Orbimed Advisors LLC

In its 13F for Q2 2026 (holdings as of June 30, 2026, filed August 14, 2026), Orbimed Advisors LLC reported 117 stock positions worth $5.3 billion. Its top holding was Edgewise Therapeutics (EWTX) at 12.0% of the portfolio, followed by Enliven Therapeutics (ELVN, 6.5%) and Eli Lilly (LLY, 5.9%). Compared with Q1 2026, it opened 31 new positions, sold out of 19, added to 33 and reduced 26. The biggest buy was a new position in Unitedhealth (UNH) and the biggest sale Boston Scientific (BSX, shares −38%).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0001055951
Portfolio Value
$5.3B (Q2 2026)
SEC Filing
0001172661-26-003740 ↗ filed Aug 14, 2026

Holdings Value

0$2.0B$4.0B$6.0B Q1 2024: $5.4B Q1 2024 Q2 2024: $5.0B Q2 2024 Q3 2024: $5.5B Q3 2024 Q4 2024: $4.8B Q4 2024 Q1 2025: $4.2B Q1 2025 Q2 2025: $4.0B Q2 2025 Q3 2025: $4.2B Q3 2025 Q4 2025: $4.9B Q4 2025 Q1 2026: $4.4B Q1 2026 Q2 2026: $5.3B $5.3B Q2 2026

