Ionis PharmaceuticalsIONS
13F holders, Q4 2025 (December 31)494holders +58
93new positions
41sold out
11famous investors
$79.09avg. 13F price*
At the end of Q4 2025, 494 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 58 from Q3 2025. 93 opened new positions and 41 sold out. The largest holders were FMR LLC ($1.9B), Capital World Investors ($1.4B) and Vanguard Group Inc. ($1.3B). 11 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 93 | $209.6M |
| Exits | 41 | $233.4M |
All 13F filers, Q3 2025 → Q4 2025: 23,061,726 shares bought and 21,909,690 shares sold, net +1,152,036 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 494 holders
| FMR LLC | 0.10% | Add +1.6% | 24,072,101 | $1.9B |
| Capital World Investors | 0.19% | Add +41.2% | 17,961,299 | $1.4B |
| Vanguard Group Inc. | 0.02% | Reduce -0.3% | 16,440,459 | $1.3B |
| BlackRock, Inc. | 0.01% | Add +1.9% | 10,647,863 | $842.4M |
| T. Rowe Price Investment Management, Inc. | 0.46% | Reduce -30.8% | 9,108,019 | $720.5M |
| Wellington Management Group LLP | 0.09% | Reduce -5.0% | 6,260,325 | $495.3M |
| Bellevue Group AG | 7.20% | Reduce -23.1% | 4,802,199 | $379.9M |
| State Street Corp. | 0.01% | Reduce -9.4% | 3,974,865 | $314.5M |
| Geode Capital Management, LLC | 0.02% | Add +2.7% | 3,148,849 | $249.2M |
| Two Sigma Advisers, LP | 0.47% | Add +47.2% | 3,052,111 | $241.5M |
| T. Rowe Price Associates Inc. | 0.03% | Add +9.5% | 2,987,840 | $236.4M |
| Two Sigma Investments, LP | 0.33% | Add +68.7% | 2,658,646 | $210.3M |
| Tweedy, Browne Co LLC | 15.74% | Reduce -15.0% | 2,464,930 | $195.0M |
| JPMorgan Chase & Co. | 0.01% | Add +323.3% | 2,304,792 | $182.3M |
| Citadel Advisors | 0.12% | Reduce -11.1% | 2,134,636 | $168.9M |
| Deerfield Management Company, L.P. | 2.29% | No change | 1,979,669 | $156.6M |
| Baker Bros. Advisors LP | 0.83% | Add +216.1% | 1,791,841 | $141.8M |
| Deep Track Capital, LP | 3.07% | Reduce -55.4% | 1,700,000 | $134.5M |
| American Century Companies Inc. | 0.06% | Add +17.9% | 1,617,106 | $127.9M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +1.4% | 1,541,841 | $122.0M |
| Summit Partners Public Asset Management, LLC | 3.26% | Add +95.0% | 1,462,706 | $115.7M |
| Pictet Asset Management Holding SA | 0.11% | Add +1.8% | 1,418,491 | $112.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Add +20.3% | 1,388,567 | $109.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.12% | Add +27.7% | 1,352,837 | $107.0M |
| Polar Capital Holdings Plc | 0.48% | Add +29.0% | 1,333,424 | $105.5M |
| Franklin Resources Inc. | 0.03% | Add +19941.6% | 1,321,345 | $104.5M |
| Invesco Ltd. | 0.01% | Add +144.5% | 1,269,290 | $100.4M |
| Artisan Partners Limited Partnership | 0.14% | Add +32.7% | 1,181,416 | $93.5M |
| Royal Bank of Canada | 0.02% | Reduce -8.8% | 1,118,797 | $88.5M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.22% | Add +22.6% | 1,076,370 | $85.2M |
| Arrowstreet Capital, Limited Partnership | 0.05% | Add +68.8% | 1,063,327 | $84.1M |
| UBS Group AG | 0.02% | Reduce -0.2% | 1,045,041 | $82.7M |
| Morgan Stanley | 0.00% | Reduce -13.6% | 1,019,906 | $80.7M |
| Nomura Asset Management International Inc. | 0.10% | — | 864,892 | $68.4M |
| Goldman Sachs Group Inc. | 0.01% | Add +10.1% | 855,966 | $67.7M |
| Nomura Holdings Inc. | 0.19% | Add +15.7% | 848,815 | $67.1M |
| Northern Trust Corp. | 0.01% | Add +0.2% | 846,718 | $67.0M |
| Barclays PLC | 0.03% | Add +18.0% | 842,871 | $66.7M |
| Massachusetts Financial Services Co. | 0.02% | Reduce -5.8% | 812,747 | $64.3M |
| GW&K Investment Management, LLC | 0.54% | Add +198.0% | 786,668 | $62.2M |
| Bank of America Corp. | 0.00% | Reduce -8.4% | 783,579 | $62.0M |
| TD Asset Management Inc | 0.05% | Reduce -19.5% | 773,184 | $61.2M |
| Groupama Asset Managment | 0.90% | Add +36.5% | 766,889 | $60.7M |
| Candriam S.C.A. | 0.27% | Add +10.9% | 677,629 | $53.6M |
| Nuveen, LLC | 0.01% | Add +59.0% | 660,769 | $52.3M |
| Ameriprise Financial Inc. | 0.01% | Reduce -21.8% | 598,748 | $47.4M |
| Voloridge Investment Management, LLC | 0.16% | Reduce -27.2% | 584,970 | $46.3M |
| Eventide Asset Management, LLC | 0.71% | New | 575,000 | $45.5M |
| Tri Locum Partners LP | 5.72% | New | 557,174 | $44.1M |
| Eversept Partners, LP | 2.39% | Reduce -0.1% | 538,218 | $42.6M |
