Ionis PharmaceuticalsIONS
13F holders, Q1 2026 (March 31)497holders +3
63new positions
63sold out
10famous investors
$75.12avg. 13F price*
At the end of Q1 2026, 497 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 3 from Q4 2025. 63 opened new positions and 63 sold out. The largest holders were FMR LLC ($1.8B), Capital World Investors ($1.6B) and BlackRock, Inc. ($784.1M). 10 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Israel Englander (0.1% of Millennium Management's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 63 | $196.7M |
| Exits | 63 | $129.4M |
All 13F filers, Q4 2025 → Q1 2026: 21,278,848 shares bought and 15,445,551 shares sold, net +5,833,297 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 497 holders
| FMR LLC | 0.10% | Add +2.0% | 24,556,637 | $1.8B |
| Capital World Investors | 0.22% | Add +18.0% | 21,186,369 | $1.6B |
| BlackRock, Inc. | 0.01% | Reduce -1.9% | 10,442,476 | $784.1M |
| Vanguard Portfolio Management LLC | 0.03% | — | 7,808,902 | $586.4M |
| Vanguard Capital Management LLC | 0.01% | — | 7,118,330 | $534.5M |
| Wellington Management Group LLP | 0.09% | Add +2.1% | 6,391,816 | $480.0M |
| T. Rowe Price Investment Management, Inc. | 0.32% | Reduce -32.4% | 6,159,027 | $462.5M |
| Two Sigma Investments, LP | 0.38% | Add +120.3% | 5,857,629 | $439.8M |
| Geode Capital Management, LLC | 0.02% | Add +26.5% | 3,984,332 | $305.2M |
| State Street Corp. | 0.01% | Add +0.5% | 3,995,564 | $300.0M |
| Royal Bank of Canada | 0.05% | Add +239.8% | 3,801,815 | $285.5M |
| T. Rowe Price Associates Inc. | 0.03% | Add +1.3% | 3,025,251 | $227.2M |
| JPMorgan Chase & Co. | 0.01% | Add +2.5% | 2,363,567 | $171.4M |
| Tweedy, Browne Co LLC | 13.57% | Reduce -7.7% | 2,275,625 | $170.9M |
| Artisan Partners Limited Partnership | 0.25% | Add +74.2% | 2,058,308 | $154.6M |
| Baker Bros. Advisors LP | 0.88% | Add +14.3% | 2,047,727 | $153.8M |
| Deerfield Management Company, L.P. | 2.07% | No change | 1,979,669 | $148.7M |
| Deep Track Capital, LP | 3.02% | Add +14.7% | 1,950,000 | $146.4M |
| Bellevue Group AG | 3.25% | Reduce -62.1% | 1,818,665 | $136.6M |
| Goldman Sachs Group Inc. | 0.02% | Add +98.6% | 1,699,847 | $127.6M |
| American Century Companies Inc. | 0.06% | Add +2.9% | 1,663,803 | $124.9M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +2.7% | 1,583,266 | $118.9M |
| Franklin Resources Inc. | 0.03% | Add +19.2% | 1,575,023 | $118.3M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Add +6.3% | 1,475,632 | $110.8M |
| Pictet Asset Management Holding SA | 0.11% | Add +1.2% | 1,434,995 | $107.1M |
| Summit Partners Public Asset Management, LLC | 4.88% | Reduce -4.0% | 1,404,033 | $105.4M |
| Invesco Ltd. | 0.01% | Add +0.6% | 1,277,358 | $95.9M |
| Millennium Management | 0.06% | Add +1027.5% | 1,051,506 | $79.0M |
| Morgan Stanley | 0.00% | Add +0.7% | 1,026,509 | $77.1M |
| Vanguard Fiduciary Trust Co. | 0.02% | — | 1,024,377 | $76.9M |
| Citadel Advisors | 0.05% | Reduce -55.9% | 942,534 | $70.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.08% | Reduce -32.9% | 907,533 | $68.1M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.15% | Reduce -18.8% | 874,089 | $65.6M |
| Northern Trust Corp. | 0.01% | Add +2.5% | 868,179 | $65.2M |
| Bank of America Corp. | 0.00% | Add +7.3% | 840,598 | $63.1M |
| Polar Capital Holdings Plc | 0.27% | Reduce -37.8% | 829,511 | $62.3M |
| Groupama Asset Managment | 0.91% | Add +7.5% | 824,540 | $61.9M |
| UBS Group AG | 0.01% | Reduce -22.6% | 808,443 | $60.7M |
| Nomura Asset Management International Inc. | 0.10% | Reduce -9.2% | 785,281 | $59.0M |
| GW&K Investment Management, LLC | 0.52% | Reduce -0.9% | 779,349 | $58.5M |
| Arrowstreet Capital, Limited Partnership | 0.03% | Reduce -30.6% | 737,859 | $55.4M |
| Squarepoint Ops LLC | 0.11% | Add +59.4% | 695,276 | $52.2M |
| Voloridge Investment Management, LLC | 0.20% | Add +15.0% | 672,858 | $50.5M |
| Massachusetts Financial Services Co. | 0.02% | Reduce -18.0% | 666,116 | $50.0M |
| Ameriprise Financial Inc. | 0.01% | Add +10.3% | 660,144 | $49.6M |
| Nuveen, LLC | 0.01% | Reduce -1.9% | 648,496 | $48.7M |
| Eversept Partners, LP | 3.13% | Add +17.4% | 632,100 | $47.5M |
| Eventide Asset Management, LLC | 0.71% | No change | 575,000 | $43.2M |
| TD Asset Management Inc | 0.03% | Reduce -31.5% | 529,954 | $39.8M |
