Ionis PharmaceuticalsIONS
13F holders, Q1 2025 (March 31)At the end of Q1 2025, 344 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, down 11 from Q4 2024. 51 opened new positions and 61 sold out. The largest holders were FMR LLC ($712.4M), Vanguard Group Inc. ($494.3M) and T. Rowe Price Investment Management, Inc. ($488.0M). 5 famous investors held it, including Cathie Wood (0.3% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 51 | $94.1M |
| Exits | 61 | $143.6M |
All 13F filers, Q4 2024 → Q1 2025: 17,861,535 shares bought and 11,659,979 shares sold, net +6,201,556 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 344 holders
| FMR LLC | 0.05% | Add +4.1% | 23,613,585 | $712.4M |
| Vanguard Group Inc. | 0.01% | Reduce -0.5% | 16,383,934 | $494.3M |
| T. Rowe Price Investment Management, Inc. | 0.32% | Add +14.2% | 16,175,533 | $488.0M |
| Capital World Investors | 0.06% | Add +7.8% | 12,361,994 | $373.0M |
| BlackRock, Inc. | 0.01% | Reduce -3.4% | 11,264,442 | $339.8M |
| Wellington Management Group LLP | 0.05% | Reduce -3.0% | 8,416,421 | $253.9M |
| Bellevue Group AG | 5.31% | Reduce -0.2% | 7,853,198 | $236.9M |
| State Street Corp. | 0.01% | Reduce -10.7% | 4,845,133 | $146.2M |
| Deep Track Capital, LP | 4.46% | Add +136.0% | 4,564,207 | $137.7M |
| Citadel Advisors | 0.10% | Add +60.7% | 3,480,062 | $105.0M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -14.7% | 3,265,034 | $98.5M |
| Tweedy, Browne Co LLC | 7.98% | Reduce -8.2% | 2,983,518 | $90.0M |
| Geode Capital Management, LLC | 0.01% | Add +5.8% | 2,842,954 | $85.8M |
| Orbimed Advisors LLC | 1.84% | Reduce -9.8% | 2,540,136 | $76.6M |
| Two Sigma Advisers, LP | 0.14% | Add +55.0% | 2,092,011 | $63.1M |
| BVF Inc. | 2.35% | New | 1,913,385 | $57.7M |
| UBS Group AG | 0.01% | Reduce -1.4% | 1,890,602 | $57.0M |
| Two Sigma Investments, LP | 0.12% | Add +83.0% | 1,685,853 | $50.9M |
| Macquarie Group Ltd. | 0.06% | Reduce -5.8% | 1,667,194 | $50.3M |
| Charles Schwab Investment Management Inc. | 0.01% | Reduce -2.5% | 1,443,629 | $43.6M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.10% | Add +10.7% | 1,196,392 | $36.1M |
| Morgan Stanley | 0.00% | Reduce -14.0% | 1,144,181 | $34.5M |
| TD Asset Management Inc | 0.03% | Add +4.8% | 1,100,466 | $33.2M |
| Adage Capital Partners Gp, L.L.C. | 0.06% | Add +291.1% | 1,075,600 | $32.5M |
| Hudson Bay Capital Management LP | 0.23% | Add +27.9% | 1,049,900 | $31.7M |
| ARK Investment Management | 0.30% | Reduce -2.4% | 1,000,527 | $30.2M |
| Candriam S.C.A. | 0.19% | Add +16.9% | 993,704 | $30.0M |
| Invesco Ltd. | 0.01% | Add +10.9% | 874,834 | $26.4M |
| Norges Bank | 0.00% | Reduce -50.0% | 858,228 | $25.9M |
| Northern Trust Corp. | 0.00% | Reduce -0.7% | 834,847 | $25.2M |
| Bank of Montreal | 0.01% | Add +150.8% | 782,835 | $23.6M |
| Bank of America Corp. | 0.00% | Add +81.5% | 767,432 | $23.2M |
| Camber Capital Management LP | 1.36% | Add +16.0% | 725,000 | $21.9M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +6.4% | 659,435 | $19.9M |
