SepternaSEPN
13F holders, Q1 2026 (March 31)124holders +2
22new positions
23sold out
3famous investors
$24.03avg. 13F price*
At the end of Q1 2026, 124 institutions reported holding Septerna Inc. (SEPN) in their 13F filings, up 2 from Q4 2025. 22 opened new positions and 23 sold out. The largest holders were Ra Capital Management, L.P. ($168.1M), TRV GP V, LLC ($149.4M) and Driehaus Capital Management LLC ($105.6M). 3 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Septerna Inc.
- CUSIP
- 81734D104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 22 | $31.9M |
| Exits | 23 | $32.9M |
All 13F filers, Q4 2025 → Q1 2026: 2,808,666 shares bought and 2,713,928 shares sold, net +94,738 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 124 holders
| Ra Capital Management, L.P. | 1.78% | No change | 6,995,858 | $168.1M |
| TRV GP V, LLC | 37.25% | No change | 6,215,591 | $149.4M |
| Driehaus Capital Management LLC | 0.78% | Reduce -8.6% | 4,395,572 | $105.6M |
| TRV GP Vi, LLC | 74.64% | No change | 4,211,659 | $101.2M |
| Samsara Biocapital, LLC | 7.35% | No change | 3,149,128 | $75.7M |
| Goldman Sachs Group Inc. | 0.01% | Add +7.0% | 2,906,427 | $69.8M |
| Siren, L.L.C. | 1.33% | No change | 2,000,000 | $48.1M |
| BlackRock, Inc. | 0.00% | Add +1.2% | 1,822,174 | $43.8M |
| BVF Inc. | 1.04% | Reduce -21.4% | 1,353,249 | $32.5M |
| Avoro Capital Advisors LLC | 0.32% | No change | 1,337,500 | $32.1M |
| Vanguard Capital Management LLC | 0.00% | — | 1,196,962 | $28.8M |
| ADAR1 Capital Management, LLC | 1.59% | Reduce -5.9% | 1,089,818 | $26.2M |
| Primecap Management Co. | 0.02% | Add +92.1% | 1,048,834 | $25.2M |
| Janus Henderson Group PLC | 0.01% | New | 890,754 | $21.3M |
| First Light Asset Management, LLC | 1.58% | Add +18.1% | 732,860 | $17.6M |
| Geode Capital Management, LLC | 0.00% | Add +12.6% | 645,146 | $15.5M |
| State Street Corp. | 0.00% | Add +16.9% | 631,447 | $15.2M |
| Casdin Capital, LLC | 1.01% | No change | 553,268 | $13.3M |
| Venrock Adviser, LLC | 0.45% | Reduce -17.1% | 506,056 | $12.2M |
| Catalio Capital Management, LP | 1.48% | No change | 294,360 | $7.1M |
| Soleus Capital Management, L.P. | 0.27% | Reduce -28.3% | 275,000 | $6.6M |
| Balyasny Asset Management L.P. | 0.01% | Add +6527.8% | 236,679 | $5.7M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +0.6% | 223,995 | $5.4M |
| Vanguard Portfolio Management LLC | 0.00% | — | 195,043 | $4.7M |
| Kalehua Capital Management LLC | 3.31% | No change | 194,544 | $4.7M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -3.0% | 181,580 | $4.4M |
| Northern Trust Corp. | 0.00% | Add +6.7% | 164,530 | $4.0M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 154,484 | $3.7M |
| Millennium Management | 0.00% | Add +15.5% | 124,101 | $3.0M |
| UBS Group AG | 0.00% | Add +70.0% | 116,979 | $2.8M |
| Morgan Stanley | 0.00% | Add +6.3% | 110,530 | $2.7M |
| Hussman Strategic Advisors, Inc. | 0.55% | New | 105,000 | $2.5M |
| Checkpoint Capital L.P. | 0.86% | New | 100,300 | $2.4M |
