Ionis PharmaceuticalsIONS
13F holders, Q3 2025 (September 30)436holders +74
111new positions
36sold out
10famous investors
$65.42avg. 13F price*
At the end of Q3 2025, 436 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 74 from Q2 2025. 111 opened new positions and 36 sold out. The largest holders were FMR LLC ($1.5B), Vanguard Group Inc. ($1.1B) and T. Rowe Price Investment Management, Inc. ($860.7M). 10 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 111 | $543.6M |
| Exits | 36 | $162.4M |
All 13F filers, Q2 2025 → Q3 2025: 20,940,307 shares bought and 21,574,154 shares sold, net −633,847 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 436 holders
| FMR LLC | 0.08% | Add +0.2% | 23,689,038 | $1.5B |
| Vanguard Group Inc. | 0.02% | Reduce -1.4% | 16,481,730 | $1.1B |
| T. Rowe Price Investment Management, Inc. | 0.53% | Reduce -18.0% | 13,156,929 | $860.7M |
| Capital World Investors | 0.11% | Add +1.5% | 12,722,728 | $832.3M |
| BlackRock, Inc. | 0.01% | Reduce -4.1% | 10,447,940 | $683.5M |
| Wellington Management Group LLP | 0.08% | Add +3.8% | 6,588,811 | $431.0M |
| Bellevue Group AG | 8.49% | Reduce -20.5% | 6,244,451 | $408.5M |
| State Street Corp. | 0.01% | Reduce -3.1% | 4,388,651 | $287.1M |
| Deep Track Capital, LP | 6.95% | Reduce -22.1% | 3,808,144 | $249.1M |
| Geode Capital Management, LLC | 0.01% | Add +6.1% | 3,066,289 | $200.6M |
| Tweedy, Browne Co LLC | 16.48% | Add +0.3% | 2,901,216 | $189.8M |
| T. Rowe Price Associates Inc. | 0.02% | Reduce -12.7% | 2,729,685 | $178.6M |
| Citadel Advisors | 0.13% | Add +60.7% | 2,402,065 | $157.1M |
| Two Sigma Advisers, LP | 0.27% | Reduce -22.3% | 2,073,111 | $135.6M |
| Deerfield Management Company, L.P. | 2.15% | New | 1,979,669 | $129.5M |
| Two Sigma Investments, LP | 0.17% | Reduce -11.9% | 1,575,943 | $103.1M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +2.2% | 1,519,951 | $99.4M |
| Pictet Asset Management Holding SA | 0.09% | Add +128.9% | 1,393,124 | $90.5M |
| American Century Companies Inc. | 0.05% | Add +190.3% | 1,372,225 | $89.8M |
| Adage Capital Partners Gp, L.L.C. | 0.14% | Reduce -65.4% | 1,315,000 | $86.0M |
| Royal Bank of Canada | 0.01% | Add +53.3% | 1,226,624 | $80.2M |
| Morgan Stanley | 0.00% | Reduce -13.3% | 1,180,316 | $77.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Add +45.9% | 1,154,166 | $75.5M |
| Macquarie Group Ltd. | 0.09% | Reduce -21.1% | 1,131,936 | $74.1M |
| Vestal Point Capital, LP | 3.19% | Add +115.0% | 1,075,000 | $70.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.18% | Reduce -21.6% | 1,059,721 | $69.3M |
| UBS Group AG | 0.01% | Reduce -31.5% | 1,046,990 | $68.5M |
| Polar Capital Holdings Plc | 0.33% | Add +3.4% | 1,033,622 | $67.6M |
| TD Asset Management Inc | 0.05% | Reduce -13.1% | 960,272 | $62.8M |
| Marshall Wace, LLP | 0.07% | Add +7219.3% | 958,829 | $62.7M |
| Artisan Partners Limited Partnership | 0.08% | Add +150.8% | 890,072 | $58.2M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.18% | Add +230.4% | 878,155 | $57.4M |
| Massachusetts Financial Services Co. | 0.02% | Add +66.1% | 862,593 | $56.4M |
| Bank of America Corp. | 0.00% | Reduce -14.1% | 855,295 | $56.0M |
| Northern Trust Corp. | 0.01% | Add +3.8% | 844,943 | $55.3M |
| Voloridge Investment Management, LLC | 0.18% | Reduce -6.0% | 803,047 | $52.5M |
| Millennium Management | 0.04% | Reduce -70.6% | 779,570 | $51.0M |
| Goldman Sachs Group Inc. | 0.01% | Reduce -0.1% | 777,570 | $50.9M |
| Ameriprise Financial Inc. | 0.01% | Add +108.0% | 765,822 | $50.1M |
| Balyasny Asset Management L.P. | 0.10% | Reduce -1.1% | 760,111 | $49.7M |
| Summit Partners Public Asset Management, LLC | 1.60% | New | 750,000 | $49.1M |
| Bank of Montreal | 0.02% | Add +54.6% | 747,402 | $48.9M |
