Orbimed Advisors LLC

In its 13F for Q4 2024 (holdings as of December 31, 2024, filed February 14, 2025), Orbimed Advisors LLC reported 111 stock positions worth $4.8 billion. Its top holding was Edgewise Therapeutics (EWTX) at 8.3% of the portfolio, followed by Sinovac Biotech (SVA, 6.9%) and Boston Scientific (BSX, 5.9%). Compared with Q3 2024, it opened 19 new positions, sold out of 17, added to 23 and reduced 21. The biggest buy was Neurocrine Biosciences (NBIX, shares +210%) and the biggest sale an exit from Amgen (AMGN).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0001055951
Portfolio Value
$4.8B (Q4 2024)
SEC Filing
0001172661-25-001136 ↗ filed Feb 14, 2025

Holdings Value

0$2.0B$4.0B$6.0B Q1 2024: $5.4B Q1 2024 Q2 2024: $5.0B Q2 2024 Q3 2024: $5.5B Q3 2024 Q4 2024: $4.8B $4.8B Q4 2024 Q1 2025: $4.2B Q1 2025 Q2 2025: $4.0B Q2 2025 Q3 2025: $4.2B Q3 2025 Q4 2025: $4.9B Q4 2025 Q1 2026: $4.4B Q1 2026 Q2 2026: $5.3B Q2 2026