| Bank of New York Mellon Corp | 0.01% | Add +1.1% | 537,886 | $42.6M |
| First Trust Advisors LP | 0.03% | Add +598.2% | 525,239 | $41.6M |
| Alyeska Investment Group, L.P. | 0.11% | Add +54.8% | 481,711 | $38.1M |
| Hudson Bay Capital Management LP | 0.24% | Reduce -7.8% | 475,000 | $37.6M |
| Pinnacle Associates Ltd. | 0.47% | Reduce -4.1% | 461,968 | $36.5M |
| Amundi | 0.01% | Add +354.0% | 460,947 | $36.5M |
| Squarepoint Ops LLC | 0.07% | Add +13.7% | 436,279 | $34.5M |
| ARK Investment Management | 0.22% | Reduce -33.0% | 422,968 | $33.5M |
| Teacher Retirement System of Texas | 0.12% | Reduce -10.8% | 422,899 | $33.5M |
| Boone Capital Management LLC | 10.37% | No change | 417,833 | $33.1M |
| C WorldWide Group Holding A/S | 0.51% | Reduce -14.1% | 366,000 | $29.0M |
| Jain Global LLC | 0.29% | Add +57.8% | 356,259 | $28.2M |
| Alliancebernstein L.P. | 0.01% | Add +530.0% | 341,849 | $27.0M |
| BNP Paribas Financial Markets | 0.02% | Reduce -12.7% | 334,608 | $26.5M |
| D. E. Shaw & Co. | 0.02% | Reduce -47.3% | 332,803 | $26.3M |
| Legal & General Group Plc | 0.01% | Add +1.8% | 325,148 | $25.7M |
| Norges Bank | 0.00% | — | 320,160 | $25.3M |
| Swiss National Bank | 0.01% | Add +1.8% | 298,500 | $23.6M |
| Wells Fargo & Company | 0.00% | Reduce -1.8% | 280,045 | $22.2M |
| Zurich Insurance Group Ltd | 0.14% | New | 261,820 | $20.7M |
| Raymond James Financial Inc. | 0.01% | Add +7.0% | 257,210 | $20.3M |
| Marshall Wace, LLP | 0.02% | Reduce -73.2% | 256,933 | $20.3M |
| New York State Common Retirement Fund | 0.03% | Add +43.8% | 241,853 | $19.1M |
| Privium Fund Management B.V. | 3.51% | Reduce -3.2% | 240,824 | $19.1M |
| Davern Capital Partners, LP | 6.10% | — | 238,477 | $18.9M |
| Orion Investment Co | 5.43% | Add +0.2% | 225,161 | $17.8M |
| Renaissance Technologies | 0.03% | Reduce -54.1% | 223,607 | $17.7M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.03% | Add +11.2% | 219,574 | $17.4M |
| DAVENPORT & Co LLC | 0.09% | Add +248.3% | 217,897 | $17.2M |
| Corient Private Wealth LP | 0.02% | Add +3184.3% | 216,438 | $17.1M |
| California Public Employees Retirement System | 0.01% | Reduce -1.1% | 213,368 | $16.9M |
| Tocqueville Asset Management L.P. | 0.24% | Add +5.5% | 203,730 | $16.1M |
| Ikarian Capital, LLC | 2.07% | Reduce -51.3% | 202,038 | $16.0M |
| Stifel Financial Corp. | 0.01% | Reduce -1.9% | 198,863 | $15.7M |
| Sector Gamma As | 3.34% | Reduce -31.7% | 184,977 | $14.6M |
| Focus Partners Wealth | 0.02% | New | 181,817 | $14.4M |
| Dimensional Fund Advisors LP | 0.00% | Add +317.0% | 176,035 | $13.9M |
| Rhumbline Advisers | 0.01% | Reduce -3.7% | 175,387 | $13.9M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0.01% | New | 167,657 | $13.3M |
| Man Group plc | 0.03% | Reduce -50.3% | 166,042 | $13.1M |
| Sicart Associates LLC | 3.43% | Reduce -0.5% | 163,557 | $12.9M |
| Rhenman & Partners Asset Management AB | 1.17% | Reduce -48.9% | 158,500 | $12.5M |
| CenterBook Partners LP | 0.60% | New | 153,949 | $12.2M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +56.3% | 153,241 | $12.1M |
| Deutsche Bank AG | 0.00% | Add +68.3% | 149,443 | $11.8M |
| Great Lakes Advisors, LLC | 0.10% | Reduce -20.2% | 149,180 | $11.8M |
| ADAR1 Capital Management, LLC | 0.87% | Add +9.9% | 147,130 | $11.6M |
| Artia Global Partners LP | 1.83% | Add +139.9% | 144,376 | $11.4M |
| California State Teachers Retirement System | 0.01% | Reduce -0.7% | 144,173 | $11.4M |
| Fisher Asset Management | 0.00% | Add +2180.4% | 141,615 | $11.2M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Reduce -89.3% | 140,000 | $11.1M |
| State Board of Administration of Florida Retirement System | 0.02% | Reduce -5.3% | 135,878 | $10.7M |
| Aquatic Capital Management LLC | 0.30% | Reduce -16.5% | 132,826 | $10.5M |
| Trexquant Investment LP | 0.09% | Reduce -38.5% | 132,241 | $10.5M |
| Algert Global LLC | 0.16% | Reduce -49.6% | 127,205 | $10.1M |
| Edmond DE Rothschild Holding S.A. | 0.14% | Reduce -22.0% | 122,190 | $9.7M |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 0.35% | — | 121,628 | $9.6M |
| Balyasny Asset Management L.P. | 0.02% | Reduce -84.1% | 120,577 | $9.5M |
| Exome Asset Management LLC | 4.55% | Reduce -11.1% | 116,515 | $9.2M |
