Amylyx PharmaceuticalsAMLX
13F holders, Q3 2025 (September 30)169holders +38
57new positions
18sold out
6famous investors
$13.59avg. 13F price*
At the end of Q3 2025, 169 institutions reported holding Amylyx Pharmaceuticals Inc. (AMLX) in their 13F filings, up 38 from Q2 2025. 57 opened new positions and 18 sold out. The largest holders were FMR LLC ($154.6M), Perceptive Advisors LLC ($121.7M) and BlackRock, Inc. ($97.0M). 6 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Amylyx Pharmaceuticals Inc.
- CUSIP
- 03237H101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 57 | $310.8M |
| Exits | 18 | $12.8M |
All 13F filers, Q2 2025 → Q3 2025: 42,909,528 shares bought and 14,758,708 shares sold, net +28,150,820 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 169 holders
| FMR LLC | 0.01% | Add +273.3% | 11,379,207 | $154.6M |
| Perceptive Advisors LLC | 3.57% | Add +13.3% | 8,952,365 | $121.7M |
| BlackRock, Inc. | 0.00% | Add +29.6% | 7,140,692 | $97.0M |
| Adage Capital Partners Gp, L.L.C. | 0.15% | Reduce -22.5% | 6,816,828 | $92.6M |
| TCG Crossover Management, LLC | 4.17% | Add +5.0% | 6,243,812 | $84.9M |
| Vanguard Group Inc. | 0.00% | Add +17.3% | 5,273,750 | $71.7M |
| Saturn V Capital Management LP | 13.72% | Add +41.2% | 4,604,878 | $62.6M |
| Commodore Capital LP | 2.70% | New | 4,075,478 | $55.4M |
| First Light Asset Management, LLC | 4.30% | New | 3,355,882 | $45.6M |
| Point72 Asset Management | 0.09% | Reduce -38.5% | 2,790,066 | $37.9M |
| Janus Henderson Group PLC | 0.02% | New | 2,536,233 | $34.5M |
| Driehaus Capital Management LLC | 0.24% | Add +91.4% | 2,420,767 | $32.9M |
| Almitas Capital LLC | 6.61% | No change | 2,122,597 | $28.8M |
| Goldman Sachs Group Inc. | 0.00% | Add +54.9% | 2,010,633 | $27.3M |
| Morgan Stanley | 0.00% | Add +300.6% | 1,950,301 | $26.5M |
| Paradigm Biocapital Advisors LP | 0.76% | New | 1,900,000 | $25.8M |
| Geode Capital Management, LLC | 0.00% | Add +7.1% | 1,812,039 | $24.6M |
| 683 Capital Management, LLC | 2.28% | Reduce -18.5% | 1,760,000 | $23.9M |
| Great Point Partners LLC | 9.65% | Reduce -15.0% | 1,700,000 | $23.1M |
| State Street Corp. | 0.00% | Add +60.7% | 1,621,260 | $22.0M |
| Eventide Asset Management, LLC | 0.34% | New | 1,512,500 | $20.6M |
| Balyasny Asset Management L.P. | 0.04% | New | 1,476,302 | $20.1M |
| Logos Global Management LP | 1.95% | New | 1,450,000 | $19.7M |
| UBS Group AG | 0.00% | Add +12.1% | 1,404,471 | $19.1M |
| Deutsche Bank AG | 0.01% | Add +121.3% | 1,365,521 | $18.6M |
| T. Rowe Price Investment Management, Inc. | 0.01% | New | 1,198,064 | $16.3M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.05% | Reduce -4.1% | 1,107,008 | $15.0M |
| Nantahala Capital Management, LLC | 0.79% | Reduce -68.1% | 935,684 | $12.7M |
| Boxer Capital Management, LLC | 3.90% | Reduce -26.5% | 900,000 | $12.2M |
| ADAR1 Capital Management, LLC | 1.17% | Reduce -28.1% | 866,202 | $11.8M |
| Woodline Partners LP | 0.05% | Reduce -29.6% | 845,290 | $11.5M |
| Northern Trust Corp. | 0.00% | Add +0.3% | 822,237 | $11.2M |