Holdings 117 stocks · $5.3B

EWTX Edgewise Therapeutics Inc. 11.97% 15,518,492 $630.5M No change
ELVN Enliven Therapeutics Inc. 6.53% 6,776,632 $343.9M Reduce -14.9%
LLY Eli Lilly & Co. 5.87% 257,900 $309.3M Add +8.9%
MBX MBX Biosciences Inc. 3.59% 3,428,736 $189.3M Reduce -5.8%
SVA Sinovac Biotech Ltd. 3.50% 2,718,735 $184.5M No change
AZN Astrazeneca PLC 3.25% 915,700 $171.1M Add +36.6%
GPCR Structure Therapeutics Inc. 2.25% 2,209,400 $118.6M Add +49.8%
SION Sionna Therapeutics Inc. 2.13% 2,555,877 $112.4M Reduce -27.6%
CRVS Corvus Pharmaceuticals Inc. 2.03% 7,165,006 $107.0M No change
AVBP Arrivent Biopharma Inc. 2.00% 3,027,328 $105.2M No change
GH Guardant Health Inc. 1.66% 583,700 $87.6M Add +34.1%
ARGX Argenx SE - ADR 1.64% 92,880 $86.2M Reduce -32.1%
MRK Merck & Co. Inc. 1.62% 663,400 $85.2M No change
QURE Uniqure NV 1.58% 1,807,486 $83.3M Reduce -15.4%
PRAX Praxis Precision Medicines I 1.46% 230,100 $77.0M Add +33.4%
EW Edwards Lifesciences Corp. 1.43% 834,900 $75.5M Reduce -32.2%
PRLD Prelude Therapeutics Inc. 1.39% 13,724,571 $73.2M Add +25.8%
ABVX Abivax SA-ADR 1.38% 546,522 $72.8M Add +17.4%
DYN Dyne Therapeutics Inc. 1.36% 3,235,684 $71.9M Add +10.9%
NTRA Natera Inc. 1.35% 262,000 $71.1M No change
CGON CG Oncology Inc. 1.31% 972,800 $69.1M Add +2.6%
UNH Unitedhealth Group Inc. 1.27% 161,100 $67.0M New
SPRY Ars Pharmaceuticals Inc. 1.26% 8,288,510 $66.4M No change
ASND Ascendis Pharma A/S 1.24% 244,456 $65.2M Add +34.3%
HUM Humana Inc. 1.24% 164,100 $65.2M New
COGT Cogent Biosciences Inc. 1.24% 1,681,300 $65.1M Add +422.0%
BSX Boston Scientific Corp. 1.20% 1,483,200 $63.3M Reduce -37.7%
ISRG Intuitive Surgical Inc. 1.19% 157,900 $62.8M Reduce -24.3%
MLYS Mineralys Therapeutics Inc. 1.08% 2,110,300 $56.9M Add +2.8%
ODTX Odyssey Therapeutics Inc. 1.07% 3,001,198 $56.2M New
XENE Xenon Pharmaceuticals Inc. 1.02% 892,471 $53.9M Reduce -15.8%
ARQT Arcutis Biotherapeutics Inc. 1.02% 2,042,000 $53.5M New
BMY Bristol-Myers Squibb Co. 1.01% 925,000 $53.3M No change
QTTB Q32 Bio Inc. 1.00% 4,127,987 $52.6M Add +83.2%
SYK Stryker Corp. 0.95% 159,100 $50.1M Reduce -12.8%
CAI Caris Life Sciences Inc. 0.95% 2,806,811 $50.0M No change
TMO Thermo Fisher Scientific Inc. 0.86% 90,700 $45.5M Add +95.0%
PVLA Palvella Therapeutics Inc. 0.85% 292,360 $44.7M Add +117.2%
ELV Elevance Health Inc. 0.84% 114,700 $44.4M No change
STTK Shattuck Labs Inc. 0.83% 6,306,127 $43.8M No change
UPB Upstream Bio Inc. 0.75% 5,693,589 $39.4M No change
CRNX Crinetics Pharmaceuticals Inc. 0.71% 999,000 $37.4M No change
RYTM Rhythm Pharmaceuticals Inc. 0.68% 322,900 $35.9M Add +2.8%
SNDX Syndax Pharmaceuticals Inc. 0.64% 1,542,000 $33.7M Add +60.2%
FBRX Forte Biosciences Inc. 0.64% 1,577,705 $33.5M Add +31.8%
CMPX Compass Therapeutics Inc. 0.63% 15,219,994 $33.3M No change
NKTR Nektar Therapeutics 0.62% 465,346 $32.5M Add +69.2%
KRYS Krystal Biotech Inc. 0.59% 83,200 $30.9M Add +20.4%
0 0.57% 5,680,186 $30.3M Reduce -8.5%
AXSM Axsome Therapeutics Inc. 0.55% 117,578 $28.8M Reduce -45.0%
KNSA Kiniksa Pharmaceuticals Inte 0.51% 420,600 $26.9M Add +132.9%
TRVI Trevi Therapeutics Inc. 0.51% 1,430,293 $26.7M Reduce -41.7%
IRON Disc Medicine Inc. 0.50% 357,535 $26.2M Reduce -66.5%
WST West Pharmaceutical Services 0.48% 70,600 $25.3M New
RLMD Relmada Therapeutics Inc. 0.48% 3,631,195 $25.1M Reduce -23.0%
URGN Urogen Pharma Ltd. 0.47% 676,187 $24.9M Reduce -22.8%