| Nomura Holdings Inc. | 0.25% | Add +2180.4% | 733,398 | $48.0M |
| Barclays PLC | 0.02% | Add +22.4% | 714,048 | $46.7M |
| ARK Investment Management | 0.25% | Reduce -29.9% | 631,215 | $41.3M |
| D. E. Shaw & Co. | 0.04% | New | 630,938 | $41.3M |
| Arrowstreet Capital, Limited Partnership | 0.03% | New | 630,136 | $41.2M |
| Candriam S.C.A. | 0.21% | Reduce -15.7% | 611,237 | $40.0M |
| Baker Bros. Advisors LP | 0.27% | New | 566,798 | $37.1M |
| Groupama Asset Managment | 0.55% | Reduce -15.0% | 561,777 | $36.8M |
| Tang Capital Management LLC | 1.39% | Add +266.7% | 550,000 | $36.0M |
| JPMorgan Chase & Co. | 0.00% | Add +37.9% | 544,468 | $35.6M |
| Eversept Partners, LP | 2.70% | Reduce -8.5% | 538,661 | $35.2M |
| Bank of New York Mellon Corp | 0.01% | Add +0.9% | 532,114 | $34.8M |
| Invesco Ltd. | 0.01% | Add +102.6% | 519,070 | $34.0M |
| Hudson Bay Capital Management LP | 0.24% | Reduce -31.3% | 515,000 | $33.7M |
| Renaissance Technologies | 0.04% | Add +79.8% | 486,714 | $31.8M |
| Pinnacle Associates Ltd. | 0.42% | Reduce -2.6% | 481,751 | $31.5M |
| Teacher Retirement System of Texas | 0.12% | Reduce -29.1% | 473,945 | $31.0M |
| C WorldWide Group Holding A/S | 0.43% | Reduce -5.3% | 426,000 | $27.9M |
| Susquehanna International Group, LLP | 0.04% | New | 420,950 | $27.5M |
| Boone Capital Management LLC | 8.96% | New | 417,833 | $27.3M |
| Nuveen, LLC | 0.01% | Add +69.6% | 415,618 | $27.2M |
| Ikarian Capital, LLC | 5.49% | New | 415,163 | $27.2M |
| AXA Investment Managers S.A. | 0.07% | — | 406,451 | $26.6M |
| Squarepoint Ops LLC | 0.05% | Add +185.6% | 383,792 | $25.1M |
| BNP Paribas Financial Markets | 0.02% | Add +115.6% | 383,226 | $25.1M |
| Jane Street Group, LLC | 0.03% | New | 365,070 | $23.9M |
| Man Group plc | 0.04% | Add +3621.9% | 333,820 | $21.8M |
| Legal & General Group Plc | 0.00% | Reduce -21.0% | 319,565 | $20.9M |
| Assenagon Asset Management S.A. | 0.03% | Add +1669.0% | 312,297 | $20.4M |
| Alyeska Investment Group, L.P. | 0.06% | Add +95.8% | 311,258 | $20.4M |
| Rhenman & Partners Asset Management AB | 2.24% | Add +70.3% | 310,000 | $20.3M |
| Swiss National Bank | 0.01% | Add +1.6% | 293,100 | $19.2M |
| Wells Fargo & Company | 0.00% | Add +36.0% | 285,293 | $18.7M |
| Sector Gamma As | 4.40% | Reduce -5.2% | 270,963 | $17.7M |
| GW&K Investment Management, LLC | 0.15% | Reduce -41.2% | 264,007 | $17.3M |
| Algert Global LLC | 0.28% | Add +562.3% | 252,281 | $16.5M |
| Privium Fund Management B.V. | 2.93% | Reduce -7.0% | 248,894 | $16.3M |
| Raymond James Financial Inc. | 0.01% | Add +14.2% | 240,424 | $15.7M |
| Jain Global LLC | 0.21% | Add +3037.4% | 225,739 | $14.8M |
| Orion Investment Co | 4.67% | Add +3.4% | 224,705 | $14.7M |
| California Public Employees Retirement System | 0.01% | Add +6.9% | 215,845 | $14.1M |
| Trexquant Investment LP | 0.15% | Add +66.9% | 215,121 | $14.1M |
| Stifel Financial Corp. | 0.01% | Add +3.2% | 202,628 | $13.3M |
| Schonfeld Strategic Advisors LLC | 0.09% | Reduce -55.3% | 200,839 | $13.1M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +31.8% | 197,434 | $12.9M |
| Tocqueville Asset Management L.P. | 0.18% | Add +3.0% | 193,045 | $12.6M |
| Great Lakes Advisors, LLC | 0.10% | Reduce -53.2% | 186,950 | $12.2M |
| Rhumbline Advisers | 0.01% | Add +0.3% | 182,061 | $11.9M |
| Cinctive Capital Management LP | 0.57% | New | 173,819 | $11.4M |
| Sovran Advisors, LLC | 0.99% | Reduce -53.1% | 150,856 | $11.2M |
| Sonora Investment Management Group, LLC | 0.79% | Add +4.1% | 169,808 | $11.1M |
| New York State Common Retirement Fund | 0.01% | Add +93.4% | 168,222 | $11.0M |
| Sicart Associates LLC | 2.91% | Reduce -11.3% | 164,318 | $10.7M |
| Boothbay Fund Management, LLC | 0.28% | New | 163,462 | $10.7M |
