Krystal BiotechKRYS

13F holders, Q2 2025 (June 30)
275holders −24
40new positions
63sold out
5famous investors
$137.49avg. 13F price*

At the end of Q2 2025, 275 institutions reported holding Krystal Biotech Inc. (KRYS) in their 13F filings, down 24 from Q1 2025. 40 opened new positions and 63 sold out. The largest holders were FMR LLC ($595.9M), BlackRock, Inc. ($528.6M) and Vanguard Group Inc. ($388.0M). 5 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).

Company
Krystal Biotech Inc.
CUSIP
501147102
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400500 Q1 2024: 234Q1 2024Q2 2024: 245Q2 2024Q3 2024: 283Q3 2024Q4 2024: 264Q4 2024Q1 2025: 299Q1 2025Q2 2025: 275Q2 2025Q3 2025: 284Q3 2025Q4 2025: 334Q4 2025Q1 2026: 368Q1 2026Q2 2026: 422Q2 2026

Total Exit/New Position Q1 2025 → Q2 2025

InstitutionsTotal Value
New Positions40$77.2M
Exits63$192.4M

All 13F filers, Q1 2025 → Q2 2025: 2,646,331 shares bought and 2,589,793 shares sold, net +56,538 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 275 holders

FMR LLC 0.03% Add +0.3% 4,334,761 $595.9M
BlackRock, Inc. 0.01% Reduce -2.5% 3,845,155 $528.6M
Vanguard Group Inc. 0.01% Reduce -0.1% 2,822,888 $388.0M
Avoro Capital Advisors LLC 6.40% Reduce -2.6% 2,660,000 $365.6M
State Street Corp. 0.01% Add +10.5% 1,355,346 $186.3M
Capital World Investors 0.02% Reduce -1.3% 942,249 $129.5M
Soleus Capital Management, L.P. 8.76% Add +108.9% 922,958 $126.9M
Braidwell LP 4.78% Add +81.6% 727,811 $100.0M
Frazier Life Sciences Management, L.P. 3.79% No change 688,460 $94.6M
Redmile Group, LLC 9.71% Reduce -10.1% 663,471 $91.2M
Geode Capital Management, LLC 0.01% Add +1.2% 619,547 $85.2M
Hood River Capital Management LLC 1.02% Add +1.6% 533,023 $73.3M
Goldman Sachs Group Inc. 0.01% Add +127.0% 530,361 $72.9M
Dimensional Fund Advisors LP 0.02% Reduce -5.3% 505,889 $69.5M
Norges Bank 0.00% Add +3.5% 282,706 $38.9M
T. Rowe Price Associates Inc. 0.00% Reduce -36.4% 261,383 $35.9M
Northern Trust Corp. 0.00% Reduce -3.3% 251,408 $34.6M
Charles Schwab Investment Management Inc. 0.01% Reduce -1.7% 246,180 $33.8M
Morgan Stanley 0.00% Reduce -21.4% 234,421 $32.2M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% Reduce -59.3% 234,320 $32.2M
First Trust Advisors LP 0.02% Add +571.3% 222,370 $30.6M
Nuveen, LLC 0.01% Reduce -19.7% 188,019 $25.8M
Bank of New York Mellon Corp 0.00% Reduce -5.1% 160,517 $22.1M
Woodline Partners LP 0.11% Reduce -32.2% 150,616 $20.7M
Segall Bryant & Hamill, LLC 0.29% Add +2.3% 148,614 $20.4M
Readystate Asset Management LP 1.53% New 147,980 $20.3M
Principal Financial Group Inc. 0.01% Add +11.5% 140,883 $19.4M
Pictet Asset Management Holding SA 0.02% Add +100.0% 130,537 $17.9M
Bank of America Corp. 0.00% Add +31.6% 121,812 $16.7M
TimesSquare Capital Management, LLC 0.23% Reduce -19.7% 114,204 $15.7M
