Ionis PharmaceuticalsIONS
13F holders, Q2 2025 (June 30)362holders +18
78new positions
61sold out
6famous investors
$39.52avg. 13F price*
At the end of Q2 2025, 362 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 18 from Q1 2025. 78 opened new positions and 61 sold out. The largest holders were FMR LLC ($934.1M), Vanguard Group Inc. ($660.4M) and T. Rowe Price Investment Management, Inc. ($634.1M). 6 famous investors held it, including Cathie Wood (0.3% of ARK Investment Management's portfolio), Israel Englander (0.1% of Millennium Management's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 78 | $212.9M |
| Exits | 61 | $136.8M |
All 13F filers, Q1 2025 → Q2 2025: 16,053,470 shares bought and 13,914,962 shares sold, net +2,138,508 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 362 holders
| FMR LLC | 0.05% | Add +0.1% | 23,642,990 | $934.1M |
| Vanguard Group Inc. | 0.01% | Add +2.0% | 16,714,846 | $660.4M |
| T. Rowe Price Investment Management, Inc. | 0.40% | Reduce -0.8% | 16,048,721 | $634.1M |
| Capital World Investors | 0.07% | Add +1.4% | 12,540,188 | $495.5M |
| BlackRock, Inc. | 0.01% | Reduce -3.3% | 10,896,937 | $430.5M |
| Bellevue Group AG | 6.84% | No change | 7,853,198 | $310.3M |
| Wellington Management Group LLP | 0.05% | Reduce -24.6% | 6,345,776 | $250.7M |
| Deep Track Capital, LP | 6.21% | Add +7.2% | 4,891,544 | $193.3M |
| State Street Corp. | 0.01% | Reduce -6.5% | 4,530,398 | $179.0M |
| Adage Capital Partners Gp, L.L.C. | 0.25% | Add +253.3% | 3,800,000 | $150.1M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -4.3% | 3,126,073 | $123.5M |
| Tweedy, Browne Co LLC | 10.60% | Reduce -3.1% | 2,891,948 | $114.3M |
| Geode Capital Management, LLC | 0.01% | Add +1.7% | 2,891,095 | $114.2M |
| Two Sigma Advisers, LP | 0.22% | Add +27.5% | 2,667,611 | $105.4M |
| Millennium Management | 0.10% | Add +317.0% | 2,649,527 | $104.7M |
| BVF Inc. | 2.70% | No change | 1,913,385 | $75.6M |
| Two Sigma Investments, LP | 0.13% | Add +6.1% | 1,788,367 | $70.7M |
| UBS Group AG | 0.01% | Reduce -19.1% | 1,529,323 | $60.4M |
| Citadel Advisors | 0.05% | Reduce -57.0% | 1,494,981 | $59.1M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +3.1% | 1,487,818 | $58.8M |
| Macquarie Group Ltd. | 0.07% | Reduce -14.0% | 1,434,073 | $56.7M |
| Morgan Stanley | 0.00% | Add +19.1% | 1,362,209 | $53.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.13% | Add +12.9% | 1,350,879 | $53.4M |
| TD Asset Management Inc | 0.04% | Add +0.4% | 1,104,690 | $43.6M |
| Polar Capital Holdings Plc | 0.21% | New | 1,000,000 | $39.5M |
| Bank of America Corp. | 0.00% | Add +29.8% | 995,890 | $39.3M |
| ARK Investment Management | 0.26% | Reduce -10.0% | 900,318 | $35.6M |
| Voloridge Investment Management, LLC | 0.12% | Add +126.6% | 854,634 | $33.8M |
| Northern Trust Corp. | 0.00% | Reduce -2.5% | 814,250 | $32.2M |
| Royal Bank of Canada | 0.01% | Add +29.8% | 799,912 | $31.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +20.0% | 791,072 | $31.3M |
| Goldman Sachs Group Inc. | 0.01% | Add +19.2% | 777,940 | $30.7M |
| Balyasny Asset Management L.P. | 0.07% | New | 768,648 | $30.4M |
| Hudson Bay Capital Management LP | 0.22% | Reduce -28.6% | 750,000 | $29.6M |
| Woodline Partners LP | 0.15% | New | 732,813 | $29.0M |
| Candriam S.C.A. | 0.17% | Reduce -27.1% | 724,740 | $28.6M |
| Teacher Retirement System of Texas | 0.11% | Add +33.5% | 668,273 | $26.4M |
| Groupama Asset Managment | 0.44% | Add +16.1% | 660,957 | $26.3M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -1.6% | 608,640 | $24.2M |
| Eversept Partners, LP | 2.35% | Add +13.9% | 588,900 | $23.3M |
| Barclays PLC | 0.01% | Add +64.8% | 583,266 | $23.0M |
| AXA S.A. | 0.06% | Add +0.1% | 566,883 | $22.4M |
| Bank of New York Mellon Corp | 0.00% | Reduce -3.2% | 527,188 | $20.8M |
| Massachusetts Financial Services Co. | 0.01% | New | 519,184 | $20.5M |
| Great Point Partners LLC | 12.84% | Add +100.0% | 500,000 | $19.8M |