| Invesco Ltd. | 0.00% | Add +38.1% | 810,640 | $11.0M |
| Orbimed Advisors LLC | 0.24% | Add +139.7% | 750,600 | $10.2M |
| Silverarc Capital Management, LLC | 1.38% | New | 700,000 | $9.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +9.7% | 645,185 | $8.8M |
| Braidwell LP | 0.34% | New | 612,841 | $8.3M |
| Parkman Healthcare Partners LLC | 0.86% | Reduce -10.9% | 579,174 | $7.9M |
| Jennison Associates LLC | 0.00% | New | 578,659 | $7.9M |
| Dimensional Fund Advisors LP | 0.00% | Add +36.4% | 509,780 | $6.9M |
| Cormorant Asset Management, LP | 0.47% | New | 500,000 | $6.8M |
| Rock Springs Capital Management LP | 0.40% | No change | 499,764 | $6.8M |
| Ally Bridge Group (NY) LLC | 4.98% | New | 437,391 | $5.9M |
| PFM Health Sciences, LP | 0.51% | Reduce -40.4% | 436,156 | $5.9M |
| Bank of America Corp. | 0.00% | Reduce -4.9% | 429,516 | $5.8M |
| Millennium Management | 0.00% | Reduce -72.4% | 417,771 | $5.7M |
| Barclays PLC | 0.00% | Add +217.9% | 414,112 | $5.6M |
| Acadian Asset Management LLC | 0.01% | Reduce -35.5% | 367,331 | $5.0M |
| Acuta Capital Partners, LLC | 4.68% | New | 333,258 | $4.5M |
| Alpha Wave Global, LP | 0.45% | Add +18.7% | 327,312 | $4.4M |
| Patient Square Capital LP | 1.15% | New | 316,312 | $4.3M |
| Stempoint Capital LP | 0.76% | New | 276,884 | $3.8M |
| Tetragon Partners GP Ltd | 0.85% | Add +18.1% | 258,242 | $3.5M |
| Wellington Management Group LLP | 0.00% | Reduce -18.2% | 236,197 | $3.2M |
| Citadel Advisors | 0.00% | Reduce -81.1% | 234,673 | $3.2M |
| Trexquant Investment LP | 0.03% | New | 222,876 | $3.0M |
| Federated Hermes, Inc. | 0.01% | Add +4.1% | 212,379 | $2.9M |
| Aldebaran Capital, LLC | 2.55% | Reduce -6.1% | 204,474 | $2.8M |
| Longaeva Partners L.P. | 0.59% | New | 200,000 | $2.7M |
| Bank of New York Mellon Corp | 0.00% | Add +21.3% | 182,956 | $2.5M |
| SummitTX Capital, L.P. | 0.10% | New | 168,000 | $2.3M |
| Qube Research & Technologies Ltd | 0.00% | Reduce -61.9% | 167,106 | $2.3M |
| Fred Alger Management, LLC | 0.01% | New | 164,042 | $2.2M |
| Nuveen, LLC | 0.00% | Add +3.1% | 160,419 | $2.2M |
| Bank of Montreal | 0.00% | Add +0.2% | 143,752 | $2.0M |
| Two Sigma Advisers, LP | 0.00% | Reduce -69.6% | 143,000 | $1.9M |
| Ameriprise Financial Inc. | 0.00% | Add +40.2% | 133,508 | $1.8M |
| Kennondale Capital Management LLC | 1.13% | Add +14.1% | 108,615 | $1.5M |
| T. Rowe Price Associates Inc. | 0.00% | Add +9.9% | 100,445 | $1.4M |
| Diadema Partners LP | 0.95% | New | 100,000 | $1.4M |
| Tang Capital Management LLC | 0.05% | No change | 100,000 | $1.4M |
| Rhumbline Advisers | 0.00% | Reduce -1.9% | 98,657 | $1.3M |
| Two Sigma Investments, LP | 0.00% | Reduce -82.4% | 98,416 | $1.3M |
| Wells Fargo & Company | 0.00% | Add +145.9% | 93,691 | $1.3M |
| Royal Bank of Canada | 0.00% | Add +666.6% | 93,012 | $1.3M |
| Dark Forest Capital Management LP | 0.04% | New | 86,795 | $1.2M |
| Informed Momentum Co LLC | 0.12% | Reduce -24.9% | 75,111 | $1.0M |
| AQR Capital Management | 0.00% | New | 73,640 | $1.0M |
