco DB Commodity Index T (DBC) at 6.4% of the portfolio, followed by Abivax SA-ADR (ABVX, 3.4%) and Revolution Medicines (RVMD, 2.9%). Compared with Q1 2026, it opened 29 new positions, sold out of 38, added to 50 and reduced 66. The biggest buy was Definium Therapeutics (DFTX, shares +31%) and the biggest sale an exit from Terns Pharmaceuticals (TERN).

Most Recent 13F
Q2 2026
Location
BOSTON, MA
CIK
0001335325
Portfolio Value
$438.6M (Q2 2026)
SEC Filing
0001172661-26-003470 ↗ filed Aug 14, 2026

Holdings Value

0$100.0M$200.0M$300.0M$400.0M$500.0M Q1 2024: $280.4M Q1 2024 Q2 2024: $273.8M Q2 2024 Q3 2024: $290.0M Q3 2024 Q4 2024: $268.8M Q4 2024 Q1 2025: $259.5M Q1 2025 Q2 2025: $272.1M Q2 2025 Q3 2025: $408.0M Q3 2025 Q4 2025: $388.3M Q4 2025 Q1 2026: $362.2M Q1 2026 Q2 2026: $438.6M $438.6M Q2 2026

Holdings 147 stocks · $438.6M
DBC Invesco DB Commodity Index T 6.43% 1,057,238 $28.2M No change
ABVX Abivax SA-ADR 3.43% 113,031 $15.1M Reduce -0.2%
RVMD Revolution Medicines Inc. 2.86% 66,983 $12.5M Reduce -3.4%
DFTX Definium Therapeutics Inc. 2.60% 242,884 $11.4M Add +30.7%
IMVT Immunovant Inc. 2.44% 277,873 $10.7M Add +23.4%
PRAX Praxis Precision Medicines I 2.31% 30,210 $10.1M Add +14.8%
RLAY Relay Therapeutics Inc. 2.16% 506,235 $9.5M Add +20.0%
ALKS Alkermes PLC 2.14% 179,256 $9.4M Add +144.9%
PCVX Vaxcyte Inc. 1.98% 149,739 $8.7M Add +20.1%
TNGX Tango Therapeutics Inc. 1.85% 260,070 $8.1M Add +149.6%
LQDA Liquidia Corp. 1.78% 97,896 $7.8M Reduce -1.9%
COGT Cogent Biosciences Inc. 1.67% 188,780 $7.3M Reduce -4.2%
GPCR Structure Therapeutics Inc. 1.60% 130,784 $7.0M Add +5.5%
ELVN Enliven Therapeutics Inc. 1.60% 137,866 $7.0M Add +88.6%
AMLX Amylyx Pharmaceuticals Inc. 1.58% 386,080 $6.9M Add +9.7%
SYRE Spyre Therapeutics Inc. 1.57% 77,807 $6.9M Reduce -46.8%
LBRX LB Pharmaceuticals Inc. 1.57% 211,511 $6.9M Add +21.8%
CYTK Cytokinetics Inc. 1.52% 78,003 $6.6M Add +33.0%
CCCC C4 Therapeutics Inc. 1.44% 1,348,136 $6.3M New
TYRA Tyra Biosciences Inc. 1.35% 184,774 $5.9M Add +40.7%
ALMS Alumis Inc. 1.28% 199,968 $5.6M Add +77.1%
PHVS Pharvaris NV 1.27% 160,494 $5.5M Add +64.0%
TARS Tarsus Pharmaceuticals Inc. 1.25% 87,060 $5.5M Add +65.9%
CMPS Compass Pathways PLC 1.20% 371,120 $5.3M Add +1.9%
DNTH Dianthus Therapeutics Inc. 1.14% 51,125 $5.0M Add +43.7%
NRIX Nurix Therapeutics Inc. 1.13% 203,739 $4.9M Reduce -10.1%
