Apellis PharmaceuticalsAPLS
13F holders, Q1 2026 (March 31)324holders +44
116new positions
75sold out
11famous investors
$39.63avg. 13F price*
At the end of Q1 2026, 324 institutions reported holding Apellis Pharmaceuticals Inc. (APLS) in their 13F filings, up 44 from Q4 2025. 116 opened new positions and 75 sold out. The largest holders were BlackRock, Inc. ($544.6M), Avoro Capital Advisors LLC ($491.7M) and Morgan Stanley ($404.0M). 11 famous investors held it, including George Soros (0.8% of Soros Fund Management's portfolio), Steve Cohen (0.3% of Point72 Asset Management's portfolio) and Paul Tudor Jones (0.1% of Tudor Investment Corporation's portfolio).
- Company
- Apellis Pharmaceuticals Inc.
- CUSIP
- 03753U106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 116 | $1.1B |
| Exits | 75 | $404.7M |
All 13F filers, Q4 2025 → Q1 2026: 57,101,717 shares bought and 44,527,637 shares sold, net +12,574,080 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 324 holders
| BlackRock, Inc. | 0.01% | Add +116.2% | 13,536,964 | $544.6M |
| Avoro Capital Advisors LLC | 4.84% | No change | 12,222,222 | $491.7M |
| Morgan Stanley | 0.02% | Add +9.5% | 10,042,399 | $404.0M |
| State Street Corp. | 0.01% | Add +48.4% | 6,844,990 | $275.4M |
| UBS Group AG | 0.04% | Add +48.3% | 6,206,681 | $249.7M |
| Vanguard Portfolio Management LLC | 0.01% | — | 5,404,559 | $217.4M |
| Pentwater Capital Management LP | 1.50% | New | 5,250,000 | $211.2M |
| Vanguard Capital Management LLC | 0.00% | — | 4,768,944 | $191.9M |
| Deep Track Capital, LP | 3.76% | Reduce -41.5% | 4,532,374 | $182.3M |
| Point72 Asset Management | 0.31% | Add +600.0% | 4,183,918 | $168.3M |
| RTW Investments, LP | 1.48% | Reduce -51.9% | 3,685,045 | $148.2M |
| HBK Investments L P | 1.95% | New | 3,550,000 | $142.8M |
| Montanova Capital, LLC | 3.84% | Reduce -15.0% | 3,518,471 | $141.5M |
| Millennium Management | 0.07% | Add +138.4% | 2,256,802 | $90.8M |
| Geode Capital Management, LLC | 0.01% | Add +2.4% | 2,075,075 | $83.5M |
| Goldman Sachs Group Inc. | 0.01% | Add +946.6% | 1,980,144 | $79.7M |
| Balyasny Asset Management L.P. | 0.16% | Add +2844.0% | 1,917,501 | $77.1M |
| Dimensional Fund Advisors LP | 0.01% | Add +640.1% | 1,338,995 | $53.7M |
| Glazer Capital, LLC | 1.16% | New | 1,294,196 | $52.1M |
| TIG Advisors, LLC | 2.41% | New | 1,252,986 | $50.4M |
| Toronto Dominion Bank | 0.10% | New | 1,236,436 | $49.7M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.08% | New | 1,202,100 | $48.4M |
| Bank of America Corp. | 0.00% | Add +24.5% | 1,190,864 | $47.9M |
| Hudson Bay Capital Management LP | 0.32% | Add +0.9% | 1,190,416 | $47.9M |
| FIL Ltd | 0.04% | New | 1,140,000 | $45.9M |
| Kryger Capital LLC | 3.13% | — | 1,100,000 | $44.3M |
| Soros Fund Management | 0.78% | New | 1,056,000 | $42.5M |