| Alliancebernstein L.P. | 0.00% | Add +133.7% | 71,500 | $972K |
| Maven Securities LTD | 0.18% | New | 70,000 | $951K |
| D. E. Shaw & Co. | 0.00% | Reduce -54.5% | 68,877 | $936K |
| Legal & General Group Plc | 0.00% | Add +808.0% | 67,212 | $913K |
| Numerai GP LLC | 0.13% | New | 67,153 | $913K |
| Verition Fund Management LLC | 0.01% | New | 63,896 | $868K |
| Readystate Asset Management LP | 0.08% | New | 59,132 | $804K |
| Brevan Howard Capital Management LP | 0.01% | New | 56,667 | $770K |
| Russell Investments Group, Ltd. | 0.00% | Add +789.5% | 55,406 | $753K |
| Gsa Capital Partners LLP | 0.06% | Reduce -69.4% | 52,107 | $708K |
| Mariner, LLC | 0.00% | Reduce -1.3% | 48,027 | $653K |
| Hennion & Walsh Asset Management, Inc. | 0.02% | Reduce -15.7% | 47,898 | $651K |
| Schonfeld Strategic Advisors LLC | 0.00% | Reduce -93.3% | 43,637 | $593K |
| MetLife Investment Management, LLC | 0.00% | No change | 42,929 | $583K |
| TD Asset Management Inc | 0.00% | New | 40,966 | $557K |
| Citigroup Inc. | 0.00% | Add +22.5% | 38,083 | $518K |
| JPMorgan Chase & Co. | 0.00% | Reduce -59.3% | 35,844 | $487K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -15.8% | 31,999 | $435K |
| Monashee Investment Management LLC | 0.21% | New | 30,000 | $408K |
| Quadrature Capital Ltd | 0.00% | Reduce -3.9% | 28,286 | $384K |
| Guggenheim Capital LLC | 0.00% | Reduce -30.4% | 24,899 | $338K |
| Campbell & CO Investment Adviser LLC | 0.03% | New | 24,482 | $333K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -8.5% | 23,790 | $323K |
| Persistent Asset Partners Ltd | 0.23% | New | 22,913 | $311K |
| New York State Common Retirement Fund | 0.00% | No change | 21,900 | $298K |
| Parsons Capital Management Inc. | 0.02% | No change | 21,645 | $294K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -0.1% | 21,101 | $287K |
| HSBC Holdings PLC | 0.00% | New | 19,369 | $278K |
| Premier Path Wealth Partners, LLC | 0.04% | No change | 20,265 | $275K |
| Brown Advisory Inc. | 0.00% | No change | 19,930 | $271K |
| Renaissance Technologies | 0.00% | Reduce -95.0% | 19,900 | $270K |
| Intech Investment Management LLC | 0.00% | Reduce -46.3% | 19,494 | $265K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +20.4% | 19,262 | $262K |
| Oxford Asset Management LLP | 0.09% | New | 19,120 | $260K |
| EntryPoint Capital, LLC | 0.09% | New | 17,166 | $233K |
| Quantbot Technologies LP | 0.01% | New | 16,653 | $226K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -12.7% | 15,630 | $212K |
| ProShare Advisors LLC | 0.00% | Reduce -14.3% | 15,038 | $204K |
| BNP Paribas Financial Markets | 0.00% | Add +101.0% | 14,609 | $199K |
| State of Wisconsin Investment Board | 0.00% | New | 13,875 | $189K |
| AlphaQuest LLC | 0.01% | New | 13,636 | $185K |
| Profund Advisors LLC | 0.01% | New | 13,418 | $182K |
| Voya Investment Management LLC | 0.00% | Reduce -33.3% | 12,990 | $177K |
| SG Americas Securities, LLC | 0.00% | New | 11,819 | $161K |
| Capstone Investment Advisors, LLC | 0.00% | New | 10,634 | $145K |
| Landscape Capital Management, L.L.C. | 0.01% | New | 10,401 | $141K |
