Ionis PharmaceuticalsIONS
13F holders, Q2 2025 (June 30)362holders +18
78new positions
61sold out
6famous investors
$39.52avg. 13F price*
At the end of Q2 2025, 362 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 18 from Q1 2025. 78 opened new positions and 61 sold out. The largest holders were FMR LLC ($934.1M), Vanguard Group Inc. ($660.4M) and T. Rowe Price Investment Management, Inc. ($634.1M). 6 famous investors held it, including Cathie Wood (0.3% of ARK Investment Management's portfolio), Israel Englander (0.1% of Millennium Management's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 78 | $212.9M |
| Exits | 61 | $136.8M |
All 13F filers, Q1 2025 → Q2 2025: 16,053,470 shares bought and 13,914,962 shares sold, net +2,138,508 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 362 holders
| FMR LLC | 0.05% | Add +0.1% | 23,642,990 | $934.1M |
| Vanguard Group Inc. | 0.01% | Add +2.0% | 16,714,846 | $660.4M |
| T. Rowe Price Investment Management, Inc. | 0.40% | Reduce -0.8% | 16,048,721 | $634.1M |
| Capital World Investors | 0.07% | Add +1.4% | 12,540,188 | $495.5M |
| BlackRock, Inc. | 0.01% | Reduce -3.3% | 10,896,937 | $430.5M |
| Bellevue Group AG | 6.84% | No change | 7,853,198 | $310.3M |
| Wellington Management Group LLP | 0.05% | Reduce -24.6% | 6,345,776 | $250.7M |
| Deep Track Capital, LP | 6.21% | Add +7.2% | 4,891,544 | $193.3M |
| State Street Corp. | 0.01% | Reduce -6.5% | 4,530,398 | $179.0M |
| Adage Capital Partners Gp, L.L.C. | 0.25% | Add +253.3% | 3,800,000 | $150.1M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -4.3% | 3,126,073 | $123.5M |
| Tweedy, Browne Co LLC | 10.60% | Reduce -3.1% | 2,891,948 | $114.3M |
| Geode Capital Management, LLC | 0.01% | Add +1.7% | 2,891,095 | $114.2M |
| Two Sigma Advisers, LP | 0.22% | Add +27.5% | 2,667,611 | $105.4M |
| Millennium Management | 0.10% | Add +317.0% | 2,649,527 | $104.7M |
| BVF Inc. | 2.70% | No change | 1,913,385 | $75.6M |
| Two Sigma Investments, LP | 0.13% | Add +6.1% | 1,788,367 | $70.7M |
| UBS Group AG | 0.01% | Reduce -19.1% | 1,529,323 | $60.4M |
| Citadel Advisors | 0.05% | Reduce -57.0% | 1,494,981 | $59.1M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +3.1% | 1,487,818 | $58.8M |
| Macquarie Group Ltd. | 0.07% | Reduce -14.0% | 1,434,073 | $56.7M |
| Morgan Stanley | 0.00% | Add +19.1% | 1,362,209 | $53.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.13% | Add +12.9% | 1,350,879 | $53.4M |
| TD Asset Management Inc | 0.04% | Add +0.4% | 1,104,690 | $43.6M |
| Polar Capital Holdings Plc | 0.21% | New | 1,000,000 | $39.5M |
| Bank of America Corp. | 0.00% | Add +29.8% | 995,890 | $39.3M |
| ARK Investment Management | 0.26% | Reduce -10.0% | 900,318 | $35.6M |
| Voloridge Investment Management, LLC | 0.12% | Add +126.6% | 854,634 | $33.8M |
| Northern Trust Corp. | 0.00% | Reduce -2.5% | 814,250 | $32.2M |
| Royal Bank of Canada | 0.01% | Add +29.8% | 799,912 | $31.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +20.0% | 791,072 | $31.3M |
| Goldman Sachs Group Inc. | 0.01% | Add +19.2% | 777,940 | $30.7M |
| Balyasny Asset Management L.P. | 0.07% | New | 768,648 | $30.4M |