AXSM Axsome Therapeutics Inc. 1.13% 20,183 $4.9M Reduce -1.2%
TVTX Travere Therapeutics Inc. 1.12% 86,233 $4.9M Add +137.4%
VERA Vera Therapeutics Inc. 1.04% 105,907 $4.5M Add +53.0%
NVDA Nvidia Corp. 0.99% 21,792 $4.4M Reduce -2.8%
GHRS GH Research PLC 0.97% 158,770 $4.3M Reduce -25.5%
PALI Palisade Bio Inc. 0.97% 2,030,927 $4.2M Add +0.6%
ARGX Argenx SE - ADR 0.96% 4,561 $4.2M Reduce -7.3%
MAZE Maze Therapeutics Inc. 0.93% 136,572 $4.1M Add +36.8%
OCUL Ocular Therapeutix Inc. 0.91% 408,534 $4.0M Reduce -7.5%
ORKA Oruka Therapeutics Inc. 0.91% 41,902 $4.0M Reduce -46.9%
DYN Dyne Therapeutics Inc. 0.87% 171,961 $3.8M Reduce -6.0%
EWTX Edgewise Therapeutics Inc. 0.84% 90,996 $3.7M Reduce -1.0%
MLTX Moonlake Immunotherapeutics 0.83% 187,946 $3.7M Reduce -3.1%
INSM Insmed Inc. 0.76% 31,256 $3.3M Add +28.5%
CLDX Celldex Therapeutics Inc. 0.74% 86,964 $3.2M Reduce -2.7%
AMZN Amazon.com Inc. 0.73% 13,397 $3.2M Reduce -40.2%
IVA Inventiva SA - ADR 0.72% 831,442 $3.1M Add +35.0%
TLN Talen Energy Corp. 0.71% 8,148 $3.1M Add +161.3%
RLMD Relmada Therapeutics Inc. 0.70% 445,799 $3.1M New
PTGX Protagonist Therapeutics Inc. 0.68% 24,460 $3.0M Reduce -27.7%
ERAS Erasca Inc. 0.67% 160,328 $2.9M Reduce -11.4%
VRDN Viridian Therapeutics Inc. 0.67% 159,885 $2.9M Add +19.1%
HPE Hewlett Packard Enterprise 0.61% 59,081 $2.7M Reduce -34.3%
MLYS Mineralys Therapeutics Inc. 0.53% 86,085 $2.3M Add +84.0%
GH Guardant Health Inc. 0.53% 15,419 $2.3M Reduce -34.0%
AVTX Avalo Therapeutics Inc. 0.52% 122,610 $2.3M Add +109.2%
JHX James Hardie Ind PLC 0.51% 85,198 $2.2M Add +29.9%
EYPT Eyepoint Inc. 0.51% 155,704 $2.2M Reduce -14.9%
MTZ Mastec Inc. 0.49% 5,137 $2.1M Add +41.6%
XENE Xenon Pharmaceuticals Inc. 0.49% 35,318 $2.1M Reduce -28.0%
RBC RBC Bearings Inc. 0.47% 3,223 $2.1M Add +21.0%
V Visa Inc. Class A 0.47% 5,961 $2.0M Reduce -16.5%
ASMB Assembly Biosciences Inc. 0.46% 73,405 $2.0M Reduce -1.8%
STOK Stoke Therapeutics Inc. 0.46% 61,316 $2.0M Reduce -2.1%
OLMA Olema Pharmaceuticals Inc. 0.46% 160,167 $2.0M Add +36.2%
RKT Rocket Cos Inc. Class A 0.45% 125,530 $2.0M Add +35.8%
XPO Xpo Inc. 0.45% 9,623 $2.0M Add +7.8%
WDC Western Digital Corp. 0.44% 3,050 $1.9M Reduce -25.6%
CORZ Core Scientific Inc. 0.44% 75,712 $1.9M Reduce -26.8%
TXN Texas Instruments Inc. 0.44% 6,500 $1.9M New
KBR KBR Inc. 0.43% 54,206 $1.9M Add +37.6%