| Capricorn Fund Managers Ltd | 3.58% | New | 162,800 | $10.7M |
| Aquatic Capital Management LLC | 0.19% | Add +0.6% | 159,045 | $10.4M |
| Edmond DE Rothschild Holding S.A. | 0.16% | Reduce -20.7% | 156,690 | $10.3M |
| Citigroup Inc. | 0.01% | Reduce -54.3% | 155,853 | $10.2M |
| Skandinaviska Enskilda Banken AB (publ) | 0.04% | Add +161.3% | 155,790 | $10.2M |
| ExodusPoint Capital Management, LP | 0.14% | New | 152,125 | $10.0M |
| Natixis | 0.05% | New | 145,286 | $9.5M |
| California State Teachers Retirement System | 0.01% | Add +0.0% | 145,112 | $9.5M |
| State Board of Administration of Florida Retirement System | 0.02% | Reduce -6.7% | 143,534 | $9.4M |
| ADAR1 Capital Management, LLC | 0.87% | Reduce -9.9% | 133,818 | $8.8M |
| Exome Asset Management LLC | 5.66% | Add +8.2% | 131,016 | $8.6M |
| Rafferty Asset Management, LLC | 0.03% | Reduce -13.1% | 125,773 | $8.2M |
| Kennedy Capital Management LLC | 0.18% | Reduce -7.0% | 122,766 | $8.0M |
| Sei Investments Co. | 0.01% | Add +21.0% | 119,028 | $7.8M |
| BLB&B Advisors, LLC | 0.33% | Reduce -21.7% | 118,600 | $7.8M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.01% | No change | 116,000 | $7.6M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -17.9% | 114,772 | $7.5M |
| Neuberger Berman Group LLC | 0.01% | Add +0.1% | 114,743 | $7.5M |
| Amova Asset Management Americas, Inc. | 0.07% | Reduce -18.0% | 114,592 | $7.5M |
| Van Eck Associates Corp. | 0.01% | Add +51.9% | 111,819 | $7.3M |
| Voya Investment Management LLC | 0.01% | Add +73.0% | 111,589 | $7.3M |
| Acadian Asset Management LLC | 0.01% | New | 110,444 | $7.2M |
| DCF Advisers, LLC | 2.69% | Add +18.2% | 108,413 | $7.1M |
| Amundi | 0.00% | New | 101,531 | $7.0M |
| Simplex Trading, LLC | 0.14% | Add +152.8% | 100,206 | $6.6M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +17.6% | 98,023 | $6.4M |
| State of Wisconsin Investment Board | 0.01% | Add +0.1% | 96,837 | $6.3M |
| J. Goldman & Co LP | 0.24% | Reduce -34.9% | 96,198 | $6.3M |
| Susquehanna Portfolio Strategies, LLC | 0.10% | Add +3.3% | 95,960 | $6.3M |
| Lisanti Capital Growth, LLC | 1.47% | New | 92,124 | $6.0M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $6.0M |
| Deutsche Bank AG | 0.00% | Add +4.1% | 88,803 | $5.8M |
| Aberdeen Group plc | 0.01% | Reduce -78.4% | 87,924 | $5.8M |
| Nicola Wealth Management LTD. | 0.51% | No change | 87,000 | $5.7M |
| Great Point Partners LLC | 2.19% | Reduce -84.0% | 80,000 | $5.2M |
| Russell Investments Group, Ltd. | 0.01% | Add +734.3% | 77,293 | $5.1M |
| First Trust Advisors LP | 0.00% | Add +33.1% | 75,224 | $4.9M |
| Hillsdale Investment Management Inc. | 0.14% | New | 70,900 | $4.6M |
| Erste Asset Management GmbH | 0.04% | Add +40.0% | 71,800 | $4.6M |
| Treasurer of the State of North Carolina | 0.01% | Reduce -3.8% | 69,862 | $4.6M |
| Police & Firemen's Retirement System of New Jersey | 0.04% | Add +16.1% | 69,324 | $4.5M |
| Janus Henderson Group PLC | 0.00% | No change | 63,877 | $4.2M |
| Lazard Asset Management LLC | 0.01% | Add +5.0% | 63,791 | $4.2M |
| DAVENPORT & Co LLC | 0.02% | Reduce -3.5% | 62,563 | $4.1M |
| Artia Global Partners LP | 0.69% | New | 60,176 | $3.9M |
| State of New Jersey Common Pension Fund D | 0.01% | Add +1.5% | 59,817 | $3.9M |
| Alpine Global Management, LLC | 0.97% | Add +119.8% | 55,900 | $3.7M |
| PDT Partners, LLC | 0.22% | No change | 54,365 | $3.6M |
| Alliancebernstein L.P. | 0.00% | Add +4.2% | 54,262 | $3.5M |
| Informed Momentum Co LLC | 0.41% | New | 54,977 | $3.5M |
| Handelsbanken Fonder AB | 0.01% | Add +20.1% | 51,911 | $3.4M |
| Creative Planning | 0.00% | Reduce -3.4% | 51,474 | $3.4M |
| Capital Counsel LLC | 0.12% | Reduce -1.2% | 49,605 | $3.2M |
