Ionis PharmaceuticalsIONS

13F holders, Q2 2026 (June 30)
515holders +18
61new positions
46sold out
9famous investors
$79.38avg. 13F price*

At the end of Q2 2026, 515 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 18 from Q1 2026. 61 opened new positions and 46 sold out. The largest holders were FMR LLC ($2.0B), Capital World Investors ($1.7B) and BlackRock, Inc. ($848.8M). 9 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Jim Simons / Peter Brown (0.1% of Renaissance Technologies's portfolio) and Joel Greenblatt (0.0% of Gotham Asset Management's portfolio).

Company
Ionis Pharmaceuticals Inc.
CUSIP
462222100
Latest filing quarter
Q2 2026

History

Number of 13F holders

0200400600 Q1 2024: 361Q1 2024Q2 2024: 357Q2 2024Q3 2024: 354Q3 2024Q4 2024: 355Q4 2024Q1 2025: 344Q1 2025Q2 2025: 362Q2 2025Q3 2025: 436Q3 2025Q4 2025: 494Q4 2025Q1 2026: 497Q1 2026Q2 2026: 515Q2 2026

Total Exit/New Position Q1 2026 → Q2 2026

InstitutionsTotal Value
New Positions61$169.5M
Exits46$77.2M

All 13F filers, Q1 2026 → Q2 2026: 18,710,228 shares bought and 11,715,154 shares sold, net +6,995,074 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 515 holders

FMR LLC 0.09% Add +0.3% 24,631,956 $2.0B
Capital World Investors 0.20% Add +2.3% 21,669,226 $1.7B
BlackRock, Inc. 0.01% Add +2.5% 10,704,660 $848.8M
Vanguard Portfolio Management LLC 0.03% Add +0.7% 7,859,529 $623.2M
Wellington Management Group LLP 0.10% Add +19.7% 7,651,415 $606.7M
Vanguard Capital Management LLC 0.01% Add +1.3% 7,211,497 $571.8M
Two Sigma Investments, LP 0.39% Add +6.7% 6,252,342 $495.7M
Royal Bank of Canada 0.08% Add +62.6% 6,182,479 $490.2M
State Street Corp. 0.01% Add +8.5% 4,334,848 $343.7M
T. Rowe Price Investment Management, Inc. 0.21% Reduce -35.7% 3,959,372 $313.9M
Geode Capital Management, LLC 0.02% Reduce -10.1% 3,584,024 $294.8M
T. Rowe Price Associates Inc. 0.03% Add +5.3% 3,184,500 $252.5M
JPMorgan Chase & Co. 0.01% Add +13.0% 2,671,717 $216.2M
Artisan Partners Limited Partnership 0.34% Add +28.3% 2,640,024 $209.3M
Tweedy, Browne Co LLC 13.70% Add +0.2% 2,280,311 $180.8M
Deep Track Capital, LP 2.57% Add +12.8% 2,200,000 $174.4M
Goldman Sachs Group Inc. 0.02% Add +24.1% 2,109,945 $167.3M
Baker Bros. Advisors LP 0.82% No change 2,047,727 $162.4M
Deerfield Management Company, L.P. 1.96% No change 1,979,669 $157.0M
American Century Companies Inc. 0.07% Add +17.0% 1,947,076 $154.4M
Franklin Resources Inc. 0.03% Add +3.1% 1,623,377 $128.7M
Charles Schwab Investment Management Inc. 0.02% Add +1.4% 1,605,054 $127.3M
Barclays PLC 0.04% Add +453.1% 1,603,136 $127.1M
Pictet Asset Management Holding SA 0.12% Add +11.3% 1,596,998 $127.0M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% Reduce -1.4% 1,454,672 $115.3M
Polar Capital Holdings Plc 0.33% Add +75.3% 1,454,021 $115.3M
Alyeska Investment Group, L.P. 0.29% Add +199.7% 1,417,916 $112.4M
Nomura Asset Management International Inc. 0.16% Add +65.6% 1,300,392 $103.1M
Morgan Stanley 0.01% Add +24.8% 1,281,444 $101.6M
Invesco Ltd. 0.01% Reduce -12.3% 1,120,707 $88.9M
Vanguard Fiduciary Trust Co. 0.02% Add +3.6% 1,060,845 $84.1M
Bellevue Group AG 1.62% Reduce -46.5% 972,258 $77.1M
Groupama Asset Managment 0.96% Add +13.7% 937,083 $75.2M
Northern Trust Corp. 0.01% Add +5.2% 913,610 $72.4M
Capital International Investors 0.01% New 823,764 $65.3M
Davern Capital Partners, LP 10.80% Add +106.4% 798,709 $63.3M
Bank of America Corp. 0.00% Reduce -5.9% 790,990 $62.7M
Summit Partners Public Asset Management, LLC 1.62% Reduce -43.9% 787,263 $62.4M
GW&K Investment Management, LLC 0.46% Reduce -4.2% 746,966 $59.2M
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% Reduce -19.1% 734,219 $58.2M
Nuveen, LLC 0.01% Add +12.0% 726,282 $57.6M
Connor, Clark & Lunn Investment Management Ltd. 0.10% Reduce -21.7% 684,236 $54.3M