| Sei Investments Co. | 0.01% | Reduce -2.6% | 115,917 | $9.2M |
| Skandinaviska Enskilda Banken AB (publ) | 0.04% | Reduce -26.0% | 115,293 | $9.1M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.01% | Reduce -5.2% | 110,000 | $8.7M |
| Kennedy Capital Management LLC | 0.18% | Reduce -11.0% | 109,291 | $8.6M |
| Neuberger Berman Group LLC | 0.01% | Reduce -5.8% | 108,044 | $8.5M |
| DCF Advisers, LLC | 2.69% | Reduce -5.0% | 103,000 | $8.1M |
| Simplex Trading, LLC | 0.21% | Reduce -3.5% | 96,647 | $7.6M |
| Susquehanna Portfolio Strategies, LLC | 0.12% | No change | 95,960 | $7.6M |
| State of Wisconsin Investment Board | 0.02% | Reduce -2.1% | 94,761 | $7.5M |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | Reduce -18.3% | 93,751 | $7.4M |
| Amova Asset Management Americas, Inc. | 0.09% | Reduce -18.3% | 93,571 | $7.4M |
| Millennium Management | 0.01% | Reduce -88.0% | 93,262 | $7.4M |
| Atle Fund Management AB | 2.33% | New | 92,377 | $7.3M |
| Envestnet Asset Management Inc. | 0.00% | Add +226.9% | 89,919 | $7.1M |
| Citigroup Inc. | 0.00% | Reduce -42.7% | 89,340 | $7.1M |
| Nicola Wealth Management LTD. | 0.63% | No change | 87,000 | $6.9M |
| ExodusPoint Capital Management, LP | 0.07% | Reduce -44.9% | 83,875 | $6.6M |
| Victory Capital Management Inc. | 0.00% | Add +343.3% | 80,729 | $6.4M |
| Boothbay Fund Management, LLC | 0.16% | Reduce -53.8% | 75,562 | $6.0M |
| EFG International AG | 0.12% | — | 75,276 | $6.0M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -41.2% | 73,983 | $5.9M |
| Voya Investment Management LLC | 0.01% | Reduce -33.9% | 73,760 | $5.8M |
| Erste Asset Management GmbH | 0.05% | No change | 71,800 | $5.7M |
| Hillsdale Investment Management Inc. | 0.15% | No change | 70,900 | $5.6M |
| Janus Henderson Group PLC | 0.00% | Add +6.8% | 68,191 | $5.4M |
| Bridgewater Associates | 0.02% | Add +55.4% | 67,706 | $5.4M |
| J. Goldman & Co LP | 0.21% | Reduce -29.7% | 67,639 | $5.4M |
| Police & Firemen's Retirement System of New Jersey | 0.04% | Reduce -3.6% | 66,849 | $5.3M |
| Treasurer of the State of North Carolina | 0.02% | Reduce -5.2% | 66,262 | $5.2M |
| BI Asset Management Fondsmaeglerselskab A/S | 0.04% | New | 62,073 | $4.9M |
| BLB&B Advisors, LLC | 0.20% | Reduce -48.1% | 61,520 | $4.9M |
| State of New Jersey Common Pension Fund D | 0.02% | Reduce -8.4% | 54,783 | $4.3M |
| Creative Planning | 0.00% | Add +6.4% | 54,774 | $4.3M |
| PDT Partners, LLC | 0.28% | No change | 54,365 | $4.3M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $4.3M |
| Informed Momentum Co LLC | 0.47% | Reduce -1.9% | 53,914 | $4.3M |
| Ensign Peak Advisors, Inc | 0.01% | Add +94.5% | 53,664 | $4.2M |
| Alpine Global Management, LLC | 1.01% | Reduce -4.1% | 53,600 | $4.2M |
| Jefferies Financial Group Inc. | 0.03% | Add +395.6% | 50,395 | $4.0M |
| Capital Counsel LLC | 0.15% | No change | 49,605 | $3.9M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.01% | Add +8.2% | 48,921 | $3.9M |
| Handelsbanken Fonder AB | 0.01% | Reduce -7.7% | 47,911 | $3.8M |
| Mariner, LLC | 0.00% | Add +97.0% | 47,740 | $3.8M |
| Public Employees Retirement System of Ohio | 0.01% | Reduce -1.9% | 47,598 | $3.8M |
| Atika Capital Management LLC | 0.52% | Add +120.9% | 47,488 | $3.8M |
| Quantinno Capital Management LP | 0.01% | Add +31.2% | 47,378 | $3.7M |
| Van Eck Associates Corp. | 0.00% | Reduce -57.9% | 47,102 | $3.7M |
| Lazard Asset Management LLC | 0.01% | Reduce -27.3% | 46,402 | $3.7M |
| One Capital Management, LLC | 0.11% | Add +26.6% | 46,121 | $3.6M |
| Future Fund LLC | 1.15% | Add +26.8% | 45,851 | $3.6M |
| Russell Investments Group, Ltd. | 0.00% | Reduce -43.2% | 43,912 | $3.5M |
| Gotham Asset Management | 0.01% | Add +34.4% | 43,212 | $3.4M |
| Arizona State Retirement System | 0.02% | Reduce -5.2% | 42,421 | $3.4M |
| China Universal Asset Management Co., Ltd. | 0.26% | Add +51.7% | 42,394 | $3.4M |
| Fred Alger Management, LLC | 0.01% | Reduce -9.4% | 38,423 | $3.0M |
| West Michigan Advisors, LLC | 0.70% | New | 38,413 | $3.0M |
| Grandfield & Dodd, LLC | 0.17% | Add +0.4% | 37,821 | $3.0M |
| Guggenheim Capital LLC | 0.02% | Add +6.7% | 37,709 | $3.0M |
| Stanley-Laman Group, Ltd. | 0.37% | Add +2.1% | 36,512 | $2.9M |