| Raiffeisen Bank International AG | 0.04% | Reduce -11.9% | 50,000 | $3.2M |
| Cubist Systematic Strategies, LLC | 0.04% | New | 48,654 | $3.2M |
| Public Employees Retirement System of Ohio | 0.01% | Add +0.6% | 48,545 | $3.2M |
| Point72 Hong Kong Ltd | 0.14% | New | 47,517 | $3.1M |
| Dark Forest Capital Management LP | 0.11% | New | 46,092 | $3.0M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.01% | Add +3.7% | 45,220 | $3.0M |
| CANADA LIFE ASSURANCE Co | 0.00% | Reduce -0.8% | 46,128 | $3.0M |
| HSBC Holdings PLC | 0.00% | Reduce -58.0% | 45,456 | $2.9M |
| Arizona State Retirement System | 0.02% | Add +1.6% | 44,731 | $2.9M |
| Bridgewater Associates | 0.01% | New | 43,578 | $2.9M |
| Fred Alger Management, LLC | 0.01% | Add +348.0% | 42,401 | $2.8M |
| Dimensional Fund Advisors LP | 0.00% | New | 42,217 | $2.8M |
| NJ State Employees Deferred Compensation Plan | 0.30% | No change | 42,000 | $2.7M |
| Grandfield & Dodd, LLC | 0.14% | Add +1.2% | 37,675 | $2.5M |
| LMR Partners LLP | 0.05% | New | 37,600 | $2.5M |
| Prelude Capital Management, LLC | 0.19% | Reduce -5.4% | 37,293 | $2.4M |
| Verition Fund Management LLC | 0.01% | Reduce -84.0% | 37,196 | $2.4M |
| One Capital Management, LLC | 0.08% | Add +22.0% | 36,426 | $2.4M |
| Future Fund LLC | 0.83% | Add +22.2% | 36,156 | $2.4M |
| Quantinno Capital Management LP | 0.01% | Add +105.9% | 36,115 | $2.4M |
| Stanley-Laman Group, Ltd. | 0.33% | New | 35,774 | $2.3M |
| Guggenheim Capital LLC | 0.02% | Reduce -13.5% | 35,357 | $2.3M |
| Blair William & Co. | 0.01% | Reduce -9.3% | 34,371 | $2.2M |
| Pathstone Holdings, LLC | 0.01% | Add +9.2% | 33,602 | $2.2M |
| Entropy Technologies, LP | 0.16% | Add +11.8% | 32,925 | $2.2M |
| Gotham Asset Management | 0.01% | Add +125.2% | 32,152 | $2.1M |
| KLP Kapitalforvaltning As | 0.01% | No change | 31,500 | $2.1M |
| Twin Tree Management, LP | 0.09% | New | 28,575 | $1.9M |
| Granite Investment Partners, LLC | 0.10% | Reduce -35.1% | 28,033 | $1.8M |
| China Universal Asset Management Co., Ltd. | 0.15% | Reduce -12.6% | 27,939 | $1.8M |
| Ensign Peak Advisors, Inc | 0.00% | Reduce -48.3% | 27,595 | $1.8M |
| Envestnet Asset Management Inc. | 0.00% | Add +103.1% | 27,509 | $1.8M |
| Wolverine Trading, LLC | 0.04% | New | 27,585 | $1.8M |
| Landscape Capital Management, L.L.C. | 0.11% | New | 26,562 | $1.7M |
| Profund Advisors LLC | 0.06% | Reduce -10.1% | 25,932 | $1.7M |
| Calamos Advisors LLC | 0.01% | New | 25,863 | $1.7M |
| Engineers Gate Manager LP | 0.02% | Reduce -22.2% | 25,779 | $1.7M |
| Baron Capital (BAMCO) | 0.00% | New | 25,000 | $1.6M |
| Bayesian Capital Management, LP | 0.33% | Add +48.9% | 24,715 | $1.6M |
| Daiwa Securities Group Inc. | 0.01% | Reduce -5.5% | 24,701 | $1.6M |
| LPL Financial LLC | 0.00% | Reduce -1.6% | 24,463 | $1.6M |
| Mariner, LLC | 0.00% | Reduce -34.4% | 24,227 | $1.6M |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 24,083 | $1.6M |
| BlueCrest Capital Management Ltd | 0.11% | New | 23,370 | $1.5M |
| Atika Capital Management LLC | 0.12% | New | 21,500 | $1.4M |
| Xponance LLC | 0.01% | Reduce -5.7% | 21,450 | $1.4M |
| Nicollet Investment Management, Inc. | 0.44% | Reduce -1.6% | 20,408 | $1.3M |
| Resolute Capital Asset Partners LLC | 0.68% | New | 20,000 | $1.3M |
| Dana Investment Advisors, Inc. | 0.04% | New | 18,818 | $1.2M |
| Victory Capital Management Inc. | 0.00% | Reduce -1.6% | 18,211 | $1.2M |
| Exchange Traded Concepts, LLC | 0.01% | Add +105.3% | 18,070 | $1.2M |
| Legato Capital Management LLC | 0.12% | New | 17,300 | $1.1M |
| Graham Capital Management, L.P. | 0.06% | Reduce -18.0% | 17,163 | $1.1M |
| North Star Asset Management Inc. | 0.04% | No change | 16,610 | $1.1M |
