Orbimed Advisors LLC

In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 15, 2025), Orbimed Advisors LLC reported 106 stock positions worth $4.2 billion. Its top holding was Sinovac Biotech (SVA) at 8.0% of the portfolio, followed by Edgewise Therapeutics (EWTX, 7.9%) and Boston Scientific (BSX, 6.8%). Compared with Q4 2024, it opened 11 new positions, sold out of 16, added to 15 and reduced 22. The biggest buy was a new position in Pfizer (PFE) and the biggest sale an exit from Sarepta Therapeutics (SRPT).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0001055951
Portfolio Value
$4.2B (Q1 2025)
SEC Filing
0001172661-25-002355 ↗ filed May 15, 2025

Holdings Value

0$2.0B$4.0B$6.0B Q1 2024: $5.4B Q1 2024 Q2 2024: $5.0B Q2 2024 Q3 2024: $5.5B Q3 2024 Q4 2024: $4.8B Q4 2024 Q1 2025: $4.2B $4.2B Q1 2025 Q2 2025: $4.0B Q2 2025 Q3 2025: $4.2B Q3 2025 Q4 2025: $4.9B Q4 2025 Q1 2026: $4.4B Q1 2026 Q2 2026: $5.3B Q2 2026

Holdings 106 stocks · $4.2B
SVA Sinovac Biotech Ltd. 8.02% 2,718,735 $334.0M No change
EWTX Edgewise Therapeutics Inc. 7.94% 15,021,721 $330.5M No change
BSX Boston Scientific Corp. 6.82% 2,813,200 $283.8M Reduce -11.0%
LLY Eli Lilly & Co. 6.70% 337,600 $278.8M No change
ELVN Enliven Therapeutics Inc. 3.76% 7,959,538 $156.6M No change
ISRG Intuitive Surgical Inc. 3.46% 291,000 $144.1M Reduce -27.6%
SYK Stryker Corp. 3.21% 359,200 $133.7M Add +4.3%
ARGX Argenx SE - ADR 2.94% 206,700 $122.3M Add +9.0%
EW Edwards Lifesciences Corp. 2.67% 1,532,000 $111.0M Add +33.8%
UNH Unitedhealth Group Inc. 2.53% 201,200 $105.4M Add +53.7%
SPRY Ars Pharmaceuticals Inc. 2.50% 8,288,510 $104.3M No change
NBIX Neurocrine Biosciences Inc. 2.48% 934,640 $103.4M Reduce -0.4%
PFE Pfizer Inc. 2.34% 3,850,200 $97.6M New
ALNY Alnylam Pharmaceuticals Inc. 2.24% 346,100 $93.5M Reduce -16.7%
ITGR Integer Holdings Corp. 1.88% 662,500 $78.2M Add +15.2%
VRTX Vertex Pharmaceuticals Inc. 1.86% 159,900 $77.5M Add +5.9%
NTRA Natera Inc. 1.86% 547,000 $77.4M Add +32.5%
IONS Ionis Pharmaceuticals Inc. 1.84% 2,540,136 $76.6M Reduce -9.8%
IRON Disc Medicine Inc. 1.69% 1,415,020 $70.2M Reduce -20.8%
TMO Thermo Fisher Scientific Inc. 1.54% 129,000 $64.2M Add +52.8%
THC Tenet Healthcare Corp. 1.50% 465,000 $62.5M Reduce -41.3%
CYTK Cytokinetics Inc. 1.46% 1,509,205 $60.7M Reduce -4.7%
CGON CG Oncology Inc. 1.45% 2,471,994 $60.5M Add +72.7%
AVBP Arrivent Biopharma Inc. 1.34% 3,027,328 $56.0M No change
RNAM Avidity Biosciences Inc. 1.29% 1,812,886 $53.5M Add +62.9%
SIBN Si-Bone Inc. 1.16% 3,442,853 $48.3M No change
AXSM Axsome Therapeutics Inc. 1.08% 386,700 $45.1M New
CMPX Compass Therapeutics Inc. 1.02% 22,362,850 $42.5M No change
SWTX Springworks Therapeutics Inc. 1.01% 950,200 $41.9M Reduce -24.3%
NPCE Neuropace Inc. 1.01% 3,406,335 $41.9M No change
SION Sionna Therapeutics Inc. 0.93% 3,704,959 $38.8M New
UPB Upstream Bio Inc. 0.84% 5,693,589 $34.8M No change
XTNT Xtant Medical Holdings Inc. 0.83% 73,114,592 $34.4M No change
TARS Tarsus Pharmaceuticals Inc. 0.81% 653,743 $33.6M New
CRNX Crinetics Pharmaceuticals Inc. 0.80% 999,000 $33.5M No change
XENE Xenon Pharmaceuticals Inc. 0.76% 947,877 $31.8M No change
APLS Apellis Pharmaceuticals Inc. 0.75% 1,432,300 $31.3M New
MBX MBX Biosciences Inc. 0.71% 4,002,887 $29.5M Add +5.0%
EXAS Exact Sciences Corp. 0.71% 679,816 $29.4M No change
GILD Gilead Sciences Inc. 0.53% 197,500 $22.1M Reduce -19.6%
CRVS Corvus Pharmaceuticals Inc. 0.53% 6,943,654 $22.1M No change
TERN Terns Pharmaceuticals Inc. 0.50% 7,562,971 $20.9M No change
JANX Janux Therapeutics Inc. 0.49% 758,566 $20.5M No change