Marshall Wace, LLP 0.02% Add +552.5% 112,382 $15.4M
S Squared Technology, LLC 6.33% Add +12.3% 109,215 $15.0M
Aberdeen Group plc 0.03% Add +190.9% 108,518 $14.9M
Logos Global Management LP 1.84% New 100,000 $13.7M
UBS Group AG 0.00% Add +19.9% 97,240 $13.4M
Barclays PLC 0.01% Add +106.4% 92,871 $12.8M
JPMorgan Chase & Co. 0.00% Reduce -9.6% 91,153 $12.5M
William Blair Investment Management, LLC 0.03% New 91,099 $12.5M
Renaissance Technologies 0.02% Add +701.8% 89,800 $12.3M
Public Sector Pension Investment Board 0.05% Add +8.0% 86,688 $11.9M
C WorldWide Group Holding A/S 0.16% No change 85,809 $11.8M
Victory Capital Management Inc. 0.01% Add +10.0% 80,123 $11.0M
Invesco Ltd. 0.00% Reduce -72.1% 70,888 $9.7M
Rhumbline Advisers 0.01% Add +3.0% 70,753 $9.7M
Raymond James Financial Inc. 0.00% Add +4.2% 68,735 $9.4M
Legal & General Group Plc 0.00% Add +2.8% 68,393 $9.4M
Handelsbanken Fonder AB 0.03% Reduce -10.1% 66,800 $9.2M
Decheng Capital LLC 2.29% Add +1.5% 66,000 $9.1M
Voya Investment Management LLC 0.01% Reduce -0.9% 63,993 $8.8M
Ameriprise Financial Inc. 0.00% Add +3.9% 62,835 $8.6M
Skandinaviska Enskilda Banken AB (publ) 0.04% No change 59,978 $8.2M
Alyeska Investment Group, L.P. 0.03% New 53,934 $7.4M
Citigroup Inc. 0.01% Reduce -28.6% 52,533 $7.2M
Federated Hermes, Inc. 0.01% Add +234.4% 42,743 $5.9M
Swiss National Bank 0.00% Reduce -1.0% 41,400 $5.7M
Corient Private Wealth LP 0.01% Reduce -3.8% 40,538 $5.6M
Palisades Investment Partners, LLC 2.42% Reduce -1.2% 40,203 $5.5M
Mutual of America Capital Management LLC 0.06% Add +5.3% 38,357 $5.3M
Kennedy Capital Management LLC 0.13% Reduce -8.1% 38,146 $5.2M
State of Wisconsin Investment Board 0.01% Add +49.2% 36,089 $5.0M
Rafferty Asset Management, LLC 0.02% Add +43.5% 34,665 $4.8M
Citadel Advisors 0.00% Add +35900.0% 34,560 $4.8M
Prudential Financial Inc. 0.01% Reduce -4.3% 26,151 $4.4M
Alliancebernstein L.P. 0.00% No change 31,120 $4.3M
Man Group plc 0.01% New 30,481 $4.2M
Susquehanna International Group, LLP 0.01% Reduce -10.6% 30,252 $4.2M
GW&K Investment Management, LLC 0.04% Reduce -11.5% 30,175 $4.1M
Los Angeles Capital Management LLC 0.01% Add +6.9% 26,638 $3.7M
Verition Fund Management LLC 0.02% Add +42.4% 26,514 $3.6M
Manufacturers Life Insurance Company, The 0.00% Reduce -23.8% 24,680 $3.4M
New York State Common Retirement Fund 0.00% No change 23,382 $3.2M
EFG Asset Management (North America) Corp. 0.44% Add +31.7% 22,878 $3.1M
Biondo Investment Advisors, LLC 0.38% New 21,240 $2.9M
CANADA LIFE ASSURANCE Co 0.00% Reduce -15.3% 20,847 $2.9M
Synovus Financial Corp. 0.03% New 20,643 $2.8M
Atle Fund Management AB 1.19% Reduce -14.2% 20,158 $2.8M
California State Teachers Retirement System 0.00% No change 20,126 $2.8M
TD Asset Management Inc 0.00% Reduce -50.1% 20,080 $2.8M
