Ionis PharmaceuticalsIONS

13F holders, Q1 2025 (March 31)
344holders −11
51new positions
61sold out
5famous investors
$30.18avg. 13F price*

At the end of Q1 2025, 344 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, down 11 from Q4 2024. 51 opened new positions and 61 sold out. The largest holders were FMR LLC ($712.4M), Vanguard Group Inc. ($494.3M) and T. Rowe Price Investment Management, Inc. ($488.0M). 5 famous investors held it, including Cathie Wood (0.3% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).

Company
Ionis Pharmaceuticals Inc.
CUSIP
462222100
Latest filing quarter
Q2 2026

History

Number of 13F holders

0200400600 Q1 2024: 361Q1 2024Q2 2024: 357Q2 2024Q3 2024: 354Q3 2024Q4 2024: 355Q4 2024Q1 2025: 344Q1 2025Q2 2025: 362Q2 2025Q3 2025: 436Q3 2025Q4 2025: 494Q4 2025Q1 2026: 497Q1 2026Q2 2026: 515Q2 2026

Total Exit/New Position Q4 2024 → Q1 2025

InstitutionsTotal Value
New Positions51$94.1M
Exits61$143.6M

All 13F filers, Q4 2024 → Q1 2025: 17,861,535 shares bought and 11,659,979 shares sold, net +6,201,556 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 344 holders

FMR LLC 0.05% Add +4.1% 23,613,585 $712.4M
Vanguard Group Inc. 0.01% Reduce -0.5% 16,383,934 $494.3M
T. Rowe Price Investment Management, Inc. 0.32% Add +14.2% 16,175,533 $488.0M
Capital World Investors 0.06% Add +7.8% 12,361,994 $373.0M
BlackRock, Inc. 0.01% Reduce -3.4% 11,264,442 $339.8M
Wellington Management Group LLP 0.05% Reduce -3.0% 8,416,421 $253.9M
Bellevue Group AG 5.31% Reduce -0.2% 7,853,198 $236.9M
State Street Corp. 0.01% Reduce -10.7% 4,845,133 $146.2M
Deep Track Capital, LP 4.46% Add +136.0% 4,564,207 $137.7M
Citadel Advisors 0.10% Add +60.7% 3,480,062 $105.0M
T. Rowe Price Associates Inc. 0.01% Reduce -14.7% 3,265,034 $98.5M
Tweedy, Browne Co LLC 7.98% Reduce -8.2% 2,983,518 $90.0M
Geode Capital Management, LLC 0.01% Add +5.8% 2,842,954 $85.8M
Orbimed Advisors LLC 1.84% Reduce -9.8% 2,540,136 $76.6M
Two Sigma Advisers, LP 0.14% Add +55.0% 2,092,011 $63.1M
BVF Inc. 2.35% New 1,913,385 $57.7M
UBS Group AG 0.01% Reduce -1.4% 1,890,602 $57.0M
Two Sigma Investments, LP 0.12% Add +83.0% 1,685,853 $50.9M
Macquarie Group Ltd. 0.06% Reduce -5.8% 1,667,194 $50.3M
Charles Schwab Investment Management Inc. 0.01% Reduce -2.5% 1,443,629 $43.6M
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.10% Add +10.7% 1,196,392 $36.1M
Morgan Stanley 0.00% Reduce -14.0% 1,144,181 $34.5M
TD Asset Management Inc 0.03% Add +4.8% 1,100,466 $33.2M
Adage Capital Partners Gp, L.L.C. 0.06% Add +291.1% 1,075,600 $32.5M
Hudson Bay Capital Management LP 0.23% Add +27.9% 1,049,900 $31.7M
ARK Investment Management 0.30% Reduce -2.4% 1,000,527 $30.2M
Candriam S.C.A. 0.19% Add +16.9% 993,704 $30.0M
Invesco Ltd. 0.01% Add +10.9% 874,834 $26.4M
Norges Bank 0.00% Reduce -50.0% 858,228 $25.9M
Northern Trust Corp. 0.00% Reduce -0.7% 834,847 $25.2M
Bank of Montreal 0.01% Add +150.8% 782,835 $23.6M