Eversept Partners, LP 2.87% Add +5.2% 664,684 $52.7M
Voloridge Investment Management, LLC 0.22% Reduce -2.6% 655,454 $52.0M
Massachusetts Financial Services Co. 0.02% Reduce -2.1% 651,816 $51.7M
Neuberger Berman Group LLC 0.03% Add +42.9% 633,533 $50.2M
Arrowstreet Capital, Limited Partnership 0.02% Reduce -14.3% 632,028 $50.1M
UBS Group AG 0.01% Reduce -22.7% 624,874 $49.5M
TimesSquare Capital Management, LLC 0.72% Add +122.8% 614,070 $48.7M
Eventide Asset Management, LLC 0.61% No change 575,000 $45.6M
Perceptive Advisors LLC 0.70% Add +12.3% 566,000 $44.9M
Renaissance Technologies 0.06% Add +83.1% 559,414 $44.4M
Bank of New York Mellon Corp 0.01% Add +5.4% 542,454 $43.0M
Teacher Retirement System of Texas 0.11% Reduce -0.3% 522,317 $41.4M
Boone Capital Management LLC 9.64% Add +3.9% 519,977 $41.2M
Jane Street Group, LLC 0.03% Add +162.6% 503,647 $39.9M
New York State Common Retirement Fund 0.05% Add +42.7% 500,050 $39.6M
BNP Paribas Financial Markets 0.02% Reduce -5.2% 454,649 $36.0M
Candriam S.C.A. 0.16% Reduce -8.1% 445,019 $35.3M
First Trust Advisors LP 0.02% Reduce -8.8% 427,197 $33.9M
Pinnacle Associates Ltd. 0.36% Reduce -3.8% 419,752 $33.3M
Nomura Holdings Inc. 0.14% Add +252.6% 402,192 $31.9M
Handelsbanken Fonder AB 0.09% Add +79.2% 383,211 $30.4M
C WorldWide Group Holding A/S 0.70% No change 366,000 $29.0M
TD Asset Management Inc 0.02% Reduce -35.7% 340,548 $27.0M
Freestone Grove Partners LP 0.18% New 339,967 $27.0M
Qube Research & Technologies Ltd 0.03% Add +679.2% 333,952 $26.5M
Capital Research Global Investors 0.00% Add +2.8% 331,936 $26.3M
Capital Fund Management S.A. 0.19% Add +131.8% 329,554 $26.1M
Alliancebernstein L.P. 0.01% Reduce -15.0% 340,450 $25.6M
Carmignac Gestion 0.33% Add +505.7% 321,000 $25.5M
Privium Fund Management B.V. 4.66% Add +10.3% 319,924 $25.4M
Swiss National Bank 0.01% Add +3.5% 315,000 $25.0M
Jump Financial, LLC 0.24% Add +48.2% 306,330 $24.3M
ARK Investment Management 0.15% Add +4.2% 300,770 $23.8M
Legal & General Group Plc 0.00% Add +1.5% 299,184 $23.7M
D. E. Shaw & Co. 0.02% Reduce -30.9% 297,041 $23.6M
Millennium Management 0.02% Reduce -72.5% 288,872 $22.9M
DAVENPORT & Co LLC 0.11% Add +19.2% 283,960 $22.5M
Aberdeen Group plc 0.03% Add +143.7% 277,400 $22.0M
California Public Employees Retirement System 0.01% Add +6.0% 270,843 $21.5M
Tocqueville Asset Management L.P. 0.26% Add +14.6% 251,215 $19.9M
Raymond James Financial Inc. 0.01% Add +0.9% 237,348 $18.8M
Citadel Advisors 0.01% Reduce -74.9% 236,284 $18.7M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.03% Add +6.3% 233,499 $18.5M
Wells Fargo & Company 0.00% Add +19.1% 226,213 $17.9M
Empowered Funds, LLC 0.09% Add +116.3% 223,142 $17.7M
Orion Investment Co 5.10% Reduce -2.1% 220,335 $17.5M
Life Cycle Investment Partners Ltd 0.08% New 219,896 $17.4M
Algert Global LLC 0.19% Add +77.5% 206,853 $16.4M
Stifel Financial Corp. 0.01% Add +3.2% 202,983 $16.1M
Corient Private Wealth LP 0.02% Add +0.0% 196,661 $15.6M
Eagle Health Investments LP 2.56% New 194,577 $15.4M
HSBC Holdings PLC 0.01% Add +1.3% 188,402 $15.0M
Sector Gamma As 3.26% Add +11.8% 189,468 $15.0M
California State Teachers Retirement System 0.01% Add +2.5% 180,949 $14.3M
Polymer Capital Management (HK) LTD 1.43% Add +190.7% 177,897 $14.1M
Deutsche Bank AG 0.00% Add +6.1% 169,614 $13.4M
ADAR1 Capital Management, LLC 0.62% Add +3.7% 166,286 $13.2M
Rhumbline Advisers 0.01% Reduce -4.9% 164,911 $13.1M
Sicart Associates LLC 3.12% Add +0.8% 160,694 $12.7M
HRT Financial LP 0.02% Reduce -37.8% 156,798 $12.4M
VANGUARD ASSET MANAGEMENT, Ltd 0.01% Add +12.8% 155,088 $12.3M
CSS LLC 1.63% Add +92.5% 152,289 $12.1M
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.01% Reduce -9.8% 151,301 $12.0M
Adage Capital Partners Gp, L.L.C. 0.02% Add +200.0% 150,000 $11.9M
Focus Partners Wealth 0.01% Reduce -10.7% 147,917 $11.7M