| Capitolis Liquid Global Markets LLC | 0.26% | — | 1,013,500 | $40.8M |
| Woodline Partners LP | 0.15% | Add +79.8% | 976,175 | $39.3M |
| Renaissance Technologies | 0.06% | Add +47.9% | 935,958 | $37.7M |
| Marshall Wace, LLP | 0.04% | Reduce -6.2% | 929,019 | $37.4M |
| Man Group plc | 0.08% | Add +534.7% | 915,689 | $36.8M |
| First Trust Advisors LP | 0.03% | Add +82.2% | 903,637 | $36.4M |
| JPMorgan Chase & Co. | 0.00% | Add +1198.2% | 2,047,927 | $35.0M |
| Magnetar Financial LLC | 0.38% | New | 869,229 | $35.0M |
| Alpine Associates Management Inc. | 2.05% | New | 864,000 | $34.8M |
| Kynam Capital Management, LP | 2.11% | Reduce -9.2% | 825,000 | $33.2M |
| Oddo BHF Asset Management Sas | 1.31% | New | 825,000 | $33.2M |
| Northern Trust Corp. | 0.00% | Add +6.0% | 738,440 | $29.7M |
| Weiss Asset Management LP | 0.72% | New | 700,000 | $28.2M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +4.9% | 675,864 | $27.2M |
| Citigroup Inc. | 0.02% | Add +5.6% | 657,223 | $26.4M |
| Vanguard Fiduciary Trust Co. | 0.01% | — | 654,922 | $26.3M |
| Tudor Investment Corporation | 0.14% | Add +202.3% | 650,000 | $26.1M |
| BNP Paribas Financial Markets | 0.02% | Add +4.8% | 584,192 | $23.5M |
| Ossiam | 0.39% | Add +28.8% | 555,953 | $22.4M |
| Bank of New York Mellon Corp | 0.00% | Add +93.0% | 524,789 | $21.1M |
| Two Sigma Investments, LP | 0.02% | Reduce -7.2% | 521,965 | $21.0M |
| Principal Financial Group Inc. | 0.01% | New | 499,053 | $20.1M |
| Absolute Gestao de Investimentos Ltda. | 2.07% | New | 450,000 | $18.1M |
| Squarepoint Ops LLC | 0.04% | Add +134.1% | 449,796 | $18.1M |
| Invesco Ltd. | 0.00% | Add +93.8% | 437,868 | $17.6M |
| AQR Capital Management | 0.01% | Reduce -81.2% | 427,970 | $17.2M |
| LMR Partners LLP | 0.19% | New | 403,622 | $16.2M |
| Verition Fund Management LLC | 0.17% | New | 400,000 | $16.1M |
| Alliancebernstein L.P. | 0.01% | Add +1748.5% | 638,291 | $16.0M |
| Public Sector Pension Investment Board | 0.05% | New | 366,674 | $14.8M |
| First Trust Capital Management L.P. | 0.74% | New | 350,800 | $14.1M |
| Susquehanna International Group, LLP | 0.02% | Reduce -36.3% | 340,086 | $13.7M |
| Gabelli Funds LLC | 0.09% | New | 321,200 | $12.9M |
| Beck Bode, LLC | 2.13% | New | 312,841 | $12.6M |
| Meteora Capital, LLC | 0.90% | New | 300,000 | $12.1M |
| O'Connor Alternative Investments LLC | 0.68% | — | 300,000 | $12.1M |
| Jump Financial, LLC | 0.19% | Add +50.4% | 291,488 | $11.7M |
| Rhumbline Advisers | 0.01% | Add +135.7% | 275,540 | $11.1M |
| Janus Henderson Group PLC | 0.00% | Add +9.5% | 252,130 | $10.1M |
| 683 Capital Management, LLC | 0.98% | Reduce -24.2% | 250,000 | $10.1M |
| Capstone Investment Advisors, LLC | 0.11% | New | 250,000 | $10.1M |
| Wellington Management Group LLP | 0.00% | Reduce -98.0% | 249,635 | $10.0M |
| Granite Investment Partners, LLC | 0.57% | Reduce -29.1% | 231,917 | $9.3M |