Bank of America Corp. 0.00% Add +81.5% 767,432 $23.2M
Camber Capital Management LP 1.36% Add +16.0% 725,000 $21.9M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% Add +6.4% 659,435 $19.9M
Goldman Sachs Group Inc. 0.00% Add +72.5% 652,518 $19.7M
Pictet Asset Management Holding SA 0.02% Reduce -0.4% 618,550 $19.2M
Millennium Management 0.02% Reduce -17.9% 635,370 $19.2M
Royal Bank of Canada 0.00% Reduce -4.2% 616,081 $18.6M
Pinnacle Associates Ltd. 0.27% Add +11.1% 608,517 $18.4M
Groupama Asset Managment 0.36% Add +10.1% 569,211 $17.7M
AXA S.A. 0.06% Reduce -6.4% 566,486 $17.1M
Schonfeld Strategic Advisors LLC 0.11% Add +50.9% 560,359 $16.9M
Bank of New York Mellon Corp 0.00% Reduce -11.6% 544,633 $16.4M
Eversept Partners, LP 1.77% Add +140.5% 517,021 $15.6M
Teacher Retirement System of Texas 0.06% Add +660.7% 500,451 $15.1M
Aberdeen Group plc 0.03% Add +11.1% 446,197 $13.5M
Citigroup Inc. 0.01% Add +152.1% 426,480 $12.9M
JPMorgan Chase & Co. 0.00% Add +1.3% 421,511 $12.7M
C WorldWide Group Holding A/S 0.15% No change 400,000 $12.1M
Voloridge Investment Management, LLC 0.04% Add +19.0% 377,204 $11.4M
Ameriprise Financial Inc. 0.00% Reduce -7.0% 360,188 $10.9M
Baker Bros. Advisors LP 0.12% No change 357,915 $10.8M
Barclays PLC 0.00% Reduce -40.6% 353,937 $10.7M
Legal & General Group Plc 0.00% Add +101.4% 338,462 $10.2M
Sovran Advisors, LLC 1.21% Add +91.4% 328,904 $9.3M
Nuveen, LLC 0.00% — 308,777 $9.3M
BNP Paribas Financial Markets 0.01% Add +21.1% 308,293 $9.3M
J. Goldman & Co LP 0.33% Reduce -49.3% 307,770 $9.3M
Squarepoint Ops LLC 0.02% Add +83.4% 305,373 $9.2M
Point72 Asset Management 0.03% New 287,204 $8.7M
Sector Gamma As 2.76% Add +21.2% 285,842 $8.6M
Swiss National Bank 0.01% Reduce -1.4% 275,300 $8.3M
Privium Fund Management B.V. 2.10% Add +0.3% 267,594 $8.1M
Wells Fargo & Company 0.00% Reduce -22.6% 256,233 $7.7M
Great Point Partners LLC 4.10% Reduce -50.5% 250,000 $7.5M
Corient Private Wealth LP 0.01% Reduce -0.8% 237,133 $7.2M
Nomura Holdings Inc. 0.04% Reduce -33.8% 236,426 $7.1M
Orion Investment Co 2.66% Reduce -0.3% 215,290 $6.5M
Artisan Partners Limited Partnership 0.01% Reduce -19.6% 203,178 $6.1M
Stifel Financial Corp. 0.01% Reduce -5.0% 200,942 $6.1M
California Public Employees Retirement System 0.00% Reduce -0.6% 191,004 $5.8M
Rhumbline Advisers 0.01% Reduce -1.9% 188,216 $5.7M
Tocqueville Asset Management L.P. 0.09% Reduce -46.8% 187,395 $5.7M
Sicart Associates LLC 1.94% Reduce -0.1% 185,646 $5.6M
GW&K Investment Management, LLC 0.05% Reduce -2.6% 182,309 $5.5M
Rafferty Asset Management, LLC 0.02% Reduce -25.7% 176,248 $5.3M
Susquehanna Fundamental Investments, LLC 0.08% Reduce -25.5% 158,609 $4.8M
Aquatic Capital Management LLC 0.12% Reduce -32.1% 156,157 $4.7M
Sonora Investment Management Group, LLC 0.37% Add +3.6% 154,147 $4.7M
Renaissance Technologies 0.01% Reduce -25.3% 153,514 $4.6M
State Board of Administration of Florida Retirement System 0.01% No change 152,315 $4.6M
