Ionis PharmaceuticalsIONS
13F holders, Q4 2024 (December 31)355holders +1
41new positions
48sold out
6famous investors
$34.97avg. 13F price*
At the end of Q4 2024, 355 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 1 from Q3 2024. 41 opened new positions and 48 sold out. The largest holders were FMR LLC ($793.2M), Vanguard Group Inc. ($575.9M) and T. Rowe Price Investment Management, Inc. ($495.4M). 6 famous investors held it, including Cathie Wood (0.3% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2024 → Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $81.9M |
| Exits | 48 | $178.8M |
All 13F filers, Q3 2024 → Q4 2024: 16,487,676 shares bought and 13,800,535 shares sold, net +2,687,141 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 355 holders
| FMR LLC | 0.05% | Add +0.9% | 22,689,491 | $793.2M |
| Vanguard Group Inc. | 0.01% | Add +9.4% | 16,472,539 | $575.9M |
| T. Rowe Price Investment Management, Inc. | 0.31% | Add +0.0% | 14,169,199 | $495.4M |
| BlackRock, Inc. | 0.01% | Add +7.9% | 11,665,548 | $407.8M |
| Capital World Investors | 0.06% | Add +46.5% | 11,465,413 | $400.8M |
| Wellington Management Group LLP | 0.06% | Reduce -0.7% | 8,672,148 | $303.2M |
| Bellevue Group AG | 5.30% | Reduce -0.1% | 7,868,700 | $275.1M |
| State Street Corp. | 0.01% | Add +11.9% | 5,426,413 | $189.7M |
| T. Rowe Price Associates Inc. | 0.02% | Reduce -9.1% | 3,826,939 | $133.8M |
| Tweedy, Browne Co LLC | 7.66% | Reduce -6.0% | 3,248,863 | $113.6M |
| Orbimed Advisors LLC | 2.05% | Add +21.2% | 2,817,347 | $98.5M |
| Geode Capital Management, LLC | 0.01% | Add +0.7% | 2,687,248 | $94.0M |
| Citadel Advisors | 0.07% | Add +439.9% | 2,165,916 | $75.7M |
| Deep Track Capital, LP | 2.53% | Reduce -12.1% | 1,933,928 | $67.6M |
| UBS Group AG | 0.01% | Add +1042.3% | 1,917,608 | $67.0M |
| Macquarie Group Ltd. | 0.07% | Reduce -5.3% | 1,769,743 | $61.9M |
| Norges Bank | 0.01% | Reduce -15.4% | 1,714,762 | $59.9M |
| Clearbridge Investments, LLC | 0.05% | Reduce -4.9% | 1,618,220 | $56.6M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +2.7% | 1,481,440 | $51.8M |
| Two Sigma Advisers, LP | 0.11% | Add +1.3% | 1,349,211 | $47.2M |
| Morgan Stanley | 0.00% | Add +1.5% | 1,329,929 | $46.5M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.09% | Add +38.5% | 1,080,341 | $37.8M |
| TD Asset Management Inc | 0.03% | Reduce -3.9% | 1,049,990 | $36.7M |
| ARK Investment Management | 0.30% | Reduce -25.9% | 1,025,260 | $35.8M |
| Two Sigma Investments, LP | 0.08% | Add +0.3% | 921,439 | $32.2M |
| Candriam S.C.A. | 0.17% | Reduce -10.4% | 849,824 | $29.7M |
| Northern Trust Corp. | 0.00% | Add +13.1% | 840,271 | $29.4M |
| Hudson Bay Capital Management LP | 0.21% | Add +7.1% | 821,200 | $28.7M |
| Marshall Wace, LLP | 0.04% | Reduce -57.7% | 812,306 | $28.4M |
| Invesco Ltd. | 0.01% | Reduce -2.7% | 788,599 | $27.6M |
| Millennium Management | 0.02% | Add +79.8% | 774,215 | $27.1M |
| Royal Bank of Canada | 0.00% | Reduce -4.0% | 643,192 | $22.5M |
| Camber Capital Management LP | 0.86% | New | 625,000 | $21.9M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -52.4% | 620,798 | $21.7M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +116.9% | 619,641 | $21.7M |
| Bank of New York Mellon Corp | 0.00% | Add +0.8% | 616,071 | $21.5M |
| J. Goldman & Co LP | 0.75% | Reduce -0.3% | 607,499 | $21.2M |
| AXA S.A. | 0.06% | Add +7.9% | 605,345 | $21.2M |
| Barclays PLC | 0.01% | Reduce -6.4% | 596,072 | $20.8M |
| Vestal Point Capital, LP | 1.23% | New | 595,000 | $20.8M |
| Pinnacle Associates Ltd. | 0.26% | Add +19.3% | 547,642 | $19.1M |
| Groupama Asset Managment | 0.38% | Add +24.3% | 517,191 | $18.1M |
| Great Point Partners LLC | 8.32% | Add +98.0% | 505,007 | $17.7M |
| Bank of America Corp. | 0.00% | Reduce -25.6% | 422,861 | $14.8M |
| JPMorgan Chase & Co. | 0.00% | Reduce -26.9% | 415,919 | $14.5M |
| Aberdeen Group plc | 0.03% | Add +32.4% | 401,501 | $14.0M |