STRO Sutro Biopharma Inc. 0.47% 743,944 $24.7M Reduce -7.1%
SVRA Savara Inc. 0.46% 3,959,900 $24.4M Add +523.6%
NPCE Neuropace Inc. 0.45% 1,505,125 $23.9M Reduce -28.2%
AURA Aura Biosciences Inc. 0.45% 3,333,333 $23.7M New
ORIC Oric Pharmaceuticals Inc. 0.41% 2,015,000 $21.8M Reduce -25.2%
HELP Cybin Inc. 0.41% 3,271,400 $21.6M Reduce -14.7%
BCRX Biocryst Pharmaceuticals Inc. 0.35% 1,852,000 $18.5M Add +29.9%
BIOA Bioage Labs Inc. 0.35% 752,153 $18.4M Add +5.7%
LXEO Lexeo Therapeutics Inc. 0.35% 3,947,850 $18.4M Add +9.6%
WHWK Whitehawk Therapeutics Inc. 0.34% 3,934,296 $18.0M Reduce -5.6%
DFTX Definium Therapeutics Inc. 0.33% 365,400 $17.2M Reduce -54.5%
SYRE Spyre Therapeutics Inc. 0.31% 186,145 $16.5M New
CRBP Corbus Pharmaceuticals Holdi 0.31% 1,737,287 $16.3M No change
VERA Vera Therapeutics Inc. 0.30% 369,596 $15.9M No change
ALMS Alumis Inc. 0.29% 548,163 $15.4M No change
EYPT Eyepoint Inc. 0.29% 1,069,147 $15.3M No change
WAT Waters Corp. 0.29% 40,300 $15.1M New
MNPR Monopar Therapeutics Inc. 0.28% 157,423 $14.6M New
TVTX Travere Therapeutics Inc. 0.27% 253,000 $14.4M New
TSHA Taysha Gene Therapies Inc. 0.26% 2,000,000 $13.6M New
BIIB Biogen Inc. 0.25% 61,600 $13.3M No change
RVMD Revolution Medicines Inc. 0.25% 70,500 $13.2M Add +35.6%
DNTH Dianthus Therapeutics Inc. 0.21% 115,000 $11.2M New
SPRB Spruce Biosciences Inc. 0.21% 200,000 $10.8M New
LFST Lifestance Health Group Inc. 0.19% 947,400 $10.1M Add +89.5%
ERAS Erasca Inc. 0.17% 495,900 $9.1M New
TARA Protara Therapeutic Inc. 0.16% 2,220,000 $8.5M New
KROS Keros Therapeutics Inc. 0.15% 759,155 $8.1M No change
JANX Janux Therapeutics Inc. 0.15% 524,700 $8.1M Reduce -46.7%
TECX Tectonic Therapeutic Inc. 0.15% 226,600 $7.8M No change
ACET Adicet Bio Inc. 0.14% 844,787 $7.3M Reduce -17.8%
PHVS Pharvaris NV 0.13% 205,400 $7.1M No change
ANRO Alto Neuroscience Inc. 0.13% 257,852 $6.8M Add +53.9%
ZNTL Zentalis Pharmaceuticals Inc. 0.13% 1,390,576 $6.7M New
DRUG Bright Minds Biosciences Inc. 0.12% 93,000 $6.5M Add +132.5%
ALXO Alx Oncology Holdings Inc. 0.11% 2,866,256 $5.9M No change
XLO Xilio Therapeutics Inc. 0.11% 592,300 $5.7M New
BCAX Bicara Therapeutics Inc. 0.11% 191,100 $5.7M Reduce -71.4%
IMA Imagenebio Inc. 0.10% 909,269 $5.4M Add +140.2%
PTGX Protagonist Therapeutics Inc. 0.10% 42,100 $5.2M No change
ALNY Alnylam Pharmaceuticals Inc. 0.10% 17,000 $5.1M Reduce -85.7%
PALI Palisade Bio Inc. 0.09% 2,333,000 $4.9M No change
ATAI Ataibeckley Inc. 0.08% 797,500 $4.2M Add +129.8%
PTCT PTC Therapeutics Inc. 0.08% 49,100 $4.0M No change
AORT Artivion Inc. 0.07% 175,000 $3.9M Add +15.9%
NMRA Neumora Therapeutics Inc. 0.07% 2,139,882 $3.6M New
ACAD Acadia Pharmaceuticals Inc. 0.07% 137,000 $3.5M New
AMLX Amylyx Pharmaceuticals Inc. 0.06% 183,400 $3.3M New
TYRA Tyra Biosciences Inc. 0.06% 102,000 $3.3M New
RAPP Rapport Therapeutics Inc. 0.06% 76,616 $3.2M New
AGMB Agomab Therapeutics NV 0.05% 192,740 $2.5M New
TARS Tarsus Pharmaceuticals Inc. 0.04% 35,581 $2.2M New
ACRS Aclaris Therapeutics Inc. 0.04% 421,500 $2.2M New
CYTK Cytokinetics Inc. 0.04% 25,800 $2.2M New
NSPR Inspiremd Inc. 0.04% 3,133,405 $2.2M No change
OCUL Ocular Therapeutix Inc. 0.04% 220,000 $2.2M New
EVMN Evommune Inc. 0.04% 161,000 $2.1M New
BLTE Belite Bio Inc. - ADR 0.04% 13,300 $2.0M New
OVID Ovid Therapeutics Inc. 0.04% 747,000 $2.0M New
EPRX Eupraxia Pharmaceuticals Inc. 0.03% 269,000 $1.8M New
TRAW Traws Pharma Inc. 0.02% 1,203,260 $1.0M Add +98.7%