| Teacher Retirement System of Texas | 0.16% | Add +23.9% | 523,932 | $39.3M |
| Bank of New York Mellon Corp | 0.01% | Reduce -4.3% | 514,617 | $38.6M |
| Perceptive Advisors LLC | 0.75% | New | 504,000 | $37.8M |
| Boone Capital Management LLC | 11.51% | Add +19.8% | 500,522 | $37.6M |
| Candriam S.C.A. | 0.19% | Reduce -28.6% | 484,053 | $36.3M |
| BNP Paribas Financial Markets | 0.02% | Add +43.3% | 479,460 | $36.0M |
| Alyeska Investment Group, L.P. | 0.10% | Reduce -1.8% | 473,150 | $35.5M |
| First Trust Advisors LP | 0.03% | Reduce -10.8% | 468,363 | $35.2M |
| Neuberger Berman Group LLC | 0.03% | Add +310.3% | 443,272 | $33.3M |
| Pinnacle Associates Ltd. | 0.42% | Reduce -5.5% | 436,457 | $32.8M |
| D. E. Shaw & Co. | 0.03% | Add +29.1% | 429,599 | $32.3M |
| Alliancebernstein L.P. | 0.01% | Add +17.2% | 400,669 | $31.7M |
| Davern Capital Partners, LP | 7.97% | Add +62.2% | 386,903 | $29.1M |
| C WorldWide Group Holding A/S | 0.59% | No change | 366,000 | $27.5M |
| New York State Common Retirement Fund | 0.04% | Add +44.9% | 350,414 | $26.3M |
| Capital Research Global Investors | 0.00% | New | 323,015 | $24.3M |
| Renaissance Technologies | 0.04% | Add +36.6% | 305,549 | $22.9M |
| Swiss National Bank | 0.01% | Add +2.0% | 304,500 | $22.9M |
| Hudson Bay Capital Management LP | 0.15% | Reduce -37.9% | 295,100 | $22.2M |
| Legal & General Group Plc | 0.01% | Reduce -9.4% | 294,679 | $22.1M |
| Privium Fund Management B.V. | 4.53% | Add +20.4% | 290,024 | $21.8M |
| Barclays PLC | 0.01% | Reduce -65.6% | 289,874 | $21.8M |
| ARK Investment Management | 0.17% | Reduce -31.7% | 288,716 | $21.7M |
| TimesSquare Capital Management, LLC | 0.35% | New | 275,674 | $20.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +51.8% | 267,215 | $20.1M |
| California Public Employees Retirement System | 0.01% | Add +19.7% | 255,485 | $19.2M |
| HRT Financial LP | 0.05% | Add +1000.2% | 252,250 | $18.9M |
| Zurich Insurance Group Ltd | 0.14% | Reduce -8.5% | 239,645 | $18.0M |
| DAVENPORT & Co LLC | 0.10% | Add +9.3% | 238,238 | $17.9M |
| J. Goldman & Co LP | 0.82% | Add +247.8% | 235,260 | $17.7M |
| Raymond James Financial Inc. | 0.01% | Reduce -8.6% | 235,121 | $17.7M |
| ExodusPoint Capital Management, LP | 0.17% | Add +170.7% | 227,084 | $17.1M |
| Orion Investment Co | 5.36% | Reduce -0.1% | 225,015 | $16.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.03% | Add +0.0% | 219,652 | $16.5M |
| Tocqueville Asset Management L.P. | 0.24% | Add +7.6% | 219,220 | $16.5M |
| Handelsbanken Fonder AB | 0.05% | Add +346.5% | 213,911 | $16.1M |
| Trexquant Investment LP | 0.12% | Add +61.6% | 213,645 | $16.0M |
| Jump Financial, LLC | 0.26% | New | 206,675 | $15.5M |
| Stifel Financial Corp. | 0.01% | Reduce -1.1% | 196,703 | $14.8M |
| Corient Private Wealth LP | 0.02% | Reduce -9.2% | 196,599 | $14.8M |
| Jane Street Group, LLC | 0.02% | Add +529.5% | 191,818 | $14.4M |
| Wells Fargo & Company | 0.00% | Reduce -32.2% | 189,853 | $14.3M |
| HSBC Holdings PLC | 0.01% | Add +590.3% | 185,967 | $14.0M |
| California State Teachers Retirement System | 0.01% | Add +22.4% | 176,485 | $13.3M |
| Rhumbline Advisers | 0.01% | Reduce -1.1% | 173,440 | $13.0M |
| Sector Gamma As | 3.00% | Reduce -8.4% | 169,468 | $12.7M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0.01% | No change | 167,657 | $12.6M |
| Focus Partners Wealth | 0.01% | Reduce -8.9% | 165,544 | $12.4M |
| ADAR1 Capital Management, LLC | 0.73% | Add +9.0% | 160,338 | $12.0M |
| Deutsche Bank AG | 0.00% | Add +7.0% | 159,891 | $12.0M |
| Sicart Associates LLC | 3.08% | Reduce -2.5% | 159,412 | $12.0M |
| Sei Investments Co. | 0.01% | Add +35.6% | 157,222 | $11.8M |
| CenterBook Partners LP | 0.61% | Reduce -2.0% | 150,912 | $11.3M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -2.4% | 149,538 | $11.2M |
| Aquatic Capital Management LLC | 0.32% | Add +11.0% | 147,379 | $11.1M |
| Citigroup Inc. | 0.01% | Add +64.0% | 146,541 | $11.0M |
| Artia Global Partners LP | 2.44% | No change | 144,376 | $10.8M |
| Capital Fund Management S.A. | 0.10% | New | 142,201 | $10.7M |
| Fisher Asset Management | 0.00% | Reduce -0.1% | 141,544 | $10.6M |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.01% | — | 137,507 | $10.3M |
| Edmond DE Rothschild Holding S.A. | 0.15% | Add +12.3% | 137,190 | $10.3M |
