Xeris Biopharma HoldingsXERS
13F holders, Q4 2025 (December 31)224holders −6
29new positions
39sold out
8famous investors
$7.85avg. 13F price*
At the end of Q4 2025, 224 institutions reported holding Xeris Biopharma Holdings Inc. (XERS) in their 13F filings, down 6 from Q3 2025. 29 opened new positions and 39 sold out. The largest holders were BlackRock, Inc. ($99.2M), Vanguard Group Inc. ($87.8M) and D. E. Shaw & Co. ($59.5M). 8 famous investors held it, including David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio), Steve Cohen (0.0% of Point72 Asset Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Xeris Biopharma Holdings Inc.
- CUSIP
- 98422E103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 29 | $19.0M |
| Exits | 39 | $22.8M |
All 13F filers, Q3 2025 → Q4 2025: 14,812,088 shares bought and 12,537,741 shares sold, net +2,274,347 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 224 holders
| BlackRock, Inc. | 0.00% | Add +6.0% | 12,639,318 | $99.2M |
| Vanguard Group Inc. | 0.00% | Add +13.8% | 11,186,677 | $87.8M |
| D. E. Shaw & Co. | 0.05% | Add +29.7% | 7,574,850 | $59.5M |
| Geode Capital Management, LLC | 0.00% | Add +3.3% | 4,275,989 | $33.6M |
| State Street Corp. | 0.00% | Add +10.1% | 4,116,924 | $32.3M |
| Qube Research & Technologies Ltd | 0.04% | Add +6.8% | 3,498,197 | $27.5M |
| Driehaus Capital Management LLC | 0.16% | Add +13.8% | 2,980,567 | $23.4M |
| Nuveen, LLC | 0.01% | Reduce -0.8% | 2,806,806 | $22.0M |
| Morgan Stanley | 0.00% | Reduce -15.9% | 2,707,783 | $21.3M |
| Wellington Management Group LLP | 0.00% | Add +293.6% | 2,286,598 | $17.9M |
| Rosalind Advisors, Inc. | 6.04% | Add +17.6% | 2,111,700 | $16.6M |
| Two Sigma Investments, LP | 0.02% | Add +7.3% | 1,732,667 | $13.6M |
| Parkman Healthcare Partners LLC | 1.26% | Reduce -5.6% | 1,691,585 | $13.3M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -12.6% | 1,568,421 | $12.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -3.0% | 1,403,824 | $11.0M |
| Legal & General Group Plc | 0.00% | Add +2.9% | 1,396,265 | $11.0M |
| CenterBook Partners LP | 0.53% | Add +99.3% | 1,391,590 | $10.9M |
| Northern Trust Corp. | 0.00% | Add +1.7% | 1,386,829 | $10.9M |
| Granahan Investment Management, LLC | 0.41% | Add +249.4% | 1,223,404 | $9.6M |
| Kennedy Capital Management LLC | 0.20% | Add +0.2% | 1,213,969 | $9.5M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | Reduce -37.7% | 1,058,692 | $8.3M |
| Acadian Asset Management LLC | 0.01% | Add +5.5% | 971,598 | $7.6M |
| Knott David M Jr | 3.53% | Reduce -4.4% | 970,000 | $7.6M |
| AQR Capital Management | 0.00% | Reduce -2.6% | 957,579 | $7.5M |
| Deutsche Bank AG | 0.00% | Reduce -40.0% | 940,592 | $7.4M |
| JPMorgan Chase & Co. | 0.00% | Reduce -1.1% | 895,059 | $7.0M |
| Millennium Management | 0.01% | Add +63.7% | 859,051 | $6.7M |
| Federated Hermes, Inc. | 0.01% | Add +21.4% | 854,888 | $6.7M |
| Two Sigma Advisers, LP | 0.01% | Reduce -4.9% | 849,334 | $6.7M |
| Voloridge Investment Management, LLC | 0.02% | Reduce -21.6% | 811,129 | $6.4M |
| Norges Bank | 0.00% | — | 800,700 | $6.3M |
| Ishara Investments LP | 7.31% | — | 800,000 | $6.3M |
| Essex Investment Management Co. LLC | 0.88% | Reduce -2.1% | 734,532 | $5.8M |