| Bank of Montreal | 0.00% | Reduce -95.1% | 36,362 | $2.9M |
| Baron Capital (BAMCO) | 0.01% | Add +44.0% | 36,000 | $2.8M |
| Raiffeisen Bank International AG | 0.04% | Reduce -30.0% | 35,000 | $2.8M |
| Acadian Asset Management LLC | 0.00% | Reduce -68.6% | 34,691 | $2.7M |
| Pathstone Holdings, LLC | 0.01% | Add +2.1% | 34,304 | $2.7M |
| Blair William & Co. | 0.01% | Reduce -1.7% | 33,788 | $2.7M |
| KLP Kapitalforvaltning As | 0.01% | Add +6.3% | 33,500 | $2.7M |
| SG Americas Securities, LLC | 0.00% | Add +548.7% | 33,409 | $2.6M |
| Calamos Advisors LLC | 0.02% | Add +28.3% | 33,189 | $2.6M |
| Lisanti Capital Growth, LLC | 0.61% | Reduce -64.4% | 32,789 | $2.6M |
| Susquehanna International Group, LLP | 0.00% | Reduce -92.3% | 32,504 | $2.6M |
| Prelude Capital Management, LLC | 0.19% | Reduce -12.9% | 32,481 | $2.6M |
| Twin Tree Management, LP | 0.26% | Add +13.7% | 32,476 | $2.6M |
| Mutual of America Capital Management LLC | 0.03% | New | 31,459 | $2.5M |
| LPL Financial LLC | 0.00% | Add +27.0% | 31,069 | $2.5M |
| PEAK6 LLC | 0.07% | Add +401.3% | 30,642 | $2.4M |
| Wolverine Asset Management LLC | 0.14% | New | 30,515 | $2.4M |
| Jane Street Group, LLC | 0.00% | Reduce -91.7% | 30,471 | $2.4M |
| Assenagon Asset Management S.A. | 0.00% | Reduce -90.6% | 29,316 | $2.3M |
| Kornitzer Capital Management Inc. | 0.05% | New | 29,105 | $2.3M |
| Aberdeen Group plc | 0.00% | Reduce -67.1% | 28,926 | $2.3M |
| Qsemble Capital Management, LP | 0.18% | New | 27,579 | $2.2M |
| Swedbank AB | 0.00% | New | 27,253 | $2.2M |
| HSBC Holdings PLC | 0.00% | Reduce -40.7% | 26,941 | $2.1M |
| Profund Advisors LLC | 0.06% | Add +2.9% | 26,673 | $2.1M |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0.29% | Add +357.9% | 25,017 | $2.0M |
| Landscape Capital Management, L.L.C. | 0.13% | Reduce -9.1% | 24,155 | $1.9M |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 24,083 | $1.9M |
| Prudential Financial Inc. | 0.00% | Add +156.9% | 24,008 | $1.9M |
| Cerity Partners LLC | 0.00% | New | 23,927 | $1.9M |
| Orion Porfolio Solutions, LLC | 0.01% | Add +136.6% | 23,574 | $1.9M |
| Xponance LLC | 0.01% | Add +7.0% | 22,941 | $1.8M |
| HRT Financial LP | 0.01% | New | 22,928 | $1.8M |
| Verition Fund Management LLC | 0.01% | Reduce -39.0% | 22,685 | $1.8M |
| Engineers Gate Manager LP | 0.02% | Reduce -13.9% | 22,191 | $1.8M |
| Natixis Advisors, LLC | 0.00% | New | 21,891 | $1.7M |
| Exchange Traded Concepts, LLC | 0.01% | Add +16.7% | 21,094 | $1.7M |
| CANADA LIFE ASSURANCE Co | 0.00% | Reduce -54.7% | 20,894 | $1.7M |
| Nicollet Investment Management, Inc. | 0.51% | Add +0.6% | 20,523 | $1.6M |
| Gilder Gagnon Howe & Co. LLC | 0.02% | New | 19,275 | $1.5M |
| AQR Capital Management | 0.00% | Add +175.3% | 18,762 | $1.5M |
| AlphaCentric Advisors LLC | 1.46% | — | 18,523 | $1.5M |
| Quantedge Capital Pte Ltd | 0.70% | New | 18,500 | $1.5M |
| Elo Mutual Pension Insurance Co | 0.02% | New | 18,417 | $1.5M |
| Dana Investment Advisors, Inc. | 0.04% | Reduce -4.2% | 18,026 | $1.4M |
| Tidal Investments LLC | 0.01% | New | 17,908 | $1.4M |
| Inceptionr LLC | 0.39% | Add +134.2% | 17,850 | $1.4M |
| Worldquant Millennium Advisors LLC | 0.01% | New | 17,410 | $1.4M |
| J. Safra Sarasin Holding AG | 0.02% | New | 17,404 | $1.4M |
| XTX Topco Ltd | 0.04% | New | 16,917 | $1.3M |
| Allianz Asset Management GmbH | 0.00% | Add +45.4% | 16,716 | $1.3M |
| North Star Asset Management Inc. | 0.05% | No change | 16,610 | $1.3M |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 15,589 | $1.2M |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.08% | Reduce -0.8% | 15,168 | $1.2M |
| LMR Partners LLP | 0.02% | Reduce -60.1% | 15,000 | $1.2M |
| Brown Advisory Inc. | 0.00% | Add +6.7% | 14,965 | $1.2M |
| DNB Asset Management AS | 0.00% | Add +59.4% | 14,838 | $1.2M |
| M&G PLC | 0.01% | New | 14,423 | $1.1M |
| Dynasty Wealth Management, LLC | 0.01% | Reduce -2.5% | 13,990 | $1.1M |
| Bleakley Financial Group, LLC | 0.02% | Reduce -0.0% | 13,875 | $1.1M |
| PNC Financial Services Group, Inc. | 0.00% | Add +14.1% | 13,816 | $1.1M |
| Cinctive Capital Management LP | 0.06% | Reduce -92.1% | 13,726 | $1.1M |
| Friedenthal Financial | 0.53% | New | 13,115 | $1.0M |
| Lighthouse Investment Partners, LLC | 0.03% | New | 13,082 | $1.0M |