| State Board of Administration of Florida Retirement System | 0.02% | No change | 135,878 | $10.2M |
| Engineers Gate Manager LP | 0.13% | Add +503.1% | 133,827 | $10.0M |
| Braidwell LP | 0.37% | New | 130,862 | $9.8M |
| Ikarian Capital, LLC | 1.36% | Reduce -37.1% | 127,038 | $9.5M |
| Atle Fund Management AB | 3.03% | Reduce -69.8% | 27,873 | $9.4M |
| Integral Health Asset Management, LLC | 0.50% | New | 125,000 | $9.4M |
| Great Lakes Advisors, LLC | 0.07% | Reduce -20.3% | 118,926 | $8.9M |
| Algert Global LLC | 0.13% | Reduce -8.4% | 116,563 | $8.8M |
| SEB Asset Management AB | 0.04% | — | 114,334 | $8.6M |
| Nomura Holdings Inc. | 0.07% | Reduce -86.6% | 114,080 | $8.6M |
| Aberdeen Group plc | 0.01% | Add +293.6% | 113,843 | $8.5M |
| Kennedy Capital Management LLC | 0.18% | Add +2.3% | 111,830 | $8.4M |
| Exome Asset Management LLC | 4.86% | Reduce -5.5% | 110,064 | $8.3M |
| Victory Capital Management Inc. | 0.01% | Add +34.7% | 108,744 | $8.2M |
| WINTON GROUP Ltd | 0.28% | New | 106,532 | $8.0M |
| Empowered Funds, LLC | 0.05% | New | 103,141 | $7.7M |
| Gotham Asset Management | 0.02% | Add +129.0% | 98,968 | $7.4M |
| State of Wisconsin Investment Board | 0.02% | Add +1.8% | 96,491 | $7.2M |
| Susquehanna Portfolio Strategies, LLC | 0.11% | No change | 95,960 | $7.2M |
| Marshall Wace, LLP | 0.01% | Reduce -62.6% | 95,954 | $7.2M |
| EFG International AG | 0.15% | Add +24.9% | 93,980 | $7.1M |
| Envestnet Asset Management Inc. | 0.00% | Add +3.9% | 93,382 | $7.0M |
| Rhenman & Partners Asset Management AB | 0.86% | Reduce -41.4% | 92,900 | $7.0M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $6.9M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -12.7% | 81,876 | $6.1M |
| Amova Asset Management Americas, Inc. | 0.09% | Reduce -12.7% | 81,696 | $6.1M |
| XTX Topco Ltd | 0.11% | Add +376.0% | 80,519 | $6.0M |
| CSS LLC | 0.94% | New | 79,093 | $5.9M |
| China Universal Asset Management Co., Ltd. | 0.44% | Add +82.4% | 77,315 | $5.8M |
| Boothbay Fund Management, LLC | 0.14% | Add +1.3% | 76,571 | $5.7M |
| Lisanti Capital Growth, LLC | 1.43% | Add +130.9% | 75,699 | $5.7M |
| Vanguard Global Advisers, LLC | 0.00% | — | 71,911 | $5.4M |
| Hillsdale Investment Management Inc. | 0.14% | No change | 70,900 | $5.3M |
| Erste Asset Management GmbH | 0.05% | No change | 71,800 | $5.2M |
| Voya Investment Management LLC | 0.01% | Reduce -6.3% | 69,136 | $5.2M |
| Edgestream Partners, L.P. | 0.17% | New | 68,369 | $5.1M |
| Janus Henderson Group PLC | 0.00% | No change | 68,191 | $5.1M |
| Treasurer of the State of North Carolina | 0.02% | Add +2.2% | 67,701 | $5.1M |
| Police & Firemen's Retirement System of New Jersey | 0.04% | Add +0.7% | 67,323 | $5.1M |
| Walleye Capital LLC | 0.03% | Add +20192.0% | 65,949 | $5.0M |
| SG Americas Securities, LLC | 0.01% | Add +89.5% | 63,295 | $4.8M |
| Russell Investments Group, Ltd. | 0.01% | Add +43.3% | 62,919 | $4.7M |
| Orion Porfolio Solutions, LLC | 0.04% | Add +160.2% | 61,344 | $4.6M |
| Polymer Capital Management (HK) LTD | 0.64% | New | 61,200 | $4.6M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -18.5% | 60,308 | $4.5M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.01% | Add +23.1% | 60,239 | $4.5M |
| Jefferies Financial Group Inc. | 0.06% | Add +17.2% | 59,065 | $4.4M |
| One Capital Management, LLC | 0.12% | Add +27.8% | 58,939 | $4.4M |
| Future Fund LLC | 1.55% | Add +28.1% | 58,732 | $4.4M |
| Panagora Asset Management Inc. | 0.02% | New | 57,446 | $4.3M |
| DCF Advisers, LLC | 1.59% | Reduce -45.6% | 56,000 | $4.2M |
| Quantinno Capital Management LP | 0.01% | Add +17.1% | 55,502 | $4.2M |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 0.14% | Reduce -55.4% | 54,269 | $4.1M |
| Carmignac Gestion | 0.06% | New | 53,000 | $4.0M |
| State of New Jersey Common Pension Fund D | 0.02% | Reduce -4.0% | 52,588 | $3.9M |
| Creative Planning | 0.00% | Reduce -4.7% | 52,228 | $3.9M |
| Nicola Wealth Management LTD. | 0.47% | Reduce -40.2% | 52,000 | $3.9M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | Reduce -64.3% | 50,000 | $3.8M |
| Capital Counsel LLC | 0.16% | Reduce -0.1% | 49,580 | $3.7M |
| Tudor Investment Corporation | 0.02% | Add +1217.8% | 48,244 | $3.6M |
| E Fund Management Co., Ltd. | 0.10% | — | 46,688 | $3.5M |
| Public Employees Retirement System of Ohio | 0.01% | Reduce -3.3% | 46,030 | $3.5M |