| Algert Global LLC | 0.09% | Add +355.1% | 718,844 | $5.6M |
| Bank of America Corp. | 0.00% | Reduce -55.0% | 717,914 | $5.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +255.1% | 651,445 | $5.1M |
| Renaissance Technologies | 0.01% | Reduce -61.8% | 619,660 | $4.9M |
| Prudential Financial Inc. | 0.01% | Reduce -56.8% | 618,949 | $4.9M |
| Point72 Asset Management | 0.01% | New | 608,080 | $4.8M |
| UBS Group AG | 0.00% | Reduce -66.2% | 601,834 | $4.7M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.01% | Add +111.6% | 537,483 | $4.2M |
| Squarepoint Ops LLC | 0.01% | Reduce -28.9% | 482,832 | $3.8M |
| Voya Investment Management LLC | 0.00% | Add +14.6% | 458,329 | $3.6M |
| Castleark Management LLC | 0.10% | New | 445,950 | $3.5M |
| FMR LLC | 0.00% | Add +22.1% | 439,705 | $3.5M |
| Bank of New York Mellon Corp | 0.00% | Reduce -1.3% | 434,262 | $3.4M |
| Citadel Advisors | 0.00% | Reduce -6.3% | 409,820 | $3.2M |
| Sei Investments Co. | 0.00% | Add +229.6% | 399,347 | $3.1M |
| Canada Pension Plan Investment Board | 0.00% | Add +4.0% | 390,600 | $3.1M |
| Voss Capital, LP | 0.16% | New | 371,709 | $2.9M |
| Russell Investments Group, Ltd. | 0.00% | Add +45.1% | 364,786 | $2.9M |
| Barclays PLC | 0.00% | Add +4.7% | 362,751 | $2.8M |
| State of Wisconsin Investment Board | 0.01% | Add +2.0% | 357,453 | $2.8M |
| Jump Financial, LLC | 0.04% | Reduce -43.5% | 341,068 | $2.7M |
| HRT Financial LP | 0.01% | Add +358.1% | 332,326 | $2.6M |
| Swiss National Bank | 0.00% | Add +2.6% | 318,400 | $2.5M |
| Harvest Investment Services, LLC | 0.43% | Reduce -10.1% | 292,677 | $2.3M |
| IHT Wealth Management, LLC | 0.05% | Add +2.1% | 263,531 | $2.1M |
| BNP Paribas Financial Markets | 0.00% | Reduce -55.6% | 258,368 | $2.0M |
| Apella Capital, LLC | 0.04% | Add +2359.0% | 245,897 | $1.9M |
| Legato Capital Management LLC | 0.16% | Add +9.5% | 237,431 | $1.9M |
| Schonfeld Strategic Advisors LLC | 0.01% | Reduce -22.9% | 234,723 | $1.8M |
| Arrowstreet Capital, Limited Partnership | 0.00% | New | 214,786 | $1.7M |
| Trexquant Investment LP | 0.01% | Reduce -6.9% | 213,581 | $1.7M |
| Raymond James Financial Inc. | 0.00% | Add +3.0% | 211,419 | $1.7M |
| Commonwealth Equity Services, LLC | 0.00% | Add +0.0% | 197,815 | $1.6M |
| Rhumbline Advisers | 0.00% | Reduce -11.3% | 189,567 | $1.5M |
| Jane Street Group, LLC | 0.00% | Reduce -80.5% | 177,822 | $1.4M |
| Caxton Associates LLP | 0.03% | Reduce -38.1% | 174,102 | $1.4M |
| T. Rowe Price Associates Inc. | 0.00% | Add +4.0% | 173,463 | $1.4M |
| Wells Fargo & Company | 0.00% | Add +75.7% | 170,796 | $1.3M |
| Diadema Partners LP | 0.80% | Add +128.2% | 170,568 | $1.3M |
| California State Teachers Retirement System | 0.00% | Reduce -0.5% | 151,171 | $1.2M |
| Principal Financial Group Inc. | 0.00% | Add +42.7% | 150,559 | $1.2M |
| Alliancebernstein L.P. | 0.00% | No change | 144,830 | $1.1M |
| Ameriprise Financial Inc. | 0.00% | Reduce -6.9% | 143,463 | $1.1M |
| Polen Capital Management LLC | 0.00% | Add +0.2% | 133,416 | $1.0M |
| Group One Trading LLC | 0.03% | Add +1951.2% | 123,561 | $970K |
| Globeflex Capital L P | 0.15% | No change | 123,184 | $967K |
| Franklin Resources Inc. | 0.00% | Add +11.3% | 121,428 | $953K |
| Susquehanna International Group, LLP | 0.00% | Add +44.0% | 117,355 | $921K |
