Xenon PharmaceuticalsXENE
13F holders, Q3 2025 (September 30)219holders +13
33new positions
19sold out
6famous investors
$40.15avg. 13F price*
At the end of Q3 2025, 219 institutions reported holding Xenon Pharmaceuticals Inc. (XENE) in their 13F filings, up 13 from Q2 2025. 33 opened new positions and 19 sold out. The largest holders were FMR LLC ($358.1M), Avoro Capital Advisors LLC ($216.8M) and BlackRock, Inc. ($191.6M). 6 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Xenon Pharmaceuticals Inc.
- CUSIP
- 98420N105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 33 | $68.2M |
| Exits | 19 | $53.3M |
All 13F filers, Q2 2025 → Q3 2025: 8,208,236 shares bought and 7,132,837 shares sold, net +1,075,399 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 219 holders
| FMR LLC | 0.02% | Add +0.4% | 8,918,907 | $358.1M |
| Avoro Capital Advisors LLC | 2.80% | No change | 5,400,000 | $216.8M |
| BlackRock, Inc. | 0.00% | Reduce -11.1% | 4,770,951 | $191.6M |
| Driehaus Capital Management LLC | 1.20% | Reduce -3.8% | 4,169,114 | $167.4M |
| Janus Henderson Group PLC | 0.07% | Add +10.2% | 3,943,885 | $158.3M |
| Wellington Management Group LLP | 0.03% | Add +66.0% | 3,609,857 | $144.9M |
| Braidwell LP | 5.85% | No change | 3,605,029 | $144.7M |
| Capital International Investors | 0.02% | Reduce 0.0% | 3,181,493 | $127.7M |
| Commodore Capital LP | 5.29% | Reduce -10.7% | 2,700,000 | $108.4M |
| Polar Capital Holdings Plc | 0.49% | Reduce -5.8% | 2,546,766 | $102.3M |
| Holocene Advisors, LP | 0.18% | Add +9.2% | 1,976,553 | $79.4M |
| Alliancebernstein L.P. | 0.02% | Add +8.9% | 1,654,417 | $66.4M |
| State Street Corp. | 0.00% | Add +6.2% | 1,466,467 | $58.9M |
| Affinity Asset Advisors, LLC | 5.40% | Add +27.3% | 1,400,000 | $56.2M |
| JPMorgan Chase & Co. | 0.00% | Add +11.3% | 1,399,033 | $56.2M |
| Millennium Management | 0.05% | Add +56.8% | 1,384,007 | $55.6M |
| Pictet Asset Management Holding SA | 0.05% | Reduce -14.4% | 1,262,579 | $50.6M |
| Westfield Capital Management Co. LP | 0.20% | Add +4.6% | 1,206,066 | $48.4M |
| Deep Track Capital, LP | 1.34% | Reduce -11.1% | 1,200,000 | $48.2M |
| Jennison Associates LLC | 0.03% | Add +63.0% | 1,135,235 | $45.6M |
| Vestal Point Capital, LP | 2.00% | Reduce -45.0% | 1,100,000 | $44.2M |
| Geode Capital Management, LLC | 0.00% | Add +0.7% | 977,435 | $39.2M |
| Citadel Advisors | 0.03% | Add +699.0% | 959,098 | $38.5M |
| Rock Springs Capital Management LP | 2.01% | Reduce -8.6% | 851,744 | $34.2M |
| Vanguard Group Inc. | 0.00% | Reduce -2.5% | 851,386 | $34.2M |
| Adage Capital Partners Gp, L.L.C. | 0.05% | Reduce -35.3% | 835,100 | $33.5M |
| Siren, L.L.C. | 1.28% | No change | 812,761 | $32.6M |
| First Turn Management, LLC | 4.82% | Add +21.1% | 799,743 | $32.1M |
| Goldman Sachs Group Inc. | 0.00% | Add +28.3% | 720,659 | $28.9M |
| Franklin Resources Inc. | 0.01% | Add +4.4% | 695,900 | $27.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.07% | Add +1.4% | 670,257 | $26.9M |
| American Century Companies Inc. | 0.01% | Reduce -3.0% | 659,257 | $26.5M |
| Capital World Investors | 0.00% | No change | 655,737 | $26.3M |