Hudson Bay Capital Management LP 0.06% Reduce -50.9% 145,000 $11.5M
Artia Global Partners LP 2.18% No change 144,376 $11.4M
Fisher Asset Management 0.00% Reduce -3.1% 137,184 $10.9M
Atle Fund Management AB 2.93% Add +392.0% 137,131 $10.9M
Lazard Asset Management LLC 0.02% Add +421.4% 132,480 $10.5M
State Board of Administration of Florida Retirement System 0.02% Reduce -3.0% 131,818 $10.5M
Sei Investments Co. 0.01% Reduce -18.7% 127,868 $10.1M
EFG International AG 0.18% Add +30.7% 122,804 $9.7M
Gotham Asset Management 0.02% Add +22.5% 121,252 $9.6M
Manufacturers Life Insurance Company, The 0.01% Reduce -19.3% 120,678 $9.6M
Braidwell LP 0.36% Reduce -10.8% 116,762 $9.3M
Norges Bank 0.00% — 114,359 $9.1M
SEB Asset Management AB 0.03% No change 114,334 $9.1M
Edmond DE Rothschild Holding S.A. 0.12% Reduce -17.4% 113,320 $9.0M
Squarepoint Ops LLC 0.02% Reduce -84.3% 109,379 $8.7M
Kennedy Capital Management LLC 0.15% Reduce -4.9% 106,342 $8.4M
Envestnet Asset Management Inc. 0.00% Add +5.1% 98,124 $7.8M
Tetragon Partners GP Ltd 1.25% Add +132.7% 97,173 $7.7M
Swedbank AB 0.01% Add +196.6% 95,666 $7.6M
State of Wisconsin Investment Board 0.02% Reduce -2.1% 94,492 $7.5M
Public Employees Retirement Association of Colorado 0.02% Add +481.1% 90,589 $7.2M
CenterBook Partners LP 0.35% Reduce -40.8% 89,280 $7.1M
Exome Asset Management LLC 4.31% Reduce -19.9% 88,177 $7.0M
Citigroup Inc. 0.00% Reduce -40.8% 86,746 $6.9M
DekaBank Deutsche Girozentrale 0.01% No change 93,807 $6.8M
Dimensional Fund Advisors LP 0.00% Reduce -68.3% 84,748 $6.7M
Russell Investments Group, Ltd. 0.01% Add +29.2% 81,319 $6.4M
Fred Alger Management, LLC 0.02% Add +177.4% 78,932 $6.3M
China Universal Asset Management Co., Ltd. 0.36% Reduce -1.3% 76,302 $6.0M
Police & Firemen's Retirement System of New Jersey 0.04% Add +11.5% 75,061 $6.0M
SG Americas Securities, LLC 0.00% Add +17.8% 74,589 $5.9M
Erste Asset Management GmbH 0.04% No change 71,800 $5.8M
Future Fund LLC 1.62% Add +21.5% 71,362 $5.7M
Hillsdale Investment Management Inc. 0.13% No change 70,900 $5.6M
Treasurer of the State of North Carolina 0.01% Add +3.4% 70,021 $5.6M
Bank of Nova Scotia 0.01% New 68,548 $5.4M
Jupiter Topco LLC 0.00% — 68,191 $5.4M
Ameriprise Financial Inc. 0.00% Reduce -89.7% 67,705 $5.4M
Y-Intercept (Hong Kong) Ltd 0.11% New 67,374 $5.3M
Great Lakes Advisors, LLC 0.04% Reduce -43.7% 66,924 $5.3M
Voya Investment Management LLC 0.01% Reduce -4.1% 66,303 $5.3M
Victory Capital Management Inc. 0.00% Reduce -39.3% 65,967 $5.2M
Vanguard Global Advisers, LLC 0.00% Reduce -8.4% 65,858 $5.2M
Zurcher Kantonalbank (Zurich Cantonalbank) 0.01% Add +8.0% 65,077 $5.2M
Quantinno Capital Management LP 0.01% Add +17.0% 64,914 $5.1M
Van Eck Associates Corp. 0.00% Add +83.7% 63,396 $5.0M
Thrivent Financial for Lutherans 0.01% Add +529.8% 62,743 $5.0M
Panagora Asset Management Inc. 0.01% Add +6.4% 61,125 $4.8M
Stanley-Laman Group, Ltd. 0.49% Add +54.8% 60,842 $4.8M
XTX Topco Ltd 0.06% Reduce -24.5% 60,776 $4.8M
Schroder Investment Management Group 0.00% New 58,865 $4.7M
Rhenman & Partners Asset Management AB 0.45% Reduce -35.5% 59,900 $4.7M
Sovran Advisors, LLC 0.35% New 84,984 $4.7M
Edgestream Partners, L.P. 0.13% Reduce -17.1% 56,715 $4.5M
One Capital Management, LLC 0.12% No change 58,939 $4.4M
Fideuram - Intesa Sanpaolo Private Banking S.P.A. 0.13% Reduce -0.9% 53,795 $4.3M
Nicola Wealth Management LTD. 0.47% No change 52,000 $4.1M
KBC Group NV 0.01% Add +69.2% 51,127 $4.1M
State of New Jersey Common Pension Fund D 0.01% Reduce -3.5% 50,743 $4.0M
Creative Planning 0.00% Reduce -3.2% 50,554 $4.0M
Campbell & CO Investment Adviser LLC 0.21% Add +1500.5% 49,632 $3.9M
Capital Counsel LLC 0.15% No change 49,580 $3.9M
Tidal Investments LLC 0.01% Add +42.8% 49,178 $3.9M