Edgestream Partners, L.P. 0.08% New 19,678 $2.7M
Sei Investments Co. 0.00% Add +3.3% 19,300 $2.7M
Deutsche Bank AG 0.00% Reduce -12.0% 19,135 $2.6M
Thrivent Financial for Lutherans 0.01% Add +0.6% 18,700 $2.6M
Franklin Resources Inc. 0.00% Reduce -3.1% 18,425 $2.5M
Erste Asset Management GmbH 0.02% No change 18,200 $2.5M
Alps Advisors Inc. 0.01% Add +809.5% 17,462 $2.4M
Wells Fargo & Company 0.00% Reduce -3.4% 16,547 $2.3M
New York State Teachers Retirement System 0.00% Reduce -2.1% 15,650 $2.2M
DekaBank Deutsche Girozentrale 0.00% No change 15,503 $2.1M
Fiera Capital Corp 0.01% Reduce -0.9% 15,511 $2.1M
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Reduce -3.8% 15,283 $2.1M
State of Alaska, Department of Revenue 0.02% Add +7.9% 15,130 $2.1M
Envestnet Asset Management Inc. 0.00% Add +21.9% 15,116 $2.1M
State of New Jersey Common Pension Fund D 0.01% Add +45.2% 15,033 $2.1M
MetLife Investment Management, LLC 0.01% Add +1.5% 14,746 $2.0M
Fieldview Capital Management, LLC 0.30% Reduce -11.0% 14,546 $2.0M
Rhenman & Partners Asset Management AB 0.22% Reduce -28.2% 12,750 $1.8M
SG Americas Securities, LLC 0.01% Add +860.9% 12,607 $1.7M
Millennium Management 0.00% Reduce -79.2% 12,562 $1.7M
Illinois Municipal Retirement Fund 0.02% Reduce -3.5% 12,311 $1.7M
Evolutionary Tree Capital Management, LLC 1.79% Reduce -7.8% 12,296 $1.7M
AQR Capital Management 0.00% Reduce -1.3% 11,968 $1.6M
Louisiana State Employees Retirement System 0.03% No change 11,900 $1.6M
D. E. Shaw & Co. 0.00% Reduce -76.5% 11,727 $1.6M
Torray Investment Partners LLC 0.23% New 11,574 $1.6M
Intech Investment Management LLC 0.01% Reduce -9.1% 10,978 $1.5M
State of Tennessee, Department of Treasury 0.01% Reduce -1.9% 10,951 $1.5M
Russell Investments Group, Ltd. 0.00% Reduce -72.6% 10,358 $1.4M
Schroder Investment Management Group 0.00% Reduce -21.6% 10,228 $1.4M
Wellington Management Group LLP 0.00% Reduce -4.2% 10,153 $1.4M
Janus Henderson Group PLC 0.00% No change 10,071 $1.4M
Yousif Capital Management, LLC 0.01% Add +0.3% 9,600 $1.3M
Privium Fund Management B.V. 0.28% Add +24.1% 9,320 $1.3M
Orbimed Advisors LLC 0.03% Reduce -60.9% 9,200 $1.3M
Perigon Wealth Management, LLC 0.03% Add +4.8% 8,898 $1.2M
Comerica Bank 0.00% Add +0.1% 8,708 $1.2M
Creative Planning 0.00% Reduce -30.9% 8,356 $1.1M
Teachers Retirement System of the State of Kentucky 0.01% Reduce -7.6% 8,329 $1.1M
Commonwealth Equity Services, LLC 0.00% Add +12.5% 8,215 $1.1M
Tealwood Asset Management Inc. 0.50% New 8,183 $1.1M
Profund Advisors LLC 0.04% Add +36.9% 8,166 $1.1M
VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% No change 7,800 $1.1M
Maryland State Retirement & Pension System 0.02% Add +1.7% 7,474 $1.0M
STRS Ohio 0.00% Add +7.3% 7,400 $1.0M
Sphera Funds Management LTD. 0.26% New 7,335 $1.0M