| Creative Planning | 0.00% | Reduce -8.2% | 116,538 | $915K |
| Invesco Ltd. | 0.00% | Reduce -80.8% | 112,130 | $880K |
| SG Americas Securities, LLC | 0.00% | Add +32.4% | 110,180 | $865K |
| Faithward Advisors, LLC | 0.12% | New | 106,730 | $838K |
| Thompson Siegel & Walmsley LLC | 0.01% | No change | 100,884 | $792K |
| Resolute Capital Asset Partners LLC | 0.38% | New | 100,000 | $785K |
| Calamos Advisors LLC | 0.00% | Reduce -27.7% | 99,117 | $778K |
| Citigroup Inc. | 0.00% | Add +40.5% | 98,746 | $775K |
| Round Rock Advisors LLC | 0.11% | Add +51.8% | 96,816 | $760K |
| Brevan Howard Capital Management LP | 0.02% | Reduce -30.1% | 92,416 | $725K |
| Y-Intercept (Hong Kong) Ltd | 0.02% | Add +10.3% | 90,645 | $712K |
| Engineers Gate Manager LP | 0.01% | Reduce -18.7% | 89,404 | $702K |
| Jefferies Financial Group Inc. | 0.01% | New | 87,800 | $689K |
| Ieq Capital, LLC | 0.00% | Reduce -19.9% | 86,520 | $679K |
| LPL Financial LLC | 0.00% | Add +154.8% | 84,861 | $666K |
| Informed Momentum Co LLC | 0.07% | Reduce -86.7% | 80,154 | $629K |
| Quarry LP | 0.11% | Reduce -3.0% | 80,000 | $628K |
| Quantbot Technologies LP | 0.02% | Add +11.9% | 77,648 | $610K |
| Western Wealth Management, LLC | 0.03% | New | 75,675 | $594K |
| Teachers Retirement System of the State of Kentucky | 0.00% | New | 72,907 | $572K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.0% | 71,311 | $560K |
| Janus Henderson Group PLC | 0.00% | No change | 69,887 | $548K |
| EntryPoint Capital, LLC | 0.21% | Add +28.4% | 68,083 | $534K |
| Integrated Quantitative Investments LLC | 0.11% | New | 66,170 | $519K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +101.4% | 65,767 | $516K |
| STRS Ohio | 0.00% | No change | 65,500 | $514K |
| Intech Investment Management LLC | 0.00% | Add +17.6% | 65,090 | $511K |
| WINTON GROUP Ltd | 0.02% | Reduce -28.9% | 64,597 | $507K |
| Cwm, LLC | 0.00% | Reduce -0.1% | 55,356 | $435K |
| Osaic Holdings, Inc. | 0.00% | Add +29.6% | 52,285 | $410K |
| Deerfield Management Company, L.P. | 0.01% | Reduce -56.8% | 52,230 | $410K |
| Dark Forest Capital Management LP | 0.02% | Reduce -61.9% | 52,043 | $409K |
| Weiss Asset Management LP | 0.01% | No change | 50,001 | $393K |
| Penn Capital Management Company, LLC | 0.03% | New | 48,064 | $377K |
| Man Group plc | 0.00% | New | 47,775 | $375K |
| Campbell & CO Investment Adviser LLC | 0.02% | Reduce -54.2% | 47,454 | $373K |
| Axq Capital, LP | 0.08% | Add +76.3% | 46,454 | $365K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -8.7% | 45,801 | $360K |
| Persistent Asset Partners Ltd | 0.17% | Add +165.1% | 45,609 | $358K |
| Arizona State Retirement System | 0.00% | Reduce -4.4% | 45,269 | $355K |
| New York State Common Retirement Fund | 0.00% | No change | 43,422 | $341K |
| AlphaCentric Advisors LLC | 0.34% | — | 43,392 | $341K |
| State of Wyoming | 0.04% | Add +229.1% | 42,458 | $333K |
| LJI Wealth Management, LLC | 0.05% | No change | 42,350 | $332K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Reduce -1.5% | 40,738 | $320K |
| Savvy Advisors, Inc. | 0.01% | No change | 40,465 | $318K |
| Profund Advisors LLC | 0.01% | Add +46.6% | 38,947 | $306K |
| Royal Bank of Canada | 0.00% | Add +6.5% | 38,636 | $304K |