| Point72 (DIFC) Ltd | 0.07% | Add +94.1% | 15,698 | $1.0M |
| Diversified Trust Co. | 0.02% | New | 15,633 | $1.0M |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 15,589 | $1.0M |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.07% | Add +15.2% | 15,284 | $1000K |
| Significant Wealth Partners LLC | 0.48% | Reduce -3.5% | 14,967 | $979K |
| Dynasty Wealth Management, LLC | 0.01% | New | 14,341 | $938K |
| Brown Advisory Inc. | 0.00% | Add +15.1% | 14,026 | $918K |
| Bleakley Financial Group, LLC | 0.02% | Reduce -23.4% | 13,878 | $908K |
| Aigen Investment Management, LP | 0.14% | Add +63.6% | 13,578 | $888K |
| Fieldview Capital Management, LLC | 0.14% | Reduce -21.9% | 13,523 | $885K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -4.3% | 13,349 | $873K |
| Westmount Partners, LLC | 0.22% | No change | 12,961 | $853K |
| Annis Gardner Whiting Capital Advisors, LLC | 0.17% | No change | 12,801 | $837K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +4.4% | 12,782 | $836K |
| &partners | 0.01% | Add +7.7% | 12,663 | $828K |
| Virtus Investment Advisers, LLC | 0.23% | No change | 12,476 | $816K |
| Horizon Kinetics Asset Management LLC | 0.01% | Add +4.4% | 12,476 | $816K |
| Tema ETFs LLC | 0.07% | Reduce -56.3% | 12,306 | $805K |
| NEOS Investment Management LLC | 0.01% | Reduce -56.3% | 12,306 | $805K |
| Amalgamated Bank | 0.01% | Add +5.8% | 12,195 | $798K |
| PNC Financial Services Group, Inc. | 0.00% | Add +6.2% | 12,113 | $792K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Add +0.1% | 12,090 | $791K |
| Vident Advisory, LLC | 0.01% | Reduce -3.7% | 11,551 | $756K |
| Allianz Asset Management GmbH | 0.00% | New | 11,500 | $752K |
| Blueshift Asset Management, LLC | 0.23% | New | 11,460 | $750K |
| Plancorp, LLC | 0.02% | No change | 11,208 | $733K |
| Montanova Capital, LLC | 0.02% | No change | 10,800 | $707K |
| Capstone Investment Advisors, LLC | 0.01% | New | 10,402 | $680K |
| Baader Bank Aktiengesellschaft | 0.06% | New | 10,228 | $668K |
| Jefferies Financial Group Inc. | 0.01% | Reduce -54.6% | 10,169 | $665K |
| Gsa Capital Partners LLP | 0.06% | New | 10,172 | $665K |
| Cypress Capital, LLC | 0.19% | No change | 10,000 | $654K |
| denkapparat Operations GmbH | 0.42% | New | 9,968 | $652K |
| Thrivent Financial for Lutherans | 0.00% | New | 9,962 | $652K |
| Orion Porfolio Solutions, LLC | 0.01% | Add +77.9% | 9,962 | $652K |
| Osaic Holdings, Inc. | 0.00% | Add +92.0% | 10,167 | $618K |
| MetLife Investment Management, LLC | 0.00% | Add +2.9% | 9,428 | $617K |
| Prudential Financial Inc. | 0.00% | Add +1.0% | 9,344 | $611K |
| DNB Asset Management AS | 0.00% | Reduce -24.1% | 9,308 | $609K |
| Sectoral Asset Management Inc. | 0.37% | No change | 9,205 | $602K |
| Utah Retirement Systems | 0.01% | Reduce -1.2% | 8,300 | $543K |
| Maryland State Retirement & Pension System | 0.01% | No change | 8,284 | $542K |
| Empire Financial Management Company, LLC | 0.12% | New | 8,000 | $523K |
| Fifth Third Bancorp | 0.00% | Add +4.5% | 7,944 | $520K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -6.0% | 7,439 | $513K |
| Stratos Wealth Partners, LTD. | 0.01% | New | 7,764 | $508K |
| Inceptionr LLC | 0.12% | New | 7,621 | $499K |
| Commerce Bank | 0.00% | No change | 7,607 | $498K |
| Savant Capital, LLC | 0.00% | Add +29.9% | 7,237 | $473K |
| Silvercrest Asset Management Group LLC | 0.00% | Add +0.7% | 7,118 | $466K |
| Atria Investments, Inc | 0.01% | Reduce -14.1% | 7,030 | $460K |
| Cetera Investment Advisers | 0.00% | New | 6,873 | $450K |
| Swiss Life Asset Management Ltd | 0.00% | New | 6,827 | $447K |
| Praxis Investment Management Inc. | 0.03% | No change | 6,770 | $443K |
| Meeder Advisory Services, Inc. | 0.02% | Add +1.9% | 6,770 | $443K |
