Ionis PharmaceuticalsIONS
13F holders, Q4 2025 (December 31)494holders +58
93new positions
41sold out
11famous investors
$79.09avg. 13F price*
At the end of Q4 2025, 494 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 58 from Q3 2025. 93 opened new positions and 41 sold out. The largest holders were FMR LLC ($1.9B), Capital World Investors ($1.4B) and Vanguard Group Inc. ($1.3B). 11 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 93 | $209.6M |
| Exits | 41 | $233.4M |
All 13F filers, Q3 2025 → Q4 2025: 23,061,726 shares bought and 21,909,690 shares sold, net +1,152,036 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 494 holders
| FMR LLC | 0.10% | Add +1.6% | 24,072,101 | $1.9B |
| Capital World Investors | 0.19% | Add +41.2% | 17,961,299 | $1.4B |
| Vanguard Group Inc. | 0.02% | Reduce -0.3% | 16,440,459 | $1.3B |
| BlackRock, Inc. | 0.01% | Add +1.9% | 10,647,863 | $842.4M |
| T. Rowe Price Investment Management, Inc. | 0.46% | Reduce -30.8% | 9,108,019 | $720.5M |
| Wellington Management Group LLP | 0.09% | Reduce -5.0% | 6,260,325 | $495.3M |
| Bellevue Group AG | 7.20% | Reduce -23.1% | 4,802,199 | $379.9M |
| State Street Corp. | 0.01% | Reduce -9.4% | 3,974,865 | $314.5M |
| Geode Capital Management, LLC | 0.02% | Add +2.7% | 3,148,849 | $249.2M |
| Two Sigma Advisers, LP | 0.47% | Add +47.2% | 3,052,111 | $241.5M |
| T. Rowe Price Associates Inc. | 0.03% | Add +9.5% | 2,987,840 | $236.4M |
| Two Sigma Investments, LP | 0.33% | Add +68.7% | 2,658,646 | $210.3M |
| Tweedy, Browne Co LLC | 15.74% | Reduce -15.0% | 2,464,930 | $195.0M |
| JPMorgan Chase & Co. | 0.01% | Add +323.3% | 2,304,792 | $182.3M |
| Citadel Advisors | 0.12% | Reduce -11.1% | 2,134,636 | $168.9M |
| Deerfield Management Company, L.P. | 2.29% | No change | 1,979,669 | $156.6M |
| Baker Bros. Advisors LP | 0.83% | Add +216.1% | 1,791,841 | $141.8M |
| Deep Track Capital, LP | 3.07% | Reduce -55.4% | 1,700,000 | $134.5M |
| American Century Companies Inc. | 0.06% | Add +17.9% | 1,617,106 | $127.9M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +1.4% | 1,541,841 | $122.0M |
| Summit Partners Public Asset Management, LLC | 3.26% | Add +95.0% | 1,462,706 | $115.7M |
| Pictet Asset Management Holding SA | 0.11% | Add +1.8% | 1,418,491 | $112.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Add +20.3% | 1,388,567 | $109.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.12% | Add +27.7% | 1,352,837 | $107.0M |
| Polar Capital Holdings Plc | 0.48% | Add +29.0% | 1,333,424 | $105.5M |
| Franklin Resources Inc. | 0.03% | Add +19941.6% | 1,321,345 | $104.5M |
| Invesco Ltd. | 0.01% | Add +144.5% | 1,269,290 | $100.4M |
| Artisan Partners Limited Partnership | 0.14% | Add +32.7% | 1,181,416 | $93.5M |
| Royal Bank of Canada | 0.02% | Reduce -8.8% | 1,118,797 | $88.5M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.22% | Add +22.6% | 1,076,370 | $85.2M |
| Arrowstreet Capital, Limited Partnership | 0.05% | Add +68.8% | 1,063,327 | $84.1M |
| UBS Group AG | 0.02% | Reduce -0.2% | 1,045,041 | $82.7M |
| Morgan Stanley | 0.00% | Reduce -13.6% | 1,019,906 | $80.7M |
| Nomura Asset Management International Inc. | 0.10% | — | 864,892 | $68.4M |
| Goldman Sachs Group Inc. | 0.01% | Add +10.1% | 855,966 | $67.7M |
| Nomura Holdings Inc. | 0.19% | Add +15.7% | 848,815 | $67.1M |
| Northern Trust Corp. | 0.01% | Add +0.2% | 846,718 | $67.0M |
| Barclays PLC | 0.03% | Add +18.0% | 842,871 | $66.7M |
| Massachusetts Financial Services Co. | 0.02% | Reduce -5.8% | 812,747 | $64.3M |
| GW&K Investment Management, LLC | 0.54% | Add +198.0% | 786,668 | $62.2M |
| Bank of America Corp. | 0.00% | Reduce -8.4% | 783,579 | $62.0M |
| TD Asset Management Inc | 0.05% | Reduce -19.5% | 773,184 | $61.2M |
| Groupama Asset Managment | 0.90% | Add +36.5% | 766,889 | $60.7M |
| Candriam S.C.A. | 0.27% | Add +10.9% | 677,629 | $53.6M |
| Nuveen, LLC | 0.01% | Add +59.0% | 660,769 | $52.3M |