Holdings 111 stocks · $4.8B
EWTX Edgewise Therapeutics Inc. 8.33% 15,021,721 $401.1M No change
SVA Sinovac Biotech Ltd. 6.94% 2,718,735 $334.0M No change
BSX Boston Scientific Corp. 5.86% 3,160,300 $282.3M Reduce -3.4%
LLY Eli Lilly & Co. 5.41% 337,600 $260.6M No change
ISRG Intuitive Surgical Inc. 4.35% 401,700 $209.7M Reduce -7.4%
ELVN Enliven Therapeutics Inc. 3.72% 7,959,538 $179.1M No change
NBIX Neurocrine Biosciences Inc. 2.66% 938,120 $128.1M Add +210.4%
SYK Stryker Corp. 2.57% 344,400 $124.0M No change
SRPT Sarepta Therapeutics Inc. 2.43% 963,400 $117.1M Add +0.9%
ARGX Argenx SE - ADR 2.42% 189,700 $116.7M Reduce -7.2%
IRON Disc Medicine Inc. 2.35% 1,785,571 $113.2M No change
THC Tenet Healthcare Corp. 2.08% 792,000 $100.0M Add +1.3%
IONS Ionis Pharmaceuticals Inc. 2.05% 2,817,347 $98.5M Add +21.2%
ALNY Alnylam Pharmaceuticals Inc. 2.03% 415,600 $97.8M Add +66.0%
UPB Upstream Bio Inc. 1.94% 5,693,589 $93.6M New
SPRY Ars Pharmaceuticals Inc. 1.82% 8,288,510 $87.4M No change
EW Edwards Lifesciences Corp. 1.76% 1,145,302 $84.8M New
MRK Merck & Co. Inc. 1.71% 829,900 $82.6M Reduce -36.9%
AVBP Arrivent Biopharma Inc. 1.67% 3,027,328 $80.6M No change
BIIB Biogen Inc. 1.62% 509,100 $77.9M Reduce -37.4%
ITGR Integer Holdings Corp. 1.58% 575,000 $76.2M No change
CYTK Cytokinetics Inc. 1.55% 1,584,005 $74.5M Add +106.5%
MBX MBX Biosciences Inc. 1.46% 3,812,215 $70.3M No change
UNH Unitedhealth Group Inc. 1.37% 130,900 $66.2M Reduce -26.9%
NTRA Natera Inc. 1.36% 413,000 $65.4M Reduce -39.9%
VRTX Vertex Pharmaceuticals Inc. 1.26% 151,000 $60.8M No change
THRD Third Harmonic Bio Inc. 1.23% 5,779,071 $59.5M No change
CRNX Crinetics Pharmaceuticals Inc. 1.06% 999,000 $51.1M Reduce -4.9%
UHS Universal Health Services-B 1.00% 269,300 $48.3M Add +72.6%
SIBN Si-Bone Inc. 1.00% 3,442,853 $48.3M Add +4.2%
SWTX Springworks Therapeutics Inc. 0.94% 1,255,031 $45.3M Reduce -9.8%
TMO Thermo Fisher Scientific Inc. 0.91% 84,400 $43.9M No change
TERN Terns Pharmaceuticals Inc. 0.87% 7,562,971 $41.9M No change
CGON CG Oncology Inc. 0.85% 1,431,114 $41.0M Add +107.1%
JANX Janux Therapeutics Inc. 0.84% 758,566 $40.6M Reduce -39.7%
EXAS Exact Sciences Corp. 0.79% 679,816 $38.2M No change
NPCE Neuropace Inc. 0.79% 3,406,335 $38.1M No change
XENE Xenon Pharmaceuticals Inc. 0.77% 947,877 $37.2M Add +4.0%
CRVS Corvus Pharmaceuticals Inc. 0.77% 6,943,654 $37.1M No change
XBI SS SPDR S&P Biotech ETF 0.70% 372,000 $33.5M New
CMPX Compass Therapeutics Inc. 0.67% 22,362,850 $32.4M No change
XTNT Xtant Medical Holdings Inc. 0.67% 73,114,592 $32.4M No change
RNAM Avidity Biosciences Inc. 0.67% 1,112,886 $32.4M Add +6.5%
VERA Vera Therapeutics Inc. 0.65% 742,572 $31.4M Add +9.9%
DYN Dyne Therapeutics Inc. 0.60% 1,227,080 $28.9M Add +73.2%
CGEM Cullinan Therapeutics Inc. 0.49% 1,942,555 $23.7M Add +81.5%
VIR Vir Biotechnology Inc. 0.49% 3,218,617 $23.6M Reduce -9.9%
GILD Gilead Sciences Inc. 0.47% 245,600 $22.7M Add +61.9%
RYTM Rhythm Pharmaceuticals Inc. 0.46% 400,000 $22.4M Reduce -8.2%
IMTX Immatics NV 0.46% 3,087,462 $22.0M Add +53.9%
FOLD Amicus Therapeutics Inc. 0.45% 2,285,400 $21.5M Add +300.7%
SCPH Scpharmaceuticals Inc. 0.45% 6,059,528 $21.5M No change
RAPT THERAPEUTICS INC 0.43% 13,135,260 $20.8M New