Worldquant Millennium Advisors LLC 0.01% Add +75.4% 48,976 $3.9M
Jones Financial Companies LLLP 0.00% Add +77.5% 47,442 $3.9M
Sumitomo Mitsui Trust Group, Inc. 0.00% Reduce -41.6% 47,836 $3.8M
Amova Asset Management Americas, Inc. 0.05% Reduce -41.7% 47,656 $3.8M
Public Employees Retirement System of Ohio 0.01% Add +1.8% 46,862 $3.7M
Coppell Advisory Solutions LLC 0.31% New 26 $3.7M
Natixis Advisors, LLC 0.00% Add +88.6% 44,728 $3.5M
Arizona State Retirement System 0.02% Add +2.5% 43,302 $3.4M
Aquatic Capital Management LLC 0.12% Reduce -71.1% 42,581 $3.4M
Guggenheim Capital LLC 0.02% Reduce -6.0% 41,405 $3.3M
Assenagon Asset Management S.A. 0.00% Add +21.5% 40,927 $3.2M
J. Goldman & Co LP 0.11% Reduce -82.8% 40,366 $3.2M
Jefferies Financial Group Inc. 0.03% Reduce -34.5% 38,665 $3.1M
Exchange Traded Concepts, LLC 0.02% Add +13.8% 38,627 $3.1M
Vanguard Investments Australia, Ltd. 0.01% No change 38,557 $3.1M
STRS Ohio 0.01% Add +32.6% 38,166 $3.0M
Rafferty Asset Management, LLC 0.01% Reduce -37.6% 37,648 $3.0M
DCF Advisers, LLC 0.78% Reduce -33.0% 37,500 $3.0M
Grandfield & Dodd, LLC 0.15% Reduce -0.7% 37,077 $2.9M
KLP Kapitalforvaltning As 0.01% Add +9.1% 37,000 $2.9M
Entropy Technologies, LP 0.12% Add +35.3% 36,815 $2.9M
DeepCurrents Investment Group LLC 3.69% Add +32.0% 36,212 $2.9M
ExodusPoint Capital Management, LP 0.03% Reduce -84.3% 35,645 $2.8M
Raiffeisen Bank International AG 0.03% Reduce -2.8% 35,000 $2.8M
Prudential Financial Inc. 0.00% Add +0.2% 35,338 $2.8M
Pathstone Holdings, LLC 0.01% Add +3.6% 34,004 $2.7M
Canada Pension Plan Investment Board 0.00% Add +136.2% 33,300 $2.6M
Jain Global LLC 0.03% Add +25.3% 32,931 $2.6M
Ethic Inc. 0.03% New 31,679 $2.5M
Blair William & Co. 0.01% Reduce -6.7% 31,606 $2.5M
Trexquant Investment LP 0.02% Reduce -85.2% 31,538 $2.5M
Mutual of America Capital Management LLC 0.02% Add +11.3% 31,299 $2.5M
LMR Partners LLP 0.02% Add +105.3% 30,800 $2.4M
PEAK6 LLC 0.06% Reduce -14.4% 29,460 $2.3M
Calamos Advisors LLC 0.01% Add +48.4% 29,358 $2.3M
Kornitzer Capital Management Inc. 0.05% No change 29,105 $2.3M
BLB&B Advisors, LLC 0.08% Reduce -18.8% 28,570 $2.3M
LPL Financial LLC 0.00% Reduce -12.7% 27,868 $2.2M
Xponance LLC 0.01% Add +1.1% 26,687 $2.1M
Intech Investment Management LLC 0.02% Reduce -32.4% 26,041 $2.1M
Jupiter Asset Management Ltd. 0.01% New 25,949 $2.1M
Bank of Montreal 0.00% Reduce -3.0% 25,782 $2.0M
BI Asset Management Fondsmaeglerselskab A/S 0.02% New 25,727 $2.0M
Orion Porfolio Solutions, LLC 0.02% Reduce -59.5% 24,870 $2.0M
CANADA LIFE ASSURANCE Co 0.00% Add +10.8% 24,515 $1.9M
Inceptionr LLC 0.47% Add +44.2% 24,251 $1.9M
Dana Investment Advisors, Inc. 0.05% Add +25.9% 23,272 $1.8M
Wolverine Asset Management LLC 0.09% Reduce -2.1% 22,340 $1.8M
AQR Capital Management 0.00% Reduce -23.4% 22,059 $1.7M
Teachers Retirement System of the State of Kentucky 0.01% Reduce -8.9% 21,945 $1.7M
Cetera Investment Advisers 0.00% Add +93.3% 21,808 $1.7M
Nicollet Investment Management, Inc. 0.50% Add +3.0% 20,240 $1.6M
Amundi 0.00% Reduce -15.7% 20,190 $1.6M
Profund Advisors LLC 0.04% Reduce -30.3% 18,321 $1.5M
DNB Asset Management AS 0.00% Reduce -5.6% 17,986 $1.4M
Gsa Capital Partners LLP 0.09% Add +445.6% 17,306 $1.4M
Allstate Corp. 0.01% Reduce -17.6% 16,943 $1.3M
Graham Capital Management, L.P. 0.05% New 16,717 $1.3M
North Star Asset Management Inc. 0.05% Reduce -0.3% 16,560 $1.3M
BIT Capital GmbH 0.04% New 16,300 $1.3M
Allianz Asset Management GmbH 0.00% Add +28.0% 16,129 $1.3M
Virtus Investment Advisers, LLC 0.29% Add +51.9% 15,870 $1.3M
Brown Advisory Inc. 0.00% Add +4.9% 15,846 $1.3M
IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.08% Add +9.9% 15,819 $1.3M
Dark Forest Capital Management LP 0.08% New 15,511 $1.2M
AlphaCentric Advisors LLC 1.04% Reduce -21.2% 15,430 $1.2M
Engineers Gate Manager LP 0.02% Reduce -88.9% 14,840 $1.2M