| Legal & General Group Plc | 0.00% | Add +167.0% | 228,255 | $9.2M |
| Westchester Capital Management, LLC | 0.44% | New | 227,489 | $9.2M |
| Nuveen, LLC | 0.00% | Reduce -67.7% | 220,114 | $8.9M |
| Jefferies Financial Group Inc. | 0.11% | Add +2412.0% | 219,000 | $8.8M |
| Bank of Montreal | 0.00% | Add +21.8% | 215,041 | $8.7M |
| Sphera Funds Management LTD. | 1.49% | Reduce -14.4% | 214,914 | $8.6M |
| Trexquant Investment LP | 0.06% | Add +5.5% | 205,219 | $8.3M |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 1.20% | New | 200,600 | $8.1M |
| Pictet Asset Management Holding SA | 0.01% | Add +9.2% | 426,821 | $7.6M |
| D. E. Shaw & Co. | 0.01% | Reduce -58.5% | 186,853 | $7.5M |
| Ameriprise Financial Inc. | 0.00% | Reduce -68.9% | 183,578 | $7.4M |
| Boothbay Fund Management, LLC | 0.18% | Add +757.0% | 183,522 | $7.4M |
| Rafferty Asset Management, LLC | 0.03% | Add +5.3% | 180,471 | $7.3M |
| Fiduciary Trust Co | 0.09% | Reduce -0.1% | 180,161 | $7.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +0.6% | 179,953 | $7.2M |
| Gardner Lewis Asset Management L P | 1.44% | New | 165,000 | $6.6M |
| Rock Springs Capital Management LP | 0.39% | Add +8.1% | 162,750 | $6.5M |
| Mackenzie Financial Corp. | 0.01% | Add +59.4% | 153,330 | $6.2M |
| Picton Mahoney Asset Management | 0.06% | New | 150,000 | $6.0M |
| Swiss National Bank | 0.00% | No change | 149,500 | $6.0M |
| Empowered Funds, LLC | 0.04% | Add +1006.3% | 148,038 | $6.0M |
| AQR Arbitrage LLC | 0.12% | New | 146,604 | $5.9M |
| Chicago Capital Management, LLC | 12.18% | New | 190,000 | $5.8M |
| Slotnik Capital, LLC | 1.61% | New | 135,000 | $5.4M |
| Twin Securities, Inc. | 2.53% | New | 127,440 | $5.1M |
| Royal Bank of Canada | 0.00% | Add +42.9% | 126,701 | $5.1M |
| Schonfeld Strategic Advisors LLC | 0.04% | New | 123,824 | $5.0M |
| Quantinno Capital Management LP | 0.01% | Add +281.8% | 121,270 | $4.9M |
| Water Island Capital LLC | 0.68% | New | 120,500 | $4.8M |
| Prelude Capital Management, LLC | 0.34% | Add +189.4% | 111,468 | $4.5M |
| T. Rowe Price Associates Inc. | 0.00% | Add +12.5% | 106,908 | $4.3M |
| Sagefield Capital LP | 0.30% | New | 104,065 | $4.2M |
| Alps Advisors Inc. | 0.02% | Add +0.3% | 104,058 | $4.2M |
| Barclays PLC | 0.00% | Reduce -47.6% | 98,327 | $4.0M |
| NINE MASTS CAPITAL Ltd | 0.87% | New | 97,478 | $3.9M |
| State Board of Administration of Florida Retirement System | 0.01% | No change | 96,125 | $3.9M |
| Deutsche Bank AG | 0.00% | Reduce -93.1% | 95,365 | $3.8M |
| California State Teachers Retirement System | 0.00% | Add +29.6% | 94,833 | $3.8M |
| Prudential Financial Inc. | 0.00% | New | 92,510 | $3.7M |
| Caitong International Asset Management Co., Ltd | 0.67% | New | 90,466 | $3.6M |
| Los Angeles Capital Management LLC | 0.01% | Reduce -91.0% | 85,913 | $3.5M |