| Marex Group Ltd | 0.01% | Reduce -91.9% | 6,722 | $440K |
| AQR Capital Management | 0.00% | New | 6,815 | $439K |
| Jones Financial Companies LLLP | 0.00% | Reduce -5.0% | 6,834 | $438K |
| Franklin Resources Inc. | 0.00% | Add +18.7% | 6,593 | $431K |
| Corient Private Wealth LP | 0.00% | Reduce -97.2% | 6,590 | $431K |
| Fiduciary Trust Co | 0.00% | Reduce -25.4% | 6,377 | $417K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -9.1% | 6,431 | $413K |
| Fisher Asset Management | 0.00% | New | 6,210 | $406K |
| Summit Trail Advisors, LLC | 0.01% | New | 6,205 | $406K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.2% | 6,162 | $403K |
| PEAK6 LLC | 0.01% | New | 6,112 | $400K |
| M&T Bank Corp | 0.00% | Reduce -21.4% | 6,010 | $393K |
| Frank, Rimerman Advisors LLC | 0.02% | Add +0.0% | 5,765 | $377K |
| ProShare Advisors LLC | 0.00% | Reduce -4.5% | 5,678 | $371K |
| Wedmont Private Capital | 0.01% | Add +1.5% | 5,363 | $370K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0.53% | New | 5,463 | $357K |
| HighTower Advisors, LLC | 0.00% | Add +1.9% | 5,458 | $357K |
| Advisors Asset Management, Inc. | 0.01% | Reduce -9.1% | 5,454 | $357K |
| Edgestream Partners, L.P. | 0.01% | New | 5,450 | $357K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Add +0.2% | 5,407 | $354K |
| O'shaughnessy Asset Management, LLC | 0.00% | New | 5,297 | $347K |
| SG Americas Securities, LLC | 0.00% | New | 5,150 | $337K |
| Pinnacle Wealth Planning Services, Inc. | 0.04% | Reduce -3.2% | 5,113 | $334K |
| International Assets Investment Management, LLC | 0.03% | No change | 8,207 | $328K |
| Moisand Fitzgerald Tamayo, LLC | 0.04% | No change | 5,000 | $327K |
| Kestra Advisory Services, LLC | 0.00% | New | 4,972 | $325K |
| NewEdge Advisors, LLC | 0.00% | Add +2360.2% | 4,822 | $315K |
| Truist Financial Corp. | 0.00% | New | 4,812 | $315K |
| Farallon Capital Management, L.L.C. | 0.00% | New | 4,800 | $314K |
| Group One Trading LLC | 0.01% | New | 4,796 | $314K |
| Principal Financial Group Inc. | 0.00% | Reduce -39.8% | 4,785 | $313K |
| Requisite Capital Management, LLC | 0.05% | New | 4,734 | $310K |
| Credit Agricole S A | 0.00% | — | 4,710 | $308K |
| US Bancorp \de | 0.00% | Add +9.8% | 4,704 | $308K |
| KBC Group NV | 0.00% | No change | 4,699 | $307K |
| CIBC Asset Management Inc | 0.00% | New | 4,608 | $301K |
| Prospera Financial Services Inc | 0.01% | New | 4,581 | $300K |
| Brevan Howard Capital Management LP | 0.00% | Reduce -86.2% | 4,516 | $295K |
| Coldstream Capital Management Inc. | 0.00% | New | 4,479 | $293K |
| Perbak Capital Partners LLP | 0.05% | Reduce -53.6% | 4,426 | $290K |
| Checchi Capital Advisers, LLC | 0.02% | New | 4,233 | $277K |
| Pitcairn Co. | 0.02% | New | 4,075 | $267K |
| Prime Capital Investment Advisors, LLC | 0.00% | New | 3,934 | $257K |
| Regions Financial Corp. | 0.00% | New | 3,800 | $249K |
| Mercer Global Advisors Inc. | 0.00% | New | 3,747 | $245K |
| STRS Ohio | 0.00% | Add +0.1% | 3,716 | $243K |
| Nwam LLC | 0.01% | New | 3,238 | $238K |
| Sanctuary Advisors, LLC | 0.00% | New | 3,637 | $238K |
| Berkshire Asset Management LLC | 0.01% | New | 3,614 | $236K |
| OneDigital Investment Advisors LLC | 0.00% | New | 3,588 | $235K |
| Mackenzie Financial Corp. | 0.00% | New | 3,588 | $235K |
| PharVision Advisers, LLC | 0.13% | New | 3,587 | $235K |
| Mitchell & Pahl Private Wealth, LLC | 0.10% | New | 3,572 | $234K |
| Bank of Nova Scotia | 0.00% | New | 3,509 | $230K |
| Massar Capital Management, LP | 0.08% | New | 3,462 | $226K |
| EntryPoint Capital, LLC | 0.09% | New | 3,458 | $226K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -15.2% | 3,429 | $224K |
| Victrix Investment Advisors | 0.12% | New | 3,400 | $222K |
| Anb Bank | 0.09% | New | 3,231 | $211K |