| Federated Hermes, Inc. | 0.00% | Add +13.2% | 89,301 | $2.1M |
| Invesco Ltd. | 0.00% | Reduce -48.9% | 82,868 | $2.0M |
| JPMorgan Chase & Co. | 0.00% | Add +23.9% | 84,674 | $2.0M |
| Two Sigma Investments, LP | 0.00% | Reduce -18.8% | 75,367 | $1.8M |
| Longaeva Partners L.P. | 0.09% | Add +49.4% | 74,567 | $1.8M |
| American Century Companies Inc. | 0.00% | Add +20.9% | 61,290 | $1.5M |
| Bank of New York Mellon Corp | 0.00% | Add +6.1% | 58,709 | $1.4M |
| Jump Financial, LLC | 0.02% | Add +531.2% | 53,011 | $1.3M |
| Sofinnova Investments, Inc. | 0.06% | New | 47,506 | $1.1M |
| Marshall Wace, LLP | 0.00% | Reduce -82.4% | 39,840 | $957K |
| Rangeley Capital, LLC | 1.04% | Reduce -39.5% | 39,800 | $956K |
| Renaissance Technologies | 0.00% | New | 37,700 | $906K |
| XTX Topco Ltd | 0.02% | Add +57.5% | 36,723 | $882K |
| Trexquant Investment LP | 0.01% | Reduce -19.8% | 35,301 | $848K |
| Alyeska Investment Group, L.P. | 0.00% | No change | 35,000 | $841K |
| Acadian Asset Management LLC | 0.00% | Add +0.3% | 30,978 | $741K |
| Nuveen, LLC | 0.00% | Add +13.1% | 29,176 | $701K |
| Jacobs Levy Equity Management, Inc. | 0.00% | Reduce -53.7% | 28,436 | $683K |
| T. Rowe Price Associates Inc. | 0.00% | Add +10.3% | 28,076 | $675K |
| Rhumbline Advisers | 0.00% | Add +0.7% | 26,604 | $639K |
| Bank of America Corp. | 0.00% | Reduce -30.9% | 25,973 | $624K |
| Y-Intercept (Hong Kong) Ltd | 0.01% | New | 25,770 | $619K |
| Adage Capital Partners Gp, L.L.C. | 0.00% | New | 24,000 | $577K |
| Logos Global Management LP | 0.03% | No change | 23,548 | $566K |
| FMR LLC | 0.00% | Add +609.0% | 23,446 | $563K |
| Alliancebernstein L.P. | 0.00% | No change | 19,600 | $546K |
| Barclays PLC | 0.00% | Reduce -40.5% | 22,714 | $546K |
| Swiss National Bank | 0.00% | New | 22,100 | $531K |
| Algert Global LLC | 0.01% | Reduce -39.8% | 21,035 | $505K |
| Squarepoint Ops LLC | 0.00% | Add +21.8% | 18,083 | $435K |
| STRS Ohio | 0.00% | Add +17.8% | 17,200 | $413K |
| Deutsche Bank AG | 0.00% | Add +13.2% | 16,843 | $405K |
| VARCOV Co. | 0.15% | Reduce -26.0% | 16,752 | $403K |
| Engineers Gate Manager LP | 0.01% | New | 16,528 | $397K |
| Vanguard Global Advisers, LLC | 0.00% | — | 16,247 | $390K |
| AQR Capital Management | 0.00% | Add +96.5% | 15,375 | $369K |
| Numerai GP LLC | 0.04% | Reduce -67.1% | 15,082 | $362K |
| Los Angeles Capital Management LLC | 0.00% | Reduce -23.4% | 14,214 | $342K |
| MetLife Investment Management, LLC | 0.00% | No change | 13,685 | $329K |
| EntryPoint Capital, LLC | 0.09% | New | 12,776 | $307K |
| Osaic Holdings, Inc. | 0.00% | Add +0.0% | 12,698 | $305K |
| Verition Fund Management LLC | 0.00% | New | 12,343 | $297K |
| China Universal Asset Management Co., Ltd. | 0.02% | Add +16.0% | 11,946 | $287K |
| Man Group plc | 0.00% | New | 11,858 | $285K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -24.8% | 11,515 | $277K |
| Seven Fleet Capital Management LP | 0.09% | No change | 11,445 | $275K |
| Virtus Investment Advisers, LLC | 0.07% | Add +2.5% | 10,719 | $258K |
