Rhythm PharmaceuticalsRYTM

13F holders, Q4 2024 (December 31)
203holders +27
38new positions
24sold out
6famous investors
$55.98avg. 13F price*

At the end of Q4 2024, 203 institutions reported holding Rhythm Pharmaceuticals Inc. (RYTM) in their 13F filings, up 27 from Q3 2024. 38 opened new positions and 24 sold out. The largest holders were BlackRock, Inc. ($389.1M), Primecap Management Co. ($367.9M) and Ra Capital Management, L.P. ($340.6M). 6 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Joel Greenblatt (0.0% of Gotham Asset Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).

Company
Rhythm Pharmaceuticals Inc.
CUSIP
76243J105
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400 Q1 2024: 167Q1 2024Q2 2024: 165Q2 2024Q3 2024: 176Q3 2024Q4 2024: 203Q4 2024Q1 2025: 228Q1 2025Q2 2025: 227Q2 2025Q3 2025: 264Q3 2025Q4 2025: 281Q4 2025Q1 2026: 285Q1 2026Q2 2026: 304Q2 2026

Total Exit/New Position Q3 2024 → Q4 2024

InstitutionsTotal Value
New Positions38$67.2M
Exits24$138.9M

All 13F filers, Q3 2024 → Q4 2024: 4,160,355 shares bought and 7,094,553 shares sold, net −2,934,198 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 203 holders