| Westmount Partners, LLC | 0.26% | No change | 12,961 | $1.0M |
| Annis Gardner Whiting Capital Advisors, LLC | 0.19% | No change | 12,801 | $1.0M |
| SBI Okasan Asset Management Co.Ltd. | 0.06% | — | 12,600 | $1.0M |
| Dark Forest Capital Management LP | 0.05% | Reduce -72.5% | 12,691 | $1.0M |
| Truist Financial Corp. | 0.00% | Add +163.1% | 12,659 | $1.0M |
| Federation des caisses Desjardins du Quebec | 0.00% | New | 12,553 | $993K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Add +3.1% | 12,461 | $986K |
| Amalgamated Bank | 0.01% | Add +2.1% | 12,455 | $985K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -6.1% | 11,998 | $949K |
| Horizon Kinetics Asset Management LLC | 0.01% | Reduce -4.2% | 11,952 | $946K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -11.6% | 11,806 | $934K |
| Osaic Holdings, Inc. | 0.00% | Add +14.6% | 11,646 | $921K |
| Oppenheimer Asset Management Inc. | 0.01% | New | 11,264 | $891K |
| Plancorp, LLC | 0.03% | No change | 11,208 | $887K |
| Baader Bank Aktiengesellschaft | 0.07% | Add +8.5% | 11,097 | $866K |
| Cetera Investment Advisers | 0.00% | Add +58.0% | 10,856 | $859K |
| Montanova Capital, LLC | 0.02% | No change | 10,800 | $854K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | New | 10,600 | $839K |
| Blueshift Asset Management, LLC | 0.24% | Reduce -8.9% | 10,443 | $826K |
| Vident Advisory, LLC | 0.01% | Reduce -11.4% | 10,235 | $810K |
| Cypress Capital, LLC | 0.22% | No change | 10,000 | $791K |
| Thrivent Financial for Lutherans | 0.00% | No change | 9,962 | $788K |
| Summit Trail Advisors, LLC | 0.01% | Add +60.2% | 9,943 | $787K |
| Ares Systematic Credit Ltd | 3.03% | — | 9,916 | $784K |
| &partners | 0.00% | Reduce -23.2% | 9,723 | $769K |
| MetLife Investment Management, LLC | 0.00% | Add +2.6% | 9,674 | $765K |
| Two Sigma Securities, LLC | 0.10% | New | 9,649 | $763K |
| Intech Investment Management LLC | 0.01% | New | 9,602 | $760K |
| KBC Group NV | 0.00% | Add +92.6% | 9,052 | $716K |
| Aigen Investment Management, LP | 0.16% | Reduce -34.7% | 8,861 | $701K |
| Assetmark, Inc. | 0.00% | Add +11433.3% | 8,650 | $684K |
| Tema ETFs LLC | 0.05% | Reduce -30.5% | 8,557 | $677K |
| NEOS Investment Management LLC | 0.00% | Reduce -30.5% | 8,557 | $677K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Add +11.0% | 8,256 | $673K |
| Virtus Investment Advisers, LLC | 0.18% | Reduce -32.2% | 8,454 | $669K |
| Sectoral Asset Management Inc. | 0.53% | Reduce -9.1% | 8,365 | $662K |
| denkapparat Operations GmbH | 0.36% | Reduce -16.1% | 8,364 | $662K |
| Utah Retirement Systems | 0.01% | No change | 8,300 | $657K |
| Maryland State Retirement & Pension System | 0.01% | No change | 8,284 | $655K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +34.1% | 8,266 | $654K |
| M&T Bank Corp | 0.00% | Add +35.6% | 8,150 | $644K |
| Commerce Bank | 0.00% | Add +6.6% | 8,111 | $642K |
| Fifth Third Bancorp | 0.00% | Reduce -0.7% | 7,888 | $624K |
| Persistent Asset Partners Ltd | 0.30% | New | 7,807 | $618K |
| Stratos Wealth Partners, LTD. | 0.01% | Reduce -0.3% | 7,740 | $612K |
| Graham Capital Management, L.P. | 0.03% | Reduce -55.7% | 7,596 | $601K |
| Fiduciary Trust Co | 0.01% | Add +16.0% | 7,399 | $585K |
| Silvercrest Asset Management Group LLC | 0.00% | Add +1.7% | 7,242 | $573K |
| Savant Capital, LLC | 0.00% | Reduce -0.7% | 7,189 | $569K |
| Meeder Advisory Services, Inc. | 0.02% | Add +5.7% | 7,156 | $566K |
| ProShare Advisors LLC | 0.00% | Add +26.0% | 7,154 | $566K |
| Callan Family Office, LLC | 0.01% | New | 7,104 | $562K |
| O'shaughnessy Asset Management, LLC | 0.00% | Add +32.8% | 7,032 | $556K |
| Swiss Life Asset Management Ltd | 0.00% | Add +1.1% | 6,903 | $546K |
| PSP Research LLC | 0.47% | — | 6,800 | $538K |
| Praxis Investment Management Inc. | 0.03% | No change | 6,770 | $536K |
| Significant Wealth Partners LLC | 0.60% | Reduce -54.8% | 6,764 | $535K |
| Coldstream Capital Management Inc. | 0.01% | Add +47.8% | 6,619 | $524K |
| Jones Financial Companies LLLP | 0.00% | Reduce -5.1% | 6,483 | $513K |
| Legato Capital Management LLC | 0.04% | Reduce -64.4% | 6,155 | $487K |
| Regions Financial Corp. | 0.00% | Add +60.2% | 6,089 | $482K |
| Natixis | 0.00% | Reduce -95.8% | 6,087 | $482K |