BLB&B Advisors, LLC 0.23% Add +0.1% 152,200 $4.6M
Kennedy Capital Management LLC 0.11% Reduce -32.6% 150,424 $4.5M
Tang Capital Management LLC 0.25% No change 150,000 $4.5M
Raymond James Financial Inc. 0.00% Add +40.8% 148,690 $4.5M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% New 143,870 $4.3M
Sumitomo Mitsui Trust Group, Inc. 0.00% Reduce -9.1% 142,433 $4.3M
Amova Asset Management Americas, Inc. 0.06% Reduce -9.1% 142,433 $4.3M
Exome Asset Management LLC 3.66% Add +121.0% 135,616 $4.1M
California State Teachers Retirement System 0.00% Reduce -1.2% 132,238 $4.0M
Connor, Clark & Lunn Investment Management Ltd. 0.02% Add +3.1% 129,273 $3.9M
Edmond DE Rothschild Holding S.A. 0.07% New 124,200 $3.7M
American Century Companies Inc. 0.00% New 116,768 $3.5M
State of Wisconsin Investment Board 0.01% Add +7.0% 108,316 $3.3M
Neuberger Berman Group LLC 0.00% Add +6.0% 102,473 $3.1M
Alliancebernstein L.P. 0.00% Add +93.2% 100,749 $3.0M
PDT Partners, LLC 0.21% Add +231.3% 96,056 $2.9M
DekaBank Deutsche Girozentrale 0.01% No change 93,807 $2.9M
DCF Advisers, LLC 1.54% Add +14.6% 95,000 $2.9M
Walleye Capital LLC 0.04% Add +484.4% 94,990 $2.9M
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.07% Add +49.9% 90,779 $2.7M
Nicola Wealth Management LTD. 0.26% No change 87,000 $2.6M
Deutsche Bank AG 0.00% Reduce -7.7% 84,810 $2.6M
Manufacturers Life Insurance Company, The 0.00% Reduce -70.8% 83,440 $2.5M
Jump Financial, LLC 0.04% Add +104.7% 81,321 $2.5M
Rhenman & Partners Asset Management AB 0.28% Reduce -61.9% 81,000 $2.4M
New York State Common Retirement Fund 0.00% Reduce -7.1% 78,261 $2.4M
HSBC Holdings PLC 0.00% Reduce -9.9% 74,833 $2.2M
Susquehanna International Group, LLP 0.00% Add +175.5% 71,811 $2.2M
Treasurer of the State of North Carolina 0.01% Add +4.1% 71,593 $2.2M
Sei Investments Co. 0.00% Add +2.1% 71,558 $2.2M
Granite Investment Partners, LLC 0.10% Reduce -7.3% 68,434 $2.1M
Janus Henderson Group PLC 0.00% No change 63,877 $2.0M
Simplex Trading, LLC 0.07% New 64,581 $1.9M
Sphera Funds Management LTD. 0.47% No change 63,821 $1.9M
Voya Investment Management LLC 0.00% Reduce -31.1% 63,767 $1.9M
Lazard Asset Management LLC 0.00% Add +826.6% 60,758 $1.8M
State of New Jersey Common Pension Fund D 0.01% Reduce -4.0% 60,662 $1.8M
Avidity Partners Management LP 0.37% New 60,000 $1.8M
Skandinaviska Enskilda Banken AB (publ) 0.01% No change 59,626 $1.8M
Capital Fund Management S.A. 0.02% New 58,014 $1.8M
Police & Firemen's Retirement System of New Jersey 0.02% Add +1.5% 57,549 $1.7M
DAVENPORT & Co LLC 0.01% Reduce -10.1% 56,393 $1.7M
Ensign Peak Advisors, Inc 0.00% Add +3.3% 55,100 $1.7M
Jane Street Group, LLC 0.00% Reduce -67.1% 54,117 $1.6M
Erste Asset Management GmbH 0.02% No change 51,300 $1.6M
Verition Fund Management LLC 0.01% Reduce -73.9% 52,287 $1.6M
Public Employees Retirement System of Ohio 0.01% Reduce -10.4% 48,177 $1.5M