BlackRock, Inc. 0.01% Add +0.9% 6,950,715 $389.1M
Primecap Management Co. 0.28% Reduce -8.9% 6,571,190 $367.9M
Ra Capital Management, L.P. 4.54% No change 6,084,412 $340.6M
Baker Bros. Advisors LP 3.69% Reduce -4.9% 6,084,249 $340.6M
Perceptive Advisors LLC 5.74% Add +3.4% 3,680,473 $206.0M
Vanguard Group Inc. 0.00% Reduce -0.1% 3,442,600 $192.7M
NEA Management Company, LLC 9.19% No change 2,909,956 $162.9M
Frazier Life Sciences Management, L.P. 4.36% Reduce -22.6% 1,869,808 $104.7M
State Street Corp. 0.00% Reduce -7.6% 1,840,870 $103.1M
Goldman Sachs Group Inc. 0.02% Reduce -53.3% 1,812,206 $101.4M
Federated Hermes, Inc. 0.19% Reduce -6.9% 1,549,635 $86.7M
Polar Capital Holdings Plc 0.47% No change 1,500,000 $84.0M
Driehaus Capital Management LLC 0.60% Reduce -0.7% 1,290,975 $72.3M
Geode Capital Management, LLC 0.01% Reduce -0.0% 1,255,799 $70.3M
Janus Henderson Group PLC 0.03% Add +103.9% 1,219,554 $68.3M
Alkeon Capital Management LLC 0.38% No change 1,167,700 $65.4M
Rock Springs Capital Management LP 2.48% Reduce -5.3% 1,162,718 $65.1M
Checkpoint Capital L.P. 20.74% Add +9.7% 727,982 $40.8M
Marshall Wace, LLP 0.05% Add +70.4% 692,803 $38.8M
T. Rowe Price Associates Inc. 0.00% Add +24.4% 685,152 $38.4M
Hood River Capital Management LLC 0.53% Add +4.7% 643,691 $36.0M
Loomis Sayles & Co. L P 0.04% Reduce -2.9% 618,485 $34.6M
Morgan Stanley 0.00% Add +20.6% 560,087 $31.4M
Northern Trust Corp. 0.00% Add +9.4% 545,314 $30.5M
Opaleye Management Inc. 4.99% No change 500,000 $28.0M
Charles Schwab Investment Management Inc. 0.00% Add +1.5% 440,250 $24.6M
Cormorant Asset Management, LP 1.23% No change 400,000 $22.4M
Orbimed Advisors LLC 0.46% Reduce -8.2% 400,000 $22.4M
Sofinnova Investments, Inc. 1.63% Add +43.6% 397,428 $22.2M
Voloridge Investment Management, LLC 0.08% Add +7.7% 380,537 $21.3M
Pictet Asset Management Holding SA 0.02% Add +14.0% 375,349 $21.0M
Candriam S.C.A. 0.11% Reduce -15.9% 332,392 $18.6M
Invesco Ltd. 0.00% Add +14.5% 302,846 $17.0M
Silverarc Capital Management, LLC 3.43% Add +7.2% 273,896 $15.3M
Franklin Resources Inc. 0.00% Add +3.4% 268,205 $15.0M
JPMorgan Chase & Co. 0.00% Add +224.3% 264,585 $14.8M
UBS Group AG 0.00% Add +231.8% 254,264 $14.2M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% Reduce -3.0% 218,544 $12.2M
Stempoint Capital LP 2.92% Add +404.1% 208,016 $11.6M
Norges Bank 0.00% Add +210.3% 205,649 $11.5M
Samsara Biocapital, LLC 1.33% No change 172,647 $9.7M
Lord, Abbett & Co. LLC 0.03% Add +56.5% 160,651 $9.0M
Integral Health Asset Management, LLC 0.74% New 150,000 $8.4M
Bank of New York Mellon Corp 0.00% Reduce -0.5% 148,246 $8.3M
Nuveen Asset Management, LLC 0.00% Reduce -0.7% 146,903 $8.2M
Walleye Capital LLC 0.09% New 144,342 $8.1M
Balyasny Asset Management L.P. 0.02% New 138,363 $7.7M
Barclays PLC 0.00% Add +27.3% 135,397 $7.6M
First Trust Advisors LP 0.01% Add +67.2% 118,337 $6.6M
FMR LLC 0.00% Add +124.9% 113,109 $6.3M
Lazard Asset Management LLC 0.01% New 106,261 $5.9M
Bank of America Corp. 0.00% Reduce -1.7% 104,488 $5.8M
Hennion & Walsh Asset Management, Inc. 0.25% Reduce -1.5% 99,447 $5.6M
Voya Investment Management LLC 0.01% Reduce -5.5% 97,169 $5.4M
Qube Research & Technologies Ltd 0.01% New 95,235 $5.3M
Swiss National Bank 0.00% Add +1.0% 90,200 $5.0M
BNP Paribas Financial Markets 0.00% Add +491.0% 85,249 $4.8M
Cinctive Capital Management LP 0.25% New 82,755 $4.6M
Rhumbline Advisers 0.00% Add +2.5% 82,731 $4.6M
Aberdeen Group plc 0.01% Reduce -28.6% 80,517 $4.5M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% — 76,084 $4.3M
Diadema Partners LP 4.73% — 75,000 $4.2M
Citigroup Inc. 0.00% Add +69.4% 69,777 $3.9M
Informed Momentum Co LLC 0.50% New 63,078 $3.5M
Alliancebernstein L.P. 0.00% Add +3.2% 61,470 $3.4M