Osaic Holdings, Inc. 0.00% Add +69.9% 14,800 $1.2M
Bleakley Financial Group, LLC 0.01% Add +3.3% 14,793 $1.2M
PNC Financial Services Group, Inc. 0.00% Add +4.7% 14,185 $1.1M
Truist Financial Corp. 0.00% Add +9.5% 14,068 $1.1M
Baron Capital (BAMCO) 0.00% Reduce -68.9% 14,000 $1.1M
Summit Trail Advisors, LLC 0.01% Add +20.6% 13,931 $1.1M
FORA Capital, LLC 0.08% Reduce -29.8% 13,833 $1.1M
Oppenheimer Asset Management Inc. 0.01% Add +16.0% 13,752 $1.1M
Dynasty Wealth Management, LLC 0.01% Reduce -3.0% 13,661 $1.1M
Mitsubishi UFJ Trust & Banking Corp 0.00% New 13,446 $1.1M
VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% Add +30.1% 13,400 $1.1M
Westmount Partners, LLC 0.23% No change 12,961 $1.0M
SBI Okasan Asset Management Co.Ltd. 0.03% No change 12,600 $1.0M
Annis Gardner Whiting Capital Advisors, LLC 0.15% No change 12,801 $1.0M
Man Group plc 0.00% Reduce -48.5% 12,361 $980K
Arrowpoint Investment Partners (Singapore) Pte. Ltd. 0.29% Reduce -68.3% 12,338 $978K
Federation des caisses Desjardins du Quebec 0.00% Add +20.1% 12,017 $953K
Vanguard Personalized Indexing Management, LLC 0.01% Add +4.5% 11,933 $946K
Boothbay Fund Management, LLC 0.02% Reduce -84.6% 11,808 $936K
Commerce Bank 0.00% Add +43.1% 11,681 $926K
Amalgamated Bank 0.01% Reduce -4.4% 11,519 $913K
Militia Capital Management LLC 0.16% New 11,400 $904K
Northwestern Mutual Wealth Management Co. 0.00% Reduce -1.8% 10,925 $866K
Horizon Kinetics Asset Management LLC 0.01% Reduce -4.6% 10,904 $865K
Montanova Capital, LLC 0.02% No change 10,800 $856K
Evolve Private Wealth, LLC 0.05% New 10,653 $845K
Axq Capital, LP 0.09% Add +171.0% 10,423 $826K
Swiss Life Asset Management Ltd 0.00% Add +12.0% 10,275 $815K
Marex Group Ltd 0.01% Add +182.2% 10,189 $808K
Vident Advisory, LLC 0.01% Add +7.4% 10,187 $808K
&partners 0.00% Reduce -6.7% 10,184 $807K
Fifth Third Bancorp 0.00% Reduce -8.6% 10,061 $798K
Assetmark, Inc. 0.00% Add +3.8% 9,939 $788K
Mackenzie Financial Corp. 0.00% Add +144.8% 9,289 $737K
Ensign Peak Advisors, Inc 0.00% Reduce -80.2% 9,120 $723K
NewEdge Wealth, LLC 0.01% New 8,977 $712K
MetLife Investment Management, LLC 0.00% Reduce -4.9% 8,776 $696K
iA Global Asset Management Inc. 0.01% New 8,658 $686K
Utah Retirement Systems 0.01% Add +3.3% 8,577 $680K
Marshall Wace, LLP 0.00% Reduce -91.1% 8,501 $674K
denkapparat Operations GmbH 0.22% No change 8,364 $663K
Maryland State Retirement & Pension System 0.01% Add +13.1% 8,343 $662K
Commonwealth Equity Services, LLC 0.00% Add +4.1% 8,153 $646K
Inspire Investing, LLC 0.03% New 8,127 $644K
Plancorp, LLC 0.02% Reduce -0.7% 11,128 $632K
Mirae Asset Global Investments Co., Ltd. 0.00% Reduce -12.9% 7,867 $624K
Stratos Wealth Partners, LTD. 0.01% Add +1.1% 7,801 $619K
Meeder Advisory Services, Inc. 0.02% Add +5.8% 7,660 $607K
M&T Bank Corp 0.00% Reduce -2.1% 7,510 $595K
Savant Capital, LLC 0.00% Reduce -11.6% 7,476 $588K
Fiduciary Trust Co 0.01% No change 7,399 $587K
Sectoral Asset Management Inc. 0.40% No change 7,200 $571K
O'shaughnessy Asset Management, LLC 0.00% Reduce -6.8% 7,166 $568K
Callan Family Office, LLC 0.01% Add +0.9% 7,143 $566K
Silvercrest Asset Management Group LLC 0.00% Add +0.0% 7,055 $559K
Mercer Global Advisors Inc. 0.00% Add +9.9% 6,918 $548K
PSP Research LLC 0.29% No change 6,800 $539K
J. Safra Sarasin Holding AG 0.01% Add +5.0% 6,751 $535K
Significant Wealth Partners LLC 0.57% Reduce -0.8% 6,613 $524K
Group One Trading LLC 0.01% Add +243.2% 6,493 $515K
US Bancorp \de 0.00% Add +26.1% 6,366 $505K
Praxis Investment Management Inc. 0.03% No change 6,232 $494K
Nykredit A/S 0.00% — 6,154 $488K
Janney Montgomery Scott LLC 0.00% New 6,138 $487K
MCF Advisors LLC 0.02% Add +12172.0% 6,136 $487K
Cypress Capital, LLC 0.13% No change 6,000 $476K
Cerity Partners LLC 0.00% Reduce -21.2% 5,989 $475K