Amalgamated Bank 0.01% Add +0.4% 7,226 $993K
Quantum Private Wealth, LLC 0.32% No change 7,205 $990K
BNP Paribas Financial Markets 0.00% Add +61.9% 7,183 $987K
M&G PLC 0.01% New 6,748 $924K
ProShare Advisors LLC 0.00% Reduce -7.4% 6,625 $911K
Ensign Peak Advisors, Inc 0.00% No change 6,569 $903K
Commonwealth of Pennsylvania Public School Empls Retrmt SYS 0.00% Add +7.8% 6,529 $897K
Shay Capital LLC 0.20% New 6,500 $893K
Summit Trail Advisors, LLC 0.02% New 6,500 $893K
Arizona State Retirement System 0.01% Add +2.4% 6,316 $868K
Guggenheim Capital LLC 0.01% Add +46.0% 6,062 $833K
Cynosure Group, LLC 0.09% Add +51.7% 5,918 $813K
Teacher Retirement System of Texas 0.00% Add +0.6% 5,841 $803K
State Board of Administration of Florida Retirement System 0.00% No change 5,807 $798K
China Universal Asset Management Co., Ltd. 0.08% Add +0.5% 5,804 $798K
Oregon Public Employees Retirement Fund 0.01% No change 5,802 $798K
Police & Firemen's Retirement System of New Jersey 0.01% Add +3.3% 5,600 $770K
Dark Forest Capital Management LP 0.03% Reduce -41.7% 5,504 $757K
Main Management ETF Advisors, LLC 0.03% Add +1.7% 5,131 $705K
CenterBook Partners LP 0.04% New 5,051 $694K
Blair William & Co. 0.00% Reduce -48.6% 4,852 $667K
Summit Global Investments 0.04% Reduce -3.5% 4,547 $625K
Martingale Asset Management L P 0.02% Reduce -12.3% 4,505 $619K
Regal Investment Advisors LLC 0.05% Add +3.0% 4,434 $609K
Bank of Montreal 0.00% Reduce -0.3% 4,407 $606K
Cetera Investment Advisers 0.00% Add +108.0% 4,344 $597K
Bryce Point Capital, LLC 0.50% Add +0.9% 4,323 $594K
Amundi 0.00% New 4,194 $593K
KLP Kapitalforvaltning As 0.00% No change 4,300 $591K
Mariner, LLC 0.00% Add +17.0% 4,255 $585K
Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% Reduce -67.6% 4,134 $568K
Pathstone Holdings, LLC 0.00% Reduce -51.4% 3,939 $541K
E Fund Management Co., Ltd. 0.03% Add +71.4% 3,870 $532K
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Reduce -32.7% 3,864 $531K
Pier 88 Investment Partners LLC 0.56% Reduce -13.8% 3,820 $525K
M&T Bank Corp 0.00% Add +2.3% 3,785 $520K
Aviva PLC 0.00% Add +9.8% 3,575 $491K
Susquehanna Portfolio Strategies, LLC 0.01% New 3,539 $486K
Hennion & Walsh Asset Management, Inc. 0.02% Reduce -68.1% 3,253 $447K
Virtus Investment Advisers, LLC 0.15% Add +53.1% 3,167 $435K
Vontobel Holding Ltd. 0.00% Add +13.9% 3,075 $423K
Cibc World Markets Corp. 0.00% Reduce -44.5% 3,055 $420K
Tower Research Capital LLC (TRC) 0.01% Add +310.7% 2,998 $412K
Confluence Wealth Services, Inc. 0.02% Add +0.1% 2,922 $402K
Resona Asset Management Co.,Ltd. 0.00% New 2,917 $401K
Advantage Alpha Capital Partners LP 0.11% Reduce -18.9% 2,894 $398K
EP Wealth Advisors, LLC 0.00% Add +4.0% 2,726 $375K
Ameritas Investment Partners, Inc. 0.01% No change 2,509 $345K