| Goldman Sachs Group Inc. | 0.00% | Add +72.5% | 652,518 | $19.7M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -0.4% | 618,550 | $19.2M |
| Millennium Management | 0.02% | Reduce -17.9% | 635,370 | $19.2M |
| Royal Bank of Canada | 0.00% | Reduce -4.2% | 616,081 | $18.6M |
| Pinnacle Associates Ltd. | 0.27% | Add +11.1% | 608,517 | $18.4M |
| Groupama Asset Managment | 0.36% | Add +10.1% | 569,211 | $17.7M |
| AXA S.A. | 0.06% | Reduce -6.4% | 566,486 | $17.1M |
| Schonfeld Strategic Advisors LLC | 0.11% | Add +50.9% | 560,359 | $16.9M |
| Bank of New York Mellon Corp | 0.00% | Reduce -11.6% | 544,633 | $16.4M |
| Eversept Partners, LP | 1.77% | Add +140.5% | 517,021 | $15.6M |
| Teacher Retirement System of Texas | 0.06% | Add +660.7% | 500,451 | $15.1M |
| Aberdeen Group plc | 0.03% | Add +11.1% | 446,197 | $13.5M |
| Citigroup Inc. | 0.01% | Add +152.1% | 426,480 | $12.9M |
| JPMorgan Chase & Co. | 0.00% | Add +1.3% | 421,511 | $12.7M |
| C WorldWide Group Holding A/S | 0.15% | No change | 400,000 | $12.1M |
| Voloridge Investment Management, LLC | 0.04% | Add +19.0% | 377,204 | $11.4M |
| Ameriprise Financial Inc. | 0.00% | Reduce -7.0% | 360,188 | $10.9M |
| Baker Bros. Advisors LP | 0.12% | No change | 357,915 | $10.8M |
| Barclays PLC | 0.00% | Reduce -40.6% | 353,937 | $10.7M |
| Legal & General Group Plc | 0.00% | Add +101.4% | 338,462 | $10.2M |
| Sovran Advisors, LLC | 1.21% | Add +91.4% | 328,904 | $9.3M |
| Nuveen, LLC | 0.00% | — | 308,777 | $9.3M |
| BNP Paribas Financial Markets | 0.01% | Add +21.1% | 308,293 | $9.3M |
| J. Goldman & Co LP | 0.33% | Reduce -49.3% | 307,770 | $9.3M |
| Squarepoint Ops LLC | 0.02% | Add +83.4% | 305,373 | $9.2M |
| Point72 Asset Management | 0.03% | New | 287,204 | $8.7M |
| Sector Gamma As | 2.76% | Add +21.2% | 285,842 | $8.6M |
| Swiss National Bank | 0.01% | Reduce -1.4% | 275,300 | $8.3M |
| Privium Fund Management B.V. | 2.10% | Add +0.3% | 267,594 | $8.1M |
| Wells Fargo & Company | 0.00% | Reduce -22.6% | 256,233 | $7.7M |
| Great Point Partners LLC | 4.10% | Reduce -50.5% | 250,000 | $7.5M |
| Corient Private Wealth LP | 0.01% | Reduce -0.8% | 237,133 | $7.2M |
| Nomura Holdings Inc. | 0.04% | Reduce -33.8% | 236,426 | $7.1M |
| Orion Investment Co | 2.66% | Reduce -0.3% | 215,290 | $6.5M |
| Artisan Partners Limited Partnership | 0.01% | Reduce -19.6% | 203,178 | $6.1M |
| Stifel Financial Corp. | 0.01% | Reduce -5.0% | 200,942 | $6.1M |
| California Public Employees Retirement System | 0.00% | Reduce -0.6% | 191,004 | $5.8M |
| Rhumbline Advisers | 0.01% | Reduce -1.9% | 188,216 | $5.7M |
| Tocqueville Asset Management L.P. | 0.09% | Reduce -46.8% | 187,395 | $5.7M |
| Sicart Associates LLC | 1.94% | Reduce -0.1% | 185,646 | $5.6M |
| GW&K Investment Management, LLC | 0.05% | Reduce -2.6% | 182,309 | $5.5M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -25.7% | 176,248 | $5.3M |