RYTM Rhythm Pharmaceuticals Inc. 0.48% 380,000 $20.1M Reduce -5.0%
THRD Third Harmonic Bio Inc. 0.48% 5,779,071 $20.1M No change
FOLD Amicus Therapeutics Inc. 0.45% 2,285,400 $18.6M No change
VSTM Verastem Inc. 0.41% 2,862,448 $17.3M No change
TYRA Tyra Biosciences Inc. 0.39% 1,752,831 $16.3M Add +19.2%
RAPT THERAPEUTICS INC 0.38% 13,135,260 $16.0M No change
SCPH Scpharmaceuticals Inc. 0.38% 6,059,528 $15.9M No change
VIR Vir Biotechnology Inc. 0.35% 2,248,249 $14.6M Reduce -30.1%
CGEM Cullinan Therapeutics Inc. 0.35% 1,923,855 $14.6M Reduce -1.0%
IMTX Immatics NV 0.33% 3,087,462 $13.9M No change
AMGN Amgen Inc. 0.33% 44,200 $13.8M New
0 0.30% 12,048,773 $12.5M No change
VERA Vera Therapeutics Inc. 0.28% 481,065 $11.6M Reduce -35.2%
GPCR Structure Therapeutics Inc. 0.27% 652,028 $11.3M No change
CCCC C4 Therapeutics Inc. 0.26% 6,830,300 $10.9M Add +56.0%
DYN Dyne Therapeutics Inc. 0.25% 1,014,611 $10.6M Reduce -17.3%
KROS Keros Therapeutics Inc. 0.25% 1,018,734 $10.4M No change
SLRN Acelyrin Inc. 0.24% 4,001,711 $9.9M No change
AGIO Agios Pharmaceuticals Inc. 0.23% 325,500 $9.5M Add +1119.1%
ABCL Abcellera Biologics Inc. 0.22% 4,180,768 $9.3M No change
ACET Adicet Bio Inc. 0.21% 11,447,140 $8.6M No change
ADCT Adc Therapeutics SA 0.20% 5,968,451 $8.4M No change
PRLD Prelude Therapeutics Inc. 0.20% 10,909,256 $8.4M No change
AVTX Avalo Therapeutics Inc. 0.19% 967,000 $7.7M No change
WHWK Whitehawk Therapeutics Inc. 0.18% 4,166,000 $7.4M New
AKRO Akero Therapeutics Inc. 0.17% 179,900 $7.3M Add +172.6%
PMVP PMV Pharmaceuticals Inc. 0.17% 6,475,291 $7.1M No change
TRVI Trevi Therapeutics Inc. 0.17% 1,120,000 $7.0M New
KMTS Kestra Medical Technologies 0.15% 250,000 $6.2M New
CRBP Corbus Pharmaceuticals Holdi 0.15% 1,172,287 $6.2M No change
NSPR Inspiremd Inc. 0.14% 2,133,405 $5.7M No change
SRRK Scholar Rock Holding Corp. 0.12% 151,800 $4.9M No change
FBRX Forte Biosciences Inc. 0.11% 593,088 $4.6M Reduce -1.1%
IKENA ONCOLOGY INC 0.11% 3,539,358 $4.5M No change
KRYS Krystal Biotech Inc. 0.10% 23,500 $4.2M No change
ENGN Engene Holdings Inc. 0.10% 891,616 $4.0M Reduce -3.1%
ORIC Oric Pharmaceuticals Inc. 0.09% 700,000 $3.9M New
BCAX Bicara Therapeutics Inc. 0.09% 298,301 $3.9M No change
QTTB Q32 Bio Inc. 0.09% 2,252,987 $3.7M No change
BIOA Bioage Labs Inc. 0.08% 921,959 $3.5M No change
RPTX Repare Therapeutics Inc. 0.08% 3,322,488 $3.3M No change
PASG Passage Bio Inc. 0.06% 7,034,626 $2.5M Reduce -5.0%
INSM Insmed Inc. 0.05% 28,659 $2.2M Reduce -69.7%
CBLL Ceribell Inc. 0.05% 112,500 $2.2M No change
TIL Instil Bio Inc. 0.05% 116,785 $2.0M No change
CMMB Chemomab Therapeutics Ltd. 0.05% 1,741,273 $1.9M No change
CRDF Cardiff Oncology Inc. 0.04% 573,884 $1.8M Reduce -62.7%
XFOR X4 Pharmaceuticals Inc. 0.04% 6,776,515 $1.6M Reduce -5.0%
NKTX Nkarta Inc. 0.04% 821,400 $1.5M No change
TRAW Traws Pharma Inc. 0.03% 605,531 $1.4M No change
FATE Fate Therapeutics Inc. 0.03% 1,680,580 $1.3M No change
TSBX Turnstone Biologics Corp. 0.03% 3,099,265 $1.3M No change
AMLX Amylyx Pharmaceuticals Inc. 0.03% 348,000 $1.2M No change
BIOMX INC 0.02% 1,787,767 $993K No change
KZR Kezar Life Sciences Inc. 0.02% 192,700 $940K No change
TNGX Tango Therapeutics Inc. 0.02% 550,000 $754K No change
IVVD Invivyd Inc. 0.01% 933,500 $565K Reduce -18.8%
KRRO Korro Bio Inc. 0.01% 32,400 $564K No change
NXTC Nextcure Inc. 0.01% 1,141,200 $548K No change
ANRO Alto Neuroscience Inc. 0.01% 250,000 $540K No change
DIH HLDG US INC 0.01% 1,915,000 $443K New
XERS Xeris Biopharma Holdings Inc. 0.01% 80,420 $442K No change
LSBCF Lakeshore Biopharma Co. Ltd. 0.01% 140,428 $344K No change