Manufacturers Life Insurance Company, The 0.00% Add +23.1% 59,969 $3.4M
Schonfeld Strategic Advisors LLC 0.02% Add +95.5% 59,700 $3.3M
Jane Street Group, LLC 0.01% Reduce -46.5% 58,415 $3.3M
Global IMC LLC 0.57% New 56,936 $3.2M
Ameriprise Financial Inc. 0.00% Add +27.4% 53,367 $3.0M
Legal & General Group Plc 0.00% Add +1.9% 51,803 $2.9M
Susquehanna International Group, LLP 0.00% Add +135.8% 50,664 $2.8M
Rafferty Asset Management, LLC 0.01% Reduce -22.0% 50,394 $2.8M
Artia Global Partners LP 1.13% New 50,000 $2.8M
Alps Advisors Inc. 0.02% New 49,700 $2.8M
Nan Fung Group Holdings Ltd 2.35% No change 49,120 $2.7M
Deutsche Bank AG 0.00% Add +46.5% 48,745 $2.7M
Wedge Capital Management L L P 0.05% Reduce -0.9% 48,411 $2.7M
D. E. Shaw & Co. 0.00% Add +1022.5% 48,198 $2.7M
TD Asset Management Inc 0.00% Add +50.3% 47,800 $2.7M
PDT Partners, LLC 0.22% Add +279.0% 43,583 $2.4M
California State Teachers Retirement System 0.00% Reduce -0.9% 43,533 $2.4M
Algert Global LLC 0.05% Reduce -23.3% 41,551 $2.3M
Citadel Advisors 0.00% Reduce -60.7% 40,419 $2.3M
HighVista Strategies LLC 0.78% No change 37,426 $2.1M
Wells Fargo & Company 0.00% Add +26.6% 37,324 $2.1M
Principal Financial Group Inc. 0.00% Add +13.2% 36,884 $2.1M
State of New Jersey Common Pension Fund D 0.01% New 35,004 $2.0M
American Century Companies Inc. 0.00% New 33,766 $1.9M
Sei Investments Co. 0.00% Add +15.5% 33,522 $1.9M
MetLife Investment Management, LLC 0.01% Add +5.8% 33,498 $1.9M
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Add +2.0% 33,156 $1.9M
State of Wisconsin Investment Board 0.00% Reduce -0.6% 32,262 $1.8M
ADAR1 Capital Management, LLC 0.37% New 30,941 $1.7M
Harbor Capital Advisors, Inc. 0.07% Reduce -26.9% 30,252 $1.7M
Intech Investment Management LLC 0.02% Add +126.8% 28,092 $1.6M
Corebridge Financial, Inc. 0.01% Reduce -7.0% 27,220 $1.5M
Wellington Management Group LLP 0.00% Reduce -7.8% 25,555 $1.4M
Crestline Management, L.P. 0.05% Add +31.9% 25,062 $1.4M
Bellevue Group AG 0.03% Add +50.3% 23,596 $1.3M
Fiduciary Trust Co 0.01% No change 20,000 $1.1M
Bryce Point Capital, LLC 0.32% — 19,607 $1.1M
Stifel Financial Corp. 0.00% Reduce -1.6% 19,516 $1.1M
Persistent Asset Partners Ltd 0.93% — 18,312 $1.1M
Engineers Gate Manager LP 0.02% New 19,183 $1.1M
Castleark Management LLC 0.04% Reduce -4.5% 18,390 $1.0M
ProShare Advisors LLC 0.00% Add +31.3% 18,328 $1.0M
Ensign Peak Advisors, Inc 0.00% No change 17,659 $989K
Victory Capital Management Inc. 0.00% Reduce -5.7% 17,152 $960K
Comerica Bank 0.00% Reduce -2.5% 17,113 $958K
Handelsbanken Fonder AB 0.00% Reduce -11.9% 17,021 $953K
New York State Common Retirement Fund 0.00% No change 16,850 $943K
HSBC Holdings PLC 0.00% New 16,287 $921K
STRS Ohio 0.00% Add +164.5% 16,400 $918K
Quantinno Capital Management LP 0.01% No change 16,120 $902K
AQR Capital Management 0.00% Reduce -51.7% 15,857 $888K
Millennium Management 0.00% Reduce -58.7% 15,259 $854K
Tudor Investment Corporation 0.01% New 15,245 $853K
State Board of Administration of Florida Retirement System 0.00% No change 14,670 $821K
Teacher Retirement System of Texas 0.00% Add +18.5% 13,586 $761K
Arizona State Retirement System 0.00% Add +0.9% 13,287 $744K
Two Sigma Advisers, LP 0.00% Add +2.3% 13,100 $733K
China Universal Asset Management Co., Ltd. 0.07% Add +10.8% 13,031 $729K
Exchange Traded Concepts, LLC 0.01% Reduce -17.8% 12,375 $693K
Police & Firemen's Retirement System of New Jersey 0.01% — 11,655 $652K
Atom Investors LP 0.08% New 11,605 $650K
CANADA LIFE ASSURANCE Co 0.00% No change 11,578 $648K
Profund Advisors LLC 0.02% Reduce -21.5% 10,481 $587K
Creative Planning 0.00% Add +19.0% 10,224 $572K
Cannon Financial Strategists, Inc. 0.10% New 10,000 $560K
KLP Kapitalforvaltning As 0.00% — 9,300 $521K
Aquatic Capital Management LLC 0.01% New 9,223 $516K