| Raab & Moskowitz Asset Management LLC | 0.05% | New | 3,115 | $204K |
| Westfield Capital Management Co. LP | 0.00% | Reduce -67.7% | 3,093 | $202K |
| Voleon Capital Management LP | 0.00% | New | 3,060 | $200K |
| Point72 Europe (London) LLP | 0.01% | New | 3,051 | $200K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +92.6% | 3,045 | $199K |
| Cwm, LLC | 0.00% | Add +7.3% | 2,488 | $163K |
| Rockefeller Capital Management L.P. | 0.00% | New | 2,203 | $144K |
| Comerica Bank | 0.00% | Add +35.3% | 2,187 | $143K |
| Ancora Advisors LLC | 0.00% | Add +6.8% | 2,137 | $140K |
| Signaturefd, LLC | 0.00% | Reduce -1.3% | 2,003 | $131K |
| Parallel Advisors, LLC | 0.00% | Add +0.3% | 1,877 | $123K |
| Harvest Fund Management Co., Ltd | 0.00% | Reduce -4.5% | 1,746 | $114K |
| Abich Financial Wealth Management LLC | 0.04% | — | 1,708 | $112K |
| Twin Lakes Capital Management, LLC | 0.05% | No change | 1,500 | $98K |
| Versant Capital Management, Inc | 0.01% | No change | 1,465 | $96K |
| CI Investments Inc. | 0.00% | Reduce -39.9% | 1,453 | $95K |
| Danske Bank A/S | 0.00% | No change | 1,400 | $92K |
| GAMMA Investing LLC | 0.00% | Add +44.2% | 1,341 | $88K |
| Root Financial Partners, LLC | 0.01% | New | 1,340 | $88K |
| Manchester Capital Management LLC | 0.01% | No change | 1,248 | $82K |
| Wexford Capital LP | 0.02% | Reduce -74.9% | 1,192 | $78K |
| Itau Unibanco Holding S.A. | 0.00% | Reduce -0.3% | 1,121 | $73K |
| Larson Financial Group LLC | 0.00% | Add +8.1% | 1,110 | $73K |
| IFP Advisors, Inc | 0.00% | Add +18.4% | 1,070 | $70K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -12.4% | 1,069 | $70K |
| Sunbelt Securities, Inc. | 0.00% | No change | 1,014 | $66K |
| Toronto Dominion Bank | 0.00% | New | 951 | $62K |
| Sterling Capital Management LLC | 0.00% | Reduce -6.7% | 898 | $59K |
| Allworth Financial LP | 0.00% | Add +13.5% | 840 | $55K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -24.9% | 827 | $54K |
| Meeder Asset Management Inc. | 0.00% | Add +620.2% | 713 | $47K |
| Johnson Financial Group, Inc. | 0.00% | New | 670 | $44K |
| Huntington National Bank | 0.00% | Reduce -17.7% | 654 | $43K |
| Quadrant Capital Group LLC | 0.00% | New | 616 | $40K |
| Archer Investment Corp | 0.01% | No change | 600 | $39K |
| Quarry LP | 0.01% | New | 588 | $38K |
| Farther Finance Advisors, LLC | 0.00% | Add +30.7% | 566 | $37K |
| AdvisorNet Financial, Inc | 0.00% | Add +9.6% | 469 | $31K |
| AlphaQuest LLC | 0.00% | Reduce -45.8% | 453 | $30K |
| Mather Group, Llc. | 0.00% | New | 410 | $27K |
| Ascentis Wealth Management, LLC | 0.01% | No change | 400 | $26K |
| Steigerwald, Gordon & Koch Inc. | 0.00% | New | 380 | $25K |
| Golden State Wealth Management, LLC | 0.00% | Add +198.4% | 376 | $25K |
| Salomon & Ludwin, LLC | 0.00% | New | 332 | $23K |
| Global X Japan Co., Ltd. | 0.00% | Add +23.9% | 321 | $21K |
| Eastern Bank | 0.00% | No change | 300 | $20K |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 295 | $19K |
| Strategic Advocates LLC | 0.00% | New | 287 | $19K |
| Lanark Financial, Inc. | 0.00% | New | 273 | $18K |
| Storebrand Asset Management As | 0.00% | No change | 271 | $18K |
| MAI Capital Management | 0.00% | Reduce -37.3% | 267 | $17K |
| SBI Securities Co., Ltd. | 0.00% | Add +3.9% | 267 | $17K |
| Union Bancaire Privee, UBP SA | 0.00% | No change | 265 | $17K |
| MTM Investment Management, LLC | 0.01% | No change | 258 | $17K |
| Wealthspire Advisors, LLC | 0.00% | New | 245 | $16K |
| Covestor Ltd | 0.01% | Reduce -19.3% | 246 | $16K |
| Parkside Financial Bank & Trust | 0.00% | Reduce -45.2% | 240 | $16K |
| Advisory Services Network, LLC | 0.00% | New | 238 | $16K |
| Westside Investment Management, Inc. | 0.00% | No change | 231 | $15K |