| Loomis Sayles & Co. L P | 0.03% | Reduce -2.5% | 640,626 | $25.7M |
| Marshall Wace, LLP | 0.03% | Reduce -40.0% | 611,982 | $24.6M |
| T. Rowe Price Investment Management, Inc. | 0.01% | Add +678.6% | 599,113 | $24.1M |
| Aberdeen Group plc | 0.04% | Add +11.1% | 579,145 | $23.3M |
| TimesSquare Capital Management, LLC | 0.32% | Reduce -2.5% | 556,800 | $22.4M |
| Deerfield Management Company, L.P. | 0.36% | No change | 542,020 | $21.8M |
| Fiera Capital Corp | 0.07% | Reduce -2.0% | 519,999 | $20.9M |
| Saturn V Capital Management LP | 4.44% | Add +7.5% | 503,701 | $20.2M |
| MPM Bioimpact LLC | 3.31% | Add +55.7% | 503,398 | $20.2M |
| Northern Trust Corp. | 0.00% | Add +1.7% | 498,147 | $20.0M |
| Dimensional Fund Advisors LP | 0.00% | Add +19.5% | 454,023 | $18.2M |
| Caligan Partners LP | 2.48% | New | 444,565 | $17.8M |
| Orbimed Advisors LLC | 0.40% | Reduce -55.7% | 419,600 | $16.8M |
| Bank of New York Mellon Corp | 0.00% | Reduce -4.0% | 418,416 | $16.8M |
| Candriam S.C.A. | 0.08% | No change | 396,636 | $15.9M |
| Baker Bros. Advisors LP | 0.11% | No change | 370,208 | $14.9M |
| Morgan Stanley | 0.00% | Reduce -5.4% | 366,572 | $14.7M |
| Tri Locum Partners LP | 3.38% | New | 366,102 | $14.7M |
| Balyasny Asset Management L.P. | 0.03% | Add +368.2% | 322,456 | $12.9M |
| DAFNA Capital Management LLC | 2.89% | No change | 287,939 | $11.6M |
| Jain Global LLC | 0.14% | New | 252,379 | $10.1M |
| DNB Asset Management AS | 0.04% | Add +6.4% | 249,081 | $10.0M |
| Federated Hermes, Inc. | 0.02% | No change | 232,500 | $9.3M |
| Nuveen, LLC | 0.00% | Reduce -1.9% | 224,289 | $9.0M |
| State of Wisconsin Investment Board | 0.02% | Add +19.2% | 208,372 | $8.4M |
| Perceptive Advisors LLC | 0.24% | No change | 200,791 | $8.1M |
| Great Point Partners LLC | 3.35% | No change | 200,000 | $8.0M |
| Bank of America Corp. | 0.00% | Reduce -44.5% | 199,106 | $8.0M |
| Stempoint Capital LP | 1.56% | New | 192,295 | $7.7M |
| ADAR1 Capital Management, LLC | 0.76% | Reduce -27.1% | 189,098 | $7.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -1.8% | 188,747 | $7.6M |
| AXA Investment Managers S.A. | 0.02% | — | 176,157 | $7.1M |
| Parkman Healthcare Partners LLC | 0.78% | Add +17.1% | 176,137 | $7.1M |
| Neuberger Berman Group LLC | 0.01% | Add +16.9% | 172,354 | $6.9M |
| New York State Common Retirement Fund | 0.01% | Add +3.1% | 171,708 | $6.9M |
| Foresite Capital Management IV, LLC | 3.52% | No change | 160,000 | $6.4M |
| BNP Paribas Financial Markets | 0.01% | Add +792.4% | 159,238 | $6.4M |
| Nan Fung Trinity (hk) Ltd. | 0.64% | No change | 158,605 | $6.4M |
| Moore Capital Management, LP | 0.11% | Add +55.6% | 140,000 | $5.6M |
| Swiss National Bank | 0.00% | Add +1.7% | 126,400 | $5.1M |
| Royal Bank of Canada | 0.00% | Reduce -18.1% | 120,545 | $4.8M |
| Nicholas Investment Partners, LP | 0.42% | Add +72.9% | 119,098 | $4.8M |
| Wells Fargo & Company | 0.00% | Add +2.4% | 115,221 | $4.6M |
| Deutsche Bank AG | 0.00% | Add +8.1% | 112,951 | $4.5M |
| Barclays PLC | 0.00% | Reduce -27.1% | 111,300 | $4.5M |
| Rhumbline Advisers | 0.00% | Reduce -2.6% | 106,791 | $4.3M |