| Massachusetts Financial Services Co. | 0.00% | New | 10,382 | $249K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +0.9% | 10,021 | $241K |
| Wells Fargo & Company | 0.00% | Reduce -62.8% | 9,869 | $237K |
| Citigroup Inc. | 0.00% | Reduce -3.8% | 9,195 | $221K |
| WINTON GROUP Ltd | 0.01% | New | 8,842 | $212K |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | — | 7,420 | $178K |
| Legal & General Group Plc | 0.00% | Add +194.9% | 5,735 | $138K |
| New York State Common Retirement Fund | 0.00% | No change | 5,600 | $135K |
| BNP Paribas Financial Markets | 0.00% | Reduce -1.6% | 5,361 | $129K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 5,175 | $124K |
| Vanguard Investments Australia, Ltd. | 0.00% | — | 3,895 | $94K |
| Public Employees Retirement System of Ohio | 0.00% | Reduce -68.2% | 3,374 | $81K |
| KLP Kapitalforvaltning As | 0.00% | New | 2,500 | $60K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +7.3% | 2,335 | $56K |
| Covestor Ltd | 0.04% | Add +16.4% | 2,260 | $54K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,944 | $47K |
| California State Teachers Retirement System | 0.00% | Reduce -12.1% | 1,157 | $28K |
| GAMMA Investing LLC | 0.00% | Add +21.2% | 1,110 | $27K |
| GF Fund Management Co. LTD. | 0.00% | Add +14.6% | 1,006 | $24K |
| Signaturefd, LLC | 0.00% | Reduce -2.3% | 966 | $23K |
| Cwm, LLC | 0.00% | Add +0.7% | 894 | $21K |
| Nisa Investment Advisors, LLC | 0.00% | Add +146.6% | 841 | $20K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -66.7% | 717 | $17K |
| Sterling Capital Management LLC | 0.00% | Reduce -42.2% | 712 | $17K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | New | 508 | $12K |
| Pinnacle Wealth Planning Services, Inc. | 0.00% | No change | 322 | $8K |
| Versant Capital Management, Inc | 0.00% | No change | 261 | $6K |
| Larson Financial Group LLC | 0.00% | New | 204 | $5K |
| Diadema Partners LP | 0.00% | New | 202 | $5K |
| US Bancorp \de | 0.00% | Add +3.7% | 197 | $5K |
| N.E.W. Advisory Services LLC | 0.00% | No change | 180 | $4K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 155 | $4K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Add +114.3% | 135 | $3K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +7.9% | 68 | $2K |
| SBI Securities Co., Ltd. | 0.00% | No change | 55 | $1K |
| Cornerstone Financial Management LLC | 0.00% | No change | 52 | $1K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -78.3% | 43 | $1K |
| Caitong International Asset Management Co., Ltd | 0.00% | Reduce -98.8% | 38 | $913 |
| Rothschild Investment LLC | 0.00% | No change | 30 | $721 |
| Fortitude Family Office, LLC | 0.00% | Reduce -71.8% | 20 | $481 |
| Allworth Financial LP | 0.00% | New | 17 | $409 |
| Farther Finance Advisors, LLC | 0.00% | Add +600.0% | 7 | $171 |
| Quadrant Capital Group LLC | 0.00% | New | 7 | $169 |
| MAI Capital Management | 0.00% | New | 6 | $145 |
"% of holder's portfolio" is SEPN's weight in each manager's 13F, not the share of Septerna Inc. the manager owns.