Options reported separately and not counted above: PFE calls ($12.7M), XBI calls ($8.1M), SWTX calls ($7.6M), GPCR calls ($2.6M).

Portfolio Sells Q4 2024 → Q1 2025
SRPT Sarepta Therapeutics Inc. Sold out 0.00% −2.43
MRK Merck & Co. Inc. Sold out 0.00% −1.71
BIIB Biogen Inc. Sold out 0.00% −1.62
UHS Universal Health Services-B Sold out 0.00% −1.00
ISRG Intuitive Surgical Inc. Reduce -27.6% 3.46% −0.89
XBI SS SPDR S&P Biotech ETF Sold out 0.00% −0.70
IRON Disc Medicine Inc. Reduce -20.8% 1.69% −0.66
THC Tenet Healthcare Corp. Reduce -41.3% 1.50% −0.57
MLYS Mineralys Therapeutics Inc. Sold out 0.00% −0.41
VERA Vera Therapeutics Inc. Reduce -35.2% 0.28% −0.37
DYN Dyne Therapeutics Inc. Reduce -17.3% 0.25% −0.35
MEDP Medpace Holdings Inc. Sold out 0.00% −0.31
ITCI Intra-Cellular Therapies Inc. Sold out 0.00% −0.28
IONS Ionis Pharmaceuticals Inc. Reduce -9.8% 1.84% −0.20
NMRA Neumora Therapeutics Inc. Sold out 0.00% −0.18
NBIX Neurocrine Biosciences Inc. Reduce -0.4% 2.48% −0.18
FBRX Forte Biosciences Inc. Reduce -1.1% 0.11% −0.17
GERN Geron Corp. Sold out 0.00% −0.16
CGEM Cullinan Therapeutics Inc. Reduce -1.0% 0.35% −0.14
VIR Vir Biotechnology Inc. Reduce -30.1% 0.35% −0.14
MIST Milestone Pharmaceuticals Inc. Sold out 0.00% −0.10
CRDF Cardiff Oncology Inc. Reduce -62.7% 0.04% −0.10
CYTK Cytokinetics Inc. Reduce -4.7% 1.46% −0.09
INSM Insmed Inc. Reduce -69.7% 0.05% −0.08
ARDT Ardent Health Inc. Sold out 0.00% −0.07
XFOR X4 Pharmaceuticals Inc. Reduce -5.0% 0.04% −0.07
PEPG Pepgen Inc. Sold out 0.00% −0.05
LYEL Lyell Immunopharma Inc. Sold out 0.00% −0.04
IMVT Immunovant Inc. Sold out 0.00% −0.04
ENGN Engene Holdings Inc. Reduce -3.1% 0.10% −0.03
PASG Passage Bio Inc. Reduce -5.0% 0.06% −0.03
ELEV Elevation Oncology Inc. Sold out 0.00% −0.01
IVVD Invivyd Inc. Reduce -18.8% 0.01% +0.00
RYTM Rhythm Pharmaceuticals Inc. Reduce -5.0% 0.48% +0.02
GILD Gilead Sciences Inc. Reduce -19.6% 0.53% +0.06
SWTX Springworks Therapeutics Inc. Reduce -24.3% 1.01% +0.07
ALNY Alnylam Pharmaceuticals Inc. Reduce -16.7% 2.24% +0.21
BSX Boston Scientific Corp. Reduce -11.0% 6.82% +0.95