Options reported separately and not counted above: XBI puts ($47.5M), ABVX calls ($26.7M), PTGX calls ($18.4M), RVMD calls ($9.4M), PVLA calls ($6.1M), UNH calls ($4.2M), ELV calls ($3.9M), SLS puts ($1.4M).

Other holdings (4): bonds, preferreds, convertibles and warrants · $12.6M (not counted above)
SecurityClassShares / PrincipalValueChange
TRAVERE THERAPEUTICS INC (TVTX 0.5 05/15/32) NOTE 0.500% 5/1 · principal 5,000,000$5.9MNew
REVOLUTION MEDICINES INC (RVMD 0.5 05/01/33) NOTE 0.500% 5/0 · principal 3,500,000$4.4MNew
COGENT BIOSCIENCES INC (COGT 1.625 11/15/31) NOTE 1.625%11/1 · principal 1,000,000$1.2MNo change
VIRIDIAN THERAPEUTICS INC NOTE 1.750% 5/1 · principal 1,000,000$1.1MNew

Total filed on the 13F, all lines: $5.3B.

Portfolio Sells Q1 2026 → Q2 2026

BSX Boston Scientific Corp. Reduce -37.7% 1.20% −2.18
PFE Pfizer Inc. Sold out 0.00% −1.24
DHR Danaher Corp. Sold out 0.00% −1.14
SION Sionna Therapeutics Inc. Reduce -27.6% 2.13% −1.07
IRON Disc Medicine Inc. Reduce -66.5% 0.50% −1.05
ISRG Intuitive Surgical Inc. Reduce -24.3% 1.19% −0.98
EW Edwards Lifesciences Corp. Reduce -32.2% 1.43% −0.80
ALNY Alnylam Pharmaceuticals Inc. Reduce -85.7% 0.10% −0.79
ESPR Esperion Therapeutics Inc. Sold out 0.00% −0.66
ARGX Argenx SE - ADR Reduce -32.1% 1.64% −0.63
ELVN Enliven Therapeutics Inc. Reduce -14.9% 6.53% −0.53
BTSG Brightspring Health Services Sold out 0.00% −0.48
SYK Stryker Corp. Reduce -12.8% 0.95% −0.41
XENE Xenon Pharmaceuticals Inc. Reduce -15.8% 1.02% −0.37
ORIC Oric Pharmaceuticals Inc. Reduce -25.2% 0.41% −0.36
AMGN Amgen Inc. Sold out 0.00% −0.32
ALHC Alignment Healthcare Inc. Sold out 0.00% −0.32
AXSM Axsome Therapeutics Inc. Reduce -45.0% 0.55% −0.27
RLMD Relmada Therapeutics Inc. Reduce -23.0% 0.48% −0.27
REGN Regeneron Pharmaceuticals Sold out 0.00% −0.26
CARL Carlsmed Inc. Sold out 0.00% −0.26
BCAX Bicara Therapeutics Inc. Reduce -71.4% 0.11% −0.19
GILD Gilead Sciences Inc. Sold out 0.00% −0.19
HRTX Heron Therapeutics Inc. Sold out 0.00% −0.18
NPCE Neuropace Inc. Reduce -28.2% 0.45% −0.17
AVTX Avalo Therapeutics Inc. Sold out 0.00% −0.16
JANX Janux Therapeutics Inc. Reduce -46.7% 0.15% −0.16
TRVI Trevi Therapeutics Inc. Reduce -41.7% 0.51% −0.16
CMPS Compass Pathways PLC Sold out 0.00% −0.14
ADCT Adc Therapeutics SA Sold out 0.00% −0.11
CGEM Cullinan Therapeutics Inc. Sold out 0.00% −0.08
JBIO Jade Biosciences Inc. Sold out 0.00% −0.06
CCCC C4 Therapeutics Inc. Sold out 0.00% −0.05
RCEL Avita Medical Inc. Sold out 0.00% −0.05
KALV Kalvista Pharmaceuticals Inc. Sold out 0.00% −0.04
VTGN Vistagen Therapeutics Inc. Sold out 0.00% −0.04
ACET Adicet Bio Inc. Reduce -17.8% 0.14% −0.02
DFTX Definium Therapeutics Inc. Reduce -54.5% 0.33% −0.02
HELP Cybin Inc. Reduce -14.7% 0.41% −0.01
WHWK Whitehawk Therapeutics Inc. Reduce -5.6% 0.34% +0.02
STRO Sutro Biopharma Inc. Reduce -7.1% 0.47% +0.02
0 Reduce -8.5% 0.57% +0.08
URGN Urogen Pharma Ltd. Reduce -22.8% 0.47% +0.12
QURE Uniqure NV Reduce -15.4% 1.58% +0.79
MBX MBX Biosciences Inc. Reduce -5.8% 3.59% +1.14