| UBS Group AG | 0.00% | Reduce -30.3% | 106,744 | $4.3M |
| Ameriprise Financial Inc. | 0.00% | Reduce -20.0% | 97,567 | $3.9M |
| Mutual of America Capital Management LLC | 0.04% | Reduce -0.7% | 94,935 | $3.8M |
| Jane Street Group, LLC | 0.00% | Add +105.8% | 89,879 | $3.6M |
| Granahan Investment Management, LLC | 0.14% | Reduce -63.6% | 87,470 | $3.5M |
| HighVista Strategies LLC | 0.81% | Add +80.2% | 82,190 | $3.3M |
| Rhenman & Partners Asset Management AB | 0.36% | Add +131.4% | 81,000 | $3.3M |
| Legal & General Group Plc | 0.00% | Reduce -2.4% | 79,848 | $3.2M |
| Schroder Investment Management Group | 0.00% | Reduce -37.1% | 81,156 | $3.2M |
| Tudor Investment Corporation | 0.02% | New | 76,824 | $3.1M |
| Raymond James Financial Inc. | 0.00% | Add +7.2% | 69,922 | $2.8M |
| Russell Investments Group, Ltd. | 0.00% | Add +34.1% | 69,892 | $2.8M |
| Voya Investment Management LLC | 0.00% | Add +2.3% | 60,858 | $2.4M |
| California State Teachers Retirement System | 0.00% | Add +0.0% | 60,237 | $2.4M |
| Verition Fund Management LLC | 0.01% | New | 57,117 | $2.3M |
| Invesco Ltd. | 0.00% | Reduce -5.9% | 56,064 | $2.3M |
| State of New Jersey Common Pension Fund D | 0.01% | Reduce -9.8% | 55,711 | $2.2M |
| Algert Global LLC | 0.04% | Reduce -47.0% | 54,255 | $2.2M |
| Avidity Partners Management LP | 0.49% | Reduce -50.5% | 53,400 | $2.1M |
| Neo Ivy Capital Management | 0.49% | New | 49,838 | $2.0M |
| Erste Asset Management GmbH | 0.02% | No change | 50,000 | $2.0M |
| D. E. Shaw & Co. | 0.00% | Reduce -65.8% | 48,455 | $1.9M |
| Susquehanna International Group, LLP | 0.00% | Reduce -79.3% | 45,907 | $1.8M |
| MetLife Investment Management, LLC | 0.01% | Reduce -2.9% | 44,221 | $1.8M |
| T. Rowe Price Associates Inc. | 0.00% | Add +9.9% | 41,692 | $1.7M |
| Artia Global Partners LP | 0.28% | No change | 40,000 | $1.6M |
| Atika Capital Management LLC | 0.13% | New | 38,000 | $1.5M |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 39,000 | $1.5M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -5.0% | 37,448 | $1.5M |
| Alps Advisors Inc. | 0.01% | Reduce -9.9% | 37,300 | $1.5M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -15.2% | 35,301 | $1.4M |
| TLS Advisors LLC | 4.02% | No change | 32,956 | $1.4M |
| J. Safra Sarasin Holding AG | 0.02% | Reduce -63.2% | 30,168 | $1.2M |
| Baron Capital (BAMCO) | 0.00% | Reduce -46.4% | 30,000 | $1.2M |
| Boothbay Fund Management, LLC | 0.03% | New | 28,859 | $1.2M |
| Campbell & CO Investment Adviser LLC | 0.09% | New | 28,669 | $1.2M |
| HighMark Wealth Management LLC | 0.46% | No change | 26,100 | $1.0M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +7.2% | 25,589 | $1.0M |
| NJ State Employees Deferred Compensation Plan | 0.11% | No change | 25,000 | $1.0M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -8.2% | 23,932 | $961K |
| Rathbones Group PLC | 0.00% | No change | 23,666 | $950K |
| Man Group plc | 0.00% | Reduce -62.9% | 23,119 | $928K |
| Intech Investment Management LLC | 0.01% | Reduce -32.7% | 23,086 | $927K |
| Cinctive Capital Management LP | 0.05% | New | 23,054 | $926K |