| Hudson Bay Capital Management LP | 0.22% | Reduce -28.6% | 750,000 | $29.6M |
| Woodline Partners LP | 0.15% | New | 732,813 | $29.0M |
| Candriam S.C.A. | 0.17% | Reduce -27.1% | 724,740 | $28.6M |
| Teacher Retirement System of Texas | 0.11% | Add +33.5% | 668,273 | $26.4M |
| Groupama Asset Managment | 0.44% | Add +16.1% | 660,957 | $26.3M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -1.6% | 608,640 | $24.2M |
| Eversept Partners, LP | 2.35% | Add +13.9% | 588,900 | $23.3M |
| Barclays PLC | 0.01% | Add +64.8% | 583,266 | $23.0M |
| AXA S.A. | 0.06% | Add +0.1% | 566,883 | $22.4M |
| Bank of New York Mellon Corp | 0.00% | Reduce -3.2% | 527,188 | $20.8M |
| Massachusetts Financial Services Co. | 0.01% | New | 519,184 | $20.5M |
| Great Point Partners LLC | 12.84% | Add +100.0% | 500,000 | $19.8M |
| Vestal Point Capital, LP | 1.04% | New | 500,000 | $19.8M |
| Pinnacle Associates Ltd. | 0.28% | Reduce -18.7% | 494,539 | $19.5M |
| Bank of Montreal | 0.01% | Reduce -38.3% | 483,289 | $19.1M |
| American Century Companies Inc. | 0.01% | Add +304.9% | 472,749 | $18.7M |
| Norges Bank | 0.00% | Reduce -47.5% | 450,254 | $17.8M |
| C WorldWide Group Holding A/S | 0.24% | Add +12.5% | 450,000 | $17.8M |
| Schonfeld Strategic Advisors LLC | 0.13% | Reduce -19.8% | 449,206 | $17.7M |
| GW&K Investment Management, LLC | 0.16% | Add +146.2% | 448,830 | $17.7M |
| Aberdeen Group plc | 0.03% | Reduce -8.8% | 406,694 | $16.2M |
| Legal & General Group Plc | 0.00% | Add +19.5% | 404,366 | $16.0M |
| Great Lakes Advisors, LLC | 0.13% | New | 399,646 | $15.8M |
| JPMorgan Chase & Co. | 0.00% | Reduce -6.3% | 394,978 | $15.6M |
| Ameriprise Financial Inc. | 0.00% | Add +2.2% | 368,119 | $14.5M |
| Artisan Partners Limited Partnership | 0.02% | Add +74.7% | 354,962 | $14.0M |
| Citigroup Inc. | 0.01% | Reduce -20.1% | 340,977 | $13.5M |
| Sovran Advisors, LLC | 1.39% | Reduce -2.1% | 321,913 | $13.3M |
| Point72 Asset Management | 0.03% | Add +1.9% | 292,647 | $11.6M |
| Swiss National Bank | 0.01% | Add +4.8% | 288,600 | $11.4M |
| Sector Gamma As | 3.69% | No change | 285,842 | $11.3M |
| Renaissance Technologies | 0.01% | Add +76.3% | 270,714 | $10.7M |
| Privium Fund Management B.V. | 2.31% | No change | 267,594 | $10.7M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.04% | Add +105.6% | 265,793 | $10.5M |
| Invesco Ltd. | 0.00% | Reduce -70.7% | 256,235 | $10.1M |
| Nuveen, LLC | 0.00% | Reduce -20.6% | 245,085 | $9.7M |
| Corient Private Wealth LP | 0.01% | Add +0.3% | 237,840 | $9.4M |
| Verition Fund Management LLC | 0.06% | Add +345.0% | 232,687 | $9.2M |
| Orion Investment Co | 3.04% | Add +1.0% | 217,370 | $8.6M |
| Raymond James Financial Inc. | 0.00% | Add +41.6% | 210,592 | $8.3M |
| Wells Fargo & Company | 0.00% | Reduce -18.1% | 209,857 | $8.3M |
| California Public Employees Retirement System | 0.01% | Add +5.8% | 201,993 | $8.0M |
| Edmond DE Rothschild Holding S.A. | 0.12% | Add +59.1% | 197,600 | $7.8M |
| Stifel Financial Corp. | 0.01% | Reduce -2.3% | 196,357 | $7.8M |
| Tocqueville Asset Management L.P. | 0.11% | Reduce -0.0% | 187,345 | $7.4M |
| Sicart Associates LLC | 2.56% | Reduce -0.2% | 185,296 | $7.3M |