| Susquehanna Fundamental Investments, LLC | 0.08% | Reduce -25.5% | 158,609 | $4.8M |
| Aquatic Capital Management LLC | 0.12% | Reduce -32.1% | 156,157 | $4.7M |
| Sonora Investment Management Group, LLC | 0.37% | Add +3.6% | 154,147 | $4.7M |
| Renaissance Technologies | 0.01% | Reduce -25.3% | 153,514 | $4.6M |
| State Board of Administration of Florida Retirement System | 0.01% | No change | 152,315 | $4.6M |
| BLB&B Advisors, LLC | 0.23% | Add +0.1% | 152,200 | $4.6M |
| Kennedy Capital Management LLC | 0.11% | Reduce -32.6% | 150,424 | $4.5M |
| Tang Capital Management LLC | 0.25% | No change | 150,000 | $4.5M |
| Raymond James Financial Inc. | 0.00% | Add +40.8% | 148,690 | $4.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | New | 143,870 | $4.3M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -9.1% | 142,433 | $4.3M |
| Amova Asset Management Americas, Inc. | 0.06% | Reduce -9.1% | 142,433 | $4.3M |
| Exome Asset Management LLC | 3.66% | Add +121.0% | 135,616 | $4.1M |
| California State Teachers Retirement System | 0.00% | Reduce -1.2% | 132,238 | $4.0M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | Add +3.1% | 129,273 | $3.9M |
| Edmond DE Rothschild Holding S.A. | 0.07% | New | 124,200 | $3.7M |
| American Century Companies Inc. | 0.00% | New | 116,768 | $3.5M |
| State of Wisconsin Investment Board | 0.01% | Add +7.0% | 108,316 | $3.3M |
| Neuberger Berman Group LLC | 0.00% | Add +6.0% | 102,473 | $3.1M |
| Alliancebernstein L.P. | 0.00% | Add +93.2% | 100,749 | $3.0M |
| PDT Partners, LLC | 0.21% | Add +231.3% | 96,056 | $2.9M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $2.9M |
| DCF Advisers, LLC | 1.54% | Add +14.6% | 95,000 | $2.9M |
| Walleye Capital LLC | 0.04% | Add +484.4% | 94,990 | $2.9M |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.07% | Add +49.9% | 90,779 | $2.7M |
| Nicola Wealth Management LTD. | 0.26% | No change | 87,000 | $2.6M |
| Deutsche Bank AG | 0.00% | Reduce -7.7% | 84,810 | $2.6M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -70.8% | 83,440 | $2.5M |
| Jump Financial, LLC | 0.04% | Add +104.7% | 81,321 | $2.5M |
| Rhenman & Partners Asset Management AB | 0.28% | Reduce -61.9% | 81,000 | $2.4M |
| New York State Common Retirement Fund | 0.00% | Reduce -7.1% | 78,261 | $2.4M |
| HSBC Holdings PLC | 0.00% | Reduce -9.9% | 74,833 | $2.2M |
| Susquehanna International Group, LLP | 0.00% | Add +175.5% | 71,811 | $2.2M |
| Treasurer of the State of North Carolina | 0.01% | Add +4.1% | 71,593 | $2.2M |
| Sei Investments Co. | 0.00% | Add +2.1% | 71,558 | $2.2M |
| Granite Investment Partners, LLC | 0.10% | Reduce -7.3% | 68,434 | $2.1M |
| Janus Henderson Group PLC | 0.00% | No change | 63,877 | $2.0M |
| Simplex Trading, LLC | 0.07% | New | 64,581 | $1.9M |
| Sphera Funds Management LTD. | 0.47% | No change | 63,821 | $1.9M |
| Voya Investment Management LLC | 0.00% | Reduce -31.1% | 63,767 | $1.9M |
| Lazard Asset Management LLC | 0.00% | Add +826.6% | 60,758 | $1.8M |