| C WorldWide Group Holding A/S | 0.17% | Add +33.3% | 400,000 | $14.0M |
| Ameriprise Financial Inc. | 0.00% | Reduce -2.6% | 387,448 | $13.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +60.5% | 378,208 | $13.2M |
| Schonfeld Strategic Advisors LLC | 0.08% | Add +2.3% | 371,381 | $13.0M |
| Baker Bros. Advisors LP | 0.14% | Add +60.2% | 357,915 | $12.5M |
| Nomura Holdings Inc. | 0.07% | Reduce -21.1% | 357,255 | $12.5M |
| Tocqueville Asset Management L.P. | 0.19% | Reduce -13.4% | 352,140 | $12.3M |
| Wells Fargo & Company | 0.00% | Reduce -3.3% | 331,009 | $11.6M |
| Voloridge Investment Management, LLC | 0.04% | Reduce -16.7% | 316,943 | $11.1M |
| Bank of Montreal | 0.01% | Add +45.9% | 312,146 | $10.9M |
| Nuveen Asset Management, LLC | 0.00% | Reduce -4.5% | 290,954 | $10.2M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -7.3% | 286,279 | $10.0M |
| Jacobs Levy Equity Management, Inc. | 0.03% | Reduce -56.7% | 281,813 | $9.9M |
| Swiss National Bank | 0.01% | Add +8.8% | 279,200 | $9.8M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Reduce -45.0% | 275,000 | $9.6M |
| Privium Fund Management B.V. | 2.13% | Add +6.4% | 266,794 | $9.3M |
| BNP Paribas Financial Markets | 0.01% | Add +45.2% | 254,521 | $8.9M |
| Artisan Partners Limited Partnership | 0.01% | Reduce -88.7% | 252,635 | $8.8M |
| Siren, L.L.C. | 0.39% | No change | 250,000 | $8.7M |
| Corient Private Wealth LP | 0.01% | Add +0.9% | 239,163 | $8.4M |
| Rafferty Asset Management, LLC | 0.03% | Add +19.4% | 237,337 | $8.3M |
| Sector Gamma As | 2.83% | Add +11.9% | 235,842 | $8.2M |
| Aquatic Capital Management LLC | 0.22% | New | 230,016 | $8.0M |
| Kennedy Capital Management LLC | 0.17% | Add +37.8% | 223,278 | $7.8M |
| Orion Investment Co | 3.01% | Reduce -1.2% | 216,000 | $7.6M |
| Eversept Partners, LP | 0.78% | Reduce -54.4% | 214,952 | $7.5M |
| Susquehanna Fundamental Investments, LLC | 0.13% | — | 213,015 | $7.4M |
| Rhenman & Partners Asset Management AB | 0.76% | Add +9.0% | 212,500 | $7.4M |
| Stifel Financial Corp. | 0.01% | Add +15.9% | 211,493 | $7.4M |
| Renaissance Technologies | 0.01% | Add +7.9% | 205,514 | $7.2M |
| Verition Fund Management LLC | 0.04% | New | 200,184 | $7.0M |
| California Public Employees Retirement System | 0.00% | Reduce -9.3% | 192,130 | $6.7M |
| Rhumbline Advisers | 0.01% | Reduce -2.6% | 191,893 | $6.7M |
| GW&K Investment Management, LLC | 0.06% | New | 187,220 | $6.5M |
| Sicart Associates LLC | 2.32% | Reduce -3.0% | 185,821 | $6.5M |
| Driehaus Capital Management LLC | 0.05% | Reduce -21.7% | 180,002 | $6.3M |
| Citigroup Inc. | 0.01% | Add +140.6% | 169,155 | $5.9M |
| Legal & General Group Plc | 0.00% | Add +6.9% | 168,080 | $5.9M |
| Squarepoint Ops LLC | 0.02% | Add +30.7% | 166,468 | $5.8M |
| Jane Street Group, LLC | 0.01% | Reduce -6.8% | 164,634 | $5.8M |
| Sovran Advisors, LLC | 0.80% | — | 171,812 | $5.6M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -20.1% | 156,657 | $5.5M |
| Amova Asset Management Americas, Inc. | 0.06% | Reduce -20.1% | 156,657 | $5.5M |
| State Board of Administration of Florida Retirement System | 0.01% | Add +0.8% | 152,315 | $5.3M |
| BLB&B Advisors, LLC | 0.27% | Reduce -0.1% | 152,050 | $5.3M |
| Tang Capital Management LLC | 0.35% | No change | 150,000 | $5.2M |
| Alyeska Investment Group, L.P. | 0.02% | Reduce -11.2% | 150,000 | $5.2M |
| Sonora Investment Management Group, LLC | 0.40% | Reduce -2.9% | 148,776 | $5.2M |
| Assenagon Asset Management S.A. | 0.01% | Add +967.2% | 141,917 | $5.0M |
| California State Teachers Retirement System | 0.01% | Add +6.1% | 133,902 | $4.7M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | Add +606.8% | 125,389 | $4.4M |
| Nicola Wealth Management LTD. | 0.41% | No change | 87,000 | $4.4M |
| Swedbank AB | 0.01% | Reduce -4.0% | 124,237 | $4.3M |
| Woodline Partners LP | 0.03% | New | 107,610 | $3.8M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.