Frank, Rimerman Advisors LLC 0.03% Add +0.5% 5,807 $460K
Regions Financial Corp. 0.00% Reduce -8.5% 5,604 $444K
Robeco Institutional Asset Management B.V. 0.00% Reduce -1.4% 5,578 $442K
E Fund Management Co., Ltd. 0.01% Reduce -88.1% 5,569 $442K
Tema ETFs LLC 0.01% Reduce -2.6% 5,525 $438K
ProShare Advisors LLC 0.00% Reduce -26.7% 5,417 $430K
VARCOV Co. 0.16% New 5,390 $427K
Coldstream Capital Management Inc. 0.01% Reduce -5.3% 5,352 $424K
OneDigital Investment Advisors LLC 0.00% Reduce -0.8% 5,345 $424K
R Squared Ltd 0.22% Add +21.9% 5,313 $421K
Captrust Financial Advisors 0.00% Add +0.6% 5,030 $399K
Granite Investment Partners, LLC 0.02% Reduce -6.0% 5,026 $399K
CIBC Asset Management Inc 0.00% No change 5,017 $398K
Moisand Fitzgerald Tamayo, LLC 0.04% No change 5,000 $396K
AlphaCore Capital LLC 0.01% Add +80.5% 4,986 $395K
Vontobel Holding Ltd. 0.00% Reduce -5.4% 4,957 $393K
Wedmont Private Capital 0.01% Add +2.4% 6,723 $392K
NewEdge Advisors, LLC 0.00% Add +0.8% 4,822 $382K
Quantbot Technologies LP 0.01% New 4,812 $382K
Azzad Asset Management Inc. 0.03% New 4,784 $379K
North Dakota State Investment Board 0.02% Add +1.7% 4,703 $373K
Atria Investments, Inc 0.00% Reduce -10.3% 4,690 $372K
Gateway Investment Advisers LLC 0.00% New 4,630 $367K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Add +2.3% 4,373 $353K
Blueshift Asset Management, LLC 0.08% Add +59.6% 4,433 $351K
Credit Agricole S A 0.00% No change 4,410 $350K
Yorktown Management & Research Co Inc 0.21% New 4,400 $349K
Kestra Advisory Services, LLC 0.00% Add +0.3% 4,384 $348K
Intrust Bank NA 0.03% Add +7.0% 4,339 $344K
Checchi Capital Advisers, LLC 0.02% Reduce -2.7% 4,308 $342K
Westfield Capital Management Co. LP 0.00% Add +20.9% 4,233 $336K
Prospera Financial Services Inc 0.00% Reduce -3.4% 4,194 $333K
HighTower Advisors, LLC 0.00% Add +7.6% 4,084 $324K
Wealth Enhancement Advisory Services, LLC 0.00% Add +30.8% 5,394 $314K
Prime Capital Investment Advisors, LLC 0.00% Reduce -0.8% 3,938 $312K
Sanctuary Advisors, LLC 0.00% Add +0.5% 3,938 $312K
Susquehanna Portfolio Strategies, LLC 0.01% Reduce -95.9% 3,935 $312K
Qsemble Capital Management, LP 0.04% Reduce -84.9% 3,887 $308K
Susquehanna International Group, LLP 0.00% Reduce -68.9% 3,839 $304K
Rockefeller Capital Management L.P. 0.00% Reduce -7.8% 3,832 $304K
Pinnacle Wealth Planning Services, Inc. 0.03% Reduce -10.3% 3,780 $300K
Bridgefront Capital, LLC 0.08% New 3,778 $300K
Anb Bank 0.11% Reduce -1.0% 3,733 $296K
Eurizon Capital SGR S.p.A. 0.00% Add +3.6% 3,639 $294K
Park Avenue Securities LLC 0.00% New 3,677 $292K
Berkshire Asset Management LLC 0.01% Reduce -0.2% 3,630 $288K
Crossmark Global Holdings, Inc. 0.00% Add +13.0% 3,615 $287K
MML Investors Services, LLC 0.00% Add +13.5% 3,600 $285K
Sequoia Financial Advisors, LLC 0.00% New 3,567 $283K
Everhart Financial Group, Inc. 0.02% Add +0.9% 3,503 $278K
GF Fund Management Co. LTD. 0.00% Reduce -3.9% 3,497 $277K
Perigon Wealth Management, LLC 0.00% Add +1.4% 3,477 $276K
New York Life Investment Management LLC 0.00% Add +28.6% 3,458 $274K
Victrix Investment Advisors 0.11% New 3,400 $270K
Mitchell & Pahl Private Wealth, LLC 0.10% No change 3,261 $259K
Nwam LLC 0.01% No change 3,238 $257K
Raab & Moskowitz Asset Management LLC 0.05% No change 3,115 $247K
QRG Capital Management, Inc. 0.00% Reduce -0.5% 3,079 $244K
M&G PLC 0.00% Reduce -78.6% 3,090 $244K
Venturi Wealth Management, LLC 0.01% No change 3,061 $243K
HB Wealth Management, LLC 0.00% Add +3.4% 3,025 $240K
Argent Trust Co 0.01% No change 3,018 $239K
Larson Financial Group LLC 0.01% Reduce -1.0% 3,000 $238K
B. Riley Wealth Advisors, Inc. 0.01% Reduce -1.6% 2,897 $234K
AlphaGrep UK Ltd 0.07% New 2,946 $234K
Integrated Wealth Concepts LLC 0.00% Add +7.4% 2,926 $232K
University of Texas/Texas Am Investment Management Co. 0.03% New 2,923 $232K