| Handelsbanken Fonder AB | 0.00% | No change | 22,700 | $911K |
| Assetmark, Inc. | 0.00% | Add +6.2% | 22,566 | $906K |
| Sei Investments Co. | 0.00% | Reduce -1.3% | 22,423 | $900K |
| Oxford Asset Management LLP | 0.29% | Add +4.8% | 22,162 | $890K |
| Sanders Morris Harris LLC | 0.12% | New | 21,500 | $863K |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Add +21.2% | 21,032 | $844K |
| Birchview Capital, LP | 0.64% | No change | 21,000 | $843K |
| Arizona State Retirement System | 0.00% | Add +1.8% | 19,290 | $774K |
| Stifel Financial Corp. | 0.00% | Reduce -9.3% | 18,715 | $751K |
| Two Sigma Advisers, LP | 0.00% | Reduce -81.0% | 18,100 | $727K |
| Natixis Advisors, LLC | 0.00% | Add +0.8% | 17,564 | $705K |
| TD Asset Management Inc | 0.00% | New | 16,230 | $652K |
| Thrivent Financial for Lutherans | 0.00% | New | 16,101 | $647K |
| Teacher Retirement System of Texas | 0.00% | Reduce -8.7% | 16,001 | $642K |
| ProShare Advisors LLC | 0.00% | Reduce -14.7% | 15,740 | $632K |
| Ensign Peak Advisors, Inc | 0.00% | Reduce -41.6% | 15,244 | $612K |
| Orion Porfolio Solutions, LLC | 0.00% | Add +0.0% | 14,918 | $599K |
| Citigroup Inc. | 0.00% | Reduce -59.0% | 14,870 | $597K |
| CenterBook Partners LP | 0.03% | Reduce -40.1% | 14,770 | $593K |
| Legato Capital Management LLC | 0.06% | Add +47.7% | 14,209 | $570K |
| China Universal Asset Management Co., Ltd. | 0.04% | Reduce -12.3% | 13,515 | $543K |
| Cibc World Market Inc. | 0.00% | Reduce -17.6% | 13,460 | $540K |
| Quantinno Capital Management LP | 0.00% | New | 13,371 | $537K |
| Creative Planning | 0.00% | New | 13,210 | $530K |
| KLP Kapitalforvaltning As | 0.00% | No change | 12,800 | $514K |
| Schonfeld Strategic Advisors LLC | 0.00% | Add +20.1% | 12,652 | $508K |
| Advisors Asset Management, Inc. | 0.01% | Reduce -6.1% | 11,464 | $460K |
| Harbor Capital Advisors, Inc. | 0.04% | Reduce -62.6% | 11,218 | $450K |
| Supplemental Annuity Collective Trust of NJ | 0.12% | No change | 11,000 | $442K |
| Knott David M Jr | 0.18% | No change | 10,962 | $440K |
| Elmwood Wealth Management, Inc. | 0.16% | Add +0.8% | 10,907 | $438K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 10,633 | $427K |
| Allianz Asset Management GmbH | 0.00% | No change | 9,400 | $377K |
| DRW Securities, LLC | 0.02% | New | 9,273 | $374K |
| Prudential Financial Inc. | 0.00% | Reduce -81.5% | 8,850 | $355K |
| CIBC Bancorp USA Inc. | 0.00% | — | 8,100 | $325K |
| Altfest L J & Co. Inc. | 0.03% | New | 7,731 | $310K |
| SG Americas Securities, LLC | 0.00% | Reduce -63.9% | 6,928 | $278K |
| PenderFund Capital Management Ltd. | 0.11% | New | 6,850 | $275K |
| CANADA LIFE ASSURANCE Co | 0.00% | No change | 7,024 | $274K |
| Freestone Grove Partners LP | 0.00% | New | 6,748 | $271K |
| Ameritas Investment Partners, Inc. | 0.01% | Reduce -15.5% | 6,558 | $263K |
| Jump Financial, LLC | 0.00% | Reduce -61.7% | 6,500 | $261K |
| Inceptionr LLC | 0.06% | New | 6,322 | $254K |
| Xponance LLC | 0.00% | New | 5,967 | $240K |
| PNC Financial Services Group, Inc. | 0.00% | Add +70.4% | 5,899 | $237K |
| Principal Financial Group Inc. | 0.00% | New | 5,818 | $234K |