| Wedmont Private Capital | 0.02% | Add +3.2% | 5,536 | $460K |
| Frank, Rimerman Advisors LLC | 0.03% | Add +0.3% | 5,781 | $457K |
| Atria Investments, Inc | 0.01% | Reduce -19.6% | 5,655 | $447K |
| Mercer Global Advisors Inc. | 0.00% | Add +48.2% | 5,554 | $439K |
| North Dakota State Investment Board | 0.02% | — | 5,480 | $434K |
| Dymon Asia Capital (singapore) Pte. LTD. | 0.09% | New | 5,350 | $423K |
| Captrust Financial Advisors | 0.00% | New | 5,293 | $419K |
| Vontobel Holding Ltd. | 0.00% | New | 5,240 | $415K |
| US Bancorp \de | 0.00% | Add +9.3% | 5,141 | $407K |
| HighTower Advisors, LLC | 0.00% | Reduce -6.2% | 5,122 | $405K |
| Cwm, LLC | 0.00% | Add +102.9% | 5,049 | $399K |
| CIBC Asset Management Inc | 0.00% | Add +8.9% | 5,017 | $397K |
| OneDigital Investment Advisors LLC | 0.00% | Add +39.5% | 5,006 | $396K |
| Moisand Fitzgerald Tamayo, LLC | 0.04% | No change | 5,000 | $396K |
| NewEdge Advisors, LLC | 0.00% | Add +2.4% | 4,938 | $391K |
| Inspire Advisors, LLC | 0.04% | New | 4,851 | $384K |
| Harvest Fund Management Co., Ltd | 0.01% | Add +175.8% | 4,816 | $381K |
| Granite Investment Partners, LLC | 0.02% | Reduce -82.9% | 4,806 | $380K |
| Farallon Capital Management, L.L.C. | 0.00% | No change | 4,800 | $380K |
| Prospera Financial Services Inc | 0.01% | Add +3.9% | 4,759 | $376K |
| Brooklyn Investment Group | 0.02% | New | 4,669 | $373K |
| Sanctuary Advisors, LLC | 0.00% | Add +23.8% | 4,502 | $356K |
| Kestra Advisory Services, LLC | 0.00% | Reduce -10.5% | 4,451 | $352K |
| Credit Agricole S A | 0.00% | Reduce -6.4% | 4,410 | $349K |
| AE Wealth Management LLC | 0.00% | New | 4,403 | $348K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -32.6% | 4,334 | $342K |
| Vise Technologies, Inc. | 0.01% | New | 4,305 | $341K |
| Voleon Capital Management LP | 0.01% | Add +40.1% | 4,288 | $339K |
| Checchi Capital Advisers, LLC | 0.02% | Add +0.9% | 4,272 | $338K |
| Bank of Nova Scotia | 0.00% | Add +19.4% | 4,189 | $331K |
| Janney Montgomery Scott LLC | 0.00% | New | 4,177 | $330K |
| Comerica Bank | 0.00% | Add +82.8% | 3,997 | $316K |
| Prime Capital Investment Advisors, LLC | 0.00% | Add +1.2% | 3,981 | $315K |
| Mackenzie Financial Corp. | 0.00% | Add +8.4% | 3,891 | $307K |
| Pinnacle Wealth Planning Services, Inc. | 0.03% | Reduce -24.4% | 3,864 | $306K |
| STRS Ohio | 0.00% | Add +1.9% | 3,788 | $300K |
| Group One Trading LLC | 0.01% | Reduce -21.2% | 3,778 | $299K |
| Cambria Investment Management, L.P. | 0.02% | New | 3,684 | $291K |
| Tudor Investment Corporation | 0.00% | New | 3,661 | $290K |
| Berkshire Asset Management LLC | 0.01% | Add +0.4% | 3,630 | $287K |
| Avanza Fonder AB | 0.01% | New | 3,596 | $284K |
| Park Avenue Securities LLC | 0.00% | New | 3,571 | $283K |
| Marex Group Ltd | 0.00% | Reduce -47.6% | 3,524 | $279K |
| Everhart Financial Group, Inc. | 0.03% | New | 3,465 | $274K |
| Mitchell & Pahl Private Wealth, LLC | 0.11% | Reduce -5.4% | 3,379 | $267K |
| Principal Financial Group Inc. | 0.00% | Reduce -30.2% | 3,339 | $264K |
| Nwam LLC | 0.01% | No change | 3,238 | $262K |
| Eurizon Capital SGR S.p.A. | 0.00% | — | 3,314 | $261K |
| MML Investors Services, LLC | 0.00% | New | 3,264 | $258K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +7.2% | 3,263 | $258K |
| Anb Bank | 0.10% | Reduce -1.2% | 3,193 | $253K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -7.2% | 3,183 | $252K |
| Westfield Capital Management Co. LP | 0.00% | Add +2.1% | 3,157 | $250K |
| Raab & Moskowitz Asset Management LLC | 0.05% | No change | 3,115 | $246K |
| Crossmark Global Holdings, Inc. | 0.00% | New | 3,102 | $245K |
| Venturi Wealth Management, LLC | 0.01% | New | 3,061 | $242K |
| Argent Trust Co | 0.01% | New | 3,018 | $239K |
| B. Riley Wealth Advisors, Inc. | 0.01% | New | 2,975 | $235K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | New | 2,957 | $234K |
| Norden Group LLC | 0.02% | New | 2,935 | $232K |
| HB Wealth Management, LLC | 0.00% | New | 2,922 | $231K |
| Impact Partnership Wealth, LLC | 0.03% | New | 2,905 | $230K |
| Axxcess Wealth Management, LLC | 0.00% | New | 2,877 | $228K |
| Advisors Asset Management, Inc. | 0.00% | Reduce -48.0% | 2,835 | $224K |