Portfolio Buys Q1 2026 → Q2 2026

UNH Unitedhealth Group Inc. New 1.27% +1.27
HUM Humana Inc. New 1.24% +1.24
ODTX Odyssey Therapeutics Inc. New 1.07% +1.07
ARQT Arcutis Biotherapeutics Inc. New 1.02% +1.02
COGT Cogent Biosciences Inc. Add +422.0% 1.24% +0.95
LLY Eli Lilly & Co. Add +8.9% 5.87% +0.95
GH Guardant Health Inc. Add +34.1% 1.66% +0.75
QTTB Q32 Bio Inc. Add +83.2% 1.00% +0.67
GPCR Structure Therapeutics Inc. Add +49.8% 2.25% +0.64
PRLD Prelude Therapeutics Inc. Add +25.8% 1.39% +0.55
WST West Pharmaceutical Services New 0.48% +0.48
PVLA Palvella Therapeutics Inc. Add +117.2% 0.85% +0.47
AURA Aura Biosciences Inc. New 0.45% +0.45
SVRA Savara Inc. Add +523.6% 0.46% +0.38
TMO Thermo Fisher Scientific Inc. Add +95.0% 0.86% +0.35
KNSA Kiniksa Pharmaceuticals Inte Add +132.9% 0.51% +0.31
SYRE Spyre Therapeutics Inc. New 0.31% +0.31
ASND Ascendis Pharma A/S Add +34.3% 1.24% +0.30
WAT Waters Corp. New 0.29% +0.29
MNPR Monopar Therapeutics Inc. New 0.28% +0.28
TVTX Travere Therapeutics Inc. New 0.27% +0.27
TSHA Taysha Gene Therapies Inc. New 0.26% +0.26
AZN Astrazeneca PLC Add +36.6% 3.25% +0.26
DNTH Dianthus Therapeutics Inc. New 0.21% +0.21
ABVX Abivax SA-ADR Add +17.4% 1.38% +0.21
PRAX Praxis Precision Medicines I Add +33.4% 1.46% +0.21
SPRB Spruce Biosciences Inc. New 0.21% +0.21
KRYS Krystal Biotech Inc. Add +20.4% 0.59% +0.18
ERAS Erasca Inc. New 0.17% +0.17
NKTR Nektar Therapeutics Add +69.2% 0.62% +0.17
DYN Dyne Therapeutics Inc. Add +10.9% 1.36% +0.17
TARA Protara Therapeutic Inc. New 0.16% +0.16
RVMD Revolution Medicines Inc. Add +35.6% 0.25% +0.14
SNDX Syndax Pharmaceuticals Inc. Add +60.2% 0.64% +0.13
ZNTL Zentalis Pharmaceuticals Inc. New 0.13% +0.13
LFST Lifestance Health Group Inc. Add +89.5% 0.19% +0.12
XLO Xilio Therapeutics Inc. New 0.11% +0.11
NMRA Neumora Therapeutics Inc. New 0.07% +0.07
BIOA Bioage Labs Inc. Add +5.7% 0.35% +0.07
ACAD Acadia Pharmaceuticals Inc. New 0.07% +0.07
RYTM Rhythm Pharmaceuticals Inc. Add +2.8% 0.68% +0.06
AMLX Amylyx Pharmaceuticals Inc. New 0.06% +0.06
TYRA Tyra Biosciences Inc. New 0.06% +0.06
RAPP Rapport Therapeutics Inc. New 0.06% +0.06
IMA Imagenebio Inc. Add +140.2% 0.10% +0.06
DRUG Bright Minds Biosciences Inc. Add +132.5% 0.12% +0.06
ATAI Ataibeckley Inc. Add +129.8% 0.08% +0.05
AGMB Agomab Therapeutics NV New 0.05% +0.05
BCRX Biocryst Pharmaceuticals Inc. Add +29.9% 0.35% +0.04
ANRO Alto Neuroscience Inc. Add +53.9% 0.13% +0.04