| Rhenman & Partners Asset Management AB | 0.91% | Add +124.7% | 182,000 | $7.2M |
| Rhumbline Advisers | 0.01% | Reduce -3.5% | 181,599 | $7.2M |
| BNP Paribas Financial Markets | 0.01% | Reduce -42.3% | 177,762 | $7.0M |
| Sonora Investment Management Group, LLC | 0.48% | Add +5.8% | 163,172 | $6.4M |
| Alyeska Investment Group, L.P. | 0.02% | New | 159,008 | $6.3M |
| Aquatic Capital Management LLC | 0.13% | Add +1.2% | 158,086 | $6.2M |
| State Board of Administration of Florida Retirement System | 0.01% | Add +1.0% | 153,895 | $6.1M |
| BLB&B Advisors, LLC | 0.28% | Reduce -0.4% | 151,550 | $6.0M |
| Tang Capital Management LLC | 0.30% | No change | 150,000 | $5.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +4.2% | 149,839 | $5.9M |
| ADAR1 Capital Management, LLC | 0.96% | New | 148,461 | $5.9M |
| J. Goldman & Co LP | 0.18% | Reduce -52.0% | 147,682 | $5.8M |
| California State Teachers Retirement System | 0.01% | Add +9.7% | 145,104 | $5.7M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -17.9% | 144,770 | $5.7M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -1.9% | 139,739 | $5.5M |
| Amova Asset Management Americas, Inc. | 0.06% | Reduce -1.9% | 139,739 | $5.5M |
| Squarepoint Ops LLC | 0.01% | Reduce -56.0% | 134,395 | $5.3M |
| Kennedy Capital Management LLC | 0.12% | Reduce -12.2% | 132,045 | $5.2M |
| Trexquant Investment LP | 0.06% | New | 128,869 | $5.1M |
| Exome Asset Management LLC | 3.95% | Reduce -10.7% | 121,116 | $4.8M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.01% | New | 116,000 | $4.6M |
| Neuberger Berman Group LLC | 0.00% | Add +11.9% | 114,623 | $4.5M |
| HSBC Holdings PLC | 0.00% | Add +44.7% | 108,294 | $4.3M |
| Sei Investments Co. | 0.00% | Add +37.4% | 98,348 | $3.9M |
| Superstring Capital Management LP | 4.84% | New | 98,267 | $3.9M |
| State of Wisconsin Investment Board | 0.01% | Reduce -10.7% | 96,694 | $3.8M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $3.7M |
| Susquehanna Portfolio Strategies, LLC | 0.08% | New | 92,900 | $3.7M |
| DCF Advisers, LLC | 1.74% | Reduce -3.4% | 91,750 | $3.6M |
| Nicola Wealth Management LTD. | 0.32% | No change | 87,000 | $3.4M |
| New York State Common Retirement Fund | 0.00% | Add +11.1% | 86,972 | $3.4M |
| Deutsche Bank AG | 0.00% | Add +0.6% | 85,278 | $3.4M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -0.1% | 83,386 | $3.3M |
| Marex Group Ltd | 0.06% | New | 83,361 | $3.3M |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.09% | Reduce -10.5% | 81,251 | $3.2M |
| Worldquant Millennium Advisors LLC | 0.01% | New | 74,438 | $2.9M |
| Van Eck Associates Corp. | 0.00% | Add +3312.9% | 73,617 | $2.9M |
| Treasurer of the State of North Carolina | 0.01% | Add +1.4% | 72,587 | $2.9M |
| Walleye Capital LLC | 0.03% | Reduce -30.0% | 66,482 | $2.6M |
| DAVENPORT & Co LLC | 0.01% | Add +15.0% | 64,843 | $2.6M |
| Voya Investment Management LLC | 0.00% | Add +1.2% | 64,517 | $2.5M |
| Janus Henderson Group PLC | 0.00% | No change | 63,877 | $2.5M |
| Lazard Asset Management LLC | 0.00% | Reduce -0.0% | 60,749 | $2.4M |