| State of New Jersey Common Pension Fund D | 0.01% | Reduce -4.0% | 60,662 | $1.8M |
| Avidity Partners Management LP | 0.37% | New | 60,000 | $1.8M |
| Skandinaviska Enskilda Banken AB (publ) | 0.01% | No change | 59,626 | $1.8M |
| Capital Fund Management S.A. | 0.02% | New | 58,014 | $1.8M |
| Police & Firemen's Retirement System of New Jersey | 0.02% | Add +1.5% | 57,549 | $1.7M |
| DAVENPORT & Co LLC | 0.01% | Reduce -10.1% | 56,393 | $1.7M |
| Ensign Peak Advisors, Inc | 0.00% | Add +3.3% | 55,100 | $1.7M |
| Jane Street Group, LLC | 0.00% | Reduce -67.1% | 54,117 | $1.6M |
| Erste Asset Management GmbH | 0.02% | No change | 51,300 | $1.6M |
| Verition Fund Management LLC | 0.01% | Reduce -73.9% | 52,287 | $1.6M |
| Public Employees Retirement System of Ohio | 0.01% | Reduce -10.4% | 48,177 | $1.5M |
| Schroder Investment Management Group | 0.00% | Reduce -54.4% | 45,950 | $1.4M |
| Readystate Asset Management LP | 0.13% | New | 46,394 | $1.4M |
| CANADA LIFE ASSURANCE Co | 0.00% | Add +11.8% | 43,853 | $1.3M |
| Handelsbanken Fonder AB | 0.01% | Reduce -1.4% | 43,211 | $1.3M |
| Raiffeisen Bank International AG | 0.02% | Add +2280.5% | 41,754 | $1.3M |
| NJ State Employees Deferred Compensation Plan | 0.16% | No change | 42,000 | $1.3M |
| Guggenheim Capital LLC | 0.01% | Add +17.1% | 41,414 | $1.2M |
| Point72 (DIFC) Ltd | 0.12% | New | 41,347 | $1.2M |
| Arizona State Retirement System | 0.01% | Reduce -1.1% | 40,687 | $1.2M |
| Blair William & Co. | 0.00% | Reduce -3.8% | 38,381 | $1.2M |
| Prelude Capital Management, LLC | 0.12% | Add +142.2% | 37,772 | $1.1M |
| Grandfield & Dodd, LLC | 0.07% | Add +5.2% | 37,761 | $1.1M |
| Capital Counsel LLC | 0.05% | No change | 37,080 | $1.1M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +0.5% | 36,509 | $1.1M |
| Creative Planning | 0.00% | Reduce -22.8% | 36,122 | $1.1M |
| SummitTX Capital, L.P. | 0.05% | — | 35,103 | $1.1M |
| Allostery Investments LP | 1.52% | Reduce -46.1% | 35,000 | $1.1M |
| Profund Advisors LLC | 0.05% | Reduce -19.9% | 34,887 | $1.1M |
| Private Advisor Group, LLC | 0.01% | Reduce -15.1% | 34,531 | $1.0M |
| Pathstone Holdings, LLC | 0.00% | Add +31.9% | 34,372 | $1.0M |
| Mariner, LLC | 0.00% | Add +21.1% | 33,483 | $1.0M |
| China Universal Asset Management Co., Ltd. | 0.09% | Reduce -4.8% | 31,886 | $962K |
| Liontrust Investment Partners LLP | 0.01% | Reduce -27.0% | 30,390 | $917K |
| Axq Capital, LP | 0.36% | New | 30,104 | $908K |
| Alpine Global Management, LLC | 0.25% | New | 28,097 | $848K |
| KLP Kapitalforvaltning As | 0.00% | Reduce -6.2% | 27,400 | $827K |
| ExodusPoint Capital Management, LP | 0.01% | New | 26,261 | $792K |
| HRT Financial LP | 0.00% | New | 25,824 | $779K |
| Tema ETFs LLC | 0.23% | Reduce -55.8% | 25,141 | $759K |
| NEOS Investment Management LLC | 0.01% | Reduce -55.8% | 25,141 | $759K |
| BlueCrest Capital Management Ltd | 0.15% | Reduce -5.3% | 24,800 | $748K |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 24,083 | $727K |