| Ensign Peak Advisors, Inc | 0.01% | Reduce -14.3% | 46,004 | $3.5M |
| Baron Capital (BAMCO) | 0.01% | Add +25.0% | 45,000 | $3.4M |
| West Michigan Advisors, LLC | 0.74% | Add +16.1% | 44,614 | $3.4M |
| Guggenheim Capital LLC | 0.03% | Add +16.8% | 44,050 | $3.3M |
| Qube Research & Technologies Ltd | 0.00% | New | 42,856 | $3.2M |
| Arizona State Retirement System | 0.02% | Reduce -0.4% | 42,266 | $3.2M |
| Tetragon Partners GP Ltd | 0.62% | New | 41,764 | $3.1M |
| Stanley-Laman Group, Ltd. | 0.36% | Add +7.7% | 39,306 | $3.0M |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 4.35% | Add +55.9% | 38,988 | $2.9M |
| Vanguard Investments Australia, Ltd. | 0.01% | — | 38,557 | $2.9M |
| Intech Investment Management LLC | 0.03% | Add +301.1% | 38,515 | $2.9M |
| Grandfield & Dodd, LLC | 0.16% | Reduce -1.3% | 37,326 | $2.8M |
| Prudential Financial Inc. | 0.00% | Add +46.9% | 35,268 | $2.6M |
| BLB&B Advisors, LLC | 0.11% | Reduce -42.8% | 35,170 | $2.6M |
| Raiffeisen Bank International AG | 0.04% | Add +2.9% | 36,000 | $2.6M |
| Van Eck Associates Corp. | 0.00% | Reduce -26.7% | 34,505 | $2.6M |
| PEAK6 LLC | 0.07% | Add +12.3% | 34,419 | $2.6M |
| Exchange Traded Concepts, LLC | 0.02% | Add +60.9% | 33,941 | $2.5M |
| KLP Kapitalforvaltning As | 0.01% | Add +1.2% | 33,900 | $2.5M |
| Blair William & Co. | 0.01% | Add +0.2% | 33,857 | $2.5M |
| Assenagon Asset Management S.A. | 0.00% | Add +14.9% | 33,673 | $2.5M |
| Tidal Investments LLC | 0.01% | Add +92.3% | 34,432 | $2.5M |
| Pathstone Holdings, LLC | 0.01% | Reduce -4.3% | 32,835 | $2.5M |
| Swedbank AB | 0.00% | Add +18.4% | 32,253 | $2.4M |
| LPL Financial LLC | 0.00% | Add +2.8% | 31,932 | $2.4M |
| KBC Group NV | 0.01% | Add +233.8% | 30,213 | $2.3M |
| Prelude Capital Management, LLC | 0.17% | Reduce -8.7% | 29,658 | $2.2M |
| Kornitzer Capital Management Inc. | 0.05% | No change | 29,105 | $2.2M |
| AQR Capital Management | 0.00% | Add +53.4% | 28,783 | $2.2M |
| STRS Ohio | 0.01% | Add +659.8% | 28,782 | $2.2M |
| Fred Alger Management, LLC | 0.01% | Reduce -25.9% | 28,452 | $2.1M |
| Mutual of America Capital Management LLC | 0.02% | Reduce -10.6% | 28,126 | $2.1M |
| Worldquant Millennium Advisors LLC | 0.01% | Add +60.4% | 27,924 | $2.1M |
| DeepCurrents Investment Group LLC | 5.64% | New | 27,422 | $2.1M |
| Entropy Technologies, LP | 0.09% | New | 27,207 | $2.0M |
| Bank of Montreal | 0.00% | Reduce -26.9% | 26,585 | $2.0M |
| Stempoint Capital LP | 0.38% | New | 26,385 | $2.0M |
| Xponance LLC | 0.01% | Add +15.0% | 26,384 | $2.0M |
| Profund Advisors LLC | 0.07% | Reduce -1.4% | 26,287 | $2.0M |
| Jain Global LLC | 0.03% | Reduce -92.6% | 26,285 | $2.0M |
| Florida Financial Advisors, LLC | 0.47% | New | 25,886 | $1.9M |
| Qsemble Capital Management, LP | 0.15% | Reduce -6.6% | 25,758 | $1.9M |
| Jones Financial Companies LLLP | 0.00% | Add +312.2% | 26,723 | $1.9M |
| Lazard Asset Management LLC | 0.00% | Reduce -45.2% | 25,410 | $1.9M |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 24,083 | $1.8M |
| Man Group plc | 0.00% | Reduce -85.5% | 24,013 | $1.8M |
| Amundi | 0.00% | Reduce -94.8% | 23,958 | $1.8M |
| Natixis Advisors, LLC | 0.00% | Add +8.4% | 23,721 | $1.8M |
| Voleon Capital Management LP | 0.04% | Add +437.5% | 23,047 | $1.7M |
| Wolverine Asset Management LLC | 0.09% | Reduce -25.2% | 22,815 | $1.7M |
| CANADA LIFE ASSURANCE Co | 0.00% | Add +5.9% | 22,135 | $1.7M |
| Informed Momentum Co LLC | 0.18% | Reduce -61.8% | 20,608 | $1.5M |
| Allstate Corp. | 0.02% | New | 20,565 | $1.5M |
| Readystate Asset Management LP | 0.16% | New | 20,436 | $1.5M |
| Landscape Capital Management, L.L.C. | 0.10% | Reduce -16.6% | 20,146 | $1.5M |
| Legato Capital Management LLC | 0.14% | Add +222.3% | 19,840 | $1.5M |
| Calamos Advisors LLC | 0.01% | Reduce -40.4% | 19,781 | $1.5M |
| FORA Capital, LLC | 0.11% | New | 19,693 | $1.5M |
| Nicollet Investment Management, Inc. | 0.51% | Reduce -4.3% | 19,646 | $1.5M |
| AlphaCentric Advisors LLC | 1.47% | Add +5.7% | 19,587 | $1.5M |
| DNB Asset Management AS | 0.01% | Add +28.4% | 19,060 | $1.4M |
| Dana Investment Advisors, Inc. | 0.04% | Add +2.6% | 18,487 | $1.4M |
| Inceptionr LLC | 0.30% | Reduce -5.8% | 16,821 | $1.3M |
| North Star Asset Management Inc. | 0.05% | No change | 16,610 | $1.2M |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 15,589 | $1.2M |