| Police & Firemen's Retirement System of New Jersey | 0.02% | Add +3.8% | 59,723 | $2.4M |
| Skandinaviska Enskilda Banken AB (publ) | 0.01% | No change | 59,626 | $2.4M |
| State of New Jersey Common Pension Fund D | 0.01% | Reduce -2.9% | 58,918 | $2.3M |
| Raiffeisen Bank International AG | 0.03% | Add +35.9% | 56,754 | $2.3M |
| First Trust Advisors LP | 0.00% | New | 56,519 | $2.2M |
| PDT Partners, LLC | 0.12% | Reduce -43.4% | 54,365 | $2.1M |
| Ensign Peak Advisors, Inc | 0.00% | Reduce -3.2% | 53,320 | $2.1M |
| Creative Planning | 0.00% | Add +47.5% | 53,289 | $2.1M |
| Alliancebernstein L.P. | 0.00% | Reduce -48.3% | 52,057 | $2.1M |
| Erste Asset Management GmbH | 0.02% | No change | 51,300 | $2.0M |
| Capital Counsel LLC | 0.08% | Add +35.4% | 50,205 | $2.0M |
| Public Employees Retirement System of Ohio | 0.01% | Add +0.1% | 48,244 | $1.9M |
| CANADA LIFE ASSURANCE Co | 0.00% | Add +6.0% | 46,501 | $1.8M |
| Schroder Investment Management Group | 0.00% | No change | 45,950 | $1.8M |
| Arizona State Retirement System | 0.01% | Add +8.2% | 44,040 | $1.7M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +19.5% | 43,615 | $1.7M |
| Handelsbanken Fonder AB | 0.01% | No change | 43,211 | $1.7M |
| Granite Investment Partners, LLC | 0.08% | Reduce -36.9% | 43,181 | $1.7M |
| NJ State Employees Deferred Compensation Plan | 0.20% | No change | 42,000 | $1.7M |
| Guggenheim Capital LLC | 0.01% | Reduce -1.3% | 40,857 | $1.6M |
| Simplex Trading, LLC | 0.04% | Reduce -38.6% | 39,638 | $1.6M |
| Prelude Capital Management, LLC | 0.15% | Add +4.4% | 39,423 | $1.6M |
| Algert Global LLC | 0.03% | New | 38,090 | $1.5M |
| Blair William & Co. | 0.00% | Reduce -1.3% | 37,891 | $1.5M |
| Y-Intercept (Hong Kong) Ltd | 0.04% | New | 37,649 | $1.5M |
| Grandfield & Dodd, LLC | 0.09% | Reduce -1.4% | 37,230 | $1.5M |
| Mariner, LLC | 0.00% | Add +10.3% | 36,914 | $1.5M |
| Engineers Gate Manager LP | 0.02% | New | 33,118 | $1.3M |
| Brevan Howard Capital Management LP | 0.01% | Add +42.5% | 32,732 | $1.3M |
| Nomura Holdings Inc. | 0.01% | Reduce -86.4% | 32,161 | $1.3M |
| China Universal Asset Management Co., Ltd. | 0.12% | Add +0.3% | 31,966 | $1.3M |
| KLP Kapitalforvaltning As | 0.01% | Add +15.0% | 31,500 | $1.2M |
| Capital Fund Management S.A. | 0.01% | Reduce -46.2% | 31,219 | $1.2M |
| Pathstone Holdings, LLC | 0.00% | Reduce -10.5% | 30,759 | $1.2M |
| One Capital Management, LLC | 0.04% | New | 29,865 | $1.2M |
| Future Fund LLC | 0.52% | New | 29,595 | $1.2M |
| Entropy Technologies, LP | 0.09% | New | 29,452 | $1.2M |
| Profund Advisors LLC | 0.04% | Reduce -17.3% | 28,859 | $1.1M |
| Tema ETFs LLC | 0.30% | Add +12.0% | 28,161 | $1.1M |
| NEOS Investment Management LLC | 0.01% | Add +12.0% | 28,161 | $1.1M |
| Daiwa Securities Group Inc. | 0.00% | Add +18.1% | 26,141 | $1.0M |
| Alpine Global Management, LLC | 0.26% | Reduce -9.5% | 25,437 | $1.0M |
| LPL Financial LLC | 0.00% | Add +3.8% | 24,872 | $983K |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 24,083 | $952K |
| Xponance LLC | 0.01% | Add +12.0% | 22,754 | $899K |
| Oxford Asset Management LLP | 0.29% | New | 22,405 | $885K |
| Jefferies Financial Group Inc. | 0.02% | Reduce -2.0% | 22,381 | $884K |