FLS Flowserve Corp. 0.42% 24,958 $1.9M No change
GOOG Alphabet Inc. Class C 0.41% 5,127 $1.8M Reduce -6.4%
STX Seagate Technology Holdings 0.41% 1,870 $1.8M Reduce -35.5%
MIRM Mirum Pharmaceuticals Inc. 0.40% 14,892 $1.7M Reduce -4.3%
DNOW Dnow Inc. 0.39% 132,900 $1.7M New
ON On Semiconductor 0.39% 18,200 $1.7M Reduce -35.0%
NUE Nucor Corp. 0.39% 7,600 $1.7M New
TDAY USA Today Co. Inc. 0.37% 188,500 $1.6M New
AVGO Broadcom Inc. 0.36% 4,199 $1.6M Reduce -25.0%
CLMT Calumet Inc. 0.36% 44,000 $1.6M New
Q Qnity Electronics Inc. 0.36% 9,700 $1.6M New
KOD Kodiak Sciences Inc. 0.36% 40,590 $1.6M Reduce -6.8%
CRDO Credo Technology Group Holdi 0.36% 5,800 $1.6M New
KNX Knight-Swift Transportation 0.36% 20,100 $1.6M Reduce -12.2%
BCO The Brink's Co. 0.35% 16,414 $1.6M New
ALAB Astera Labs Inc. 0.35% 3,198 $1.5M New
SPGI S&P Global Inc. 0.35% 3,782 $1.5M New
MDGL Madrigal Pharmaceuticals Inc. 0.35% 2,852 $1.5M Add +9.8%
EFX Equifax Inc. 0.35% 9,572 $1.5M New
RYTM Rhythm Pharmaceuticals Inc. 0.35% 13,657 $1.5M Reduce -18.7%
SVRA Savara Inc. 0.34% 242,379 $1.5M Reduce -3.4%
DPZ Domino's Pizza Inc. 0.34% 4,991 $1.5M New
BLTE Belite Bio Inc. - ADR 0.34% 9,554 $1.5M Add +18.9%
MU Micron Technology Inc. 0.33% 1,260 $1.5M Reduce -66.8%
CIEN Ciena Corp. 0.33% 2,925 $1.4M Reduce -44.6%
CELC Celcuity Inc. 0.32% 13,472 $1.4M Add +2.8%
QXO Qxo Inc. 0.32% 81,420 $1.4M Add +209.3%
IMCR Immunocore Holdings PLC-ADR 0.31% 43,185 $1.4M Reduce -26.4%
CGON CG Oncology Inc. 0.31% 18,867 $1.3M Reduce -5.3%
USFD US Foods Holding Corp. 0.30% 13,000 $1.3M New
TDG Transdigm Group Inc. 0.30% 985 $1.3M Reduce -14.0%
LITE Lumentum Holdings Inc. 0.30% 1,517 $1.3M Reduce -51.3%
FE Firstenergy Corp. 0.28% 26,100 $1.2M New
MA Mastercard Inc. Class A 0.28% 2,384 $1.2M Reduce -18.5%
ETR Entergy Corp. 0.28% 10,628 $1.2M Reduce -21.4%
KRYS Krystal Biotech Inc. 0.28% 3,260 $1.2M Add +78.7%
MCO Moody's Corp. 0.28% 2,670 $1.2M New
AMAT Applied Materials Inc. 0.27% 1,640 $1.2M New
XEL Xcel Energy Inc. 0.27% 14,758 $1.2M Add +17.5%
NEE Nextera Energy Inc. 0.27% 13,338 $1.2M Add +20.3%
UTHR United Therapeutics Corp. 0.26% 2,095 $1.1M Add +38.4%
GLNG Golar LNG Ltd. 0.25% 22,100 $1.1M New
DASH DoorDash Inc. Class A 0.24% 5,810 $1.1M Reduce -13.4%
IBN Icici Bank Ltd.-Spon ADR 0.24% 35,884 $1.0M Add +28.7%
IRON Disc Medicine Inc. 0.24% 14,219 $1.0M New
APH Amphenol Corp. Class A 0.23% 5,781 $1.0M Reduce -40.9%