Schroder Investment Management Group 0.00% Reduce -54.4% 45,950 $1.4M
Readystate Asset Management LP 0.13% New 46,394 $1.4M
CANADA LIFE ASSURANCE Co 0.00% Add +11.8% 43,853 $1.3M
Handelsbanken Fonder AB 0.01% Reduce -1.4% 43,211 $1.3M
Raiffeisen Bank International AG 0.02% Add +2280.5% 41,754 $1.3M
NJ State Employees Deferred Compensation Plan 0.16% No change 42,000 $1.3M
Guggenheim Capital LLC 0.01% Add +17.1% 41,414 $1.2M
Point72 (DIFC) Ltd 0.12% New 41,347 $1.2M
Arizona State Retirement System 0.01% Reduce -1.1% 40,687 $1.2M
Blair William & Co. 0.00% Reduce -3.8% 38,381 $1.2M
Prelude Capital Management, LLC 0.12% Add +142.2% 37,772 $1.1M
Grandfield & Dodd, LLC 0.07% Add +5.2% 37,761 $1.1M
Capital Counsel LLC 0.05% No change 37,080 $1.1M
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Add +0.5% 36,509 $1.1M
Creative Planning 0.00% Reduce -22.8% 36,122 $1.1M
SummitTX Capital, L.P. 0.05% — 35,103 $1.1M
Allostery Investments LP 1.52% Reduce -46.1% 35,000 $1.1M
Profund Advisors LLC 0.05% Reduce -19.9% 34,887 $1.1M
Private Advisor Group, LLC 0.01% Reduce -15.1% 34,531 $1.0M
Pathstone Holdings, LLC 0.00% Add +31.9% 34,372 $1.0M
Mariner, LLC 0.00% Add +21.1% 33,483 $1.0M
China Universal Asset Management Co., Ltd. 0.09% Reduce -4.8% 31,886 $962K
Liontrust Investment Partners LLP 0.01% Reduce -27.0% 30,390 $917K
Axq Capital, LP 0.36% New 30,104 $908K
Alpine Global Management, LLC 0.25% New 28,097 $848K
KLP Kapitalforvaltning As 0.00% Reduce -6.2% 27,400 $827K
ExodusPoint Capital Management, LP 0.01% New 26,261 $792K
HRT Financial LP 0.00% New 25,824 $779K
Tema ETFs LLC 0.23% Reduce -55.8% 25,141 $759K
NEOS Investment Management LLC 0.01% Reduce -55.8% 25,141 $759K
BlueCrest Capital Management Ltd 0.15% Reduce -5.3% 24,800 $748K
Teachers Retirement System of the State of Kentucky 0.01% No change 24,083 $727K
LPL Financial LLC 0.00% Reduce -40.6% 23,966 $723K
Castle Hook Partners LP 0.02% No change 23,940 $722K
Brevan Howard Capital Management LP 0.02% Add +7.5% 22,973 $693K
Jefferies Financial Group Inc. 0.01% Add +2.1% 22,841 $689K
Bleakley Financial Group, LLC 0.02% Add +31.5% 22,284 $672K
Daiwa Securities Group Inc. 0.00% Add +3992.6% 22,141 $667K
Tidal Investments LLC 0.01% Add +25.4% 21,833 $659K
Nicollet Investment Management, Inc. 0.23% Add +8.4% 21,451 $647K
Bridgefront Capital, LLC 0.18% Reduce -5.8% 20,528 $619K
Xponance LLC 0.01% Add +5.1% 20,319 $613K
SG Americas Securities, LLC 0.00% Reduce -16.2% 20,050 $605K
Victory Capital Management Inc. 0.00% Add +3.5% 18,641 $562K
NBT Bank, N.A. 0.04% No change 17,050 $514K
VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% — 16,522 $498K
E Fund Management Co., Ltd. 0.02% Reduce -2.4% 16,471 $497K
Commonwealth Equity Services, LLC 0.00% Reduce -24.9% 16,398 $495K
Twinbeech Capital LP 0.01% New 15,938 $481K
Public Employees Retirement Association of Colorado 0.00% No change 15,589 $470K