| Caption Management, LLC | 0.06% | New | 15,591 | $1.2M |
| Brown Advisory Inc. | 0.00% | Add +0.9% | 15,105 | $1.1M |
| LMR Partners LLP | 0.01% | No change | 15,000 | $1.1M |
| M&G PLC | 0.01% | No change | 14,423 | $1.1M |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.08% | Reduce -5.1% | 14,389 | $1.1M |
| Bleakley Financial Group, LLC | 0.02% | Add +3.2% | 14,316 | $1.1M |
| Canada Pension Plan Investment Board | 0.00% | New | 14,100 | $1.1M |
| Dynasty Wealth Management, LLC | 0.01% | Add +0.6% | 14,080 | $1.1M |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -2.0% | 13,545 | $1.0M |
| Westmount Partners, LLC | 0.24% | No change | 12,961 | $973K |
| Truist Financial Corp. | 0.00% | Add +1.5% | 12,846 | $965K |
| Highland Capital Management, LLC | 0.05% | New | 12,819 | $963K |
| Annis Gardner Whiting Capital Advisors, LLC | 0.15% | No change | 12,801 | $961K |
| Allianz Asset Management GmbH | 0.00% | Reduce -24.6% | 12,601 | $946K |
| Susquehanna International Group, LLP | 0.00% | Reduce -62.0% | 12,359 | $928K |
| SBI Okasan Asset Management Co.Ltd. | 0.04% | No change | 12,600 | $914K |
| Amalgamated Bank | 0.01% | Reduce -3.2% | 12,054 | $905K |
| Oppenheimer Asset Management Inc. | 0.01% | Add +5.2% | 11,853 | $890K |
| Summit Trail Advisors, LLC | 0.01% | Add +16.1% | 11,549 | $867K |
| Horizon Kinetics Asset Management LLC | 0.01% | Reduce -4.4% | 11,428 | $858K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Reduce -8.4% | 11,414 | $857K |
| Cetera Investment Advisers | 0.00% | Add +3.9% | 11,280 | $847K |
| Plancorp, LLC | 0.02% | No change | 11,208 | $843K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -7.3% | 11,123 | $835K |
| Capstone Capital Management Ltd | 0.84% | New | 21,447 | $832K |
| Fifth Third Bancorp | 0.00% | Add +39.6% | 11,011 | $827K |
| &partners | 0.00% | Add +12.2% | 10,909 | $819K |
| Montanova Capital, LLC | 0.02% | No change | 10,800 | $811K |
| Virtus Investment Advisers, LLC | 0.22% | Add +23.6% | 10,445 | $784K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | Reduce -2.8% | 10,300 | $773K |
| Federation des caisses Desjardins du Quebec | 0.00% | Reduce -20.3% | 10,005 | $751K |
| Thrivent Financial for Lutherans | 0.00% | No change | 9,962 | $748K |
| Assetmark, Inc. | 0.00% | Add +10.7% | 9,574 | $719K |
| Vident Advisory, LLC | 0.01% | Reduce -7.3% | 9,489 | $713K |
| MetLife Investment Management, LLC | 0.00% | Reduce -4.7% | 9,224 | $693K |
| Swiss Life Asset Management Ltd | 0.00% | Add +32.9% | 9,175 | $689K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +9.2% | 9,029 | $678K |
| Aigen Investment Management, LP | 0.17% | Reduce -0.8% | 8,790 | $660K |
| Osaic Holdings, Inc. | 0.00% | Reduce -25.2% | 8,710 | $654K |
| Savant Capital, LLC | 0.00% | Add +17.7% | 8,461 | $635K |
| denkapparat Operations GmbH | 0.26% | No change | 8,364 | $628K |
| Utah Retirement Systems | 0.01% | No change | 8,300 | $623K |
| Sectoral Asset Management Inc. | 0.51% | Reduce -13.9% | 7,200 | $617K |
| Commerce Bank | 0.00% | Add +0.7% | 8,165 | $613K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -33.7% | 7,829 | $588K |
| Stratos Wealth Partners, LTD. | 0.01% | Reduce -0.3% | 7,715 | $579K |
| O'shaughnessy Asset Management, LLC | 0.00% | Add +9.3% | 7,687 | $577K |
| M&T Bank Corp | 0.00% | Reduce -5.9% | 7,671 | $575K |
| Cerity Partners LLC | 0.00% | Reduce -68.3% | 7,596 | $570K |
| Fiduciary Trust Co | 0.01% | No change | 7,399 | $556K |
| ProShare Advisors LLC | 0.00% | Add +3.3% | 7,390 | $555K |
| Maryland State Retirement & Pension System | 0.01% | Reduce -10.9% | 7,380 | $554K |
| Ground Swell Capital, LLC | 1.13% | New | 7,285 | $547K |
| Meeder Advisory Services, Inc. | 0.02% | Add +1.2% | 7,239 | $544K |
| Callan Family Office, LLC | 0.01% | Reduce -0.3% | 7,082 | $532K |
| Silvercrest Asset Management Group LLC | 0.00% | Reduce -2.6% | 7,053 | $530K |
| Principal Financial Group Inc. | 0.00% | Add +110.2% | 7,019 | $527K |
| PSP Research LLC | 0.36% | No change | 6,800 | $511K |
| Significant Wealth Partners LLC | 0.62% | Reduce -1.5% | 6,664 | $500K |
| Wedmont Private Capital | 0.02% | Add +18.6% | 6,564 | $492K |
| J. Safra Sarasin Holding AG | 0.01% | Reduce -63.0% | 6,431 | $483K |
| Mercer Global Advisors Inc. | 0.00% | Add +13.4% | 6,296 | $473K |