Cambria Investment Management, L.P. 0.01% No change 2,885 $229K
Voleon Capital Management LP 0.00% Reduce -87.6% 2,862 $227K
Montis Financial, LLC 0.04% No change 2,700 $214K
Norden Group LLC 0.02% Reduce -7.1% 2,685 $213K
IFG Advisory, LLC 0.01% New 2,678 $212K
KOM Wealth Management Group, LLC 0.13% New 2,654 $210K
Mitsubishi UFJ Asset Management Co., Ltd. 0.00% Reduce -2.8% 2,618 $208K
Mesirow Financial Investment Management, Inc. 0.00% Reduce -53.7% 2,530 $201K
Steward Partners Investment Advisory, LLC 0.00% Reduce -35.3% 2,355 $187K
Global Retirement Partners, LLC 0.00% — 2,282 $181K
Ancora Advisors LLC 0.00% Reduce -7.4% 2,215 $176K
GAMMA Investing LLC 0.01% Add +22.8% 2,168 $172K
State of Wyoming 0.02% New 2,024 $160K
Signaturefd, LLC 0.00% Reduce -9.5% 1,880 $149K
Caption Management, LLC 0.01% Reduce -88.7% 1,759 $139K
Parallel Advisors, LLC 0.00% Reduce -10.6% 1,684 $134K
Versant Capital Management, Inc 0.01% Reduce -6.1% 1,460 $116K
Smartleaf Asset Management LLC 0.00% No change 1,416 $114K
Harbor Investment Advisory, LLC 0.01% New 1,407 $112K
Sterling Capital Management LLC 0.00% Reduce -9.5% 1,289 $102K
Graticule Asia Macro Advisors LLC 0.01% New 1,264 $100K
International Assets Investment Management, LLC 0.01% Add +0.9% 1,232 $98K
Farther Finance Advisors, LLC 0.00% Reduce -41.0% 1,111 $88K
IMA Advisory Services, Inc. 0.01% Add +3603.6% 1,037 $82K
Arax Advisory Partners 0.00% New 1,004 $80K
IFP Advisors, Inc 0.00% Add +0.2% 952 $75K
AdvisorNet Financial, Inc 0.00% Add +57.8% 904 $72K
Tripletail Wealth Management, LLC 0.08% New 850 $70K
EverSource Wealth Advisors, LLC 0.00% Reduce -52.2% 858 $68K
Huntington National Bank 0.00% Add +7.8% 734 $58K
Los Angeles Capital Management LLC 0.00% No change 700 $56K
Pacer Advisors, Inc. 0.00% New 629 $50K
Archer Investment Corp 0.01% No change 600 $48K
Nisa Investment Advisors, LLC 0.00% Add +57900.0% 580 $46K
Harbour Investments, Inc. 0.00% Add +2.2% 558 $44K
Silvant Capital Management LLC 0.00% New 540 $43K
Allworth Financial LP 0.00% Reduce -1.1% 516 $41K
Mather Group, Llc. 0.00% No change 410 $33K
Ascentis Wealth Management, LLC 0.01% No change 400 $32K
Cassaday & Co Wealth Management LLC 0.00% No change 400 $32K
Golden State Wealth Management, LLC 0.00% No change 376 $30K
CoreCap Advisors, LLC 0.00% No change 370 $29K
Brown Brothers Harriman & Co. 0.00% No change 341 $27K
Salomon & Ludwin, LLC 0.00% No change 332 $26K
Wellington-Altus USA Inc. 0.02% No change 317 $24K
Eastern Bank 0.00% No change 300 $24K
Capital Advisors, Ltd. LLC 0.00% No change 295 $23K
Global X Japan Co., Ltd. 0.00% Add +118.0% 279 $22K
Lanark Financial, Inc. 0.00% No change 273 $22K
Nomura Asset Management Co. Ltd. 0.00% Add +0.0% 270 $21K
Steigerwald, Gordon & Koch Inc. 0.00% Reduce -10.2% 265 $21K
SMA Capital LLC 0.01% New 260 $21K
E Fund Management (Hong Kong) Co., Ltd. 0.01% Add +33.3% 260 $21K
MTM Investment Management, LLC 0.01% No change 258 $20K
Parkside Financial Bank & Trust 0.00% Reduce -1.6% 254 $20K
Trust Co 0.00% New 250 $20K
Caitong International Asset Management Co., Ltd 0.00% Add +3442.9% 248 $20K
UMB Bank, n.a. 0.00% Add +13.9% 245 $19K
Harvest Fund Management Co., Ltd 0.00% No change 234 $19K
Westside Investment Management, Inc. 0.00% No change 231 $18K
FIL Ltd 0.00% Add +37.6% 227 $18K
Cedar Mountain Advisors, LLC 0.00% No change 223 $18K
Zions Bancorporation, National Association 0.00% Add +20.9% 214 $17K
Global Trust Asset Management, LLC 0.01% Reduce -2.3% 213 $17K
Owl Creek Wealth Partners LLC 0.00% Add +23.5% 210 $17K
Covestor Ltd 0.01% Add +7.7% 196 $16K
CX Institutional 0.00% Add +0.5% 203 $16K
MH & Associates Securities Management Corp. 0.01% No change 200 $16K
LifeSteps Financial, Inc. 0.01% New 200 $16K
Atlantic Union Bankshares Corp 0.00% No change 200 $16K