Envestnet Asset Management Inc. 0.00% Reduce -71.5% 15,039 $454K
Jones Financial Companies LLLP 0.00% Add +47.1% 13,735 $428K
North Star Asset Management Inc. 0.02% Reduce -0.2% 13,610 $411K
Significant Wealth Partners LLC 0.21% Add +24.8% 13,605 $410K
Westmount Partners, LLC 0.12% Reduce -3.7% 12,961 $391K
Point72 Hong Kong Ltd 0.03% New 12,862 $388K
Horizon Kinetics Asset Management LLC 0.00% No change 12,476 $376K
XTX Topco Ltd 0.02% Reduce -51.1% 12,404 $374K
Northwestern Mutual Wealth Management Co. 0.00% Add +9.1% 12,358 $373K
Intech Investment Management LLC 0.00% New 12,207 $368K
Brown Advisory Inc. 0.00% Reduce -5.5% 12,026 $363K
SIH Partners, LLLP 0.03% New 11,999 $362K
FORA Capital, LLC 0.04% New 11,570 $349K
Twin Tree Management, LP 0.01% Reduce -87.2% 11,385 $343K
&partners 0.00% Add +6.7% 11,004 $343K
Plancorp, LLC 0.01% No change 11,128 $336K
PNC Financial Services Group, Inc. 0.00% Reduce -0.1% 10,987 $331K
Montanova Capital, LLC 0.01% No change 10,800 $326K
Annis Gardner Whiting Capital Advisors, LLC 0.14% No change 10,736 $324K
Amalgamated Bank 0.00% Add +2.7% 10,573 $319K
Harbor Advisors LLC 0.06% No change 10,500 $317K
Principal Financial Group Inc. 0.00% Reduce -23.3% 10,447 $315K
Capula Management Ltd 0.00% New 10,382 $313K
Vanguard Personalized Indexing Management, LLC 0.00% Reduce -16.0% 10,313 $311K
Teza Capital Management LLC 0.14% Add +20.2% 10,244 $309K
Man Group plc 0.00% Add +20.7% 10,033 $303K
Cypress Capital, LLC 0.09% No change 10,000 $302K
Fifth Third Bancorp 0.00% Add +4.8% 9,989 $301K
Tower Research Capital LLC (TRC) 0.01% Reduce -30.3% 9,873 $298K
Focus Partners Wealth 0.00% Add +22.1% 9,832 $297K
Virtus Investment Advisers, LLC 0.08% New 9,701 $293K
Sectoral Asset Management Inc. 0.22% Add +31.1% 9,440 $285K
Walleye Trading LLC 0.01% Reduce -5.6% 9,361 $282K
MetLife Investment Management, LLC 0.00% Reduce -0.2% 9,144 $276K
Marshall Wace, LLP 0.00% Reduce -98.9% 9,102 $275K
Jain Global LLC 0.01% New 8,595 $259K
Quantinno Capital Management LP 0.00% New 8,515 $257K
Bayesian Capital Management, LP 0.04% New 8,500 $256K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Reduce -13.2% 8,206 $256K
Utah Retirement Systems 0.00% No change 8,400 $253K
Maryland State Retirement & Pension System 0.01% No change 8,284 $250K
International Assets Investment Management, LLC 0.02% No change 8,207 $248K
IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.03% New 8,059 $243K
Fiduciary Trust Co 0.00% New 7,738 $233K
Semanteon Capital Management, LP 0.12% New 7,543 $228K
Commerce Bank 0.00% Reduce -46.4% 7,275 $219K
ProShare Advisors LLC 0.00% Reduce -4.1% 7,171 $216K
Clearstead Advisors, LLC 0.00% Reduce -2.6% 7,000 $211K
Prudential Financial Inc. 0.00% New 6,263 $210K
Silvercrest Asset Management Group LLC 0.00% Add +4.3% 6,902 $208K
Cambridge Investment Research Advisors, Inc. 0.00% Reduce -12.4% 6,804 $205K
Praxis Investment Management Inc. 0.01% No change 6,770 $204K