| Cetera Investment Advisers | 0.00% | Reduce -3.4% | 38,647 | $303K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 37,970 | $298K |
| Virtus Investment Advisers, LLC | 0.08% | Add +44.1% | 37,102 | $291K |
| Ausbil Investment Management Ltd | 0.17% | New | 37,000 | $290K |
| Gotham Asset Management | 0.00% | Reduce -17.1% | 35,412 | $278K |
| ProShare Advisors LLC | 0.00% | Add +10.6% | 35,390 | $278K |
| Gsa Capital Partners LLP | 0.02% | Reduce -49.5% | 34,665 | $272K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | No change | 34,642 | $272K |
| Rafferty Asset Management, LLC | 0.00% | Add +93.5% | 33,689 | $264K |
| KLP Kapitalforvaltning As | 0.00% | No change | 33,400 | $262K |
| Diversified Trust Co. | 0.00% | No change | 32,062 | $252K |
| VARCOV Co. | 0.10% | — | 31,005 | $243K |
| Cerity Partners LLC | 0.00% | Reduce -4.7% | 29,578 | $232K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -0.0% | 31,105 | $216K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -4.5% | 27,037 | $212K |
| Asset Management Group, Inc. | 0.03% | No change | 26,480 | $208K |
| Fox Run Management, L.L.C. | 0.03% | New | 26,174 | $205K |
| Swiss Life Asset Management Ltd | 0.00% | New | 26,059 | $205K |
| 9823 Capital, L.P. | 0.13% | — | 24,917 | $196K |
| Quantinno Capital Management LP | 0.00% | Add +39.6% | 24,696 | $194K |
| Janney Montgomery Scott LLC | 0.00% | Reduce -6.7% | 24,450 | $192K |
| Palumbo Wealth Management LLC | 0.05% | Reduce -61.5% | 24,349 | $191K |
| Teacher Retirement System of Texas | 0.00% | Reduce -39.1% | 23,936 | $188K |
| Pictet Asset Management Holding SA | 0.00% | No change | 23,196 | $182K |
| Tudor Investment Corporation | 0.00% | Reduce -41.6% | 22,186 | $174K |
| Los Angeles Capital Management LLC | 0.00% | No change | 17,901 | $174K |
| Van Hulzen Asset Management, LLC | 0.01% | Reduce -8.1% | 20,382 | $160K |
| Aspiriant, LLC | 0.00% | No change | 20,000 | $157K |
| Victory Capital Management Inc. | 0.00% | Add +3.4% | 17,840 | $140K |
| Modern Wealth Management, LLC | 0.00% | Add +0.1% | 17,712 | $139K |
| Dynamic Technology Lab Private Ltd | 0.03% | New | 17,200 | $135K |
| Numerai GP LLC | 0.02% | Reduce -7.3% | 17,148 | $135K |
| Jacksonville Wealth Management, LLC | 0.09% | No change | 17,000 | $133K |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0.00% | Add +17.7% | 16,070 | $126K |
| Landscape Capital Management, L.L.C. | 0.01% | No change | 15,709 | $123K |
| Bailard, Inc. | 0.00% | New | 15,300 | $120K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +7.9% | 14,192 | $111K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 12,827 | $101K |
| Aigen Investment Management, LP | 0.02% | Reduce -35.9% | 12,262 | $96K |
| Xponance LLC | 0.00% | Add +1.1% | 12,112 | $95K |
| Captrust Financial Advisors | 0.00% | Reduce -0.7% | 11,816 | $93K |
| Brooklyn Investment Group | 0.00% | New | 12,195 | $91K |
| O'shaughnessy Asset Management, LLC | 0.00% | Add +12.4% | 11,423 | $90K |
| Jain Global LLC | 0.00% | New | 11,114 | $87K |
| Pallas Capital Advisors LLC | 0.00% | Reduce -0.2% | 11,003 | $86K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +141.1% | 10,740 | $84K |
| Cibc World Markets Corp. | 0.00% | — | 10,158 | $80K |