| LPL Financial LLC | 0.00% | Reduce -40.6% | 23,966 | $723K |
| Castle Hook Partners LP | 0.02% | No change | 23,940 | $722K |
| Brevan Howard Capital Management LP | 0.02% | Add +7.5% | 22,973 | $693K |
| Jefferies Financial Group Inc. | 0.01% | Add +2.1% | 22,841 | $689K |
| Bleakley Financial Group, LLC | 0.02% | Add +31.5% | 22,284 | $672K |
| Daiwa Securities Group Inc. | 0.00% | Add +3992.6% | 22,141 | $667K |
| Tidal Investments LLC | 0.01% | Add +25.4% | 21,833 | $659K |
| Nicollet Investment Management, Inc. | 0.23% | Add +8.4% | 21,451 | $647K |
| Bridgefront Capital, LLC | 0.18% | Reduce -5.8% | 20,528 | $619K |
| Xponance LLC | 0.01% | Add +5.1% | 20,319 | $613K |
| SG Americas Securities, LLC | 0.00% | Reduce -16.2% | 20,050 | $605K |
| Victory Capital Management Inc. | 0.00% | Add +3.5% | 18,641 | $562K |
| NBT Bank, N.A. | 0.04% | No change | 17,050 | $514K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | — | 16,522 | $498K |
| E Fund Management Co., Ltd. | 0.02% | Reduce -2.4% | 16,471 | $497K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -24.9% | 16,398 | $495K |
| Twinbeech Capital LP | 0.01% | New | 15,938 | $481K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 15,589 | $470K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -71.5% | 15,039 | $454K |
| Jones Financial Companies LLLP | 0.00% | Add +47.1% | 13,735 | $428K |
| North Star Asset Management Inc. | 0.02% | Reduce -0.2% | 13,610 | $411K |
| Significant Wealth Partners LLC | 0.21% | Add +24.8% | 13,605 | $410K |
| Westmount Partners, LLC | 0.12% | Reduce -3.7% | 12,961 | $391K |
| Point72 Hong Kong Ltd | 0.03% | New | 12,862 | $388K |
| Horizon Kinetics Asset Management LLC | 0.00% | No change | 12,476 | $376K |
| XTX Topco Ltd | 0.02% | Reduce -51.1% | 12,404 | $374K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +9.1% | 12,358 | $373K |
| Intech Investment Management LLC | 0.00% | New | 12,207 | $368K |
| Brown Advisory Inc. | 0.00% | Reduce -5.5% | 12,026 | $363K |
| SIH Partners, LLLP | 0.03% | New | 11,999 | $362K |
| FORA Capital, LLC | 0.04% | New | 11,570 | $349K |
| Twin Tree Management, LP | 0.01% | Reduce -87.2% | 11,385 | $343K |
| &partners | 0.00% | Add +6.7% | 11,004 | $343K |
| Plancorp, LLC | 0.01% | No change | 11,128 | $336K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -0.1% | 10,987 | $331K |
| Montanova Capital, LLC | 0.01% | No change | 10,800 | $326K |
| Annis Gardner Whiting Capital Advisors, LLC | 0.14% | No change | 10,736 | $324K |
| Amalgamated Bank | 0.00% | Add +2.7% | 10,573 | $319K |
| Harbor Advisors LLC | 0.06% | No change | 10,500 | $317K |
| Principal Financial Group Inc. | 0.00% | Reduce -23.3% | 10,447 | $315K |
| Capula Management Ltd | 0.00% | New | 10,382 | $313K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -16.0% | 10,313 | $311K |
| Teza Capital Management LLC | 0.14% | Add +20.2% | 10,244 | $309K |
| Man Group plc | 0.00% | Add +20.7% | 10,033 | $303K |
