Silence Therapeutics PLC-ADRSLN
13F holders, Q4 2025 (December 31)58holders +4
12new positions
10sold out
3famous investors
$5.86avg. 13F price*
At the end of Q4 2025, 58 institutions reported holding Silence Therapeutics PLC-ADR (SLN) in their 13F filings, up 4 from Q3 2025. 12 opened new positions and 10 sold out. The largest holders were TCG Crossover Management, LLC ($18.4M), Siren, L.L.C. ($17.7M) and Redmile Group, LLC ($13.2M). 3 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Steve Cohen (0.0% of Point72 Asset Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Silence Therapeutics PLC-ADR
- CUSIP
- 82686Q101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 12 | $9.4M |
| Exits | 10 | $9.8M |
All 13F filers, Q3 2025 → Q4 2025: 2,746,774 shares bought and 4,748,760 shares sold, net −2,001,986 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 58 holders
| TCG Crossover Management, LLC | 0.61% | No change | 3,033,560 | $18.4M |
| Siren, L.L.C. | 0.53% | No change | 2,911,438 | $17.7M |
| Redmile Group, LLC | 0.97% | No change | 2,164,777 | $13.2M |
| Nantahala Capital Management, LLC | 0.56% | Add +48.0% | 1,542,427 | $9.4M |
| Vivo Capital, LLC | 0.43% | No change | 1,105,454 | $6.7M |
| Nextech Invest Ltd. | 0.56% | No change | 952,400 | $5.8M |
| Great Point Partners LLC | 1.59% | New | 808,032 | $4.9M |
| Millennium Management | 0.00% | Add +121.0% | 659,592 | $4.0M |
| 5AM Venture Management, LLC | 0.91% | No change | 476,200 | $2.9M |
| Tetragon Partners GP Ltd | 0.47% | New | 365,369 | $2.2M |
| Morgan Stanley | 0.00% | Reduce -73.1% | 324,630 | $2.0M |
| Ikarian Capital, LLC | 0.22% | Reduce -3.9% | 865,784 | $1.7M |
| SG Americas Securities, LLC | 0.00% | Reduce -16.9% | 256,340 | $1.6M |
| Citadel Advisors | 0.00% | Add +1034.9% | 244,061 | $1.5M |
| Ishara Investments LP | 1.70% | — | 240,000 | $1.5M |
| Boothbay Fund Management, LLC | 0.03% | Reduce -25.2% | 209,088 | $1.3M |
| UBS Group AG | 0.00% | Reduce -32.5% | 207,513 | $1.3M |
| Lombard Odier Asset Management (USA) Corp | 0.62% | Reduce -86.1% | 255,901 | $1.2M |
| M28 Capital Management LP | 0.82% | No change | 185,100 | $1.1M |
| HSBC Holdings PLC | 0.00% | Reduce -0.0% | 172,834 | $1.1M |
| Bank of Montreal | 0.00% | Add +4.3% | 160,474 | $976K |
| Marshall Wace, LLP | 0.00% | Add +87.1% | 155,680 | $947K |
| Seven Fleet Capital Management LP | 0.61% | — | 147,600 | $897K |
| Point72 Asset Management | 0.00% | New | 114,070 | $694K |
| Opaleye Management Inc. | 0.06% | New | 78,926 | $480K |
| BlackRock, Inc. | 0.00% | Add +18.3% | 73,153 | $445K |
| Quadrature Capital Ltd | 0.00% | New | 54,380 | $331K |
| Two Sigma Investments, LP | 0.00% | Reduce -37.8% | 39,344 | $239K |
| Qube Research & Technologies Ltd | 0.00% | New | 34,962 | $213K |
| Geode Capital Management, LLC | 0.00% | No change | 29,538 | $180K |
| Jane Street Group, LLC | 0.00% | New | 29,168 | $177K |
| Raymond James Financial Inc. | 0.00% | New | 25,000 | $152K |
| ADAR1 Capital Management, LLC | 0.01% | Add +26.8% | 23,643 | $144K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -20.0% | 18,114 | $110K |
| Susquehanna International Group, LLP | 0.00% | New | 16,866 | $103K |
| Two Sigma Advisers, LP | 0.00% | Reduce -62.7% | 15,900 | $97K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +65.8% | 13,653 | $83K |
| Rhumbline Advisers | 0.00% | Add +121.6% | 12,999 | $79K |
| BNP Paribas Financial Markets | 0.00% | Add +1904.5% | 12,027 | $73K |
| XTX Topco Ltd | 0.00% | New | 11,718 | $71K |
| GAMMA Investing LLC | 0.00% | Add +2.0% | 10,112 | $61K |
| JPMorgan Chase & Co. | 0.00% | Add +2.3% | 7,942 | $48K |
| Barclays PLC | 0.00% | Reduce -29.0% | 5,065 | $31K |
| Simplex Trading, LLC | 0.00% | Add +513.1% | 3,991 | $24K |
| Bank of America Corp. | 0.00% | Reduce -16.0% | 2,966 | $18K |
| Jones Financial Companies LLLP | 0.00% | No change | 2,500 | $15K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +0.0% | 2,448 | $15K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +25.7% | 2,282 | $14K |
| Citigroup Inc. | 0.00% | Reduce -8.6% | 1,621 | $10K |
| Parallel Advisors, LLC | 0.00% | No change | 1,300 | $8K |
| Global Retirement Partners, LLC | 0.00% | New | 1,000 | $6K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -5.7% | 922 | $6K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 100 | $608 |
| Rockefeller Capital Management L.P. | 0.00% | No change | 45 | $274 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -3.5% | 28 | $170 |
| SageView Advisory Group, LLC | 0.00% | New | 11 | $67 |
| Osaic Holdings, Inc. | 0.00% | Reduce -100.0% | 3 | $18 |
| Royal Bank of Canada | 0.00% | Reduce -98.6% | 16 | $0 |
"% of holder's portfolio" is SLN's weight in each manager's 13F, not the share of Silence Therapeutics PLC-ADR the manager owns.