TYRA Tyra Biosciences Inc. 0.42% 1,470,086 $20.4M Add +91.3%
MLYS Mineralys Therapeutics Inc. 0.41% 1,611,637 $19.8M Reduce -19.5%
0 0.37% 12,048,773 $17.7M No change
GPCR Structure Therapeutics Inc. 0.37% 652,028 $17.7M Add +69.9%
KROS Keros Therapeutics Inc. 0.33% 1,018,734 $16.1M No change
CCCC C4 Therapeutics Inc. 0.33% 4,377,900 $15.8M No change
MEDP Medpace Holdings Inc. 0.31% 44,900 $14.9M No change
VSTM Verastem Inc. 0.31% 2,862,448 $14.8M No change
PRLD Prelude Therapeutics Inc. 0.29% 10,909,256 $13.9M No change
CRBP Corbus Pharmaceuticals Holdi 0.29% 1,172,287 $13.8M Add +28.5%
FBRX Forte Biosciences Inc. 0.28% 600,000 $13.6M New
ITCI Intra-Cellular Therapies Inc. 0.28% 163,000 $13.6M New
SLRN Acelyrin Inc. 0.26% 4,001,711 $12.6M No change
ABCL Abcellera Biologics Inc. 0.25% 4,180,768 $12.2M No change
ADCT Adc Therapeutics SA 0.25% 5,968,451 $11.9M Add +31.6%
ACET Adicet Bio Inc. 0.23% 11,447,140 $11.0M No change
PMVP PMV Pharmaceuticals Inc. 0.20% 6,475,291 $9.8M No change
NMRA Neumora Therapeutics Inc. 0.18% 804,996 $8.5M Reduce -46.3%
QTTB Q32 Bio Inc. 0.16% 2,252,987 $7.8M No change
GERN Geron Corp. 0.16% 2,168,000 $7.7M New
AVTX Avalo Therapeutics Inc. 0.15% 967,000 $7.2M No change
CRDF Cardiff Oncology Inc. 0.14% 1,538,462 $6.7M New
SRRK Scholar Rock Holding Corp. 0.14% 151,800 $6.6M Reduce -79.5%
INSM Insmed Inc. 0.14% 94,559 $6.5M New
ENGN Engene Holdings Inc. 0.13% 920,339 $6.1M New
IKENA ONCOLOGY INC 0.12% 3,539,358 $5.8M No change
NSPR Inspiremd Inc. 0.12% 2,133,405 $5.6M No change
TRAW Traws Pharma Inc. 0.11% 605,531 $5.4M No change
BIOA Bioage Labs Inc. 0.11% 921,959 $5.3M Reduce -35.2%
XFOR X4 Pharmaceuticals Inc. 0.11% 7,133,515 $5.2M No change
BCAX Bicara Therapeutics Inc. 0.11% 298,301 $5.2M Add +9.7%
MIST Milestone Pharmaceuticals Inc. 0.10% 2,000,000 $4.7M No change
RPTX Repare Therapeutics Inc. 0.09% 3,322,488 $4.4M No change
PASG Passage Bio Inc. 0.09% 7,404,869 $4.2M Reduce -24.6%
KRYS Krystal Biotech Inc. 0.08% 23,500 $3.7M No change
ARDT Ardent Health Inc. 0.07% 206,000 $3.5M No change
CMMB Chemomab Therapeutics Ltd. 0.07% 1,741,273 $3.2M No change
CBLL Ceribell Inc. 0.06% 112,500 $2.9M New
FATE Fate Therapeutics Inc. 0.06% 1,680,580 $2.8M No change
PEPG Pepgen Inc. 0.05% 653,016 $2.5M Reduce -18.1%
TIL Instil Bio Inc. 0.05% 116,785 $2.2M Add +246.5%
NKTX Nkarta Inc. 0.04% 821,400 $2.0M Reduce -44.5%
LYEL Lyell Immunopharma Inc. 0.04% 3,103,623 $2.0M Reduce -49.0%
IMVT Immunovant Inc. 0.04% 78,500 $1.9M New
AKRO Akero Therapeutics Inc. 0.04% 66,000 $1.8M New
TNGX Tango Therapeutics Inc. 0.04% 550,000 $1.7M New
TSBX Turnstone Biologics Corp. 0.03% 3,099,265 $1.5M No change
AMLX Amylyx Pharmaceuticals Inc. 0.03% 348,000 $1.3M New
BIOMX INC 0.03% 1,787,767 $1.3M No change
KZR Kezar Life Sciences Inc. 0.03% 192,700 $1.3M No change
KRRO Korro Bio Inc. 0.03% 32,400 $1.2M New
ANRO Alto Neuroscience Inc. 0.02% 250,000 $1.1M New
NXTC Nextcure Inc. 0.02% 1,141,200 $880K No change
AGIO Agios Pharmaceuticals Inc. 0.02% 26,700 $877K New
ELEV Elevation Oncology Inc. 0.01% 941,275 $530K No change
IVVD Invivyd Inc. 0.01% 1,149,300 $509K Reduce -33.5%
LSBCF Lakeshore Biopharma Co. Ltd. 0.01% 140,428 $486K New
XERS Xeris Biopharma Holdings Inc. 0.01% 80,420 $273K No change