Tanaka Capital Management Inc. 0.48% Reduce -2.6% 6,714 $203K
KBC Group NV 0.00% Add +0.5% 6,515 $197K
Mitsubishi UFJ Asset Management Co., Ltd. 0.00% Add +8.5% 6,135 $185K
Advisors Asset Management, Inc. 0.00% Reduce -0.4% 6,048 $182K
Russell Investments Group, Ltd. 0.00% Reduce -90.8% 5,753 $174K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +1.1% 5,319 $166K
Moisand Fitzgerald Tamayo, LLC 0.02% New 5,000 $151K
GF Fund Management Co. LTD. 0.00% Add +21.9% 4,042 $122K
Amundi 0.00% Reduce -66.0% 3,873 $110K
Exchange Traded Concepts, LLC 0.00% Add +1722.5% 3,244 $98K
US Bancorp \de 0.00% Reduce -25.2% 3,157 $95K
Quarry LP 0.02% Reduce -50.0% 3,000 $91K
Corebridge Financial, Inc. 0.00% Reduce -3.7% 2,657 $80K
CI Investments Inc. 0.00% Reduce -37.9% 2,542 $77K
Sandia Investment Management LP 0.22% Reduce -50.0% 2,500 $75K
Cwm, LLC 0.00% Add +18.7% 2,435 $73K
Osaic Holdings, Inc. 0.00% Reduce -40.5% 2,373 $72K
Coldstream Capital Management Inc. 0.00% New 2,345 $71K
Van Eck Associates Corp. 0.00% Reduce -96.5% 2,157 $65K
Point72 Asia (Singapore) Pte. Ltd. 0.02% New 2,082 $63K
Ancora Advisors LLC 0.00% New 2,000 $60K
NewEdge Advisors, LLC 0.00% Reduce -10.9% 1,621 $49K
Twin Lakes Capital Management, LLC 0.03% No change 1,500 $45K
IFP Advisors, Inc 0.00% No change 1,150 $42K
Signaturefd, LLC 0.00% Add +45.6% 1,382 $42K
Comerica Bank 0.00% Reduce -82.2% 1,320 $40K
Manchester Capital Management LLC 0.00% Add +24.2% 1,248 $38K
EverSource Wealth Advisors, LLC 0.00% Add +147.2% 1,157 $35K
Itau Unibanco Holding S.A. 0.00% Reduce -0.7% 1,143 $34K
Sterling Capital Management LLC 0.00% Reduce -63.4% 1,101 $33K
Huntington National Bank 0.00% Add +14.9% 1,093 $33K
Steward Partners Investment Advisory, LLC 0.00% Reduce -64.5% 1,090 $33K
Sunbelt Securities, Inc. 0.00% No change 1,014 $31K
GAMMA Investing LLC 0.00% Add +28.8% 961 $29K
Harbour Investments, Inc. 0.00% No change 900 $27K
Parallel Advisors, LLC 0.00% Reduce -22.3% 745 $22K
AlphaQuest LLC 0.00% New 635 $19K
Archer Investment Corp 0.00% No change 600 $18K
Laurel Wealth Advisors LLC 0.00% No change 600 $18K
Danske Bank A/S 0.00% No change 500 $15K
Riverview Trust Co 0.01% No change 476 $14K
Lindbrook Capital, LLC 0.00% Reduce -57.5% 440 $13K
Farther Finance Advisors, LLC 0.00% Reduce -27.5% 472 $13K
Mather Group, Llc. 0.00% Reduce -37.0% 410 $12K
Global Trust Asset Management, LLC 0.01% No change 399 $12K
Quadrant Capital Group LLC 0.00% Reduce -64.9% 381 $11K
Parkside Financial Bank & Trust 0.00% Reduce -9.8% 377 $11K
Ascentis Wealth Management, LLC 0.00% No change 400 $11K
Larson Financial Group LLC 0.00% Add +1805.6% 343 $10K
Oakworth Capital, Inc. 0.00% New 300 $9K
Eastern Bank 0.00% New 300 $9K
Covestor Ltd 0.01% Add +21.1% 298 $9K
Union Bancaire Privee, UBP SA 0.00% No change 265 $8K
Storebrand Asset Management As 0.00% No change 271 $8K
MassMutual Private Wealth & Trust, FSB 0.00% Add +12.4% 262 $8K
MAI Capital Management 0.00% No change 260 $8K