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Reduce -0.7% 9,034 $506K
Verition Fund Management LLC 0.00% New 8,037 $450K
Trexquant Investment LP 0.01% New 7,798 $437K
XTX Topco Ltd 0.04% New 7,605 $426K
OMERS ADMINISTRATION Corp 0.00% New 7,600 $425K
Advisors Asset Management, Inc. 0.01% New 7,074 $396K
Farringdon Capital, Ltd. 0.16% — 6,854 $384K
Gotham Asset Management 0.00% Reduce -28.4% 6,786 $380K
Jain Global LLC 0.01% — 6,700 $375K
Virtus Advisers, LLC 0.14% Reduce -15.4% 6,280 $352K
Allianz Asset Management GmbH 0.00% Add +48.8% 6,100 $341K
Connor, Clark & Lunn Investment Management Ltd. 0.00% New 6,089 $341K
Y-Intercept (Hong Kong) Ltd 0.02% New 5,866 $328K
Jasper Ridge Partners, L.P. 0.01% No change 5,639 $316K
Ameritas Investment Partners, Inc. 0.01% No change 5,546 $310K
Public Employees Retirement Association of Colorado 0.00% No change 5,463 $306K
JGP Global Gestao de Recursos Ltda. 0.69% Reduce -90.5% 5,378 $301K
Dark Forest Capital Management LP 0.04% New 5,211 $292K
Cibc World Markets Corp. 0.00% New 5,123 $287K
Bridgefront Capital, LLC 0.09% New 4,604 $258K
Tower Research Capital LLC (TRC) 0.01% Add +1100.8% 4,539 $254K
Mariner, LLC 0.00% New 4,525 $254K
Mackenzie Financial Corp. 0.00% No change 4,343 $243K
Texas Treasury Safekeeping Trust Co. 0.01% No change 4,230 $237K
LPL Financial LLC 0.00% Reduce -50.9% 4,175 $234K
Prudential Financial Inc. 0.00% Reduce -2.4% 4,155 $234K
Xponance LLC 0.00% New 4,168 $233K
Raymond James Financial Inc. 0.00% — 3,892 $218K
Chicago Partners Investment Group LLC 0.01% Reduce -21.8% 3,696 $214K
Freestone Capital Holdings, LLC 0.01% New 3,700 $207K
Simplex Trading, LLC 0.00% New 2,475 $138K
KBC Group NV 0.00% Add +78.2% 2,251 $126K
Mirae Asset Global Investments Co., Ltd. 0.00% Reduce -7.4% 2,048 $114K
Elevation Wealth Partners, LLC 0.05% No change 1,971 $110K
Amalgamated Bank 0.00% No change 1,875 $105K
Whittier Trust Co. 0.00% Reduce -12.0% 1,760 $99K
Cwm, LLC 0.00% Add +45.0% 1,344 $75K
GF Fund Management Co. LTD. 0.00% — 1,290 $72K
Nisa Investment Advisors, LLC 0.00% Reduce -98.1% 1,285 $72K
Royal Bank of Canada 0.00% Reduce -80.7% 1,214 $68K
Ascentis Wealth Management, LLC 0.02% No change 1,206 $68K
State of Wyoming 0.01% New 1,084 $61K
Natixis 0.00% Reduce -91.1% 997 $56K
Russell Investments Group, Ltd. 0.00% Add +0.3% 997 $56K
R Squared Ltd 0.04% — 780 $44K
Osaic Holdings, Inc. 0.00% Add +0.8% 673 $38K
SBI Securities Co., Ltd. 0.00% — 666 $37K
Raleigh Capital Management Inc. 0.01% New 500 $28K
Arax Advisory Partners 0.00% Add +740.7% 454 $25K
Ameriflex Group, Inc. 0.01% — 360 $21K
PNC Financial Services Group, Inc. 0.00% Add +147.2% 304 $17K
Jones Financial Companies LLLP 0.00% No change 231 $13K
Signaturefd, LLC 0.00% Add +4.2% 222 $12K
GAMMA Investing LLC 0.00% Add +66.1% 201 $11K
Daiwa Securities Group Inc. 0.00% Reduce -10.6% 203 $11K
Smartleaf Asset Management LLC 0.00% Add +60.8% 193 $11K
US Bancorp \de 0.00% No change 141 $8K
Truvestments Capital LLC 0.00% No change 138 $8K
Lindbrook Capital, LLC 0.00% No change 126 $7K
Rothschild Investment LLC 0.00% Add +550.0% 65 $4K
Sterling Capital Management LLC 0.00% No change 56 $3K
Bessemer Group Inc. 0.00% No change 30 $2K
Parallel Advisors, LLC 0.00% No change 19 $1K
Covestor Ltd 0.00% Add +233.3% 10 $1K
Farther Finance Advisors, LLC 0.00% No change 14 $784
CVA Family Office, LLC 0.00% No change 12 $672
EverSource Wealth Advisors, LLC 0.00% New 12 $672
Whipplewood Advisors, LLC 0.00% — 11 $616
Hexagon Capital Partners LLC 0.00% New 7 $392
IFP Advisors, Inc 0.00% New 1 $56
AlphaQuest LLC 0.00% Reduce -100.0% 1 $56

"% of holder's portfolio" is RYTM's weight in each manager's 13F, not the share of Rhythm Pharmaceuticals Inc. the manager owns.