Ionis PharmaceuticalsIONS
13F holders, Q3 2025 (September 30)436holders +74
111new positions
36sold out
10famous investors
$65.42avg. 13F price*
At the end of Q3 2025, 436 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 74 from Q2 2025. 111 opened new positions and 36 sold out. The largest holders were FMR LLC ($1.5B), Vanguard Group Inc. ($1.1B) and T. Rowe Price Investment Management, Inc. ($860.7M). 10 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 111 | $543.6M |
| Exits | 36 | $162.4M |
All 13F filers, Q2 2025 → Q3 2025: 20,940,307 shares bought and 21,574,154 shares sold, net −633,847 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 436 holders
| FMR LLC | 0.08% | Add +0.2% | 23,689,038 | $1.5B |
| Vanguard Group Inc. | 0.02% | Reduce -1.4% | 16,481,730 | $1.1B |
| T. Rowe Price Investment Management, Inc. | 0.53% | Reduce -18.0% | 13,156,929 | $860.7M |
| Capital World Investors | 0.11% | Add +1.5% | 12,722,728 | $832.3M |
| BlackRock, Inc. | 0.01% | Reduce -4.1% | 10,447,940 | $683.5M |
| Wellington Management Group LLP | 0.08% | Add +3.8% | 6,588,811 | $431.0M |
| Bellevue Group AG | 8.49% | Reduce -20.5% | 6,244,451 | $408.5M |
| State Street Corp. | 0.01% | Reduce -3.1% | 4,388,651 | $287.1M |
| Deep Track Capital, LP | 6.95% | Reduce -22.1% | 3,808,144 | $249.1M |
| Geode Capital Management, LLC | 0.01% | Add +6.1% | 3,066,289 | $200.6M |
| Tweedy, Browne Co LLC | 16.48% | Add +0.3% | 2,901,216 | $189.8M |
| T. Rowe Price Associates Inc. | 0.02% | Reduce -12.7% | 2,729,685 | $178.6M |
| Citadel Advisors | 0.13% | Add +60.7% | 2,402,065 | $157.1M |
| Two Sigma Advisers, LP | 0.27% | Reduce -22.3% | 2,073,111 | $135.6M |
| Deerfield Management Company, L.P. | 2.15% | New | 1,979,669 | $129.5M |
| Two Sigma Investments, LP | 0.17% | Reduce -11.9% | 1,575,943 | $103.1M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +2.2% | 1,519,951 | $99.4M |
| Pictet Asset Management Holding SA | 0.09% | Add +128.9% | 1,393,124 | $90.5M |
| American Century Companies Inc. | 0.05% | Add +190.3% | 1,372,225 | $89.8M |
| Adage Capital Partners Gp, L.L.C. | 0.14% | Reduce -65.4% | 1,315,000 | $86.0M |
| Royal Bank of Canada | 0.01% | Add +53.3% | 1,226,624 | $80.2M |
| Morgan Stanley | 0.00% | Reduce -13.3% | 1,180,316 | $77.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Add +45.9% | 1,154,166 | $75.5M |
| Macquarie Group Ltd. | 0.09% | Reduce -21.1% | 1,131,936 | $74.1M |
| Vestal Point Capital, LP | 3.19% | Add +115.0% | 1,075,000 | $70.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.18% | Reduce -21.6% | 1,059,721 | $69.3M |
| UBS Group AG | 0.01% | Reduce -31.5% | 1,046,990 | $68.5M |
| Polar Capital Holdings Plc | 0.33% | Add +3.4% | 1,033,622 | $67.6M |
| TD Asset Management Inc | 0.05% | Reduce -13.1% | 960,272 | $62.8M |
| Marshall Wace, LLP | 0.07% | Add +7219.3% | 958,829 | $62.7M |
| Artisan Partners Limited Partnership | 0.08% | Add +150.8% | 890,072 | $58.2M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.18% | Add +230.4% | 878,155 | $57.4M |
| Massachusetts Financial Services Co. | 0.02% | Add +66.1% | 862,593 | $56.4M |
| Bank of America Corp. | 0.00% | Reduce -14.1% | 855,295 | $56.0M |
| Northern Trust Corp. | 0.01% | Add +3.8% | 844,943 | $55.3M |
| Voloridge Investment Management, LLC | 0.18% | Reduce -6.0% | 803,047 | $52.5M |
| Millennium Management | 0.04% | Reduce -70.6% | 779,570 | $51.0M |
| Goldman Sachs Group Inc. | 0.01% | Reduce -0.1% | 777,570 | $50.9M |
| Ameriprise Financial Inc. | 0.01% | Add +108.0% | 765,822 | $50.1M |
| Balyasny Asset Management L.P. | 0.10% | Reduce -1.1% | 760,111 | $49.7M |
| Summit Partners Public Asset Management, LLC | 1.60% | New | 750,000 | $49.1M |
| Bank of Montreal | 0.02% | Add +54.6% | 747,402 | $48.9M |
| Nomura Holdings Inc. | 0.25% | Add +2180.4% | 733,398 | $48.0M |
| Barclays PLC | 0.02% | Add +22.4% | 714,048 | $46.7M |
| ARK Investment Management | 0.25% | Reduce -29.9% | 631,215 | $41.3M |