| Global Trust Asset Management, LLC | 0.01% | No change | 218 | $14K |
| Harbour Investments, Inc. | 0.00% | Add +5.0% | 210 | $14K |
| Atlantic Union Bankshares Corp | 0.00% | No change | 200 | $13K |
| UMB Bank, n.a. | 0.00% | New | 200 | $13K |
| AllSquare Wealth Management LLC | 0.01% | No change | 198 | $13K |
| Bayforest Capital Ltd | 0.00% | New | 154 | $10K |
| Pacifica Partners Inc. | 0.00% | No change | 150 | $10K |
| Wealth Preservation Advisors, LLC | 0.01% | No change | 150 | $10K |
| Bessemer Group Inc. | 0.00% | Add +241.0% | 133 | $9K |
| Spire Wealth Management | 0.00% | No change | 125 | $8K |
| GPS Wealth Strategies Group, LLC | 0.00% | No change | 119 | $8K |
| Bogart Wealth, LLC | 0.00% | No change | 118 | $8K |
| Principal Securities, Inc. | 0.00% | Add +76.2% | 111 | $7K |
| Smartleaf Asset Management LLC | 0.00% | New | 104 | $7K |
| Creekmur Asset Management LLC | 0.00% | No change | 100 | $7K |
| Quent Capital, LLC | 0.00% | New | 98 | $6K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Reduce -13.6% | 89 | $6K |
| Ameritas Advisory Services, LLC | 0.00% | Reduce -40.4% | 87 | $6K |
| Orion Capital Management LLC | 0.00% | No change | 80 | $5K |
| TD Private Client Wealth LLC | 0.00% | Add +81.8% | 80 | $5K |
| Assetmark, Inc. | 0.00% | No change | 75 | $5K |
| Clear Investment Research, LLC | 0.01% | No change | 71 | $5K |
| WPG Advisers, LLC | 0.00% | No change | 70 | $5K |
| Private Wealth Management Group, LLC | 0.00% | No change | 65 | $4K |
| Leonteq Securities AG | 0.00% | No change | 63 | $4K |
| Bell Investment Advisors, Inc | 0.00% | No change | 61 | $4K |
| Crewe Advisors LLC | 0.00% | New | 48 | $3K |
| FIL Ltd | 0.00% | New | 47 | $3K |
| Sachetta, LLC | 0.00% | No change | 45 | $3K |
| CoreCap Advisors, LLC | 0.00% | No change | 45 | $3K |
| Highline Wealth Partners LLC | 0.00% | No change | 38 | $2K |
| Rossby Financial, LCC | 0.00% | No change | 34 | $2K |
| SouthState Bank Corp | 0.00% | Reduce -35.3% | 33 | $2K |
| Cheviot Value Management, LLC | 0.00% | No change | 28 | $2K |
| Hemington Wealth Management | 0.00% | Reduce -4.5% | 42 | $2K |
| Hantz Financial Services, Inc. | 0.00% | No change | 36 | $2K |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $2K |
| Principia Wealth Advisory, LLC | 0.00% | Add +4.0% | 26 | $2K |
| Bruce G. Allen Investments, LLC | 0.00% | No change | 23 | $2K |
| Global Retirement Partners, LLC | 0.00% | Add +43.8% | 23 | $2K |
| Horizon Investments, LLC | 0.00% | Add +46.7% | 22 | $1K |
| TFC Financial Management, Inc. | 0.00% | No change | 21 | $1K |
| Heartwood Wealth Advisors LLC | 0.00% | New | 21 | $1K |
| Key Financial Inc | 0.00% | No change | 19 | $1K |
| Cromwell Holdings LLC | 0.00% | No change | 18 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 17 | $1K |
| Quaker Wealth Management, LLC | 0.00% | No change | 14 | $916 |
| Mascoma Wealth Management LLC | 0.00% | No change | 14 | $916 |
| Rothschild Investment LLC | 0.00% | Add +30.0% | 13 | $850 |
| Rakuten Securities, Inc. | 0.00% | New | 11 | $720 |
| CIBC Private Wealth Group LLC | 0.00% | Add +450.0% | 11 | $720 |
| Blue Trust, Inc. | 0.00% | New | 10 | $654 |
| Essential Partners LLC | 0.00% | New | 7 | $458 |
| True Wealth Design, LLC | 0.00% | No change | 7 | $458 |
| Kayne Anderson Rudnick Investment Management LLC | 0.00% | No change | 7 | $458 |
| Cornerstone Planning Group LLC | 0.00% | Reduce -58.3% | 5 | $371 |
| IMA Advisory Services, Inc. | 0.00% | No change | 5 | $327 |
| Clearstead Advisors, LLC | 0.00% | Reduce -100.0% | 3 | $197 |
| American Capital Advisory, LLC | 0.00% | New | 2 | $131 |
| Truvestments Capital LLC | 0.00% | No change | 1 | $49 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.