Crossmark Global Holdings, Inc. 0.01% Add +3.7% 2,457 $338K
Graham Capital Management, L.P. 0.01% Add +11.8% 2,435 $335K
Tempus Wealth Planning, LLC 0.08% New 2,379 $327K
Public Employees Retirement Association of Colorado 0.00% No change 2,363 $325K
Nebula Research & Development LLC 0.03% Reduce -62.1% 2,355 $324K
Janney Montgomery Scott LLC 0.00% Reduce -94.9% 2,340 $322K
Capstone Investment Advisors, LLC 0.00% New 2,196 $302K
Ballentine Partners, LLC 0.00% Reduce -1.0% 2,115 $291K
Allspring Global Investments Holdings, LLC 0.00% Reduce -60.1% 2,068 $287K
Farallon Capital Management, L.L.C. 0.00% No change 2,000 $275K
Campbell & CO Investment Adviser LLC 0.02% New 1,991 $274K
Vident Advisory, LLC 0.00% Reduce -28.9% 1,982 $272K
Sound View Wealth Advisors Group, LLC 0.02% Add +28.5% 1,947 $268K
Aigen Investment Management, LP 0.04% New 1,944 $267K
Xponance LLC 0.00% Add +3.0% 1,929 $265K
Freestone Grove Partners LP 0.00% New 1,895 $260K
OmniStar Financial Group, Inc. 0.19% Reduce -7.3% 1,878 $258K
Parallel Advisors, LLC 0.01% Add +7.6% 1,863 $256K
Royal Bank of Canada 0.00% Add +11.2% 1,811 $249K
Mitsubishi UFJ Asset Management Co., Ltd. 0.00% Add +20.3% 1,795 $247K
DNB Asset Management AS 0.00% Reduce -2.7% 1,731 $238K
Vanguard Personalized Indexing Management, LLC 0.00% Reduce -12.9% 1,695 $233K
Mackenzie Financial Corp. 0.00% Add +4.2% 1,597 $220K
Cwm, LLC 0.00% Add +7.3% 1,583 $218K
Algert Global LLC 0.00% New 1,500 $206K
Hilltop Holdings Inc. 0.01% Add +22.7% 1,468 $202K
PNC Financial Services Group, Inc. 0.00% Reduce -33.6% 1,422 $195K
Covestor Ltd 0.11% Reduce -8.3% 1,373 $189K
Elevation Point Wealth Partners, LLC 0.01% Add +1.0% 1,251 $172K
Bellevue Group AG 0.00% Reduce -52.8% 1,250 $172K
Financiere des Professionnels - Fonds d'investissement inc. 0.01% New 1,182 $162K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +15.8% 1,116 $153K
Canada Pension Plan Investment Board 0.00% Reduce -23.1% 1,000 $137K
Avanza Fonder AB 0.00% Reduce -25.3% 941 $129K
Nisa Investment Advisors, LLC 0.00% Reduce -3.7% 886 $122K
GF Fund Management Co. LTD. 0.00% No change 736 $101K
KBC Group NV 0.00% Reduce -27.1% 685 $94K
Asset Management One Co., Ltd. 0.00% New 617 $85K
AlphaQuest LLC 0.01% Reduce -65.2% 579 $80K
Headlands Technologies LLC 0.01% Reduce -47.8% 527 $72K
US Bancorp \de 0.00% Reduce -21.1% 504 $69K
Pacer Advisors, Inc. 0.00% Reduce -35.7% 455 $63K
Osaic Holdings, Inc. 0.00% Add +41.4% 393 $54K
GAMMA Investing LLC 0.00% Reduce -57.6% 285 $39K
Huntington National Bank 0.00% Add +20.2% 256 $35K
Caldwell Trust Co 0.00% No change 250 $34K
First Horizon Advisors, Inc. 0.00% Add +212.8% 244 $34K
Wilmington Savings Fund Society, FSB 0.00% Reduce -2.2% 220 $30K
Smartleaf Asset Management LLC 0.00% Reduce -33.3% 210 $29K