Options reported separately and not counted above: GILD calls ($18.5M), UHS calls ($9.0M), PFE calls ($6.6M), GPCR calls ($4.1M), SIBN calls ($3.5M), THC calls ($3.2M), CCCC calls ($540K).

Portfolio Sells Q3 2024 → Q4 2024
AMGN Amgen Inc. Sold out 0.00% −1.49
BIIB Biogen Inc. Reduce -37.4% 1.62% −1.27
MRK Merck & Co. Inc. Reduce -36.9% 1.71% −1.02
ELV Elevance Health Inc. Sold out 0.00% −1.01
REGN Regeneron Pharmaceuticals Sold out 0.00% −0.87
EVH Evolent Health Inc. Class A Sold out 0.00% −0.86
PCVX Vaxcyte Inc. Sold out 0.00% −0.81
SNDX Syndax Pharmaceuticals Inc. Sold out 0.00% −0.68
APLS Apellis Pharmaceuticals Inc. Sold out 0.00% −0.67
ICLR Icon PLC Sold out 0.00% −0.65
UNH Unitedhealth Group Inc. Reduce -26.9% 1.37% −0.54
PHAT Phathom Pharmaceuticals Inc. Sold out 0.00% −0.48
BIOA Bioage Labs Inc. Reduce -35.2% 0.11% −0.43
APGE Apogee Therapeutics Inc. Sold out 0.00% −0.41
LXRX Lexicon Pharmaceuticals Inc. Sold out 0.00% −0.32
NTRA Natera Inc. Reduce -39.9% 1.36% −0.24
BNTX Biontech SE-ADR Sold out 0.00% −0.22
ACAD Acadia Pharmaceuticals Inc. Sold out 0.00% −0.22
JANX Janux Therapeutics Inc. Reduce -39.7% 0.84% −0.20
NMRA Neumora Therapeutics Inc. Reduce -46.3% 0.18% −0.19
OSCR Oscar Health Inc. Class A Sold out 0.00% −0.14
LYEL Lyell Immunopharma Inc. Reduce -49.0% 0.04% −0.11
LBPH Longboard Pharmaceuticals Inc. Sold out 0.00% −0.10
TELA Tela Bio Inc. Sold out 0.00% −0.10
NKTX Nkarta Inc. Reduce -44.5% 0.04% −0.08
PEPG Pepgen Inc. Reduce -18.1% 0.05% −0.07
PASG Passage Bio Inc. Reduce -24.6% 0.09% −0.04
MLYS Mineralys Therapeutics Inc. Reduce -19.5% 0.41% −0.03
VIGL Vigil Neuroscience Inc. Sold out 0.00% −0.03
IVVD Invivyd Inc. Reduce -33.5% 0.01% −0.02
VIR Vir Biotechnology Inc. Reduce -9.9% 0.49% +0.00
SRRK Scholar Rock Holding Corp. Reduce -79.5% 0.14% +0.03
RYTM Rhythm Pharmaceuticals Inc. Reduce -8.2% 0.46% +0.05
CRNX Crinetics Pharmaceuticals Inc. Reduce -4.9% 1.06% +0.08
SWTX Springworks Therapeutics Inc. Reduce -9.8% 0.94% +0.13
ARGX Argenx SE - ADR Reduce -7.2% 2.42% +0.39
ISRG Intuitive Surgical Inc. Reduce -7.4% 4.35% +0.45
BSX Boston Scientific Corp. Reduce -3.4% 5.86% +0.84

