Structure TherapeuticsGPCR
13F holders, Q1 2026 (March 31)196holders −1
37new positions
39sold out
4famous investors
$48.29avg. 13F price*
At the end of Q1 2026, 196 institutions reported holding Structure Therapeutics Inc. (GPCR) in their 13F filings, down 1 from Q4 2025. 37 opened new positions and 39 sold out. The largest holders were FMR LLC ($405.0M), Wellington Management Group LLP ($349.9M) and Avoro Capital Advisors LLC ($316.0M). 4 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Structure Therapeutics Inc.
- CUSIP
- 86366E106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 37 | $84.1M |
| Exits | 39 | $195.8M |
All 13F filers, Q4 2025 → Q1 2026: 6,879,512 shares bought and 6,549,624 shares sold, net +329,888 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 196 holders
| FMR LLC | 0.02% | Reduce -3.5% | 8,403,449 | $405.0M |
| Wellington Management Group LLP | 0.07% | Add +1.9% | 7,260,287 | $349.9M |
| Avoro Capital Advisors LLC | 3.11% | No change | 6,555,555 | $316.0M |
| Janus Henderson Group PLC | 0.12% | Add +5.2% | 5,354,981 | $258.3M |
| Deep Track Capital, LP | 4.26% | Add +4.1% | 4,279,848 | $206.3M |
| BVF Inc. | 5.31% | Reduce -0.6% | 3,459,358 | $166.7M |
| Morgan Stanley | 0.01% | Add +10.4% | 2,305,457 | $111.1M |
| T. Rowe Price Associates Inc. | 0.01% | Add +19.7% | 2,000,696 | $96.4M |
| Principal Financial Group Inc. | 0.05% | Add +36.6% | 1,753,764 | $84.5M |
| Driehaus Capital Management LLC | 0.56% | Reduce -4.0% | 1,577,356 | $76.0M |
| Orbimed Advisors LLC | 1.61% | Add +27.0% | 1,475,403 | $71.1M |
| American Century Companies Inc. | 0.04% | Add +183.7% | 1,438,031 | $69.3M |
| Baker Bros. Advisors LP | 0.40% | No change | 1,432,529 | $69.0M |
| Siren, L.L.C. | 1.78% | Add +23.2% | 1,328,698 | $64.0M |
| Casdin Capital, LLC | 4.29% | No change | 1,175,000 | $56.6M |
| Capitolis Liquid Global Markets LLC | 0.35% | — | 1,151,300 | $55.5M |
| Alliancebernstein L.P. | 0.01% | Reduce -24.7% | 638,813 | $44.4M |
| Deerfield Management Company, L.P. | 0.52% | No change | 767,993 | $37.0M |
| Pacific Heights Asset Management LLC | 1.21% | Add +7.1% | 750,000 | $36.1M |
| Rock Springs Capital Management LP | 1.82% | Reduce -14.4% | 640,217 | $30.9M |
| Paradigm Biocapital Advisors LP | 0.54% | New | 545,287 | $26.3M |
| Franklin Resources Inc. | 0.01% | Reduce -38.9% | 531,595 | $25.6M |
| Logos Global Management LP | 1.24% | Reduce -16.7% | 500,000 | $24.1M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.04% | No change | 467,800 | $22.5M |
| BlackRock, Inc. | 0.00% | Add +2.8% | 441,975 | $21.3M |
| Aberdeen Group plc | 0.03% | Add +47.9% | 391,809 | $18.9M |
| Deutsche Bank AG | 0.01% | Reduce -60.5% | 331,867 | $16.0M |
| National Bank of Canada | 0.02% | Add +15.1% | 305,400 | $14.7M |
| Balyasny Asset Management L.P. | 0.03% | Add +41.0% | 304,934 | $14.7M |
| Goldman Sachs Group Inc. | 0.00% | Add +16.1% | 260,543 | $12.6M |
| Catalio Capital Management, LP | 2.57% | Add +1.0% | 255,379 | $12.3M |
| Voloridge Investment Management, LLC | 0.05% | Add +2.0% | 254,969 | $12.3M |
| SEB Asset Management AB | 0.05% | — | 245,043 | $11.8M |
| Pentwater Capital Management LP | 0.08% | New | 245,000 | $11.8M |
| Parkman Healthcare Partners LLC | 1.16% | Add +322.0% | 232,093 | $11.2M |
| Bank of America Corp. | 0.00% | Add +617.0% | 227,132 | $10.9M |
| Ameriprise Financial Inc. | 0.00% | Reduce -23.1% | 219,516 | $10.6M |
| UBS Group AG | 0.00% | Add +5.2% | 212,919 | $10.3M |
| Sio Capital Management, LLC | 1.45% | Add +3.8% | 209,093 | $10.1M |