| Cypress Capital, LLC | 0.09% | No change | 10,000 | $302K |
| Fifth Third Bancorp | 0.00% | Add +4.8% | 9,989 | $301K |
| Tower Research Capital LLC (TRC) | 0.01% | Reduce -30.3% | 9,873 | $298K |
| Focus Partners Wealth | 0.00% | Add +22.1% | 9,832 | $297K |
| Virtus Investment Advisers, LLC | 0.08% | New | 9,701 | $293K |
| Sectoral Asset Management Inc. | 0.22% | Add +31.1% | 9,440 | $285K |
| Walleye Trading LLC | 0.01% | Reduce -5.6% | 9,361 | $282K |
| MetLife Investment Management, LLC | 0.00% | Reduce -0.2% | 9,144 | $276K |
| Marshall Wace, LLP | 0.00% | Reduce -98.9% | 9,102 | $275K |
| Jain Global LLC | 0.01% | New | 8,595 | $259K |
| Quantinno Capital Management LP | 0.00% | New | 8,515 | $257K |
| Bayesian Capital Management, LP | 0.04% | New | 8,500 | $256K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -13.2% | 8,206 | $256K |
| Utah Retirement Systems | 0.00% | No change | 8,400 | $253K |
| Maryland State Retirement & Pension System | 0.01% | No change | 8,284 | $250K |
| International Assets Investment Management, LLC | 0.02% | No change | 8,207 | $248K |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.03% | New | 8,059 | $243K |
| Fiduciary Trust Co | 0.00% | New | 7,738 | $233K |
| Semanteon Capital Management, LP | 0.12% | New | 7,543 | $228K |
| Commerce Bank | 0.00% | Reduce -46.4% | 7,275 | $219K |
| ProShare Advisors LLC | 0.00% | Reduce -4.1% | 7,171 | $216K |
| Clearstead Advisors, LLC | 0.00% | Reduce -2.6% | 7,000 | $211K |
| Prudential Financial Inc. | 0.00% | New | 6,263 | $210K |
| Silvercrest Asset Management Group LLC | 0.00% | Add +4.3% | 6,902 | $208K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -12.4% | 6,804 | $205K |
| Praxis Investment Management Inc. | 0.01% | No change | 6,770 | $204K |
| Tanaka Capital Management Inc. | 0.48% | Reduce -2.6% | 6,714 | $203K |
| KBC Group NV | 0.00% | Add +0.5% | 6,515 | $197K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Add +8.5% | 6,135 | $185K |
| Advisors Asset Management, Inc. | 0.00% | Reduce -0.4% | 6,048 | $182K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -90.8% | 5,753 | $174K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +1.1% | 5,319 | $166K |
| Moisand Fitzgerald Tamayo, LLC | 0.02% | New | 5,000 | $151K |
| GF Fund Management Co. LTD. | 0.00% | Add +21.9% | 4,042 | $122K |
| Amundi | 0.00% | Reduce -66.0% | 3,873 | $110K |
| Exchange Traded Concepts, LLC | 0.00% | Add +1722.5% | 3,244 | $98K |
| US Bancorp \de | 0.00% | Reduce -25.2% | 3,157 | $95K |
| Quarry LP | 0.02% | Reduce -50.0% | 3,000 | $91K |
| Corebridge Financial, Inc. | 0.00% | Reduce -3.7% | 2,657 | $80K |
| CI Investments Inc. | 0.00% | Reduce -37.9% | 2,542 | $77K |
| Sandia Investment Management LP | 0.22% | Reduce -50.0% | 2,500 | $75K |
| Cwm, LLC | 0.00% | Add +18.7% | 2,435 | $73K |
| Osaic Holdings, Inc. | 0.00% | Reduce -40.5% | 2,373 | $72K |
| Coldstream Capital Management Inc. | 0.00% | New | 2,345 | $71K |
