Ionis PharmaceuticalsIONS
13F holders, Q1 2025 (March 31)344holders −11
51new positions
61sold out
5famous investors
$30.18avg. 13F price*
At the end of Q1 2025, 344 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, down 11 from Q4 2024. 51 opened new positions and 61 sold out. The largest holders were FMR LLC ($712.4M), Vanguard Group Inc. ($494.3M) and T. Rowe Price Investment Management, Inc. ($488.0M). 5 famous investors held it, including Cathie Wood (0.3% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 51 | $94.1M |
| Exits | 61 | $143.6M |
All 13F filers, Q4 2024 → Q1 2025: 17,861,535 shares bought and 11,659,979 shares sold, net +6,201,556 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 344 holders
| FMR LLC | 0.05% | Add +4.1% | 23,613,585 | $712.4M |
| Vanguard Group Inc. | 0.01% | Reduce -0.5% | 16,383,934 | $494.3M |
| T. Rowe Price Investment Management, Inc. | 0.32% | Add +14.2% | 16,175,533 | $488.0M |
| Capital World Investors | 0.06% | Add +7.8% | 12,361,994 | $373.0M |
| BlackRock, Inc. | 0.01% | Reduce -3.4% | 11,264,442 | $339.8M |
| Wellington Management Group LLP | 0.05% | Reduce -3.0% | 8,416,421 | $253.9M |
| Bellevue Group AG | 5.31% | Reduce -0.2% | 7,853,198 | $236.9M |
| State Street Corp. | 0.01% | Reduce -10.7% | 4,845,133 | $146.2M |
| Deep Track Capital, LP | 4.46% | Add +136.0% | 4,564,207 | $137.7M |
| Citadel Advisors | 0.10% | Add +60.7% | 3,480,062 | $105.0M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -14.7% | 3,265,034 | $98.5M |
| Tweedy, Browne Co LLC | 7.98% | Reduce -8.2% | 2,983,518 | $90.0M |
| Geode Capital Management, LLC | 0.01% | Add +5.8% | 2,842,954 | $85.8M |
| Orbimed Advisors LLC | 1.84% | Reduce -9.8% | 2,540,136 | $76.6M |
| Two Sigma Advisers, LP | 0.14% | Add +55.0% | 2,092,011 | $63.1M |
| BVF Inc. | 2.35% | New | 1,913,385 | $57.7M |
| UBS Group AG | 0.01% | Reduce -1.4% | 1,890,602 | $57.0M |
| Two Sigma Investments, LP | 0.12% | Add +83.0% | 1,685,853 | $50.9M |
| Macquarie Group Ltd. | 0.06% | Reduce -5.8% | 1,667,194 | $50.3M |
| Charles Schwab Investment Management Inc. | 0.01% | Reduce -2.5% | 1,443,629 | $43.6M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.10% | Add +10.7% | 1,196,392 | $36.1M |
| Morgan Stanley | 0.00% | Reduce -14.0% | 1,144,181 | $34.5M |
| TD Asset Management Inc | 0.03% | Add +4.8% | 1,100,466 | $33.2M |
| Adage Capital Partners Gp, L.L.C. | 0.06% | Add +291.1% | 1,075,600 | $32.5M |
| Hudson Bay Capital Management LP | 0.23% | Add +27.9% | 1,049,900 | $31.7M |
| ARK Investment Management | 0.30% | Reduce -2.4% | 1,000,527 | $30.2M |
| Candriam S.C.A. | 0.19% | Add +16.9% | 993,704 | $30.0M |
| Invesco Ltd. | 0.01% | Add +10.9% | 874,834 | $26.4M |
| Norges Bank | 0.00% | Reduce -50.0% | 858,228 | $25.9M |
| Northern Trust Corp. | 0.00% | Reduce -0.7% | 834,847 | $25.2M |
| Bank of Montreal | 0.01% | Add +150.8% | 782,835 | $23.6M |
| Bank of America Corp. | 0.00% | Add +81.5% | 767,432 | $23.2M |
| Camber Capital Management LP | 1.36% | Add +16.0% | 725,000 | $21.9M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +6.4% | 659,435 | $19.9M |
| Goldman Sachs Group Inc. | 0.00% | Add +72.5% | 652,518 | $19.7M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -0.4% | 618,550 | $19.2M |
| Millennium Management | 0.02% | Reduce -17.9% | 635,370 | $19.2M |
| Royal Bank of Canada | 0.00% | Reduce -4.2% | 616,081 | $18.6M |
| Pinnacle Associates Ltd. | 0.27% | Add +11.1% | 608,517 | $18.4M |
| Groupama Asset Managment | 0.36% | Add +10.1% | 569,211 | $17.7M |
| AXA S.A. | 0.06% | Reduce -6.4% | 566,486 | $17.1M |
| Schonfeld Strategic Advisors LLC | 0.11% | Add +50.9% | 560,359 | $16.9M |
| Bank of New York Mellon Corp | 0.00% | Reduce -11.6% | 544,633 | $16.4M |
| Eversept Partners, LP | 1.77% | Add +140.5% | 517,021 | $15.6M |
| Teacher Retirement System of Texas | 0.06% | Add +660.7% | 500,451 | $15.1M |