| D. E. Shaw & Co. | 0.01% | Add +2274.9% | 204,790 | $9.9M |
| TD Asset Management Inc | 0.01% | Add +17.2% | 204,762 | $9.9M |
| Stempoint Capital LP | 1.86% | Reduce -43.0% | 200,267 | $9.7M |
| JPMorgan Chase & Co. | 0.00% | Add +1542.5% | 212,803 | $9.4M |
| Woodline Partners LP | 0.03% | Add +54.0% | 190,808 | $9.2M |
| ArrowMark Colorado Holdings LLC | 0.24% | Reduce -30.6% | 188,195 | $9.1M |
| Two Sigma Investments, LP | 0.01% | Add +89.9% | 181,415 | $8.7M |
| Cormorant Asset Management, LP | 0.43% | New | 175,000 | $8.4M |
| Millennium Management | 0.01% | Add +10.7% | 168,931 | $8.1M |
| Schonfeld Strategic Advisors LLC | 0.07% | Add +1795.6% | 165,426 | $8.0M |
| Holocene Advisors, LP | 0.02% | New | 159,009 | $7.7M |
| TCG Crossover Management, LLC | 0.19% | Reduce -84.8% | 140,411 | $6.8M |
| Eversept Partners, LP | 0.44% | Add +8.2% | 138,036 | $6.7M |
| Nomura Asset Management International Inc. | 0.01% | Add +62.2% | 134,015 | $6.5M |
| NEXTBio Capital Management LP | 2.98% | Add +41.1% | 133,239 | $6.4M |
| HSG Holding Ltd | 0.38% | No change | 266,062 | $6.2M |
| Rhenman & Partners Asset Management AB | 0.76% | Reduce -13.2% | 128,100 | $6.2M |
| B Group, Inc. | 4.56% | Add +41.7% | 127,500 | $6.1M |
| Davern Capital Partners, LP | 1.67% | New | 126,461 | $6.1M |
| PFM Health Sciences, LP | 0.65% | Add +85.2% | 126,383 | $6.1M |
| HighVista Strategies LLC | 1.65% | Reduce -35.8% | 123,909 | $6.0M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +19.1% | 114,814 | $5.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +32.0% | 109,638 | $5.3M |
| Trexquant Investment LP | 0.04% | Add +19.9% | 107,884 | $5.2M |
| Jump Financial, LLC | 0.09% | New | 107,857 | $5.2M |
| Jones Hill Capital LP | 1.04% | — | 100,593 | $4.8M |
| Birchview Capital, LP | 2.74% | Add +11.1% | 100,000 | $4.8M |
| Peregrine Capital Management LLC | 0.17% | Add +15.2% | 97,117 | $4.7M |
| Soleus Capital Management, L.P. | 0.16% | Reduce -11.1% | 80,000 | $3.9M |
| Tudor Investment Corporation | 0.02% | Add +114.8% | 75,301 | $3.6M |
| Boxer Capital Management, LLC | 0.47% | No change | 75,000 | $3.6M |
| Qube Research & Technologies Ltd | 0.01% | New | 73,599 | $3.5M |
| Diadema Partners LP | 1.44% | New | 72,234 | $3.5M |
| Marshall Wace, LLP | 0.00% | Reduce -59.0% | 69,107 | $3.3M |
| Geode Capital Management, LLC | 0.00% | Add +23.1% | 67,862 | $3.3M |
| Platinum Investment Management Ltd. | 0.81% | Reduce -23.9% | 66,864 | $3.2M |
| Jefferies Financial Group Inc. | 0.04% | Reduce -39.2% | 62,592 | $3.0M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | Reduce -11.1% | 60,517 | $2.9M |
| Burkehill Global Management, LP | 0.15% | No change | 60,000 | $2.9M |
| Alps Advisors Inc. | 0.01% | Add +16.0% | 57,667 | $2.8M |
| Susquehanna International Group, LLP | 0.00% | Add +520.5% | 55,842 | $2.7M |
| Renaissance Technologies | 0.00% | Reduce -51.6% | 55,800 | $2.7M |
| Sphera Funds Management LTD. | 0.42% | Add +23.9% | 50,800 | $2.4M |
| Monashee Investment Management LLC | 1.56% | Reduce -77.8% | 50,000 | $2.4M |
| Buckland Partners Management Co LLC | 1.46% | No change | 50,000 | $2.4M |
| Seven Grand Managers, LLC | 0.16% | No change | 50,000 | $2.4M |
| Banque Pictet & Cie SA | 0.03% | Reduce -17.6% | 49,367 | $2.4M |
| State Street Corp. | 0.00% | Reduce -1.3% | 47,581 | $2.3M |
| Pier Capital, LLC | 0.38% | Reduce -2.5% | 47,551 | $2.3M |
| DAFNA Capital Management LLC | 0.52% | Add +25.7% | 46,500 | $2.2M |
| Brevan Howard Capital Management LP | 0.02% | Reduce -45.2% | 47,266 | $2.2M |