Aster Capital Management (DIFC) Ltd 0.00% Reduce -65.5% 190 $15K
Tower Research Capital LLC (TRC) 0.00% Reduce -95.9% 185 $15K
United Financial Planning Group LLC 0.01% No change 158 $13K
Strategic Wealth Partners, Ltd. 0.00% No change 150 $12K
Silver Grove Financial Group, Inc. 0.01% New 143 $11K
SBI Securities Co., Ltd. 0.00% Reduce -18.0% 132 $10K
Bogart Wealth, LLC 0.00% No change 123 $10K
Fiduciary Financial Advisors 0.00% New 118 $9K
LRI Investments, LLC 0.00% No change 110 $9K
Quent Capital, LLC 0.00% Add +6.1% 105 $8K
WPG Advisers, LLC 0.00% Add +47.1% 103 $8K
Spire Wealth Management 0.00% Reduce -19.2% 101 $8K
Main Street Group, LTD 0.00% No change 100 $8K
Danske Bank A/S 0.00% No change 100 $8K
Basecamp Wealth Advisors LLC 0.00% Reduce -47.0% 98 $8K
TD Private Client Wealth LLC 0.00% Add +22.5% 98 $8K
MassMutual Private Wealth & Trust, FSB 0.00% Reduce -37.1% 90 $7K
Bessemer Group Inc. 0.00% No change 94 $7K
Keating Financial Advisory Services, Inc. 0.00% Reduce -2.2% 88 $7K
Ameriflex Group, Inc. 0.00% New 87 $7K
Orion Capital Management LLC 0.00% No change 80 $6K
Rossby Financial, LCC 0.00% No change 74 $6K
Leonteq Securities AG 0.00% No change 73 $6K
Meeder Asset Management Inc. 0.00% Reduce -52.6% 72 $6K
Truvestments Capital LLC 0.00% Add +6900.0% 70 $6K
Private Wealth Management Group, LLC 0.00% No change 65 $5K
First Horizon Corp. 0.00% Add +10.7% 62 $5K
Bell Investment Advisors, Inc 0.00% No change 61 $5K
Hilton Head Capital Partners, LLC 0.00% Reduce -84.4% 55 $4K
Triumph Capital Management 0.00% No change 50 $4K
TD Waterhouse Canada Inc. 0.00% No change 48 $4K
Sachetta, LLC 0.00% Add +4.4% 47 $4K
Highline Wealth Partners LLC 0.00% No change 38 $3K
Hantz Financial Services, Inc. 0.00% No change 36 $3K
Cromwell Holdings LLC 0.00% Add +88.9% 34 $3K
Principia Wealth Advisory, LLC 0.00% No change 32 $3K
Quarry LP 0.00% New 29 $2K
Raffa Wealth Management, LLC 0.00% No change 28 $2K
Cheviot Value Management, LLC 0.00% No change 28 $2K
Horizon Investments, LLC 0.00% Reduce -45.8% 26 $2K
Bruce G. Allen Investments, LLC 0.00% No change 23 $2K
Wilmington Savings Fund Society, FSB 0.00% New 22 $2K
TFC Financial Management, Inc. 0.00% No change 21 $2K
Transamerica Financial Advisors, LLC 0.00% Reduce -36.4% 21 $2K
NBT Bank, N.A. 0.00% No change 20 $2K
Clearstead Advisors, LLC 0.00% Add +58.3% 19 $2K
Fortitude Family Office, LLC 0.00% No change 17 $1K
MJT & Associates Financial Advisory Group, Inc. 0.00% New 15 $1K
Quaker Wealth Management, LLC 0.00% No change 15 $1K
Cornerstone Financial Management LLC 0.00% No change 15 $1K
Whipplewood Advisors, LLC 0.00% No change 15 $1K
SouthState Bank Corp 0.00% No change 14 $1K
Cape Investment Advisory, Inc. 0.00% New 14 $1K
Mascoma Wealth Management LLC 0.00% No change 14 $1K
Rothschild Investment LLC 0.00% No change 13 $1K
Signature Equity Partners, LLC 0.00% New 12 $951
Valley National Advisers Inc. 0.00% New 11 $873
Planning Strategies Inc. 0.00% — 8 $634
Hughes Financial Services, LLC 0.00% Add +33.3% 8 $634
True Wealth Design, LLC 0.00% No change 7 $556
Essential Partners LLC 0.00% No change 7 $555
Kayne Anderson Rudnick Investment Management LLC 0.00% No change 7 $555
American Capital Advisory, LLC 0.00% Reduce -14.3% 6 $476
Downshift Financial, LLC 0.00% New 4 $317
SHP Wealth Management 0.00% New 4 $317
Cornerstone Planning Group LLC 0.00% Reduce -50.0% 5 $270
3 Factor Indexing, LLC 0.00% No change 2 $159
Manchester Capital Management LLC 0.00% Reduce -60.0% 2 $159
Plante Moran Financial Advisors, LLC 0.00% New 2 $159
Walleye Capital LLC 0.00% Reduce -100.0% 2 $159
Wealth Enhancement Trust Services, Inc. 0.00% New 2 $159
Activest Wealth Management 0.00% New 1 $79
Medallion Wealth Advisors, LLC 0.00% New 1 $79
Evolution Advisers, Inc. 0.00% New 2 $0

"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.