| Campbell & CO Investment Adviser LLC | 0.01% | New | 2,784 | $220K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Reduce -49.1% | 2,750 | $219K |
| Rockefeller Capital Management L.P. | 0.00% | Add +23.7% | 2,726 | $216K |
| Clearbridge Investments, LLC | 0.00% | New | 2,715 | $215K |
| Montis Financial, LLC | 0.04% | New | 2,700 | $214K |
| KOM Wealth Management Group, LLC | 0.15% | New | 2,695 | $213K |
| IFG Advisory, LLC | 0.01% | New | 2,678 | $212K |
| PharVision Advisers, LLC | 0.11% | Reduce -25.8% | 2,661 | $211K |
| Motley Fool Asset Management LLC | 0.01% | New | 2,630 | $208K |
| Ancora Advisors LLC | 0.00% | Add +9.6% | 2,342 | $185K |
| Larson Financial Group LLC | 0.01% | Add +110.8% | 2,340 | $185K |
| Signaturefd, LLC | 0.00% | Add +1.9% | 2,041 | $161K |
| Parallel Advisors, LLC | 0.00% | Add +0.3% | 1,882 | $149K |
| Global Retirement Partners, LLC | 0.00% | Add +8056.5% | 1,876 | $148K |
| GAMMA Investing LLC | 0.01% | Add +29.2% | 1,733 | $137K |
| Sterling Capital Management LLC | 0.00% | Add +90.8% | 1,713 | $136K |
| Twin Lakes Capital Management, LLC | 0.05% | No change | 1,500 | $119K |
| Versant Capital Management, Inc | 0.01% | Add +2.1% | 1,496 | $118K |
| Danske Bank A/S | 0.00% | No change | 1,400 | $111K |
| Smartleaf Asset Management LLC | 0.00% | Add +1234.6% | 1,388 | $110K |
| Employees Retirement System of Texas | 0.00% | New | 1,354 | $107K |
| Root Financial Partners, LLC | 0.01% | Reduce -0.1% | 1,339 | $106K |
| International Assets Investment Management, LLC | 0.01% | Reduce -85.2% | 1,217 | $96K |
| Farther Finance Advisors, LLC | 0.00% | Add +111.8% | 1,199 | $95K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +37.5% | 1,137 | $90K |
| Bayforest Capital Ltd | 0.06% | Add +608.4% | 1,091 | $86K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 1,069 | $85K |
| Sunbelt Securities, Inc. | 0.01% | No change | 1,014 | $80K |
| IFP Advisors, Inc | 0.00% | Reduce -5.2% | 1,014 | $80K |
| Allworth Financial LP | 0.00% | Add +9.5% | 920 | $73K |
| MAI Capital Management | 0.00% | Add +237.1% | 900 | $71K |
| Arax Advisory Partners | 0.00% | New | 774 | $61K |
| Summit Securities Group LLC | 0.01% | New | 748 | $59K |
| Meeder Asset Management Inc. | 0.00% | Add +0.4% | 716 | $57K |
| Elequin Capital, LP | 0.01% | New | 711 | $56K |
| Huntington National Bank | 0.00% | Add +6.3% | 695 | $55K |
| AlphaQuest LLC | 0.00% | Add +47.9% | 670 | $53K |
| Los Angeles Capital Management LLC | 0.00% | New | 700 | $52K |
| Quadrant Capital Group LLC | 0.00% | No change | 616 | $49K |
| AdvisorNet Financial, Inc | 0.00% | Add +30.7% | 613 | $48K |
| Archer Investment Corp | 0.01% | No change | 600 | $47K |
| Laurel Wealth Advisors LLC | 0.01% | New | 600 | $47K |
| Hilton Head Capital Partners, LLC | 0.03% | — | 599 | $47K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -98.0% | 481 | $38K |
| Ascentis Wealth Management, LLC | 0.01% | No change | 400 | $32K |
| Steigerwald, Gordon & Koch Inc. | 0.00% | No change | 380 | $30K |
| Golden State Wealth Management, LLC | 0.00% | No change | 376 | $30K |
| CoreCap Advisors, LLC | 0.00% | Add +722.2% | 370 | $29K |
| Wellington-Altus USA Inc. | 0.02% | — | 351 | $28K |
| Brown Brothers Harriman & Co. | 0.00% | New | 341 | $27K |
| Salomon & Ludwin, LLC | 0.00% | No change | 332 | $26K |
| Walleye Capital LLC | 0.00% | New | 325 | $26K |
| Eastern Bank | 0.00% | No change | 300 | $24K |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 295 | $23K |
| Strategic Advocates LLC | 0.01% | No change | 287 | $23K |
| SBI Securities Co., Ltd. | 0.00% | Add +7.1% | 286 | $23K |
| Covestor Ltd | 0.01% | Add +11.0% | 273 | $22K |
| Sound Income Strategies, LLC | 0.00% | New | 286 | $22K |
| Lanark Financial, Inc. | 0.00% | No change | 273 | $22K |
| MTM Investment Management, LLC | 0.01% | No change | 258 | $20K |
| Parkside Financial Bank & Trust | 0.00% | Add +4.2% | 250 | $20K |
| Westside Investment Management, Inc. | 0.00% | No change | 231 | $18K |
| Harbour Investments, Inc. | 0.00% | Add +8.6% | 228 | $18K |
| Global Trust Asset Management, LLC | 0.01% | No change | 218 | $17K |
| SageView Advisory Group, LLC | 0.00% | New | 215 | $17K |
| UMB Bank, n.a. | 0.00% | Add +7.0% | 214 | $17K |
| MH & Associates Securities Management Corp. | 0.01% | — | 200 | $16K |
