Ionis PharmaceuticalsIONS
13F holders, Q1 2026 (March 31)497holders +3
63new positions
63sold out
10famous investors
$75.12avg. 13F price*
At the end of Q1 2026, 497 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 3 from Q4 2025. 63 opened new positions and 63 sold out. The largest holders were FMR LLC ($1.8B), Capital World Investors ($1.6B) and BlackRock, Inc. ($784.1M). 10 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Israel Englander (0.1% of Millennium Management's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 63 | $196.7M |
| Exits | 63 | $129.4M |
All 13F filers, Q4 2025 → Q1 2026: 21,278,848 shares bought and 15,445,551 shares sold, net +5,833,297 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 497 holders
| FMR LLC | 0.10% | Add +2.0% | 24,556,637 | $1.8B |
| Capital World Investors | 0.22% | Add +18.0% | 21,186,369 | $1.6B |
| BlackRock, Inc. | 0.01% | Reduce -1.9% | 10,442,476 | $784.1M |
| Vanguard Portfolio Management LLC | 0.03% | — | 7,808,902 | $586.4M |
| Vanguard Capital Management LLC | 0.01% | — | 7,118,330 | $534.5M |
| Wellington Management Group LLP | 0.09% | Add +2.1% | 6,391,816 | $480.0M |
| T. Rowe Price Investment Management, Inc. | 0.32% | Reduce -32.4% | 6,159,027 | $462.5M |
| Two Sigma Investments, LP | 0.38% | Add +120.3% | 5,857,629 | $439.8M |
| Geode Capital Management, LLC | 0.02% | Add +26.5% | 3,984,332 | $305.2M |
| State Street Corp. | 0.01% | Add +0.5% | 3,995,564 | $300.0M |
| Royal Bank of Canada | 0.05% | Add +239.8% | 3,801,815 | $285.5M |
| T. Rowe Price Associates Inc. | 0.03% | Add +1.3% | 3,025,251 | $227.2M |
| JPMorgan Chase & Co. | 0.01% | Add +2.5% | 2,363,567 | $171.4M |
| Tweedy, Browne Co LLC | 13.57% | Reduce -7.7% | 2,275,625 | $170.9M |
| Artisan Partners Limited Partnership | 0.25% | Add +74.2% | 2,058,308 | $154.6M |
| Baker Bros. Advisors LP | 0.88% | Add +14.3% | 2,047,727 | $153.8M |
| Deerfield Management Company, L.P. | 2.07% | No change | 1,979,669 | $148.7M |
| Deep Track Capital, LP | 3.02% | Add +14.7% | 1,950,000 | $146.4M |
| Bellevue Group AG | 3.25% | Reduce -62.1% | 1,818,665 | $136.6M |
| Goldman Sachs Group Inc. | 0.02% | Add +98.6% | 1,699,847 | $127.6M |
| American Century Companies Inc. | 0.06% | Add +2.9% | 1,663,803 | $124.9M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +2.7% | 1,583,266 | $118.9M |
| Franklin Resources Inc. | 0.03% | Add +19.2% | 1,575,023 | $118.3M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Add +6.3% | 1,475,632 | $110.8M |
| Pictet Asset Management Holding SA | 0.11% | Add +1.2% | 1,434,995 | $107.1M |
| Summit Partners Public Asset Management, LLC | 4.88% | Reduce -4.0% | 1,404,033 | $105.4M |
| Invesco Ltd. | 0.01% | Add +0.6% | 1,277,358 | $95.9M |
| Millennium Management | 0.06% | Add +1027.5% | 1,051,506 | $79.0M |
| Morgan Stanley | 0.00% | Add +0.7% | 1,026,509 | $77.1M |
| Vanguard Fiduciary Trust Co. | 0.02% | — | 1,024,377 | $76.9M |
| Citadel Advisors | 0.05% | Reduce -55.9% | 942,534 | $70.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.08% | Reduce -32.9% | 907,533 | $68.1M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.15% | Reduce -18.8% | 874,089 | $65.6M |
| Northern Trust Corp. | 0.01% | Add +2.5% | 868,179 | $65.2M |
| Bank of America Corp. | 0.00% | Add +7.3% | 840,598 | $63.1M |
| Polar Capital Holdings Plc | 0.27% | Reduce -37.8% | 829,511 | $62.3M |
| Groupama Asset Managment | 0.91% | Add +7.5% | 824,540 | $61.9M |
| UBS Group AG | 0.01% | Reduce -22.6% | 808,443 | $60.7M |
| Nomura Asset Management International Inc. | 0.10% | Reduce -9.2% | 785,281 | $59.0M |
| GW&K Investment Management, LLC | 0.52% | Reduce -0.9% | 779,349 | $58.5M |
| Arrowstreet Capital, Limited Partnership | 0.03% | Reduce -30.6% | 737,859 | $55.4M |
| Squarepoint Ops LLC | 0.11% | Add +59.4% | 695,276 | $52.2M |
| Voloridge Investment Management, LLC | 0.20% | Add +15.0% | 672,858 | $50.5M |
| Massachusetts Financial Services Co. | 0.02% | Reduce -18.0% | 666,116 | $50.0M |