U Unity Software Inc. 0.23% 35,163 $1.0M Reduce -44.0%
FERG Ferguson Enterprises Inc. 0.23% 4,173 $990K Reduce -10.7%
TRVI Trevi Therapeutics Inc. 0.23% 53,033 $989K Reduce -0.9%
STM Stmicroelectronics NV-NY SHS 0.23% 13,200 $989K New
SEPN Septerna Inc. 0.22% 29,337 $982K New
YMM Full Truck Alliance -SPN ADR 0.22% 120,847 $981K Add +56.6%
BBIO Bridgebio Pharma Inc. 0.22% 13,156 $980K Reduce -73.5%
ARM Arm Holdings PLC-ADR 0.22% 2,700 $957K New
TPR Tapestry Inc. 0.22% 6,500 $951K New
EDU New Oriental Educatio-SP ADR 0.21% 20,537 $943K Add +66.7%
SIMO Silicon Motion Technol-ADR 0.21% 2,800 $933K New
APG Api Group Corp. 0.21% 21,958 $930K Reduce -17.6%
URGN Urogen Pharma Ltd. 0.21% 24,968 $919K Reduce -5.8%
MSFT Microsoft Corp. 0.21% 2,413 $900K Reduce -62.6%
ZYME Zymeworks Inc. 0.20% 34,013 $889K Reduce -0.2%
AEIS Advanced Energy Industries 0.19% 2,240 $835K New
KSPI JSC Kaspi.kz ADR filed as KASPI KZ JSC 0.19% 9,400 $814K New
HDB HDFC Bank Ltd.-ADR 0.18% 30,927 $799K Add +18.4%
VST Vistra Corp. 0.18% 4,900 $777K New
JANX Janux Therapeutics Inc. 0.17% 48,376 $743K Reduce -2.0%
NAMS Newamsterdam Pharma Co. NV 0.16% 20,905 $708K Add +4.2%
META Meta Platforms Inc. Class A 0.15% 1,162 $655K Reduce -33.3%
MBX MBX Biosciences Inc. 0.15% 11,634 $642K Add +1.4%
NU Nu Holdings Ltd./Cayman Isl-A filed as NU HLDGS LTD 0.15% 47,970 $641K Reduce -3.2%
CTMX Cytomx Therapeutics Inc. 0.15% 169,831 $637K Reduce -41.0%
MELI MercadoLibre Inc. 0.15% 375 $637K Reduce -13.8%
CEG Constellation Energy 0.14% 2,490 $618K Reduce -56.7%
NKTR Nektar Therapeutics 0.14% 8,708 $608K Reduce -40.2%
AKAM Akamai Technologies Inc. 0.13% 4,900 $579K New
XNCR Xencor Inc. 0.10% 26,822 $432K Reduce -49.4%
KYMR Kymera Therapeutics Inc. 0.10% 3,731 $428K Reduce -1.4%
PDD PDD Holdings Inc. 0.10% 5,500 $420K Reduce -20.3%
JD Jd.com Inc.-ADR 0.08% 14,163 $361K Add +5.2%
BBD Banco Bradesco-ADR 0.08% 103,132 $358K Reduce -50.5%

Portfolio Sells Q1 2026 → Q2 2026
TERN Terns Pharmaceuticals Inc. Sold out 0.00% −1.66
NUVL Nuvalent Inc. Class A Sold out 0.00% −1.60
SLNO Soleno Therapeutics Inc. Sold out 0.00% −1.53
APGE Apogee Therapeutics Inc. Sold out 0.00% −0.83
BBIO Bridgebio Pharma Inc. Reduce -73.5% 0.22% −0.79
JAZZ Jazz Pharmaceuticals PLC Sold out 0.00% −0.57
AMZN Amazon.com Inc. Reduce -40.2% 0.73% −0.56
NATL NCR Atleos Corp. Sold out 0.00% −0.48