Portfolio Buys Q4 2024 → Q1 2025
PFE Pfizer Inc. New 2.34% +2.34
UNH Unitedhealth Group Inc. Add +53.7% 2.53% +1.16
AXSM Axsome Therapeutics Inc. New 1.08% +1.08
SION Sionna Therapeutics Inc. New 0.93% +0.93
EW Edwards Lifesciences Corp. Add +33.8% 2.67% +0.91
TARS Tarsus Pharmaceuticals Inc. New 0.81% +0.81
APLS Apellis Pharmaceuticals Inc. New 0.75% +0.75
SYK Stryker Corp. Add +4.3% 3.21% +0.64
TMO Thermo Fisher Scientific Inc. Add +52.8% 1.54% +0.63
RNAM Avidity Biosciences Inc. Add +62.9% 1.29% +0.61
CGON CG Oncology Inc. Add +72.7% 1.45% +0.60
VRTX Vertex Pharmaceuticals Inc. Add +5.9% 1.86% +0.60
ARGX Argenx SE - ADR Add +9.0% 2.94% +0.52
NTRA Natera Inc. Add +32.5% 1.86% +0.50
AMGN Amgen Inc. New 0.33% +0.33
ITGR Integer Holdings Corp. Add +15.2% 1.88% +0.30
AGIO Agios Pharmaceuticals Inc. Add +1119.1% 0.23% +0.21
WHWK Whitehawk Therapeutics Inc. New 0.18% +0.18
TRVI Trevi Therapeutics Inc. New 0.17% +0.17
KMTS Kestra Medical Technologies New 0.15% +0.15
AKRO Akero Therapeutics Inc. Add +172.6% 0.17% +0.14
ORIC Oric Pharmaceuticals Inc. New 0.09% +0.09
DIH HLDG US INC New 0.01% +0.01
TYRA Tyra Biosciences Inc. Add +19.2% 0.39% −0.03
CCCC C4 Therapeutics Inc. Add +56.0% 0.26% −0.06
MBX MBX Biosciences Inc. Add +5.0% 0.71% −0.75

Options Activity Q4 2024 → Q1 2025
GILD Gilead Sciences Inc. call Sold out 200,000 $18.5Mbefore exit
PFE Pfizer Inc. call Add +100.0% 500,000 $12.7M
UHS Universal Health Services-B call Sold out 50,000 $9.0Mbefore exit
XBI SS SPDR S&P Biotech ETF call New 100,000 $8.1M
SWTX Springworks Therapeutics Inc. call New 172,600 $7.6M
SIBN Si-Bone Inc. call Sold out 250,000 $3.5Mbefore exit
THC Tenet Healthcare Corp. call Sold out 25,000 $3.2Mbefore exit
CCCC C4 Therapeutics Inc. call Sold out 150,000 $540Kbefore exit

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 117$5.3BEWTX, ELVN, LLY, MBX, SVA
Q1 2026 105$4.4BEWTX, ELVN, LLY, SVA, BSX
Q4 2025 104$4.9BEWTX, LLY, BSX, SVA, EW
Q3 2025 98$4.2BEWTX, BSX, LLY, SVA, ELVN
Q2 2025 97$4.0BSVA, BSX, LLY, EWTX, ELVN
Q1 2025 106$4.2BSVA, EWTX, BSX, LLY, ELVN
Q4 2024 111$4.8BEWTX, SVA, BSX, LLY, ISRG
Q3 2024 109$5.5BEWTX, SVA, LLY, BSX, ISRG
Q2 2024 108$5.0BSVA, LLY, EWTX, BSX, ISRG
Q1 2024 112$5.4BSVA, LLY, EWTX, BSX, ISRG