| ANTIPODES PARTNERS Ltd | 0.04% | Reduce -2.0% | 45,361 | $2.2M |
| Raymond James Financial Inc. | 0.00% | Add +1.7% | 45,139 | $2.2M |
| Osaic Holdings, Inc. | 0.00% | Reduce -25.0% | 44,416 | $2.1M |
| Voya Investment Management LLC | 0.00% | Reduce -19.7% | 44,410 | $2.1M |
| Bank of Montreal | 0.00% | Reduce -26.4% | 39,984 | $1.9M |
| Headlands Technologies LLC | 0.20% | Reduce -15.0% | 37,156 | $1.8M |
| Flax Pond Capital, LLC | 1.40% | Reduce -26.1% | 36,000 | $1.7M |
| PSquared Asset Management AG | 0.59% | New | 35,000 | $1.7M |
| Mariner, LLC | 0.00% | Reduce -21.9% | 34,480 | $1.7M |
| Private Capital Advisors, Inc. | 0.19% | Add +368.0% | 34,389 | $1.7M |
| TrueMark Investments, LLC | 0.32% | Add +1.4% | 34,377 | $1.7M |
| Nomura Asset Management Co. Ltd. | 0.00% | Add +12.5% | 32,790 | $1.6M |
| Capital Fund Management S.A. | 0.01% | New | 32,436 | $1.6M |
| XTX Topco Ltd | 0.03% | Add +61.1% | 30,921 | $1.5M |
| Avidity Partners Management LP | 0.29% | New | 30,000 | $1.4M |
| Verition Fund Management LLC | 0.01% | Reduce -64.1% | 28,074 | $1.4M |
| DCF Advisers, LLC | 0.50% | Reduce -8.3% | 27,500 | $1.3M |
| Exchange Traded Concepts, LLC | 0.01% | Reduce -2.3% | 25,378 | $1.2M |
| Squarepoint Ops LLC | 0.00% | New | 22,646 | $1.1M |
| Walleye Capital LLC | 0.01% | Add +1067900.0% | 21,360 | $1.0M |
| CenterBook Partners LP | 0.06% | New | 21,237 | $1.0M |
| Citigroup Inc. | 0.00% | Add +179.4% | 20,494 | $988K |
| Barclays PLC | 0.00% | Add +145.0% | 19,188 | $925K |
| Persistent Asset Partners Ltd | 0.34% | Add +649.7% | 18,263 | $880K |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 17,297 | $834K |
| Aquatic Capital Management LLC | 0.02% | New | 14,814 | $714K |
| Sectoral Asset Management Inc. | 0.59% | Reduce -40.9% | 14,102 | $711K |
| Sei Investments Co. | 0.00% | Reduce -6.1% | 13,990 | $674K |
| MML Investors Services, LLC | 0.00% | Add +77.5% | 13,887 | $669K |
| China Universal Asset Management Co., Ltd. | 0.05% | Add +27.0% | 13,824 | $666K |
| Gsa Capital Partners LLP | 0.04% | New | 13,811 | $666K |
| Wexford Capital LP | 0.11% | Reduce -7.6% | 13,709 | $661K |
| Brandywine Managers, LLC | 0.38% | No change | 13,357 | $644K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -1.7% | 11,377 | $548K |
| Stifel Financial Corp. | 0.00% | Add +134.8% | 11,342 | $547K |
| Verdad Advisers, LP | 0.61% | New | 11,335 | $546K |
| BNP Paribas Financial Markets | 0.00% | Add +24.4% | 10,879 | $524K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -59.3% | 10,701 | $516K |
| Quinn Opportunity Partners LLC | 0.03% | Reduce -60.0% | 10,000 | $482K |
| HighTower Advisors, LLC | 0.00% | Add +3.2% | 9,620 | $464K |
| LPL Financial LLC | 0.00% | Add +14.2% | 9,260 | $446K |
| Gilbert & Cook, Inc. | 0.06% | Add +61.8% | 9,193 | $443K |
| SmartHarvest Portfolios, LLC | 0.18% | No change | 9,056 | $436K |
| Seven Fleet Capital Management LP | 0.14% | New | 9,000 | $434K |
| Cinctive Capital Management LP | 0.03% | New | 8,714 | $420K |
| Allianz Asset Management GmbH | 0.00% | Reduce -28.3% | 8,600 | $415K |
| DNB Asset Management AS | 0.00% | Reduce -35.2% | 8,188 | $395K |
| Axq Capital, LP | 0.05% | New | 7,916 | $382K |
| Wells Fargo & Company | 0.00% | Add +38.0% | 7,818 | $377K |
| Cetera Investment Advisers | 0.00% | Add +17.0% | 7,720 | $372K |
| Mission Wealth Management, LP | 0.01% | Reduce -20.9% | 7,583 | $366K |
| Vestmark Advisory Solutions, Inc. | 0.00% | No change | 7,534 | $363K |