Options Activity Q1 2026 → Q2 2026

MDXH Mdxhealth call Sold out 124,306,000 $285.9Mbefore exit
RCEL Avita Medical Inc. call Sold out 40,966,100 $154.4Mbefore exit
XBI SS SPDR S&P Biotech ETF put New 300,000 $47.5M
ABVX Abivax SA-ADR call New 200,000 $26.7M
PTGX Protagonist Therapeutics Inc. call New 150,000 $18.4M
QGEN Qiagen N.V. call Sold out 250,000 $10.0Mbefore exit
RVMD Revolution Medicines Inc. call New 50,000 $9.4M
PVLA Palvella Therapeutics Inc. call Reduce -20.0% 40,000 $6.1M
UNH Unitedhealth Group Inc. call New 10,000 $4.2M
ELV Elevance Health Inc. call New 10,000 $3.9M
SLNO Soleno Therapeutics Inc. call Sold out 100,000 $3.3Mbefore exit
SLS Sellas Life Sciences Group I put New 92,500 $1.4M

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

Notes & Other Activity Q1 2026 → Q2 2026

MYGN Myriad Genetics Inc. COM · principal Sold out 125,000,000 $122.9Mbefore exit
RCEL Avita Medical Inc. COM · principal Sold out 40,500,000 $40.5Mbefore exit
TRAVERE THERAPEUTICS INC (TVTX 0.5 05/15/32) NOTE 0.500% 5/1 · principal New 5,000,000 $5.9M
REVOLUTION MEDICINES INC (RVMD 0.5 05/01/33) NOTE 0.500% 5/0 · principal New 3,500,000 $4.4M
VIRIDIAN THERAPEUTICS INC NOTE 1.750% 5/1 · principal New 1,000,000 $1.1M

Bonds, preferreds, convertibles and warrants; not part of the stock holdings or percentages above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 117$5.3BEWTX, ELVN, LLY, MBX, SVA
Q1 2026 105$4.4BEWTX, ELVN, LLY, SVA, BSX
Q4 2025 104$4.9BEWTX, LLY, BSX, SVA, EW
Q3 2025 98$4.2BEWTX, BSX, LLY, SVA, ELVN
Q2 2025 97$4.0BSVA, BSX, LLY, EWTX, ELVN
Q1 2025 106$4.2BSVA, EWTX, BSX, LLY, ELVN
Q4 2024 111$4.8BEWTX, SVA, BSX, LLY, ISRG
Q3 2024 109$5.5BEWTX, SVA, LLY, BSX, ISRG
Q2 2024 108$5.0BSVA, LLY, EWTX, BSX, ISRG
Q1 2024 112$5.4BSVA, LLY, EWTX, BSX, ISRG