| Praxis Investment Management Inc. | 0.03% | Reduce -8.0% | 6,232 | $468K |
| Regions Financial Corp. | 0.00% | Add +0.5% | 6,122 | $460K |
| Cypress Capital, LLC | 0.13% | Reduce -40.0% | 6,000 | $451K |
| Frank, Rimerman Advisors LLC | 0.03% | No change | 5,781 | $434K |
| Tema ETFs LLC | 0.03% | Reduce -33.7% | 5,673 | $426K |
| Robeco Institutional Asset Management B.V. | 0.00% | New | 5,660 | $425K |
| Coldstream Capital Management Inc. | 0.01% | Reduce -14.6% | 5,653 | $424K |
| Cynosure Group, LLC | 0.05% | New | 5,614 | $422K |
| Mesirow Financial Investment Management, Inc. | 0.01% | New | 5,460 | $410K |
| OneDigital Investment Advisors LLC | 0.00% | Add +7.7% | 5,390 | $405K |
| Granite Investment Partners, LLC | 0.02% | Add +11.2% | 5,345 | $401K |
| Virtu Financial LLC | 0.02% | New | 5,342 | $401K |
| Vontobel Holding Ltd. | 0.00% | No change | 5,240 | $393K |
| Atria Investments, Inc | 0.00% | Reduce -7.6% | 5,227 | $392K |
| US Bancorp \de | 0.00% | Reduce -1.8% | 5,047 | $379K |
| CIBC Asset Management Inc | 0.00% | No change | 5,017 | $377K |
| Moisand Fitzgerald Tamayo, LLC | 0.04% | No change | 5,000 | $375K |
| Captrust Financial Advisors | 0.00% | Reduce -5.5% | 5,000 | $375K |
| Lighthouse Investment Partners, LLC | 0.01% | Reduce -62.0% | 4,970 | $373K |
| Farallon Capital Management, L.L.C. | 0.00% | No change | 4,800 | $360K |
| NewEdge Advisors, LLC | 0.00% | Reduce -3.1% | 4,786 | $359K |
| North Dakota State Investment Board | 0.01% | Reduce -15.6% | 4,623 | $347K |
| Vise Technologies, Inc. | 0.01% | No change | 4,305 | $341K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +36.9% | 4,466 | $335K |
| Checchi Capital Advisers, LLC | 0.02% | Add +3.7% | 4,429 | $333K |
| Credit Agricole S A | 0.00% | No change | 4,410 | $331K |
| Kestra Advisory Services, LLC | 0.00% | Reduce -1.8% | 4,372 | $328K |
| R Squared Ltd | 0.18% | New | 4,359 | $327K |
| Prospera Financial Services Inc | 0.01% | Reduce -8.8% | 4,341 | $326K |
| Pinnacle Wealth Planning Services, Inc. | 0.03% | Add +9.0% | 4,213 | $316K |
| Rockefeller Capital Management L.P. | 0.00% | Add +52.4% | 4,155 | $312K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -1.4% | 4,273 | $310K |
| Inspire Advisors, LLC | 0.03% | Reduce -15.1% | 4,120 | $309K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -50.0% | 4,125 | $309K |
| Intrust Bank NA | 0.02% | New | 4,056 | $305K |
| Optas, LLC | 0.05% | New | 4,034 | $303K |
| Prime Capital Investment Advisors, LLC | 0.00% | Reduce -0.3% | 3,971 | $298K |
| Congress Asset Management Co. | 0.00% | New | 3,946 | $296K |
| Sanctuary Advisors, LLC | 0.00% | Reduce -13.0% | 3,918 | $294K |
| Axq Capital, LP | 0.04% | New | 3,846 | $289K |
| HighTower Advisors, LLC | 0.00% | Reduce -25.9% | 3,797 | $285K |
| Mackenzie Financial Corp. | 0.00% | Reduce -2.5% | 3,795 | $285K |
| Anb Bank | 0.11% | Add +18.0% | 3,769 | $283K |
| Cwm, LLC | 0.00% | Reduce -26.4% | 3,717 | $279K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +240.4% | 3,639 | $273K |
| Berkshire Asset Management LLC | 0.01% | Add +0.2% | 3,637 | $273K |
| GF Fund Management Co. LTD. | 0.00% | Add +14.3% | 3,637 | $273K |
| Marex Group Ltd | 0.00% | Add +2.4% | 3,610 | $271K |
| Westfield Capital Management Co. LP | 0.00% | Add +10.9% | 3,502 | $263K |
| Everhart Financial Group, Inc. | 0.02% | Add +0.1% | 3,470 | $261K |
| Perigon Wealth Management, LLC | 0.00% | New | 3,430 | $258K |
| Eurizon Capital SGR S.p.A. | 0.00% | Add +6.0% | 3,514 | $256K |
| Mitchell & Pahl Private Wealth, LLC | 0.10% | Reduce -3.5% | 3,261 | $245K |
| Nwam LLC | 0.01% | No change | 3,238 | $243K |
| Crossmark Global Holdings, Inc. | 0.00% | Add +3.1% | 3,199 | $240K |
| MML Investors Services, LLC | 0.00% | Reduce -2.8% | 3,173 | $238K |
| Gsa Capital Partners LLP | 0.01% | New | 3,172 | $238K |
| Raab & Moskowitz Asset Management LLC | 0.05% | No change | 3,115 | $234K |
| Campbell & CO Investment Adviser LLC | 0.01% | Add +11.4% | 3,101 | $233K |
| QRG Capital Management, Inc. | 0.00% | New | 3,094 | $232K |
| Venturi Wealth Management, LLC | 0.01% | No change | 3,061 | $230K |
| Larson Financial Group LLC | 0.01% | Add +29.5% | 3,031 | $228K |
| Argent Trust Co | 0.01% | No change | 3,018 | $227K |
| EntryPoint Capital, LLC | 0.07% | New | 2,963 | $222K |