| Van Eck Associates Corp. | 0.00% | Reduce -96.5% | 2,157 | $65K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.02% | New | 2,082 | $63K |
| Ancora Advisors LLC | 0.00% | New | 2,000 | $60K |
| NewEdge Advisors, LLC | 0.00% | Reduce -10.9% | 1,621 | $49K |
| Twin Lakes Capital Management, LLC | 0.03% | No change | 1,500 | $45K |
| IFP Advisors, Inc | 0.00% | No change | 1,150 | $42K |
| Signaturefd, LLC | 0.00% | Add +45.6% | 1,382 | $42K |
| Comerica Bank | 0.00% | Reduce -82.2% | 1,320 | $40K |
| Manchester Capital Management LLC | 0.00% | Add +24.2% | 1,248 | $38K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +147.2% | 1,157 | $35K |
| Itau Unibanco Holding S.A. | 0.00% | Reduce -0.7% | 1,143 | $34K |
| Sterling Capital Management LLC | 0.00% | Reduce -63.4% | 1,101 | $33K |
| Huntington National Bank | 0.00% | Add +14.9% | 1,093 | $33K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -64.5% | 1,090 | $33K |
| Sunbelt Securities, Inc. | 0.00% | No change | 1,014 | $31K |
| GAMMA Investing LLC | 0.00% | Add +28.8% | 961 | $29K |
| Harbour Investments, Inc. | 0.00% | No change | 900 | $27K |
| Parallel Advisors, LLC | 0.00% | Reduce -22.3% | 745 | $22K |
| AlphaQuest LLC | 0.00% | New | 635 | $19K |
| Archer Investment Corp | 0.00% | No change | 600 | $18K |
| Laurel Wealth Advisors LLC | 0.00% | No change | 600 | $18K |
| Danske Bank A/S | 0.00% | No change | 500 | $15K |
| Riverview Trust Co | 0.01% | No change | 476 | $14K |
| Lindbrook Capital, LLC | 0.00% | Reduce -57.5% | 440 | $13K |
| Farther Finance Advisors, LLC | 0.00% | Reduce -27.5% | 472 | $13K |
| Mather Group, Llc. | 0.00% | Reduce -37.0% | 410 | $12K |
| Global Trust Asset Management, LLC | 0.01% | No change | 399 | $12K |
| Quadrant Capital Group LLC | 0.00% | Reduce -64.9% | 381 | $11K |
| Parkside Financial Bank & Trust | 0.00% | Reduce -9.8% | 377 | $11K |
| Ascentis Wealth Management, LLC | 0.00% | No change | 400 | $11K |
| Larson Financial Group LLC | 0.00% | Add +1805.6% | 343 | $10K |
| Oakworth Capital, Inc. | 0.00% | New | 300 | $9K |
| Eastern Bank | 0.00% | New | 300 | $9K |
| Covestor Ltd | 0.01% | Add +21.1% | 298 | $9K |
| Union Bancaire Privee, UBP SA | 0.00% | No change | 265 | $8K |
| Storebrand Asset Management As | 0.00% | No change | 271 | $8K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Add +12.4% | 262 | $8K |
| MAI Capital Management | 0.00% | No change | 260 | $8K |
| SBI Securities Co., Ltd. | 0.00% | Add +1.6% | 260 | $8K |
| Blue Trust, Inc. | 0.00% | No change | 259 | $8K |
| Riggs Asset Managment Co. Inc. | 0.00% | No change | 250 | $8K |
| Allworth Financial LP | 0.00% | Reduce -73.9% | 223 | $7K |
| NFSG Corp | 0.00% | No change | 200 | $6K |
| AllSquare Wealth Management LLC | 0.00% | No change | 198 | $6K |
| Whittier Trust Co. | 0.00% | No change | 192 | $6K |
| Wealth Preservation Advisors, LLC | 0.00% | — | 150 | $5K |
| Pacifica Partners Inc. | 0.00% | No change | 150 | $4K |
| Kestra Investment Management, LLC | 0.00% | New | 137 | $4K |