| Graham Capital Management, L.P. | 0.03% | New | 20,935 | $827K |
| Nicollet Investment Management, Inc. | 0.27% | Reduce -3.3% | 20,747 | $820K |
| Victory Capital Management Inc. | 0.00% | Reduce -0.7% | 18,516 | $732K |
| Bleakley Financial Group, LLC | 0.02% | Reduce -18.6% | 18,129 | $716K |
| Assenagon Asset Management S.A. | 0.00% | New | 17,654 | $698K |
| Quantinno Capital Management LP | 0.00% | Add +106.0% | 17,542 | $693K |
| Fieldview Capital Management, LLC | 0.10% | New | 17,306 | $684K |
| SummitTX Capital, L.P. | 0.03% | Reduce -51.1% | 17,149 | $678K |
| North Star Asset Management Inc. | 0.03% | Add +22.0% | 16,610 | $656K |
| Bayesian Capital Management, LP | 0.10% | Add +95.3% | 16,600 | $656K |
| E Fund Management Co., Ltd. | 0.03% | Reduce -1.9% | 16,160 | $638K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 15,589 | $616K |
| Significant Wealth Partners LLC | 0.30% | Add +14.0% | 15,504 | $613K |
| Corton Capital Inc. | 0.66% | New | 14,424 | $570K |
| Vestmark Advisory Solutions, Inc. | 0.01% | New | 14,341 | $567K |
| Gotham Asset Management | 0.00% | New | 14,279 | $564K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -15.0% | 13,942 | $551K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -9.9% | 13,544 | $535K |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.05% | Add +64.6% | 13,263 | $524K |
| Marshall Wace, LLP | 0.00% | Add +43.9% | 13,100 | $518K |
| Westmount Partners, LLC | 0.14% | No change | 12,961 | $512K |
| Annis Gardner Whiting Capital Advisors, LLC | 0.18% | Add +19.2% | 12,801 | $506K |
| Paloma Partners Management Co | 0.21% | New | 12,557 | $496K |
| Virtus Investment Advisers, LLC | 0.17% | Add +28.6% | 12,476 | $493K |
| DNB Asset Management AS | 0.00% | New | 12,271 | $485K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -0.9% | 12,244 | $484K |
| Brown Advisory Inc. | 0.00% | Add +1.4% | 12,191 | $482K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Add +17.1% | 12,072 | $477K |
| Vident Advisory, LLC | 0.01% | New | 12,000 | $474K |
| Horizon Kinetics Asset Management LLC | 0.01% | Reduce -4.2% | 11,952 | $472K |
| &partners | 0.00% | Add +6.8% | 11,758 | $465K |
| Amalgamated Bank | 0.00% | Add +9.0% | 11,526 | $455K |
| PNC Financial Services Group, Inc. | 0.00% | Add +3.9% | 11,411 | $451K |
| Plancorp, LLC | 0.02% | Add +0.7% | 11,208 | $443K |
| Fox Run Management, L.L.C. | 0.07% | New | 10,988 | $434K |
| Montanova Capital, LLC | 0.02% | No change | 10,800 | $427K |
| Harbor Advisors LLC | 0.07% | No change | 10,500 | $415K |
| Focus Partners Wealth | 0.00% | Add +2.3% | 10,056 | $397K |
| Cypress Capital, LLC | 0.11% | No change | 10,000 | $395K |
| Westfield Capital Management Co. LP | 0.00% | New | 9,561 | $378K |
| Perbak Capital Partners LLP | 0.09% | New | 9,538 | $377K |
| Semanteon Capital Management, LP | 0.57% | Add +26.4% | 9,536 | $377K |
| Fred Alger Management, LLC | 0.00% | New | 9,464 | $374K |
| Russell Investments Group, Ltd. | 0.00% | Add +61.0% | 9,265 | $366K |
| Sectoral Asset Management Inc. | 0.24% | Reduce -2.5% | 9,205 | $364K |