Portfolio Buys Q3 2024 → Q4 2024
NBIX Neurocrine Biosciences Inc. Add +210.4% 2.66% +2.02
UPB Upstream Bio Inc. New 1.94% +1.94
EW Edwards Lifesciences Corp. New 1.76% +1.76
CYTK Cytokinetics Inc. Add +106.5% 1.55% +0.81
ALNY Alnylam Pharmaceuticals Inc. Add +66.0% 2.03% +0.77
XBI SS SPDR S&P Biotech ETF New 0.70% +0.70
RAPT THERAPEUTICS INC New 0.43% +0.43
CGON CG Oncology Inc. Add +107.1% 0.85% +0.38
UHS Universal Health Services-B Add +72.6% 1.00% +0.35
IONS Ionis Pharmaceuticals Inc. Add +21.2% 2.05% +0.34
FOLD Amicus Therapeutics Inc. Add +300.7% 0.45% +0.34
FBRX Forte Biosciences Inc. New 0.28% +0.28
ITCI Intra-Cellular Therapies Inc. New 0.28% +0.28
SRPT Sarepta Therapeutics Inc. Add +0.9% 2.43% +0.25
GILD Gilead Sciences Inc. Add +61.9% 0.47% +0.24
CGEM Cullinan Therapeutics Inc. Add +81.5% 0.49% +0.16
GERN Geron Corp. New 0.16% +0.16
SIBN Si-Bone Inc. Add +4.2% 1.00% +0.16
CRDF Cardiff Oncology Inc. New 0.14% +0.14
INSM Insmed Inc. New 0.14% +0.14
DYN Dyne Therapeutics Inc. Add +73.2% 0.60% +0.13
ENGN Engene Holdings Inc. New 0.13% +0.13
XENE Xenon Pharmaceuticals Inc. Add +4.0% 0.77% +0.11
VERA Vera Therapeutics Inc. Add +9.9% 0.65% +0.11
TYRA Tyra Biosciences Inc. Add +91.3% 0.42% +0.09
CBLL Ceribell Inc. New 0.06% +0.06
GPCR Structure Therapeutics Inc. Add +69.9% 0.37% +0.06
IMVT Immunovant Inc. New 0.04% +0.04
AKRO Akero Therapeutics Inc. New 0.04% +0.04
IMTX Immatics NV Add +53.9% 0.46% +0.04
TNGX Tango Therapeutics Inc. New 0.04% +0.04
AMLX Amylyx Pharmaceuticals Inc. New 0.03% +0.03
KRRO Korro Bio Inc. New 0.03% +0.03
ANRO Alto Neuroscience Inc. New 0.02% +0.02
AGIO Agios Pharmaceuticals Inc. New 0.02% +0.02
LSBCF Lakeshore Biopharma Co. Ltd. New 0.01% +0.01
TIL Instil Bio Inc. Add +246.5% 0.05% +0.00
ADCT Adc Therapeutics SA Add +31.6% 0.25% −0.01
BCAX Bicara Therapeutics Inc. Add +9.7% 0.11% −0.02
CRBP Corbus Pharmaceuticals Holdi Add +28.5% 0.29% −0.06
RNAM Avidity Biosciences Inc. Add +6.5% 0.67% −0.21
THC Tenet Healthcare Corp. Add +1.3% 2.08% −0.30

Options Activity Q3 2024 → Q4 2024
GILD Gilead Sciences Inc. call New 200,000 $18.5M
UHS Universal Health Services-B call New 50,000 $9.0M
EVH Evolent Health Inc. Class A call Sold out 258,400 $7.3Mbefore exit
MRNA Moderna Inc. call Sold out 100,000 $6.7Mbefore exit
PFE Pfizer Inc. call New 250,000 $6.6M
SRPT Sarepta Therapeutics Inc. call Sold out 50,000 $6.2Mbefore exit
SOLV Solventum Corp. call Sold out 69,300 $4.8Mbefore exit
RNAM Avidity Biosciences Inc. call Sold out 100,000 $4.6Mbefore exit
GPCR Structure Therapeutics Inc. call New 150,000 $4.1M
THC Tenet Healthcare Corp. call New 25,000 $3.2M
FLNA Filana Therapeutics Inc. put Sold out 95,000 $2.8Mbefore exit
GERN Geron Corp. call Sold out 400,000 $1.8Mbefore exit

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 117$5.3BEWTX, ELVN, LLY, MBX, SVA
Q1 2026 105$4.4BEWTX, ELVN, LLY, SVA, BSX
Q4 2025 104$4.9BEWTX, LLY, BSX, SVA, EW
Q3 2025 98$4.2BEWTX, BSX, LLY, SVA, ELVN
Q2 2025 97$4.0BSVA, BSX, LLY, EWTX, ELVN
Q1 2025 106$4.2BSVA, EWTX, BSX, LLY, ELVN
Q4 2024 111$4.8BEWTX, SVA, BSX, LLY, ISRG
Q3 2024 109$5.5BEWTX, SVA, LLY, BSX, ISRG
Q2 2024 108$5.0BSVA, LLY, EWTX, BSX, ISRG
Q1 2024 112$5.4BSVA, LLY, EWTX, BSX, ISRG