SBI Securities Co., Ltd. 0.00% Add +1.6% 260 $8K
Blue Trust, Inc. 0.00% No change 259 $8K
Riggs Asset Managment Co. Inc. 0.00% No change 250 $8K
Allworth Financial LP 0.00% Reduce -73.9% 223 $7K
NFSG Corp 0.00% No change 200 $6K
AllSquare Wealth Management LLC 0.00% No change 198 $6K
Whittier Trust Co. 0.00% No change 192 $6K
Wealth Preservation Advisors, LLC 0.00% — 150 $5K
Pacifica Partners Inc. 0.00% No change 150 $4K
Kestra Investment Management, LLC 0.00% New 137 $4K
Smartleaf Asset Management LLC 0.00% Reduce -60.1% 131 $4K
Golden State Wealth Management, LLC 0.00% No change 126 $4K
Spire Wealth Management 0.00% No change 125 $4K
Anderson Financial Strategies, LLC 0.00% New 121 $4K
GPS Wealth Strategies Group, LLC 0.00% No change 119 $4K
SouthState Bank Corp 0.00% New 119 $4K
Brooklyn Investment Group 0.00% Add +42.5% 114 $3K
First Horizon Advisors, Inc. 0.00% No change 112 $3K
MPWM Advisory Solutions, LLC 0.00% New 110 $3K
Arax Advisory Partners 0.00% No change 104 $3K
Bogart Wealth, LLC 0.00% Add +43.7% 102 $3K
Versant Capital Management, Inc 0.00% Add +83.6% 101 $3K
Creekmur Asset Management LLC 0.00% No change 100 $3K
Picton Mahoney Asset Management 0.00% New 89 $3K
Meeder Asset Management Inc. 0.00% New 95 $3K
Semmax Financial Advisors Inc. 0.00% No change 79 $3K
Dynamic Wealth Strategies, LLC 0.00% New 80 $2K
Orion Capital Management LLC 0.00% No change 80 $2K
Principal Securities, Inc. 0.00% No change 67 $2K
Bell Investment Advisors, Inc 0.00% No change 71 $2K
Bessemer Group Inc. 0.00% New 73 $2K
Leonteq Securities AG 0.00% No change 63 $2K
Clear Investment Research, LLC 0.00% No change 51 $2K
Blume Capital Management, Inc. 0.00% No change 55 $2K
Quent Capital, LLC 0.00% Reduce -28.4% 53 $2K
CoreCap Advisors, LLC 0.00% Add +15.6% 52 $2K
Wolff Wiese Magana LLC 0.00% No change 41 $1K
Truvestments Capital LLC 0.00% New 40 $1K
Highline Wealth Partners LLC 0.00% New 38 $1K
Avion Wealth 0.00% No change 54 $1K
Hemington Wealth Management 0.00% Reduce -30.1% 58 $1K
Cheviot Value Management, LLC 0.00% New 28 $942
Caitong International Asset Management Co., Ltd 0.00% Add +833.3% 28 $845
Raffa Wealth Management, LLC 0.00% No change 28 $845
CIBC Private Wealth Group LLC 0.00% Reduce -97.3% 30 $765
TFC Financial Management, Inc. 0.00% No change 21 $634
Key Financial Inc 0.00% No change 19 $573
Bokf, NA 0.00% No change 18 $543
Sachetta, LLC 0.00% Reduce -40.7% 16 $483
Private Wealth Management Group, LLC 0.00% Add +60.0% 16 $483
Assetmark, Inc. 0.00% Reduce -53.1% 15 $453
Mascoma Wealth Management LLC 0.00% No change 14 $422
True Wealth Design, LLC 0.00% New 13 $393
Bruce G. Allen Investments, LLC 0.00% New 13 $392
Hexagon Capital Partners LLC 0.00% New 9 $272
UMB Bank, n.a. 0.00% New 6 $181
AdvisorNet Financial, Inc 0.00% Add +200.0% 3 $91
MV Capital Management, Inc. 0.00% Reduce -93.0% 3 $91

"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.