| MetLife Investment Management, LLC | 0.00% | Add +0.2% | 9,161 | $362K |
| Jump Financial, LLC | 0.00% | Reduce -88.9% | 9,018 | $356K |
| Man Group plc | 0.00% | Reduce -10.6% | 8,969 | $354K |
| Exchange Traded Concepts, LLC | 0.00% | Add +171.3% | 8,802 | $348K |
| Prudential Financial Inc. | 0.00% | Add +47.8% | 9,254 | $341K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | New | 7,915 | $340K |
| Fiduciary Trust Co | 0.00% | Add +10.5% | 8,551 | $338K |
| Utah Retirement Systems | 0.00% | No change | 8,400 | $332K |
| Aigen Investment Management, LP | 0.04% | New | 8,298 | $328K |
| Maryland State Retirement & Pension System | 0.01% | No change | 8,284 | $327K |
| International Assets Investment Management, LLC | 0.03% | No change | 8,207 | $324K |
| Atria Investments, Inc | 0.00% | New | 8,186 | $323K |
| Point72 (DIFC) Ltd | 0.03% | Reduce -80.4% | 8,087 | $320K |
| Principal Financial Group Inc. | 0.00% | Reduce -23.9% | 7,951 | $314K |
| M&T Bank Corp | 0.00% | New | 7,651 | $303K |
| Commerce Bank | 0.00% | Add +4.6% | 7,607 | $301K |
| Fifth Third Bancorp | 0.00% | Reduce -23.9% | 7,598 | $300K |
| Jones Financial Companies LLLP | 0.00% | Reduce -47.6% | 7,196 | $286K |
| Jain Global LLC | 0.00% | Reduce -16.3% | 7,195 | $284K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -13.8% | 7,071 | $281K |
| Silvercrest Asset Management Group LLC | 0.00% | Add +2.4% | 7,068 | $279K |
| Clearstead Advisors, LLC | 0.00% | No change | 7,000 | $277K |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 6,813 | $269K |
| Praxis Investment Management Inc. | 0.02% | No change | 6,770 | $267K |
| Meeder Advisory Services, Inc. | 0.01% | New | 6,644 | $263K |
| Teza Capital Management LLC | 0.19% | Reduce -35.5% | 6,604 | $261K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +15.6% | 6,148 | $243K |
| Advisors Asset Management, Inc. | 0.00% | Reduce -0.8% | 5,999 | $237K |
| ProShare Advisors LLC | 0.00% | Reduce -17.1% | 5,943 | $235K |
| Frank, Rimerman Advisors LLC | 0.02% | New | 5,763 | $228K |
| Wedmont Private Capital | 0.01% | New | 5,282 | $226K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -16.5% | 5,682 | $224K |
| Orion Porfolio Solutions, LLC | 0.00% | New | 5,600 | $221K |
| Savant Capital, LLC | 0.00% | New | 5,570 | $220K |
| Franklin Resources Inc. | 0.00% | New | 5,556 | $220K |
| Castle Rock Wealth Management, LLC | 0.05% | New | 5,122 | $215K |
| Callan Family Office, LLC | 0.01% | New | 5,400 | $213K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Reduce -12.0% | 5,398 | $213K |
| HighTower Advisors, LLC | 0.00% | New | 5,357 | $212K |
| Osaic Holdings, Inc. | 0.00% | Add +123.2% | 5,296 | $209K |
| Pinnacle Wealth Planning Services, Inc. | 0.03% | New | 5,284 | $209K |
| Empowered Funds, LLC | 0.00% | New | 5,067 | $200K |
| Moisand Fitzgerald Tamayo, LLC | 0.03% | No change | 5,000 | $198K |
| Wexford Capital LP | 0.05% | New | 4,749 | $188K |
| KBC Group NV | 0.00% | Reduce -27.9% | 4,699 | $186K |
| US Bancorp \de | 0.00% | Add +35.7% | 4,285 | $169K |
| GF Fund Management Co. LTD. | 0.00% | No change | 4,042 | $160K |
| STRS Ohio | 0.00% | New | 3,714 | $147K |