| Vestal Point Capital, LP | 1.04% | New | 500,000 | $19.8M |
| Pinnacle Associates Ltd. | 0.28% | Reduce -18.7% | 494,539 | $19.5M |
| Bank of Montreal | 0.01% | Reduce -38.3% | 483,289 | $19.1M |
| American Century Companies Inc. | 0.01% | Add +304.9% | 472,749 | $18.7M |
| Norges Bank | 0.00% | Reduce -47.5% | 450,254 | $17.8M |
| C WorldWide Group Holding A/S | 0.24% | Add +12.5% | 450,000 | $17.8M |
| Schonfeld Strategic Advisors LLC | 0.13% | Reduce -19.8% | 449,206 | $17.7M |
| GW&K Investment Management, LLC | 0.16% | Add +146.2% | 448,830 | $17.7M |
| Aberdeen Group plc | 0.03% | Reduce -8.8% | 406,694 | $16.2M |
| Legal & General Group Plc | 0.00% | Add +19.5% | 404,366 | $16.0M |
| Great Lakes Advisors, LLC | 0.13% | New | 399,646 | $15.8M |
| JPMorgan Chase & Co. | 0.00% | Reduce -6.3% | 394,978 | $15.6M |
| Ameriprise Financial Inc. | 0.00% | Add +2.2% | 368,119 | $14.5M |
| Artisan Partners Limited Partnership | 0.02% | Add +74.7% | 354,962 | $14.0M |
| Citigroup Inc. | 0.01% | Reduce -20.1% | 340,977 | $13.5M |
| Sovran Advisors, LLC | 1.39% | Reduce -2.1% | 321,913 | $13.3M |
| Point72 Asset Management | 0.03% | Add +1.9% | 292,647 | $11.6M |
| Swiss National Bank | 0.01% | Add +4.8% | 288,600 | $11.4M |
| Sector Gamma As | 3.69% | No change | 285,842 | $11.3M |
| Renaissance Technologies | 0.01% | Add +76.3% | 270,714 | $10.7M |
| Privium Fund Management B.V. | 2.31% | No change | 267,594 | $10.7M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.04% | Add +105.6% | 265,793 | $10.5M |
| Invesco Ltd. | 0.00% | Reduce -70.7% | 256,235 | $10.1M |
| Nuveen, LLC | 0.00% | Reduce -20.6% | 245,085 | $9.7M |
| Corient Private Wealth LP | 0.01% | Add +0.3% | 237,840 | $9.4M |
| Verition Fund Management LLC | 0.06% | Add +345.0% | 232,687 | $9.2M |
| Orion Investment Co | 3.04% | Add +1.0% | 217,370 | $8.6M |
| Raymond James Financial Inc. | 0.00% | Add +41.6% | 210,592 | $8.3M |
| Wells Fargo & Company | 0.00% | Reduce -18.1% | 209,857 | $8.3M |
| California Public Employees Retirement System | 0.01% | Add +5.8% | 201,993 | $8.0M |
| Edmond DE Rothschild Holding S.A. | 0.12% | Add +59.1% | 197,600 | $7.8M |
| Stifel Financial Corp. | 0.01% | Reduce -2.3% | 196,357 | $7.8M |
| Tocqueville Asset Management L.P. | 0.11% | Reduce -0.0% | 187,345 | $7.4M |
| Sicart Associates LLC | 2.56% | Reduce -0.2% | 185,296 | $7.3M |
| Rhenman & Partners Asset Management AB | 0.91% | Add +124.7% | 182,000 | $7.2M |
| Rhumbline Advisers | 0.01% | Reduce -3.5% | 181,599 | $7.2M |
| BNP Paribas Financial Markets | 0.01% | Reduce -42.3% | 177,762 | $7.0M |
| Sonora Investment Management Group, LLC | 0.48% | Add +5.8% | 163,172 | $6.4M |
| Alyeska Investment Group, L.P. | 0.02% | New | 159,008 | $6.3M |
| Aquatic Capital Management LLC | 0.13% | Add +1.2% | 158,086 | $6.2M |
| State Board of Administration of Florida Retirement System | 0.01% | Add +1.0% | 153,895 | $6.1M |
| BLB&B Advisors, LLC | 0.28% | Reduce -0.4% | 151,550 | $6.0M |
| Tang Capital Management LLC | 0.30% | No change | 150,000 | $5.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +4.2% | 149,839 | $5.9M |
| ADAR1 Capital Management, LLC | 0.96% | New | 148,461 | $5.9M |
| J. Goldman & Co LP | 0.18% | Reduce -52.0% | 147,682 | $5.8M |
| California State Teachers Retirement System | 0.01% | Add +9.7% | 145,104 | $5.7M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -17.9% | 144,770 | $5.7M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -1.9% | 139,739 | $5.5M |
| Amova Asset Management Americas, Inc. | 0.06% | Reduce -1.9% | 139,739 | $5.5M |
| Squarepoint Ops LLC | 0.01% | Reduce -56.0% | 134,395 | $5.3M |
| Kennedy Capital Management LLC | 0.12% | Reduce -12.2% | 132,045 | $5.2M |
| Trexquant Investment LP | 0.06% | New | 128,869 | $5.1M |
| Exome Asset Management LLC | 3.95% | Reduce -10.7% | 121,116 | $4.8M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.01% | New | 116,000 | $4.6M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.