| Kingsview Wealth Management, LLC | 0.00% | New | 10,000 | $79K |
| Kemnay Advisory Services Inc. | 0.01% | New | 8,480 | $67K |
| State of Alaska, Department of Revenue | 0.00% | No change | 8,457 | $66K |
| Truvestments Capital LLC | 0.01% | Add +96.1% | 8,118 | $64K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +29.1% | 8,063 | $63K |
| CIBC Private Wealth Group LLC | 0.00% | No change | 6,664 | $52K |
| Jones Financial Companies LLLP | 0.00% | Add +105.2% | 5,707 | $45K |
| Amalgamated Bank | 0.00% | Reduce -0.2% | 4,824 | $38K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -6.2% | 3,260 | $26K |
| Kestra Advisory Services, LLC | 0.00% | New | 3,192 | $25K |
| Webster Bank, N. A. | 0.00% | Reduce -25.0% | 3,000 | $24K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -63.8% | 2,821 | $22K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +50.1% | 2,818 | $22K |
| Farther Finance Advisors, LLC | 0.00% | Add +8.0% | 2,571 | $20K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | New | 2,353 | $18K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 2,204 | $17K |
| Creative Financial Designs Inc. | 0.00% | No change | 2,200 | $17K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -0.3% | 1,907 | $15K |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +2042.5% | 1,714 | $13K |
| Arax Advisory Partners | 0.00% | Reduce -89.7% | 1,632 | $13K |
| Fortitude Family Office, LLC | 0.00% | No change | 1,553 | $12K |
| Essential Partners LLC | 0.00% | Reduce -9.7% | 1,288 | $10K |
| AlphaQuest LLC | 0.00% | Reduce -72.0% | 1,204 | $9K |
| Sound Income Strategies, LLC | 0.00% | New | 1,149 | $9K |
| Sterling Capital Management LLC | 0.00% | Add +174.2% | 1,020 | $8K |
| True Wealth Design, LLC | 0.00% | No change | 1,011 | $8K |
| Activest Wealth Management | 0.00% | No change | 1,000 | $8K |
| Hillsdale Investment Management Inc. | 0.00% | No change | 1,000 | $8K |
| Tsfg, LLC | 0.00% | Reduce -33.1% | 708 | $6K |
| Signaturefd, LLC | 0.00% | Add +14.1% | 720 | $6K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Reduce -24.2% | 678 | $5K |
| Rockefeller Capital Management L.P. | 0.00% | New | 594 | $5K |
| Rothschild Investment LLC | 0.00% | Add +6.9% | 449 | $4K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -35.8% | 399 | $3K |
| Daiwa Securities Group Inc. | 0.00% | No change | 404 | $3K |
| Smartleaf Asset Management LLC | 0.00% | New | 225 | $2K |
| Spurstone Advisory Services, LLC | 0.02% | No change | 200 | $2K |
| Parkside Financial Bank & Trust | 0.00% | No change | 155 | $1K |
| IFP Advisors, Inc | 0.00% | Add +600.0% | 140 | $1K |
| Covestor Ltd | 0.00% | Reduce -45.5% | 175 | $1K |
| Bessemer Group Inc. | 0.00% | No change | 68 | $1K |
| Sunbelt Securities, Inc. | 0.00% | No change | 81 | $636 |
| Steigerwald, Gordon & Koch Inc. | 0.00% | No change | 37 | $290 |
| Atlantic Private Wealth, LLC | 0.00% | New | 30 | $236 |
| MAI Capital Management | 0.00% | New | 27 | $212 |
| GAMMA Investing LLC | 0.00% | Reduce -4.2% | 23 | $181 |
| SJS Investment Consulting Inc. | 0.00% | New | 19 | $150 |
| Clearstead Advisors, LLC | 0.00% | Reduce -99.7% | 2 | $16 |
"% of holder's portfolio" is XERS's weight in each manager's 13F, not the share of Xeris Biopharma Holdings Inc. the manager owns.