| CI Investments Inc. | 0.00% | Reduce -5.0% | 2,416 | $95K |
| Cwm, LLC | 0.00% | Reduce -4.8% | 2,318 | $92K |
| Allianz SE | 0.00% | New | 2,100 | $83K |
| Signaturefd, LLC | 0.00% | Add +46.9% | 2,030 | $80K |
| Ancora Advisors LLC | 0.00% | No change | 2,000 | $79K |
| Parallel Advisors, LLC | 0.00% | Add +151.3% | 1,872 | $74K |
| Harvest Fund Management Co., Ltd | 0.00% | New | 1,829 | $72K |
| Comerica Bank | 0.00% | Add +22.5% | 1,617 | $64K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -84.0% | 1,581 | $62K |
| Twin Lakes Capital Management, LLC | 0.04% | No change | 1,500 | $59K |
| Versant Capital Management, Inc | 0.01% | Add +1350.5% | 1,465 | $58K |
| Danske Bank A/S | 0.00% | Add +180.0% | 1,400 | $55K |
| Manchester Capital Management LLC | 0.01% | No change | 1,248 | $49K |
| IFP Advisors, Inc | 0.00% | Reduce -21.4% | 904 | $49K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +12.0% | 1,221 | $48K |
| Itau Unibanco Holding S.A. | 0.00% | Reduce -1.7% | 1,124 | $44K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -4.8% | 1,101 | $44K |
| Larson Financial Group LLC | 0.00% | Add +199.4% | 1,027 | $41K |
| Sterling Capital Management LLC | 0.00% | Reduce -12.6% | 962 | $38K |
| GAMMA Investing LLC | 0.00% | Reduce -3.2% | 930 | $37K |
| Sunbelt Securities, Inc. | 0.00% | No change | 1,014 | $35K |
| AlphaQuest LLC | 0.00% | Add +31.5% | 835 | $33K |
| Huntington National Bank | 0.00% | Reduce -27.3% | 795 | $31K |
| Allworth Financial LP | 0.00% | Add +231.8% | 740 | $29K |
| Archer Investment Corp | 0.01% | No change | 600 | $24K |
| Parkside Financial Bank & Trust | 0.00% | Add +16.2% | 438 | $17K |
| Farther Finance Advisors, LLC | 0.00% | Reduce -8.3% | 433 | $17K |
| AdvisorNet Financial, Inc | 0.00% | Add +14166.7% | 428 | $17K |
| MAI Capital Management | 0.00% | Add +63.9% | 426 | $17K |
| Ascentis Wealth Management, LLC | 0.00% | No change | 400 | $16K |
| Covestor Ltd | 0.01% | Add +2.4% | 305 | $12K |
| Capital Advisors, Ltd. LLC | 0.00% | New | 295 | $12K |
| Eastern Bank | 0.00% | No change | 300 | $12K |
| Storebrand Asset Management As | 0.00% | No change | 271 | $11K |
| Brooklyn Investment Group | 0.00% | Add +135.1% | 268 | $11K |
| Union Bancaire Privee, UBP SA | 0.00% | No change | 265 | $11K |
| Global X Japan Co., Ltd. | 0.00% | New | 259 | $10K |
| MTM Investment Management, LLC | 0.00% | New | 258 | $10K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -1.1% | 257 | $10K |
| Westside Investment Management, Inc. | 0.00% | New | 231 | $9K |
| Twin Peaks Wealth Advisors, LLC | 0.00% | New | 215 | $9K |
| Global Trust Asset Management, LLC | 0.00% | Reduce -45.4% | 218 | $9K |
| Harbour Investments, Inc. | 0.00% | Reduce -77.8% | 200 | $8K |
| Atlantic Union Bankshares Corp | 0.00% | New | 200 | $8K |
| AllSquare Wealth Management LLC | 0.00% | No change | 198 | $8K |
| NewEdge Advisors, LLC | 0.00% | Reduce -87.9% | 196 | $8K |
| Riggs Asset Managment Co. Inc. | 0.00% | Reduce -25.2% | 187 | $7K |
| Arax Advisory Partners | 0.00% | Add +50.0% | 156 | $6K |
| Pacifica Partners Inc. | 0.00% | No change | 150 | $6K |
| Wealth Preservation Advisors, LLC | 0.00% | No change | 150 | $6K |