| HB Wealth Management, LLC | 0.00% | Add +0.1% | 2,926 | $220K |
| Norden Group LLC | 0.02% | Reduce -1.6% | 2,889 | $217K |
| Cambria Investment Management, L.P. | 0.01% | Reduce -21.7% | 2,885 | $217K |
| B. Riley Wealth Advisors, Inc. | 0.01% | Reduce -1.0% | 2,945 | $214K |
| Blueshift Asset Management, LLC | 0.06% | Reduce -73.4% | 2,777 | $209K |
| AlphaCore Capital LLC | 0.00% | New | 2,762 | $207K |
| Integrated Wealth Concepts LLC | 0.00% | New | 2,724 | $205K |
| Montis Financial, LLC | 0.04% | No change | 2,700 | $203K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Reduce -2.1% | 2,693 | $202K |
| New York Life Investment Management LLC | 0.00% | New | 2,688 | $202K |
| Fideuram Asset Management (Ireland) dac | 0.02% | New | 2,213 | $182K |
| Ancora Advisors LLC | 0.00% | Add +2.1% | 2,391 | $180K |
| Signaturefd, LLC | 0.00% | Add +1.8% | 2,078 | $156K |
| Group One Trading LLC | 0.00% | Reduce -49.9% | 1,892 | $142K |
| Farther Finance Advisors, LLC | 0.00% | Add +57.0% | 1,883 | $141K |
| Parallel Advisors, LLC | 0.00% | Add +0.1% | 1,883 | $141K |
| Advisors Asset Management, Inc. | 0.00% | Reduce -33.8% | 1,878 | $141K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +57.8% | 1,794 | $135K |
| GAMMA Investing LLC | 0.01% | Add +1.9% | 1,766 | $133K |
| Versant Capital Management, Inc | 0.01% | Add +3.9% | 1,555 | $117K |
| Sterling Capital Management LLC | 0.00% | Reduce -16.8% | 1,425 | $107K |
| Smartleaf Asset Management LLC | 0.00% | Add +2.0% | 1,416 | $103K |
| International Assets Investment Management, LLC | 0.01% | Add +0.3% | 1,221 | $92K |
| Stephens Inc. | 0.00% | New | 26,761 | $91K |
| Sunbelt Securities, Inc. | 0.00% | No change | 1,014 | $76K |
| IFP Advisors, Inc | 0.00% | Reduce -6.3% | 950 | $71K |
| MAI Capital Management | 0.00% | Add +4.4% | 940 | $71K |
| Los Angeles Capital Management LLC | 0.00% | No change | 700 | $53K |
| Root Financial Partners, LLC | 0.00% | Reduce -49.1% | 681 | $51K |
| Huntington National Bank | 0.00% | Reduce -2.0% | 681 | $51K |
| Quadrant Capital Group LLC | 0.00% | No change | 616 | $46K |
| Advisory Services Network, LLC | 0.00% | New | 604 | $45K |
| Archer Investment Corp | 0.01% | No change | 600 | $45K |
| AdvisorNet Financial, Inc | 0.00% | Reduce -6.5% | 573 | $43K |
| Harbour Investments, Inc. | 0.00% | Add +139.5% | 546 | $41K |
| Allworth Financial LP | 0.00% | Reduce -43.3% | 522 | $39K |
| Bayforest Capital Ltd | 0.03% | Reduce -62.1% | 413 | $31K |
| Mather Group, Llc. | 0.00% | New | 410 | $31K |
| Ascentis Wealth Management, LLC | 0.01% | No change | 400 | $30K |
| Cassaday & Co Wealth Management LLC | 0.00% | New | 400 | $30K |
| Golden State Wealth Management, LLC | 0.00% | No change | 376 | $28K |
| Destiny Wealth Partners, LLC | 0.00% | New | 375 | $28K |
| Employees Retirement System of Texas | 0.00% | Reduce -72.1% | 378 | $28K |
| CoreCap Advisors, LLC | 0.00% | No change | 370 | $28K |
| Hilton Head Capital Partners, LLC | 0.01% | Reduce -41.1% | 353 | $27K |
| Brown Brothers Harriman & Co. | 0.00% | No change | 341 | $26K |
| Wellington-Altus USA Inc. | 0.01% | Reduce -9.7% | 317 | $25K |
| Salomon & Ludwin, LLC | 0.00% | No change | 332 | $25K |
| Sound Income Strategies, LLC | 0.00% | Add +4.9% | 300 | $23K |
| Eastern Bank | 0.00% | No change | 300 | $23K |
| Steigerwald, Gordon & Koch Inc. | 0.00% | Reduce -22.4% | 295 | $22K |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 295 | $22K |
| Lanark Financial, Inc. | 0.00% | No change | 273 | $20K |
| Parkside Financial Bank & Trust | 0.00% | Add +3.2% | 258 | $19K |
| MTM Investment Management, LLC | 0.01% | No change | 258 | $19K |
| Harvest Fund Management Co., Ltd | 0.00% | Reduce -95.1% | 234 | $18K |
| Westside Investment Management, Inc. | 0.00% | No change | 231 | $17K |
| Cedar Mountain Advisors, LLC | 0.00% | New | 223 | $17K |
| Aster Capital Management (DIFC) Ltd | 0.01% | Add +3566.7% | 550 | $17K |
| Global Trust Asset Management, LLC | 0.01% | No change | 218 | $16K |
| Twin Peaks Wealth Advisors, LLC | 0.00% | New | 215 | $16K |
| UMB Bank, n.a. | 0.00% | Add +0.5% | 215 | $16K |
| Elequin Capital, LP | 0.00% | Reduce -70.8% | 208 | $16K |
| MH & Associates Securities Management Corp. | 0.01% | No change | 200 | $15K |
| Atlantic Union Bankshares Corp | 0.00% | No change | 200 | $15K |