| Renaissance Technologies | 0.00% | Reduce -39.5% | 5,200 | $209K |
| EntryPoint Capital, LLC | 0.08% | New | 5,028 | $202K |
| Citizens Financial Group Inc. | 0.00% | New | 5,000 | $201K |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 5,000 | $201K |
| Group One Trading LLC | 0.00% | Reduce -23.6% | 3,556 | $143K |
| Virtus Investment Advisers, LLC | 0.04% | Add +21.0% | 3,469 | $139K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.6% | 2,981 | $120K |
| Amalgamated Bank | 0.00% | No change | 2,595 | $104K |
| Quarry LP | 0.03% | Add +25.0% | 2,500 | $100K |
| IFP Advisors, Inc | 0.00% | Add +2.3% | 1,908 | $77K |
| KBC Group NV | 0.00% | No change | 1,871 | $75K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -15.0% | 1,659 | $67K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -71.7% | 1,517 | $61K |
| Osaic Holdings, Inc. | 0.00% | Add +12.2% | 1,374 | $55K |
| State of Wyoming | 0.01% | Add +112.8% | 1,151 | $46K |
| Aster Capital Management (DIFC) Ltd | 0.02% | New | 959 | $39K |
| Nisa Investment Advisors, LLC | 0.00% | Add +34.1% | 924 | $37K |
| Farther Finance Advisors, LLC | 0.00% | Add +7.9% | 846 | $34K |
| Danske Bank A/S | 0.00% | No change | 800 | $32K |
| Signaturefd, LLC | 0.00% | Reduce -37.1% | 416 | $17K |
| Clearstead Advisors, LLC | 0.00% | Add +11.2% | 386 | $15K |
| Cwm, LLC | 0.00% | Add +41.4% | 335 | $13K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | No change | 276 | $11K |
| Daiwa Securities Group Inc. | 0.00% | No change | 252 | $10K |
| United Community Bank | 0.00% | No change | 200 | $8K |
| Rockefeller Capital Management L.P. | 0.00% | New | 200 | $8K |
| National Bank of Canada | 0.00% | Reduce -14.9% | 200 | $8K |
| GAMMA Investing LLC | 0.00% | Add +1221.4% | 185 | $7K |
| Sterling Capital Management LLC | 0.00% | No change | 184 | $7K |
| US Bancorp \de | 0.00% | Reduce -3.3% | 175 | $7K |
| Parallel Advisors, LLC | 0.00% | Add +8.9% | 147 | $6K |
| Allworth Financial LP | 0.00% | Add +260.0% | 126 | $5K |
| Arax Advisory Partners | 0.00% | New | 119 | $5K |
| Rothschild Investment LLC | 0.00% | Reduce -11.5% | 115 | $5K |
| J.Safra Asset Management Corp | 0.00% | No change | 87 | $3K |
| Principal Securities, Inc. | 0.00% | No change | 68 | $3K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +53.9% | 40 | $2K |
| Cape Investment Advisory, Inc. | 0.00% | No change | 39 | $2K |
| Rossby Financial, LCC | 0.00% | New | 40 | $2K |
| CVA Family Office, LLC | 0.00% | No change | 33 | $1K |
| Parkside Financial Bank & Trust | 0.00% | No change | 30 | $1K |
| Blue Trust, Inc. | 0.00% | No change | 28 | $1K |
| Park Place Capital Corp | 0.00% | No change | 16 | $642 |
| Bell Investment Advisors, Inc | 0.00% | No change | 11 | $442 |
| American National Bank & Trust | 0.00% | No change | 5 | $201 |
| Tortoise Investment Management, LLC | 0.00% | New | 2 | $80 |
| Larson Financial Group LLC | 0.00% | New | 2 | $80 |
| SBI Securities Co., Ltd. | 0.00% | New | 1 | $40 |
| Covestor Ltd | 0.00% | New | 3 | $0 |
"% of holder's portfolio" is XENE's weight in each manager's 13F, not the share of Xenon Pharmaceuticals Inc. the manager owns.