Brooklyn Investment Group 0.00% Add +43.3% 202 $28K
Danske Bank A/S 0.00% New 200 $27K
Hantz Financial Services, Inc. 0.00% Add +8950.0% 181 $25K
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% New 174 $24K
MAI Capital Management 0.00% Add +17.9% 158 $22K
Lazard Asset Management LLC 0.00% Reduce -61.6% 155 $21K
Key Financial Inc 0.00% No change 151 $21K
Daiwa Securities Group Inc. 0.00% Add +9.5% 104 $14K
Reyes Financial Architecture, Inc. 0.01% New 100 $14K
Fifth Third Bancorp 0.00% Reduce -47.4% 90 $12K
Signaturefd, LLC 0.00% Reduce -39.2% 79 $11K
Bessemer Group Inc. 0.00% Add +4.3% 72 $10K
SBI Securities Co., Ltd. 0.00% Reduce -1.4% 70 $10K
Versant Capital Management, Inc 0.00% Add +86.5% 69 $9K
Rise Advisors, LLC 0.00% No change 66 $9K
MassMutual Private Wealth & Trust, FSB 0.00% Add +15.4% 60 $8K
Sterling Capital Management LLC 0.00% Add +130.8% 60 $8K
Private Wealth Management Group, LLC 0.00% Add +1000.0% 55 $8K
Federation des caisses Desjardins du Quebec 0.00% No change 50 $7K
Allworth Financial LP 0.00% Add +69.2% 44 $6K
Bare Financial Services, Inc 0.00% Add +290.9% 43 $6K
UMB Bank, n.a. 0.00% Reduce -41.1% 43 $6K
Rothschild Investment LLC 0.00% Reduce -15.2% 39 $5K
Twin Peaks Wealth Advisors, LLC 0.00% New 35 $5K
NewEdge Advisors, LLC 0.00% No change 34 $5K
Jones Financial Companies LLLP 0.00% New 32 $4K
EverSource Wealth Advisors, LLC 0.00% Reduce -43.6% 31 $4K
Clearstead Advisors, LLC 0.00% No change 24 $3K
Farther Finance Advisors, LLC 0.00% Add +4.3% 24 $3K
Trust Co. of Vermont 0.00% No change 20 $3K
Bell Investment Advisors, Inc 0.00% No change 19 $3K
Parkside Financial Bank & Trust 0.00% Reduce -28.6% 15 $2K
Farmers & Merchants Investments Inc. 0.00% No change 15 $2K
Global Retirement Partners, LLC 0.00% — 11 $2K
Sound Income Strategies, LLC 0.00% No change 10 $1K
Principal Securities, Inc. 0.00% Add +42.9% 10 $1K
IFP Advisors, Inc 0.00% New 10 $1K
Wolff Wiese Magana LLC 0.00% No change 8 $1K
Geneos Wealth Management Inc. 0.00% No change 8 $1K
Arax Advisory Partners 0.00% New 6 $825
Blue Trust, Inc. 0.00% Reduce -33.3% 6 $825
Clearstead Trust, LLC 0.00% New 5 $688
Rakuten Securities, Inc. 0.00% No change 5 $687
Glen Eagle Advisors, LLC 0.00% No change 5 $687
Kestra Investment Management, LLC 0.00% No change 5 $687
Fortitude Family Office, LLC 0.00% New 4 $550
Hughes Financial Services, LLC 0.00% New 4 $544
Parkworth Wealth Management, Inc. 0.00% New 2 $275
JFS Wealth Advisors, LLC 0.00% No change 2 $275
Larson Financial Group LLC 0.00% New 2 $275
Tradewinds Capital Management, LLC 0.00% New 1 $138
Abound Wealth Management 0.00% No change 1 $138
Essential Partners LLC 0.00% — 1 $137
Avion Wealth 0.00% New 4 $0

"% of holder's portfolio" is KRYS's weight in each manager's 13F, not the share of Krystal Biotech Inc. the manager owns.