| CX Institutional | 0.00% | New | 202 | $15K |
| E Fund Management (Hong Kong) Co., Ltd. | 0.01% | New | 195 | $15K |
| Covestor Ltd | 0.01% | Reduce -33.3% | 182 | $14K |
| Basecamp Wealth Advisors LLC | 0.00% | No change | 185 | $14K |
| Zions Bancorporation, National Association | 0.00% | Reduce -5.8% | 177 | $13K |
| Owl Creek Wealth Partners LLC | 0.00% | — | 170 | $13K |
| FIL Ltd | 0.00% | Add +251.1% | 165 | $12K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -43.7% | 161 | $12K |
| United Financial Planning Group LLC | 0.01% | Add +1875.0% | 158 | $12K |
| Meeder Asset Management Inc. | 0.00% | Reduce -78.8% | 152 | $11K |
| Wealth Preservation Advisors, LLC | 0.01% | No change | 150 | $11K |
| Strategic Wealth Partners, Ltd. | 0.00% | No change | 150 | $11K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Add +57.1% | 143 | $11K |
| Global X Japan Co., Ltd. | 0.00% | Reduce -25.1% | 128 | $10K |
| Spire Wealth Management | 0.00% | No change | 125 | $9K |
| Bogart Wealth, LLC | 0.00% | Reduce -3.9% | 123 | $9K |
| LRI Investments, LLC | 0.00% | No change | 110 | $8K |
| Main Street Group, LTD | 0.00% | New | 100 | $8K |
| Danske Bank A/S | 0.00% | Reduce -92.9% | 100 | $8K |
| Quent Capital, LLC | 0.00% | No change | 99 | $7K |
| Bessemer Group Inc. | 0.00% | Reduce -29.3% | 94 | $7K |
| Keating Financial Advisory Services, Inc. | 0.00% | Add +462.5% | 90 | $7K |
| Orion Capital Management LLC | 0.00% | No change | 80 | $6K |
| TD Private Client Wealth LLC | 0.00% | Reduce -2.4% | 80 | $6K |
| Rossby Financial, LCC | 0.00% | Add +51.0% | 74 | $6K |
| Leonteq Securities AG | 0.00% | Add +15.9% | 73 | $5K |
| Clear Investment Research, LLC | 0.01% | New | 71 | $5K |
| WPG Advisers, LLC | 0.00% | No change | 70 | $5K |
| Private Wealth Management Group, LLC | 0.00% | No change | 65 | $5K |
| Bell Investment Advisors, Inc | 0.00% | No change | 61 | $5K |
| First Horizon Corp. | 0.00% | Add +124.0% | 56 | $4K |
| MCF Advisors LLC | 0.00% | New | 50 | $4K |
| Triumph Capital Management | 0.00% | No change | 50 | $4K |
| Crewe Advisors LLC | 0.00% | No change | 48 | $4K |
| TD Waterhouse Canada Inc. | 0.00% | New | 48 | $4K |
| Horizon Investments, LLC | 0.00% | Add +118.2% | 48 | $4K |
| Sachetta, LLC | 0.00% | No change | 45 | $3K |
| Hantz Financial Services, Inc. | 0.00% | No change | 36 | $3K |
| Highline Wealth Partners LLC | 0.00% | No change | 38 | $3K |
| Transamerica Financial Advisors, LLC | 0.00% | New | 33 | $2K |
| Principia Wealth Advisory, LLC | 0.00% | Add +23.1% | 32 | $2K |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $2K |
| Cheviot Value Management, LLC | 0.00% | No change | 28 | $2K |
| IMA Advisory Services, Inc. | 0.00% | Add +460.0% | 28 | $2K |
| Bruce G. Allen Investments, LLC | 0.00% | No change | 23 | $2K |
| TFC Financial Management, Inc. | 0.00% | No change | 21 | $2K |
| Aspect Partners, LLC | 0.00% | No change | 20 | $2K |
| NBT Bank, N.A. | 0.00% | New | 20 | $2K |
| Cromwell Holdings LLC | 0.00% | No change | 18 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 17 | $1K |
| Quaker Wealth Management, LLC | 0.00% | Add +7.1% | 15 | $1K |
| Cornerstone Financial Management LLC | 0.00% | No change | 15 | $1K |
| Whipplewood Advisors, LLC | 0.00% | New | 15 | $1K |
| SouthState Bank Corp | 0.00% | No change | 14 | $1K |
| Mascoma Wealth Management LLC | 0.00% | No change | 14 | $1K |
| Rothschild Investment LLC | 0.00% | Reduce -31.6% | 13 | $976 |
| Clearstead Advisors, LLC | 0.00% | Reduce -20.0% | 12 | $902 |
| Cornerstone Planning Group LLC | 0.00% | Add +100.0% | 10 | $753 |
| American Capital Advisory, LLC | 0.00% | Add +250.0% | 7 | $526 |
| Essential Partners LLC | 0.00% | No change | 7 | $526 |
| Caitong International Asset Management Co., Ltd | 0.00% | New | 7 | $526 |
| True Wealth Design, LLC | 0.00% | No change | 7 | $526 |
| Kayne Anderson Rudnick Investment Management LLC | 0.00% | No change | 7 | $526 |
| Hughes Financial Services, LLC | 0.00% | New | 6 | $451 |
| Manchester Capital Management LLC | 0.00% | No change | 5 | $376 |
| Dunhill Financial, LLC | 0.00% | Reduce -33.3% | 2 | $201 |
| 3 Factor Indexing, LLC | 0.00% | — | 2 | $151 |
| Nisa Investment Advisors, LLC | 0.00% | No change | 1 | $75 |
| Truvestments Capital LLC | 0.00% | No change | 1 | $56 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.