| Aberdeen Group plc | 0.03% | Add +11.1% | 446,197 | $13.5M |
| Citigroup Inc. | 0.01% | Add +152.1% | 426,480 | $12.9M |
| JPMorgan Chase & Co. | 0.00% | Add +1.3% | 421,511 | $12.7M |
| C WorldWide Group Holding A/S | 0.15% | No change | 400,000 | $12.1M |
| Voloridge Investment Management, LLC | 0.04% | Add +19.0% | 377,204 | $11.4M |
| Ameriprise Financial Inc. | 0.00% | Reduce -7.0% | 360,188 | $10.9M |
| Baker Bros. Advisors LP | 0.12% | No change | 357,915 | $10.8M |
| Barclays PLC | 0.00% | Reduce -40.6% | 353,937 | $10.7M |
| Legal & General Group Plc | 0.00% | Add +101.4% | 338,462 | $10.2M |
| Sovran Advisors, LLC | 1.21% | Add +91.4% | 328,904 | $9.3M |
| Nuveen, LLC | 0.00% | — | 308,777 | $9.3M |
| BNP Paribas Financial Markets | 0.01% | Add +21.1% | 308,293 | $9.3M |
| J. Goldman & Co LP | 0.33% | Reduce -49.3% | 307,770 | $9.3M |
| Squarepoint Ops LLC | 0.02% | Add +83.4% | 305,373 | $9.2M |
| Point72 Asset Management | 0.03% | New | 287,204 | $8.7M |
| Sector Gamma As | 2.76% | Add +21.2% | 285,842 | $8.6M |
| Swiss National Bank | 0.01% | Reduce -1.4% | 275,300 | $8.3M |
| Privium Fund Management B.V. | 2.10% | Add +0.3% | 267,594 | $8.1M |
| Wells Fargo & Company | 0.00% | Reduce -22.6% | 256,233 | $7.7M |
| Great Point Partners LLC | 4.10% | Reduce -50.5% | 250,000 | $7.5M |
| Corient Private Wealth LP | 0.01% | Reduce -0.8% | 237,133 | $7.2M |
| Nomura Holdings Inc. | 0.04% | Reduce -33.8% | 236,426 | $7.1M |
| Orion Investment Co | 2.66% | Reduce -0.3% | 215,290 | $6.5M |
| Artisan Partners Limited Partnership | 0.01% | Reduce -19.6% | 203,178 | $6.1M |
| Stifel Financial Corp. | 0.01% | Reduce -5.0% | 200,942 | $6.1M |
| California Public Employees Retirement System | 0.00% | Reduce -0.6% | 191,004 | $5.8M |
| Rhumbline Advisers | 0.01% | Reduce -1.9% | 188,216 | $5.7M |
| Tocqueville Asset Management L.P. | 0.09% | Reduce -46.8% | 187,395 | $5.7M |
| Sicart Associates LLC | 1.94% | Reduce -0.1% | 185,646 | $5.6M |
| GW&K Investment Management, LLC | 0.05% | Reduce -2.6% | 182,309 | $5.5M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -25.7% | 176,248 | $5.3M |
| Susquehanna Fundamental Investments, LLC | 0.08% | Reduce -25.5% | 158,609 | $4.8M |
| Aquatic Capital Management LLC | 0.12% | Reduce -32.1% | 156,157 | $4.7M |
| Sonora Investment Management Group, LLC | 0.37% | Add +3.6% | 154,147 | $4.7M |
| Renaissance Technologies | 0.01% | Reduce -25.3% | 153,514 | $4.6M |
| State Board of Administration of Florida Retirement System | 0.01% | No change | 152,315 | $4.6M |
| BLB&B Advisors, LLC | 0.23% | Add +0.1% | 152,200 | $4.6M |
| Kennedy Capital Management LLC | 0.11% | Reduce -32.6% | 150,424 | $4.5M |
| Tang Capital Management LLC | 0.25% | No change | 150,000 | $4.5M |
| Raymond James Financial Inc. | 0.00% | Add +40.8% | 148,690 | $4.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | New | 143,870 | $4.3M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -9.1% | 142,433 | $4.3M |
| Amova Asset Management Americas, Inc. | 0.06% | Reduce -9.1% | 142,433 | $4.3M |
| Exome Asset Management LLC | 3.66% | Add +121.0% | 135,616 | $4.1M |
| California State Teachers Retirement System | 0.00% | Reduce -1.2% | 132,238 | $4.0M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | Add +3.1% | 129,273 | $3.9M |
| Edmond DE Rothschild Holding S.A. | 0.07% | New | 124,200 | $3.7M |
| American Century Companies Inc. | 0.00% | New | 116,768 | $3.5M |
| State of Wisconsin Investment Board | 0.01% | Add +7.0% | 108,316 | $3.3M |
| Neuberger Berman Group LLC | 0.00% | Add +6.0% | 102,473 | $3.1M |
| Alliancebernstein L.P. | 0.00% | Add +93.2% | 100,749 | $3.0M |
| PDT Partners, LLC | 0.21% | Add +231.3% | 96,056 | $2.9M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $2.9M |
| DCF Advisers, LLC | 1.54% | Add +14.6% | 95,000 | $2.9M |
| Walleye Capital LLC | 0.04% | Add +484.4% | 94,990 | $2.9M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.