| Exome Asset Management LLC | 2.02% | Reduce -37.0% | 85,517 | $3.4M |
| Corient Private Wealth LP | 0.00% | New | 84,571 | $3.4M |
| New York State Common Retirement Fund | 0.00% | Reduce -18.8% | 84,451 | $3.4M |
| Abc Arbitrage SA | 0.45% | New | 83,317 | $3.4M |
| Profund Advisors LLC | 0.12% | Add +31.3% | 81,190 | $3.3M |
| Perceptive Advisors LLC | 0.06% | New | 80,956 | $3.3M |
| CANADA LIFE ASSURANCE Co | 0.01% | Add +849.5% | 80,662 | $3.2M |
| State of Wisconsin Investment Board | 0.01% | Add +19.1% | 79,680 | $3.2M |
| Gotham Asset Management | 0.01% | Reduce -53.3% | 78,750 | $3.2M |
| HGC Investment Management Inc. | 0.67% | New | 75,000 | $3.0M |
| Acadian Asset Management LLC | 0.00% | Reduce -63.7% | 74,716 | $3.0M |
| ADAR1 Capital Management, LLC | 0.18% | Add +262.5% | 72,500 | $2.9M |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | — | 71,855 | $2.9M |
| Harvest Management LLC | 1.50% | New | 70,000 | $2.8M |
| WINTON GROUP Ltd | 0.10% | Reduce -20.0% | 69,291 | $2.8M |
| Thrivent Financial for Lutherans | 0.01% | New | 68,407 | $2.8M |
| Capital Fund Management S.A. | 0.02% | New | 68,112 | $2.7M |
| FNY Investment Advisers, LLC | 1.13% | New | 63,092 | $2.5M |
| ExodusPoint Capital Management, LP | 0.03% | Reduce -63.2% | 62,989 | $2.5M |
| Raymond James Financial Inc. | 0.00% | Reduce -6.5% | 62,631 | $2.5M |
| Jacobs Levy Equity Management, Inc. | 0.01% | New | 61,681 | $2.5M |
| Burney Co./ | 0.08% | New | 61,578 | $2.5M |
| IMC-Chicago, LLC | 0.04% | Add +177.8% | 59,232 | $2.4M |
| Guggenheim Capital LLC | 0.02% | Add +55.0% | 56,801 | $2.3M |
| Capula Management Ltd | 0.02% | New | 56,266 | $2.3M |
| One68 Global Capital, LLC | 7.21% | New | 55,347 | $2.2M |
| Virtu Financial LLC | 0.09% | New | 54,785 | $2.2M |
| PNC Financial Services Group, Inc. | 0.00% | Add +1.8% | 54,474 | $2.2M |
| PDT Partners, LLC | 0.13% | No change | 53,951 | $2.2M |
| Versor Investments LP | 5.04% | New | 51,146 | $2.1M |
| State of Alaska, Department of Revenue | 0.02% | New | 50,562 | $2.0M |
| Hennion & Walsh Asset Management, Inc. | 0.07% | Reduce -3.0% | 50,374 | $2.0M |
| CIBRA Capital Ltd | 0.97% | New | 50,000 | $2.0M |
| Elmind Capital, LP | 0.57% | No change | 50,000 | $2.0M |
| TPG GP A, LLC | 0.06% | New | 50,000 | $2.0M |
| Treasurer of the State of North Carolina | 0.01% | Add +2.2% | 46,153 | $1.9M |
| Police & Firemen's Retirement System of New Jersey | 0.02% | No change | 46,009 | $1.9M |
| Louisiana State Employees Retirement System | 0.03% | New | 45,400 | $1.8M |
| Russell Investments Group, Ltd. | 0.00% | Add +347.7% | 44,757 | $1.8M |
| Voya Investment Management LLC | 0.00% | Add +0.0% | 43,669 | $1.8M |
| CSS LLC | 0.27% | New | 42,818 | $1.7M |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | Add +71.0% | 41,665 | $1.7M |
| XTX Topco Ltd | 0.03% | New | 41,627 | $1.7M |