| Smartleaf Asset Management LLC | 0.00% | Reduce -60.1% | 131 | $4K |
| Golden State Wealth Management, LLC | 0.00% | No change | 126 | $4K |
| Spire Wealth Management | 0.00% | No change | 125 | $4K |
| Anderson Financial Strategies, LLC | 0.00% | New | 121 | $4K |
| GPS Wealth Strategies Group, LLC | 0.00% | No change | 119 | $4K |
| SouthState Bank Corp | 0.00% | New | 119 | $4K |
| Brooklyn Investment Group | 0.00% | Add +42.5% | 114 | $3K |
| First Horizon Advisors, Inc. | 0.00% | No change | 112 | $3K |
| MPWM Advisory Solutions, LLC | 0.00% | New | 110 | $3K |
| Arax Advisory Partners | 0.00% | No change | 104 | $3K |
| Bogart Wealth, LLC | 0.00% | Add +43.7% | 102 | $3K |
| Versant Capital Management, Inc | 0.00% | Add +83.6% | 101 | $3K |
| Creekmur Asset Management LLC | 0.00% | No change | 100 | $3K |
| Picton Mahoney Asset Management | 0.00% | New | 89 | $3K |
| Meeder Asset Management Inc. | 0.00% | New | 95 | $3K |
| Semmax Financial Advisors Inc. | 0.00% | No change | 79 | $3K |
| Dynamic Wealth Strategies, LLC | 0.00% | New | 80 | $2K |
| Orion Capital Management LLC | 0.00% | No change | 80 | $2K |
| Principal Securities, Inc. | 0.00% | No change | 67 | $2K |
| Bell Investment Advisors, Inc | 0.00% | No change | 71 | $2K |
| Bessemer Group Inc. | 0.00% | New | 73 | $2K |
| Leonteq Securities AG | 0.00% | No change | 63 | $2K |
| Clear Investment Research, LLC | 0.00% | No change | 51 | $2K |
| Blume Capital Management, Inc. | 0.00% | No change | 55 | $2K |
| Quent Capital, LLC | 0.00% | Reduce -28.4% | 53 | $2K |
| CoreCap Advisors, LLC | 0.00% | Add +15.6% | 52 | $2K |
| Wolff Wiese Magana LLC | 0.00% | No change | 41 | $1K |
| Truvestments Capital LLC | 0.00% | New | 40 | $1K |
| Highline Wealth Partners LLC | 0.00% | New | 38 | $1K |
| Avion Wealth | 0.00% | No change | 54 | $1K |
| Hemington Wealth Management | 0.00% | Reduce -30.1% | 58 | $1K |
| Cheviot Value Management, LLC | 0.00% | New | 28 | $942 |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +833.3% | 28 | $845 |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $845 |
| CIBC Private Wealth Group LLC | 0.00% | Reduce -97.3% | 30 | $765 |
| TFC Financial Management, Inc. | 0.00% | No change | 21 | $634 |
| Key Financial Inc | 0.00% | No change | 19 | $573 |
| Bokf, NA | 0.00% | No change | 18 | $543 |
| Sachetta, LLC | 0.00% | Reduce -40.7% | 16 | $483 |
| Private Wealth Management Group, LLC | 0.00% | Add +60.0% | 16 | $483 |
| Assetmark, Inc. | 0.00% | Reduce -53.1% | 15 | $453 |
| Mascoma Wealth Management LLC | 0.00% | No change | 14 | $422 |
| True Wealth Design, LLC | 0.00% | New | 13 | $393 |
| Bruce G. Allen Investments, LLC | 0.00% | New | 13 | $392 |
| Hexagon Capital Partners LLC | 0.00% | New | 9 | $272 |
| UMB Bank, n.a. | 0.00% | New | 6 | $181 |
| AdvisorNet Financial, Inc | 0.00% | Add +200.0% | 3 | $91 |
| MV Capital Management, Inc. | 0.00% | Reduce -93.0% | 3 | $91 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.