| D. E. Shaw & Co. | 0.04% | New | 630,938 | $41.3M |
| Arrowstreet Capital, Limited Partnership | 0.03% | New | 630,136 | $41.2M |
| Candriam S.C.A. | 0.21% | Reduce -15.7% | 611,237 | $40.0M |
| Baker Bros. Advisors LP | 0.27% | New | 566,798 | $37.1M |
| Groupama Asset Managment | 0.55% | Reduce -15.0% | 561,777 | $36.8M |
| Tang Capital Management LLC | 1.39% | Add +266.7% | 550,000 | $36.0M |
| JPMorgan Chase & Co. | 0.00% | Add +37.9% | 544,468 | $35.6M |
| Eversept Partners, LP | 2.70% | Reduce -8.5% | 538,661 | $35.2M |
| Bank of New York Mellon Corp | 0.01% | Add +0.9% | 532,114 | $34.8M |
| Invesco Ltd. | 0.01% | Add +102.6% | 519,070 | $34.0M |
| Hudson Bay Capital Management LP | 0.24% | Reduce -31.3% | 515,000 | $33.7M |
| Renaissance Technologies | 0.04% | Add +79.8% | 486,714 | $31.8M |
| Pinnacle Associates Ltd. | 0.42% | Reduce -2.6% | 481,751 | $31.5M |
| Teacher Retirement System of Texas | 0.12% | Reduce -29.1% | 473,945 | $31.0M |
| C WorldWide Group Holding A/S | 0.43% | Reduce -5.3% | 426,000 | $27.9M |
| Susquehanna International Group, LLP | 0.04% | New | 420,950 | $27.5M |
| Boone Capital Management LLC | 8.96% | New | 417,833 | $27.3M |
| Nuveen, LLC | 0.01% | Add +69.6% | 415,618 | $27.2M |
| Ikarian Capital, LLC | 5.49% | New | 415,163 | $27.2M |
| AXA Investment Managers S.A. | 0.07% | — | 406,451 | $26.6M |
| Squarepoint Ops LLC | 0.05% | Add +185.6% | 383,792 | $25.1M |
| BNP Paribas Financial Markets | 0.02% | Add +115.6% | 383,226 | $25.1M |
| Jane Street Group, LLC | 0.03% | New | 365,070 | $23.9M |
| Man Group plc | 0.04% | Add +3621.9% | 333,820 | $21.8M |
| Legal & General Group Plc | 0.00% | Reduce -21.0% | 319,565 | $20.9M |
| Assenagon Asset Management S.A. | 0.03% | Add +1669.0% | 312,297 | $20.4M |
| Alyeska Investment Group, L.P. | 0.06% | Add +95.8% | 311,258 | $20.4M |
| Rhenman & Partners Asset Management AB | 2.24% | Add +70.3% | 310,000 | $20.3M |
| Swiss National Bank | 0.01% | Add +1.6% | 293,100 | $19.2M |
| Wells Fargo & Company | 0.00% | Add +36.0% | 285,293 | $18.7M |
| Sector Gamma As | 4.40% | Reduce -5.2% | 270,963 | $17.7M |
| GW&K Investment Management, LLC | 0.15% | Reduce -41.2% | 264,007 | $17.3M |
| Algert Global LLC | 0.28% | Add +562.3% | 252,281 | $16.5M |
| Privium Fund Management B.V. | 2.93% | Reduce -7.0% | 248,894 | $16.3M |
| Raymond James Financial Inc. | 0.01% | Add +14.2% | 240,424 | $15.7M |
| Jain Global LLC | 0.21% | Add +3037.4% | 225,739 | $14.8M |
| Orion Investment Co | 4.67% | Add +3.4% | 224,705 | $14.7M |
| California Public Employees Retirement System | 0.01% | Add +6.9% | 215,845 | $14.1M |
| Trexquant Investment LP | 0.15% | Add +66.9% | 215,121 | $14.1M |
| Stifel Financial Corp. | 0.01% | Add +3.2% | 202,628 | $13.3M |
| Schonfeld Strategic Advisors LLC | 0.09% | Reduce -55.3% | 200,839 | $13.1M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +31.8% | 197,434 | $12.9M |
| Tocqueville Asset Management L.P. | 0.18% | Add +3.0% | 193,045 | $12.6M |
| Great Lakes Advisors, LLC | 0.10% | Reduce -53.2% | 186,950 | $12.2M |
| Rhumbline Advisers | 0.01% | Add +0.3% | 182,061 | $11.9M |
| Cinctive Capital Management LP | 0.57% | New | 173,819 | $11.4M |
| Sovran Advisors, LLC | 0.99% | Reduce -53.1% | 150,856 | $11.2M |
| Sonora Investment Management Group, LLC | 0.79% | Add +4.1% | 169,808 | $11.1M |
| New York State Common Retirement Fund | 0.01% | Add +93.4% | 168,222 | $11.0M |
| Sicart Associates LLC | 2.91% | Reduce -11.3% | 164,318 | $10.7M |
| Boothbay Fund Management, LLC | 0.28% | New | 163,462 | $10.7M |
| Capricorn Fund Managers Ltd | 3.58% | New | 162,800 | $10.7M |
| Aquatic Capital Management LLC | 0.19% | Add +0.6% | 159,045 | $10.4M |
| Edmond DE Rothschild Holding S.A. | 0.16% | Reduce -20.7% | 156,690 | $10.3M |
| Citigroup Inc. | 0.01% | Reduce -54.3% | 155,853 | $10.2M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.