| Ameriprise Financial Inc. | 0.01% | Add +10.3% | 660,144 | $49.6M |
| Nuveen, LLC | 0.01% | Reduce -1.9% | 648,496 | $48.7M |
| Eversept Partners, LP | 3.13% | Add +17.4% | 632,100 | $47.5M |
| Eventide Asset Management, LLC | 0.71% | No change | 575,000 | $43.2M |
| TD Asset Management Inc | 0.03% | Reduce -31.5% | 529,954 | $39.8M |
| Teacher Retirement System of Texas | 0.16% | Add +23.9% | 523,932 | $39.3M |
| Bank of New York Mellon Corp | 0.01% | Reduce -4.3% | 514,617 | $38.6M |
| Perceptive Advisors LLC | 0.75% | New | 504,000 | $37.8M |
| Boone Capital Management LLC | 11.51% | Add +19.8% | 500,522 | $37.6M |
| Candriam S.C.A. | 0.19% | Reduce -28.6% | 484,053 | $36.3M |
| BNP Paribas Financial Markets | 0.02% | Add +43.3% | 479,460 | $36.0M |
| Alyeska Investment Group, L.P. | 0.10% | Reduce -1.8% | 473,150 | $35.5M |
| First Trust Advisors LP | 0.03% | Reduce -10.8% | 468,363 | $35.2M |
| Neuberger Berman Group LLC | 0.03% | Add +310.3% | 443,272 | $33.3M |
| Pinnacle Associates Ltd. | 0.42% | Reduce -5.5% | 436,457 | $32.8M |
| D. E. Shaw & Co. | 0.03% | Add +29.1% | 429,599 | $32.3M |
| Alliancebernstein L.P. | 0.01% | Add +17.2% | 400,669 | $31.7M |
| Davern Capital Partners, LP | 7.97% | Add +62.2% | 386,903 | $29.1M |
| C WorldWide Group Holding A/S | 0.59% | No change | 366,000 | $27.5M |
| New York State Common Retirement Fund | 0.04% | Add +44.9% | 350,414 | $26.3M |
| Capital Research Global Investors | 0.00% | New | 323,015 | $24.3M |
| Renaissance Technologies | 0.04% | Add +36.6% | 305,549 | $22.9M |
| Swiss National Bank | 0.01% | Add +2.0% | 304,500 | $22.9M |
| Hudson Bay Capital Management LP | 0.15% | Reduce -37.9% | 295,100 | $22.2M |
| Legal & General Group Plc | 0.01% | Reduce -9.4% | 294,679 | $22.1M |
| Privium Fund Management B.V. | 4.53% | Add +20.4% | 290,024 | $21.8M |
| Barclays PLC | 0.01% | Reduce -65.6% | 289,874 | $21.8M |
| ARK Investment Management | 0.17% | Reduce -31.7% | 288,716 | $21.7M |
| TimesSquare Capital Management, LLC | 0.35% | New | 275,674 | $20.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +51.8% | 267,215 | $20.1M |
| California Public Employees Retirement System | 0.01% | Add +19.7% | 255,485 | $19.2M |
| HRT Financial LP | 0.05% | Add +1000.2% | 252,250 | $18.9M |
| Zurich Insurance Group Ltd | 0.14% | Reduce -8.5% | 239,645 | $18.0M |
| DAVENPORT & Co LLC | 0.10% | Add +9.3% | 238,238 | $17.9M |
| J. Goldman & Co LP | 0.82% | Add +247.8% | 235,260 | $17.7M |
| Raymond James Financial Inc. | 0.01% | Reduce -8.6% | 235,121 | $17.7M |
| ExodusPoint Capital Management, LP | 0.17% | Add +170.7% | 227,084 | $17.1M |
| Orion Investment Co | 5.36% | Reduce -0.1% | 225,015 | $16.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.03% | Add +0.0% | 219,652 | $16.5M |
| Tocqueville Asset Management L.P. | 0.24% | Add +7.6% | 219,220 | $16.5M |
| Handelsbanken Fonder AB | 0.05% | Add +346.5% | 213,911 | $16.1M |
| Trexquant Investment LP | 0.12% | Add +61.6% | 213,645 | $16.0M |
| Jump Financial, LLC | 0.26% | New | 206,675 | $15.5M |
| Stifel Financial Corp. | 0.01% | Reduce -1.1% | 196,703 | $14.8M |
| Corient Private Wealth LP | 0.02% | Reduce -9.2% | 196,599 | $14.8M |
| Jane Street Group, LLC | 0.02% | Add +529.5% | 191,818 | $14.4M |
| Wells Fargo & Company | 0.00% | Reduce -32.2% | 189,853 | $14.3M |
| HSBC Holdings PLC | 0.01% | Add +590.3% | 185,967 | $14.0M |
| California State Teachers Retirement System | 0.01% | Add +22.4% | 176,485 | $13.3M |
| Rhumbline Advisers | 0.01% | Reduce -1.1% | 173,440 | $13.0M |
| Sector Gamma As | 3.00% | Reduce -8.4% | 169,468 | $12.7M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0.01% | No change | 167,657 | $12.6M |
| Focus Partners Wealth | 0.01% | Reduce -8.9% | 165,544 | $12.4M |
| ADAR1 Capital Management, LLC | 0.73% | Add +9.0% | 160,338 | $12.0M |
| Deutsche Bank AG | 0.00% | Add +7.0% | 159,891 | $12.0M |
| Sicart Associates LLC | 3.08% | Reduce -2.5% | 159,412 | $12.0M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.