SYRE Spyre Therapeutics Inc. Reduce -46.8% 1.57% −0.46
MSFT Microsoft Corp. Reduce -62.6% 0.21% −0.45
CLH Clean Harbors Inc. Sold out 0.00% −0.44
COGT Cogent Biosciences Inc. Reduce -4.2% 1.67% −0.43
CRM Salesforce Inc. Sold out 0.00% −0.43
XOMA Xoma Royalty Corporation Sold out 0.00% −0.41
AVTR Avantor Inc. Sold out 0.00% −0.40
ASND Ascendis Pharma A/S Sold out 0.00% −0.37
INTU Intuit Inc. Sold out 0.00% −0.36
BKNG Booking Holdings Inc. Sold out 0.00% −0.33
KRC Kilroy Realty Corp. Sold out 0.00% −0.33
EQT Eqt Corp. Sold out 0.00% −0.32
LITE Lumentum Holdings Inc. Reduce -51.3% 0.30% −0.31
PBR.A Petroleo Brasil-SP Pref ADR Sold out 0.00% −0.31
CEG Constellation Energy Reduce -56.7% 0.14% −0.30
PTGX Protagonist Therapeutics Inc. Reduce -27.7% 0.68% −0.30
XENE Xenon Pharmaceuticals Inc. Reduce -28.0% 0.49% −0.30
WDAY Workday Inc. Class A Sold out 0.00% −0.30
PTC PTC Inc. Sold out 0.00% −0.29
GEV GE Vernova Inc. Sold out 0.00% −0.29
AGX Argan Inc. Sold out 0.00% −0.29
AMRZ Amrize Ltd. Sold out 0.00% −0.26
RDDT Reddit Inc. Class A Sold out 0.00% −0.26
MMM 3M Co. Sold out 0.00% −0.25
UNP Union Pacific Corp. Sold out 0.00% −0.25
CPNG Coupang Inc. Sold out 0.00% −0.24
CIEN Ciena Corp. Reduce -44.6% 0.33% −0.24
CLF Cleveland-Cliffs Inc. Sold out 0.00% −0.24
CTMX Cytomx Therapeutics Inc. Reduce -41.0% 0.15% −0.23
P Everpure Inc. Class A Sold out 0.00% −0.23
CAAP Corp. America Airports SA Sold out 0.00% −0.21
PVLA Palvella Therapeutics Inc. Sold out 0.00% −0.20
BBOT Bridgebio Oncology Therapeut Sold out 0.00% −0.19
RLX RLX Technology Inc.-ADR Sold out 0.00% −0.19
PFSI Pennymac Financial Services Sold out 0.00% −0.18
IMCR Immunocore Holdings PLC-ADR Reduce -26.4% 0.31% −0.18
RXO Rxo Inc. Sold out 0.00% −0.17
SE Sea Ltd.-ADR Sold out 0.00% −0.17
MLTX Moonlake Immunotherapeutics Reduce -3.1% 0.83% −0.16
ORKA Oruka Therapeutics Inc. Reduce -46.9% 0.91% −0.16
NOK Nokia Corp.-Spon ADR Sold out 0.00% −0.16
U Unity Software Inc. Reduce -44.0% 0.23% −0.15

Portfolio Buys Q1 2026 → Q2 2026
DFTX Definium Therapeutics Inc. Add +30.7% 2.60% +1.64
CCCC C4 Therapeutics Inc. New 1.44% +1.44
ALKS Alkermes PLC Add +144.9% 2.14% +1.43
TNGX Tango Therapeutics Inc. Add +149.6% 1.85% +1.25
RLAY Relay Therapeutics Inc. Add +20.0% 2.16% +1.00
IMVT Immunovant Inc. Add +23.4% 2.44% +0.90
TVTX Travere Therapeutics Inc. Add +137.4% 1.12% +0.82