| Ameriprise Financial Inc. | 0.01% | Reduce -21.8% | 598,748 | $47.4M |
| Voloridge Investment Management, LLC | 0.16% | Reduce -27.2% | 584,970 | $46.3M |
| Eventide Asset Management, LLC | 0.71% | New | 575,000 | $45.5M |
| Tri Locum Partners LP | 5.72% | New | 557,174 | $44.1M |
| Eversept Partners, LP | 2.39% | Reduce -0.1% | 538,218 | $42.6M |
| Bank of New York Mellon Corp | 0.01% | Add +1.1% | 537,886 | $42.6M |
| First Trust Advisors LP | 0.03% | Add +598.2% | 525,239 | $41.6M |
| Alyeska Investment Group, L.P. | 0.11% | Add +54.8% | 481,711 | $38.1M |
| Hudson Bay Capital Management LP | 0.24% | Reduce -7.8% | 475,000 | $37.6M |
| Pinnacle Associates Ltd. | 0.47% | Reduce -4.1% | 461,968 | $36.5M |
| Amundi | 0.01% | Add +354.0% | 460,947 | $36.5M |
| Squarepoint Ops LLC | 0.07% | Add +13.7% | 436,279 | $34.5M |
| ARK Investment Management | 0.22% | Reduce -33.0% | 422,968 | $33.5M |
| Teacher Retirement System of Texas | 0.12% | Reduce -10.8% | 422,899 | $33.5M |
| Boone Capital Management LLC | 10.37% | No change | 417,833 | $33.1M |
| C WorldWide Group Holding A/S | 0.51% | Reduce -14.1% | 366,000 | $29.0M |
| Jain Global LLC | 0.29% | Add +57.8% | 356,259 | $28.2M |
| Alliancebernstein L.P. | 0.01% | Add +530.0% | 341,849 | $27.0M |
| BNP Paribas Financial Markets | 0.02% | Reduce -12.7% | 334,608 | $26.5M |
| D. E. Shaw & Co. | 0.02% | Reduce -47.3% | 332,803 | $26.3M |
| Legal & General Group Plc | 0.01% | Add +1.8% | 325,148 | $25.7M |
| Norges Bank | 0.00% | — | 320,160 | $25.3M |
| Swiss National Bank | 0.01% | Add +1.8% | 298,500 | $23.6M |
| Wells Fargo & Company | 0.00% | Reduce -1.8% | 280,045 | $22.2M |
| Zurich Insurance Group Ltd | 0.14% | New | 261,820 | $20.7M |
| Raymond James Financial Inc. | 0.01% | Add +7.0% | 257,210 | $20.3M |
| Marshall Wace, LLP | 0.02% | Reduce -73.2% | 256,933 | $20.3M |
| New York State Common Retirement Fund | 0.03% | Add +43.8% | 241,853 | $19.1M |
| Privium Fund Management B.V. | 3.51% | Reduce -3.2% | 240,824 | $19.1M |
| Davern Capital Partners, LP | 6.10% | — | 238,477 | $18.9M |
| Orion Investment Co | 5.43% | Add +0.2% | 225,161 | $17.8M |
| Renaissance Technologies | 0.03% | Reduce -54.1% | 223,607 | $17.7M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.03% | Add +11.2% | 219,574 | $17.4M |
| DAVENPORT & Co LLC | 0.09% | Add +248.3% | 217,897 | $17.2M |
| Corient Private Wealth LP | 0.02% | Add +3184.3% | 216,438 | $17.1M |
| California Public Employees Retirement System | 0.01% | Reduce -1.1% | 213,368 | $16.9M |
| Tocqueville Asset Management L.P. | 0.24% | Add +5.5% | 203,730 | $16.1M |
| Ikarian Capital, LLC | 2.07% | Reduce -51.3% | 202,038 | $16.0M |
| Stifel Financial Corp. | 0.01% | Reduce -1.9% | 198,863 | $15.7M |
| Sector Gamma As | 3.34% | Reduce -31.7% | 184,977 | $14.6M |
| Focus Partners Wealth | 0.02% | New | 181,817 | $14.4M |
| Dimensional Fund Advisors LP | 0.00% | Add +317.0% | 176,035 | $13.9M |
| Rhumbline Advisers | 0.01% | Reduce -3.7% | 175,387 | $13.9M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0.01% | New | 167,657 | $13.3M |
| Man Group plc | 0.03% | Reduce -50.3% | 166,042 | $13.1M |
| Sicart Associates LLC | 3.43% | Reduce -0.5% | 163,557 | $12.9M |
| Rhenman & Partners Asset Management AB | 1.17% | Reduce -48.9% | 158,500 | $12.5M |
| CenterBook Partners LP | 0.60% | New | 153,949 | $12.2M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +56.3% | 153,241 | $12.1M |
| Deutsche Bank AG | 0.00% | Add +68.3% | 149,443 | $11.8M |
| Great Lakes Advisors, LLC | 0.10% | Reduce -20.2% | 149,180 | $11.8M |
| ADAR1 Capital Management, LLC | 0.87% | Add +9.9% | 147,130 | $11.6M |
| Artia Global Partners LP | 1.83% | Add +139.9% | 144,376 | $11.4M |
| California State Teachers Retirement System | 0.01% | Reduce -0.7% | 144,173 | $11.4M |
| Fisher Asset Management | 0.00% | Add +2180.4% | 141,615 | $11.2M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.