Silence Therapeutics PLC-ADRSLN
13F holders, Q2 2025 (June 30)55holders −4
9new positions
13sold out
1famous investor
$5.47avg. 13F price*
At the end of Q2 2025, 55 institutions reported holding Silence Therapeutics PLC-ADR (SLN) in their 13F filings, down 4 from Q1 2025. 9 opened new positions and 13 sold out. The largest holders were TCG Crossover Management, LLC ($17.6M), Siren, L.L.C. ($16.9M) and Redmile Group, LLC ($12.6M). One famous investor held it Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Silence Therapeutics PLC-ADR
- CUSIP
- 82686Q101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 9 | $2.2M |
| Exits | 13 | $2.7M |
All 13F filers, Q1 2025 → Q2 2025: 1,157,407 shares bought and 3,314,237 shares sold, net −2,156,830 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 55 holders
| TCG Crossover Management, LLC | 2.01% | No change | 3,033,560 | $17.6M |
| Siren, L.L.C. | 0.87% | Add +4.4% | 2,911,438 | $16.9M |
| Redmile Group, LLC | 1.34% | Reduce -2.3% | 2,164,777 | $12.6M |
| Lombard Odier Asset Management (USA) Corp | 2.42% | No change | 1,849,734 | $7.8M |
| Morgan Stanley | 0.00% | Reduce -39.4% | 1,211,758 | $7.0M |
| Vivo Capital, LLC | 0.66% | No change | 1,105,454 | $6.4M |
| Nantahala Capital Management, LLC | 0.43% | No change | 1,042,427 | $6.0M |
| Frazier Life Sciences Management, L.P. | 0.23% | Reduce -15.5% | 970,130 | $5.6M |
| Nextech Invest Ltd. | 1.05% | No change | 952,400 | $5.5M |
| Cantor Fitzgerald, L. P. | 0.11% | Add +2.0% | 789,039 | $4.6M |
| 5AM Venture Management, LLC | 1.06% | No change | 476,200 | $2.8M |
| SG Americas Securities, LLC | 0.01% | Add +0.0% | 308,331 | $1.8M |
| Boothbay Fund Management, LLC | 0.05% | Add +1.0% | 252,421 | $1.5M |
| Ikarian Capital, LLC | 0.46% | New | 873,568 | $1.4M |
| UBS Group AG | 0.00% | Reduce -28.5% | 228,509 | $1.3M |
| Millennium Management | 0.00% | Reduce -50.0% | 198,647 | $1.2M |
| M28 Capital Management LP | 1.83% | No change | 185,100 | $1.1M |
| HSBC Holdings PLC | 0.00% | No change | 172,834 | $1.0M |
| Marshall Wace, LLP | 0.00% | Reduce -23.0% | 175,862 | $1.0M |
| BlackRock, Inc. | 0.00% | Reduce -6.8% | 168,235 | $976K |
| Bank of Montreal | 0.00% | Reduce -8.1% | 145,812 | $846K |
| Osaic Holdings, Inc. | 0.00% | Reduce -3.0% | 69,381 | $402K |
| Woodline Partners LP | 0.00% | Reduce -53.6% | 62,459 | $362K |
| Two Sigma Investments, LP | 0.00% | Reduce -22.0% | 59,312 | $344K |
| Two Sigma Advisers, LP | 0.00% | Reduce -19.5% | 39,600 | $230K |
| Jane Street Group, LLC | 0.00% | New | 37,813 | $219K |
| Saturn V Capital Management LP | 0.08% | Reduce -95.3% | 34,737 | $201K |
| Geode Capital Management, LLC | 0.00% | Add +0.4% | 29,538 | $171K |
| Susquehanna International Group, LLP | 0.00% | New | 27,797 | $161K |
| Wexford Capital LP | 0.04% | New | 27,149 | $157K |
| Massar Capital Management, LP | 0.09% | New | 19,863 | $115K |
| ADAR1 Capital Management, LLC | 0.02% | No change | 18,643 | $108K |
| Rathbones Group PLC | 0.00% | No change | 18,421 | $107K |
| Virtus Investment Advisers, LLC | 0.03% | Reduce -32.3% | 16,837 | $98K |
| Beacon Pointe Advisors, LLC | 0.00% | New | 11,615 | $67K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | New | 10,194 | $59K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +0.1% | 9,446 | $55K |
| GAMMA Investing LLC | 0.00% | Add +134.1% | 8,333 | $48K |
| JPMorgan Chase & Co. | 0.00% | Reduce -79.4% | 7,283 | $42K |
| Barclays PLC | 0.00% | Add +2.6% | 7,035 | $41K |
| Rhumbline Advisers | 0.00% | Add +230.4% | 6,196 | $36K |
| Bank of America Corp. | 0.00% | Reduce -92.2% | 5,095 | $30K |
| Citigroup Inc. | 0.00% | Reduce -94.3% | 3,474 | $20K |
| Jones Financial Companies LLLP | 0.00% | No change | 2,500 | $14K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +2.6% | 2,428 | $14K |
| Royal Bank of Canada | 0.00% | Reduce -42.3% | 2,462 | $14K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +15.5% | 1,817 | $11K |
| Parallel Advisors, LLC | 0.00% | No change | 1,300 | $8K |
| GF Fund Management Co. LTD. | 0.00% | No change | 1,165 | $7K |
| BNP Paribas Financial Markets | 0.00% | Reduce -85.4% | 700 | $4K |
| Simplex Trading, LLC | 0.00% | Add +165.7% | 667 | $3K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 100 | $580 |
| SBI Securities Co., Ltd. | 0.00% | No change | 28 | $162 |
| Principal Securities, Inc. | 0.00% | New | 17 | $99 |
| EverSource Wealth Advisors, LLC | 0.00% | New | 10 | $58 |
"% of holder's portfolio" is SLN's weight in each manager's 13F, not the share of Silence Therapeutics PLC-ADR the manager owns.