ELVN Enliven Therapeutics Inc. Add +88.6% 1.60% +0.80
RLMD Relmada Therapeutics Inc. New 0.70% +0.70
CMPS Compass Pathways PLC Add +1.9% 1.20% +0.64
ALMS Alumis Inc. Add +77.1% 1.28% +0.60
PHVS Pharvaris NV Add +64.0% 1.27% +0.50
CYTK Cytokinetics Inc. Add +33.0% 1.52% +0.45
TXN Texas Instruments Inc. New 0.44% +0.44
TLN Talen Energy Corp. Add +161.3% 0.71% +0.44
DNOW Dnow Inc. New 0.39% +0.39
NUE Nucor Corp. New 0.39% +0.39
LBRX LB Pharmaceuticals Inc. Add +21.8% 1.57% +0.38
TDAY USA Today Co. Inc. New 0.37% +0.37
CLMT Calumet Inc. New 0.36% +0.36
Q Qnity Electronics Inc. New 0.36% +0.36
CRDO Credo Technology Group Holdi New 0.36% +0.36
BCO The Brink's Co. New 0.35% +0.35
ALAB Astera Labs Inc. New 0.35% +0.35
SPGI S&P Global Inc. New 0.35% +0.35
EFX Equifax Inc. New 0.35% +0.35
DPZ Domino's Pizza Inc. New 0.34% +0.34
DNTH Dianthus Therapeutics Inc. Add +43.7% 1.14% +0.31
USFD US Foods Holding Corp. New 0.30% +0.30
FE Firstenergy Corp. New 0.28% +0.28
MCO Moody's Corp. New 0.28% +0.28
AVTX Avalo Therapeutics Inc. Add +109.2% 0.52% +0.27
AMAT Applied Materials Inc. New 0.27% +0.27
VERA Vera Therapeutics Inc. Add +53.0% 1.04% +0.27
GLNG Golar LNG Ltd. New 0.25% +0.25
IRON Disc Medicine Inc. New 0.24% +0.24
TARS Tarsus Pharmaceuticals Inc. Add +65.9% 1.25% +0.23
AMLX Amylyx Pharmaceuticals Inc. Add +9.7% 1.58% +0.23
STM Stmicroelectronics NV-NY SHS New 0.23% +0.23
SEPN Septerna Inc. New 0.22% +0.22
ARM Arm Holdings PLC-ADR New 0.22% +0.22
TPR Tapestry Inc. New 0.22% +0.22
SIMO Silicon Motion Technol-ADR New 0.21% +0.21
AEIS Advanced Energy Industries New 0.19% +0.19
KSPI JSC Kaspi.kz ADR New 0.19% +0.19
MLYS Mineralys Therapeutics Inc. Add +84.0% 0.53% +0.18
QXO Qxo Inc. Add +209.3% 0.32% +0.18
VST Vistra Corp. New 0.18% +0.18
JHX James Hardie Ind PLC Add +29.9% 0.51% +0.17
MTZ Mastec Inc. Add +41.6% 0.49% +0.17

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 147$438.6MDBC, ABVX, RVMD, DFTX, IMVT
Q1 2026 156$362.2MDBC, ABVX, PRAX, COGT, SYRE
Q4 2025 145$388.3MDBC, GPCR, COGT, VRDN, ABVX
Q3 2025 148$408.0MDBC, ABVX, MRUS, VRDN, RVMD
Q2 2025 146$272.1MDBC, VRDN, ANSS, MSFT, MRUS
Q1 2025 148$259.5MDBC, HES, JNPR, ACI, ANSS
Q4 2024 137$268.8MDBC, AMZN, HCP, MSFT, ANSS
Q3 2024 142$290.0MDBC, AMZN, PCVX, ACLX, CTLT
Q2 2024 137$273.8MDBC, INSM, MRUS, CRM, AXSM
Q1 2024 131$280.4MDBC, APGE, SYRE, MRUS, MSFT