| Ameritas Advisory Services, LLC | 0.00% | New | 146 | $6K |
| Geneos Wealth Management Inc. | 0.00% | New | 139 | $5K |
| Golden State Wealth Management, LLC | 0.00% | No change | 126 | $5K |
| Spire Wealth Management | 0.00% | No change | 125 | $5K |
| GPS Wealth Strategies Group, LLC | 0.00% | No change | 119 | $5K |
| Bogart Wealth, LLC | 0.00% | Add +15.7% | 118 | $5K |
| MPWM Advisory Solutions, LLC | 0.00% | No change | 110 | $4K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Reduce -60.7% | 103 | $4K |
| Creekmur Asset Management LLC | 0.00% | No change | 100 | $4K |
| Meeder Asset Management Inc. | 0.00% | Add +4.2% | 99 | $4K |
| Semmax Financial Advisors Inc. | 0.00% | No change | 79 | $3K |
| Orion Capital Management LLC | 0.00% | No change | 80 | $3K |
| Assetmark, Inc. | 0.00% | Add +400.0% | 75 | $3K |
| Clear Investment Research, LLC | 0.00% | Add +39.2% | 71 | $3K |
| WPG Advisers, LLC | 0.00% | New | 70 | $3K |
| Private Wealth Management Group, LLC | 0.00% | Add +306.3% | 65 | $3K |
| Leonteq Securities AG | 0.00% | No change | 63 | $2K |
| Principal Securities, Inc. | 0.00% | Reduce -6.0% | 63 | $2K |
| Bell Investment Advisors, Inc | 0.00% | Reduce -14.1% | 61 | $2K |
| Asset Dedication, LLC | 0.00% | New | 59 | $2K |
| SouthState Bank Corp | 0.00% | Reduce -57.1% | 51 | $2K |
| Bessemer Group Inc. | 0.00% | Reduce -46.6% | 39 | $2K |
| Sachetta, LLC | 0.00% | Add +181.3% | 45 | $2K |
| CoreCap Advisors, LLC | 0.00% | Reduce -13.5% | 45 | $2K |
| TD Private Client Wealth LLC | 0.00% | New | 44 | $2K |
| Highline Wealth Partners LLC | 0.00% | No change | 38 | $2K |
| Rossby Financial, LCC | 0.00% | New | 34 | $1K |
| Cheviot Value Management, LLC | 0.00% | No change | 28 | $1K |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $1K |
| Hemington Wealth Management | 0.00% | Reduce -24.1% | 44 | $1K |
| Hantz Financial Services, Inc. | 0.00% | New | 36 | $1K |
| Principia Wealth Advisory, LLC | 0.00% | New | 25 | $988 |
| Bruce G. Allen Investments, LLC | 0.00% | Add +76.9% | 23 | $909 |
| TFC Financial Management, Inc. | 0.00% | No change | 21 | $830 |
| Key Financial Inc | 0.00% | No change | 19 | $751 |
| Cromwell Holdings LLC | 0.00% | New | 18 | $711 |
| Fortitude Family Office, LLC | 0.00% | New | 17 | $672 |
| Global Retirement Partners, LLC | 0.00% | — | 16 | $632 |
| Horizon Investments, LLC | 0.00% | New | 15 | $593 |
| Quaker Wealth Management, LLC | 0.00% | — | 14 | $554 |
| Mascoma Wealth Management LLC | 0.00% | No change | 14 | $553 |
| Cornerstone Planning Group LLC | 0.00% | New | 12 | $517 |
| Rothschild Investment LLC | 0.00% | New | 10 | $395 |
| Parkworth Wealth Management, Inc. | 0.00% | New | 8 | $316 |
| True Wealth Design, LLC | 0.00% | Reduce -46.1% | 7 | $277 |
| Kayne Anderson Rudnick Investment Management LLC | 0.00% | New | 7 | $277 |
| WealthTrak Capital Management LLC | 0.00% | New | 5 | $198 |
| IMA Advisory Services, Inc. | 0.00% | New | 5 | $198 |
| CIBC Private Wealth Group LLC | 0.00% | Reduce -93.3% | 2 | $79 |
| Truvestments Capital LLC | 0.00% | Reduce -97.5% | 1 | $30 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.