| Prudential Financial Inc. | 0.00% | Reduce -35.0% | 10,155 | $138K |
| Valeo Financial Advisors, LLC | 0.00% | No change | 10,000 | $136K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -11.8% | 6,590 | $90K |
| Point72 (DIFC) Ltd | 0.01% | New | 5,967 | $81K |
| Ameritas Investment Partners, Inc. | 0.00% | Reduce -18.2% | 5,794 | $79K |
| Cubist Systematic Strategies, LLC | 0.00% | Reduce -95.5% | 5,603 | $76K |
| California State Teachers Retirement System | 0.00% | Add +0.1% | 4,331 | $59K |
| US Bancorp \de | 0.00% | No change | 4,000 | $54K |
| Aster Capital Management (DIFC) Ltd | 0.02% | New | 3,568 | $48K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.1% | 3,447 | $47K |
| STRS Ohio | 0.00% | Reduce -53.4% | 3,400 | $46K |
| Amalgamated Bank | 0.00% | No change | 2,369 | $32K |
| Arax Advisory Partners | 0.00% | New | 2,244 | $30K |
| GF Fund Management Co. LTD. | 0.00% | Add +12.8% | 1,918 | $26K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -32.5% | 1,906 | $26K |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 0.00% | No change | 1,803 | $26K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -25.0% | 1,500 | $20K |
| SBI Securities Co., Ltd. | 0.00% | Add +125000.0% | 1,251 | $17K |
| Sterling Capital Management LLC | 0.00% | Add +119.0% | 1,209 | $16K |
| Summit Securities Group LLC | 0.01% | New | 1,191 | $16K |
| Cwm, LLC | 0.00% | Add +33.3% | 1,186 | $16K |
| Global Retirement Partners, LLC | 0.00% | Reduce -60.0% | 1,000 | $14K |
| Dunhill Financial, LLC | 0.00% | No change | 600 | $8K |
| North Capital, Inc. | 0.01% | Add +0.2% | 501 | $7K |
| PNC Financial Services Group, Inc. | 0.00% | Add +815.1% | 485 | $7K |
| Caitong International Asset Management Co., Ltd | 0.00% | Reduce -87.4% | 366 | $5K |
| Daiwa Securities Group Inc. | 0.00% | No change | 266 | $4K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 285 | $4K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 274 | $4K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | New | 240 | $3K |
| Osaic Holdings, Inc. | 0.00% | Reduce -6.3% | 225 | $3K |
| Evolution Wealth Management Inc. | 0.00% | New | 165 | $2K |
| GAMMA Investing LLC | 0.00% | New | 125 | $2K |
| Harbour Investments, Inc. | 0.00% | No change | 90 | $1K |
| Catherine Avery Investment Management LLC | 0.00% | No change | 87 | $1K |
| Rise Advisors, LLC | 0.00% | New | 64 | $870 |
| Salem Investment Counselors Inc. | 0.00% | No change | 55 | $748 |
| Jones Financial Companies LLLP | 0.00% | New | 30 | $436 |
| Financial Consulate, Inc. | 0.00% | New | 25 | $340 |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 25 | $340 |
| Farther Finance Advisors, LLC | 0.00% | New | 20 | $272 |
| Essential Partners LLC | 0.00% | New | 16 | $217 |
| Allworth Financial LP | 0.00% | New | 12 | $164 |
| Rockefeller Capital Management L.P. | 0.00% | New | 5 | $68 |
| IFP Advisors, Inc | 0.00% | New | 1 | $14 |
"% of holder's portfolio" is AMLX's weight in each manager's 13F, not the share of Amylyx Pharmaceuticals Inc. the manager owns.