| Atlantic Union Bankshares Corp | 0.00% | No change | 200 | $16K |
| Zions Bancorporation, National Association | 0.00% | New | 188 | $15K |
| Basecamp Wealth Advisors LLC | 0.00% | — | 185 | $15K |
| Quarry LP | 0.00% | Reduce -69.4% | 180 | $14K |
| Global X Japan Co., Ltd. | 0.00% | Reduce -46.7% | 171 | $14K |
| Wealth Preservation Advisors, LLC | 0.01% | No change | 150 | $12K |
| Strategic Wealth Partners, Ltd. | 0.00% | New | 150 | $12K |
| Torren Management, LLC | 0.01% | — | 137 | $11K |
| Bogart Wealth, LLC | 0.00% | Add +8.5% | 128 | $10K |
| Bessemer Group Inc. | 0.00% | No change | 133 | $10K |
| Spire Wealth Management | 0.00% | No change | 125 | $10K |
| Garner Asset Management Corp | 0.00% | New | 115 | $9K |
| LRI Investments, LLC | 0.00% | New | 110 | $9K |
| Quent Capital, LLC | 0.00% | Add +1.0% | 99 | $8K |
| CIBC Private Wealth Group LLC | 0.00% | Add +800.0% | 99 | $8K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Add +2.3% | 91 | $7K |
| Rakuten Securities, Inc. | 0.00% | Add +718.2% | 90 | $7K |
| TD Private Client Wealth LLC | 0.00% | Add +2.5% | 82 | $6K |
| Orion Capital Management LLC | 0.00% | No change | 80 | $6K |
| Kemnay Advisory Services Inc. | 0.00% | New | 71 | $6K |
| WPG Advisers, LLC | 0.00% | No change | 70 | $6K |
| Private Wealth Management Group, LLC | 0.00% | No change | 65 | $5K |
| Leonteq Securities AG | 0.00% | No change | 63 | $5K |
| Bell Investment Advisors, Inc | 0.00% | No change | 61 | $5K |
| Triumph Capital Management | 0.00% | New | 50 | $4K |
| Rossby Financial, LCC | 0.00% | Add +44.1% | 49 | $4K |
| Crewe Advisors LLC | 0.00% | No change | 48 | $4K |
| FIL Ltd | 0.00% | No change | 47 | $4K |
| Sachetta, LLC | 0.00% | No change | 45 | $4K |
| Highline Wealth Partners LLC | 0.00% | No change | 38 | $3K |
| Hantz Financial Services, Inc. | 0.00% | No change | 36 | $3K |
| Activest Wealth Management | 0.00% | New | 32 | $3K |
| Cheviot Value Management, LLC | 0.00% | No change | 28 | $2K |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $2K |
| Principia Wealth Advisory, LLC | 0.00% | No change | 26 | $2K |
| First Horizon Corp. | 0.00% | New | 25 | $2K |
| Bruce G. Allen Investments, LLC | 0.00% | No change | 23 | $2K |
| Horizon Investments, LLC | 0.00% | No change | 22 | $2K |
| TFC Financial Management, Inc. | 0.00% | No change | 21 | $2K |
| Aspect Partners, LLC | 0.00% | New | 20 | $2K |
| Rothschild Investment LLC | 0.00% | Add +46.1% | 19 | $2K |
| Cromwell Holdings LLC | 0.00% | No change | 18 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 17 | $1K |
| Keating Financial Advisory Services, Inc. | 0.00% | — | 16 | $1K |
| Cornerstone Financial Management LLC | 0.00% | — | 15 | $1K |
| Aster Capital Management (DIFC) Ltd | 0.00% | New | 15 | $1K |
| Clearstead Advisors, LLC | 0.00% | Add +400.0% | 15 | $1K |
| Quaker Wealth Management, LLC | 0.00% | No change | 14 | $1K |
| Mascoma Wealth Management LLC | 0.00% | No change | 14 | $1K |
| SouthState Bank Corp | 0.00% | Reduce -57.6% | 14 | $1K |
| Optima Capital LLC | 0.00% | New | 12 | $949 |
| Private Trust Co. NA | 0.00% | New | 11 | $870 |
| United Financial Planning Group LLC | 0.00% | New | 8 | $633 |
| True Wealth Design, LLC | 0.00% | No change | 7 | $554 |
| Essential Partners LLC | 0.00% | No change | 7 | $554 |
| Marquette Asset Management, LLC | 0.00% | New | 7 | $554 |
| Kayne Anderson Rudnick Investment Management LLC | 0.00% | No change | 7 | $554 |
| Cape Investment Advisory, Inc. | 0.00% | New | 6 | $475 |
| Bare Financial Services, Inc | 0.00% | New | 6 | $475 |
| Cornerstone Planning Group LLC | 0.00% | No change | 5 | $410 |
| Manchester Capital Management LLC | 0.00% | Reduce -99.6% | 5 | $396 |
| IMA Advisory Services, Inc. | 0.00% | No change | 5 | $395 |
| Rachor Investment Advisory Services, LLC | 0.00% | — | 4 | $317 |
| Stone House Investment Management, LLC | 0.00% | New | 3 | $237 |
| Dunhill Financial, LLC | 0.00% | New | 3 | $212 |
| American Capital Advisory, LLC | 0.00% | No change | 2 | $159 |
| Nisa Investment Advisors, LLC | 0.00% | New | 1 | $79 |
| Truvestments Capital LLC | 0.00% | No change | 1 | $59 |
| Avion Wealth | 0.00% | New | 6 | $0 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.