| Independent Advisor Alliance | 0.00% | Add +63.9% | 7,444 | $359K |
| Parallel Advisors, LLC | 0.01% | No change | 7,352 | $354K |
| Scientech Research LLC | 0.28% | New | 6,958 | $335K |
| Janney Montgomery Scott LLC | 0.00% | New | 6,819 | $329K |
| Bellevue Group AG | 0.01% | Reduce -95.3% | 6,803 | $328K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +21.7% | 6,411 | $309K |
| PEAK6 LLC | 0.01% | Reduce -23.9% | 6,055 | $292K |
| Advisory Services Network, LLC | 0.00% | New | 5,879 | $283K |
| Jain Global LLC | 0.00% | Reduce -94.2% | 5,772 | $278K |
| Concurrent Investment Advisors, LLC | 0.00% | No change | 5,000 | $241K |
| Quadcap Wealth Management, LLC | 0.03% | Reduce -36.8% | 4,729 | $228K |
| Tidal Investments LLC | 0.00% | New | 4,643 | $224K |
| Invesco Ltd. | 0.00% | Add +43.2% | 4,581 | $221K |
| E. Ohman J:or Asset Management AB | 0.01% | No change | 4,518 | $218K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0.30% | New | 4,190 | $202K |
| Virtus Investment Advisers, LLC | 0.05% | Add +2.5% | 4,065 | $196K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -27.3% | 2,854 | $138K |
| SG Americas Securities, LLC | 0.00% | Reduce -73.9% | 2,649 | $128K |
| Assetmark, Inc. | 0.00% | Add +21.4% | 2,544 | $123K |
| Rockefeller Capital Management L.P. | 0.00% | Add +203.7% | 2,220 | $107K |
| Penserra Capital Management LLC | 0.00% | New | 1,738 | $83K |
| Nano Cap New Millennium Growth Fund L P | 0.07% | New | 1,500 | $72K |
| GF Fund Management Co. LTD. | 0.00% | Add +14.3% | 1,500 | $72K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -44.9% | 1,400 | $67K |
| GAMMA Investing LLC | 0.00% | Add +7.4% | 999 | $48K |
| Farther Finance Advisors, LLC | 0.00% | Add +34.9% | 931 | $47K |
| Royal Bank of Canada | 0.00% | Reduce -92.9% | 722 | $35K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +1475.6% | 646 | $31K |
| Sterling Capital Management LLC | 0.00% | New | 590 | $28K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -3.5% | 558 | $27K |
| State of Wyoming | 0.00% | Reduce -75.4% | 433 | $21K |
| Wolff Wiese Magana LLC | 0.01% | No change | 400 | $19K |
| North Star Investment Management Corp. | 0.00% | No change | 330 | $16K |
| Jones Financial Companies LLLP | 0.00% | Reduce -67.4% | 341 | $16K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | New | 212 | $10K |
| SOA Wealth Advisors, LLC. | 0.00% | Reduce -42.9% | 200 | $10K |
| Dynamic Wealth Strategies, LLC | 0.00% | No change | 150 | $7K |
| Cwm, LLC | 0.00% | Reduce -74.0% | 125 | $6K |
| Key Financial Inc | 0.00% | New | 100 | $5K |
| SHP Wealth Management | 0.00% | No change | 100 | $5K |
| Farmers & Merchants Investments Inc. | 0.00% | New | 100 | $5K |
| Signaturefd, LLC | 0.00% | Reduce -98.5% | 100 | $5K |
| Basecamp Wealth Advisors LLC | 0.00% | New | 84 | $4K |
| Rakuten Securities, Inc. | 0.00% | New | 60 | $3K |
| Transamerica Financial Advisors, LLC | 0.00% | New | 22 | $1K |
| Capital Analysts, LLC | 0.00% | No change | 18 | $1K |
| Smartleaf Asset Management LLC | 0.00% | New | 17 | $747 |
| US Bancorp \de | 0.00% | New | 10 | $482 |
| Ancora Advisors LLC | 0.00% | No change | 10 | $482 |
| Allworth Financial LP | 0.00% | New | 9 | $434 |
| Cullen/Frost Bankers, Inc. | 0.00% | No change | 8 | $386 |
| Larson Financial Group LLC | 0.00% | No change | 5 | $241 |
| Huntington National Bank | 0.00% | No change | 2 | $96 |
| IMA Advisory Services, Inc. | 0.00% | New | 2 | $96 |
"% of holder's portfolio" is GPCR's weight in each manager's 13F, not the share of Structure Therapeutics Inc. the manager owns.