| Vanguard Global Advisers, LLC | 0.00% | — | 40,745 | $1.6M |
| State of Tennessee, Department of Treasury | 0.01% | New | 40,180 | $1.6M |
| Fortress Investment Group LLC | 0.41% | New | 40,000 | $1.6M |
| Citadel Advisors | 0.00% | Reduce -94.0% | 38,887 | $1.6M |
| Handelsbanken Fonder AB | 0.00% | No change | 35,400 | $1.4M |
| Carmignac Gestion | 0.02% | New | 35,127 | $1.4M |
| Bridgewater Associates | 0.01% | Reduce -75.7% | 34,913 | $1.4M |
| Amalgamated Bank | 0.01% | Add +297.5% | 34,726 | $1.4M |
| Readystate Asset Management LP | 0.14% | New | 34,100 | $1.4M |
| DRW Securities, LLC | 0.07% | New | 33,573 | $1.4M |
| Virtus Investment Advisers, LLC | 0.37% | Add +23.5% | 33,462 | $1.3M |
| Public Employees Retirement System of Ohio | 0.00% | Reduce -3.3% | 31,378 | $1.3M |
| Odyssean, LLC | 0.46% | Add +61.6% | 31,032 | $1.2M |
| Amundi | 0.00% | No change | 30,721 | $1.2M |
| Carlson Capital, L.P. | 0.48% | New | 30,000 | $1.2M |
| SG Americas Securities, LLC | 0.00% | Reduce -94.8% | 29,601 | $1.2M |
| Stifel Financial Corp. | 0.00% | Reduce -23.0% | 28,220 | $1.1M |
| Yousif Capital Management, LLC | 0.01% | New | 27,997 | $1.1M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +10.1% | 27,921 | $1.1M |
| Jain Global LLC | 0.02% | Add +64.7% | 27,793 | $1.1M |
| State of New Jersey Common Pension Fund D | 0.00% | Add +0.1% | 25,896 | $1.0M |
| Commonwealth of Pennsylvania Public School Empls Retrmt SYS | 0.01% | New | 25,344 | $1.0M |
| Teachers Retirement System of the State of Kentucky | 0.01% | New | 25,000 | $1.0M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +8.4% | 24,765 | $996K |
| Two Sigma Securities, LLC | 0.11% | New | 23,779 | $957K |
| Transmarket Holdings LP | 0.51% | New | 23,585 | $949K |
| Oregon Public Employees Retirement Fund | 0.01% | New | 23,400 | $941K |
| E Fund Management Co., Ltd. | 0.03% | — | 22,686 | $913K |
| China Universal Asset Management Co., Ltd. | 0.07% | Add +10.0% | 22,684 | $913K |
| Fifth Third Bancorp | 0.00% | New | 22,102 | $889K |
| Mint Tower Capital Management B.V. | 0.19% | New | 22,000 | $885K |
| GAMCO Investors | 0.01% | New | 21,000 | $845K |
| Maryland State Retirement & Pension System | 0.02% | New | 20,816 | $837K |
| Arizona State Retirement System | 0.00% | Reduce -0.9% | 20,813 | $837K |
| Rockefeller Capital Management L.P. | 0.00% | Add +4002.2% | 20,634 | $830K |
| JBF Capital, Inc. | 0.12% | New | 20,532 | $826K |
| SummitTX Capital, L.P. | 0.03% | New | 20,351 | $819K |
| Clear Harbor Asset Management, LLC | 0.06% | New | 20,000 | $805K |
| Victory Capital Management Inc. | 0.00% | Add +30.4% | 19,817 | $797K |
| Canada Pension Plan Investment Board | 0.00% | Reduce -91.2% | 19,600 | $789K |
| Vanguard Investments Australia, Ltd. | 0.00% | — | 19,240 | $774K |
| Engineers Gate Manager LP | 0.01% | New | 19,197 | $772K |
| Xponance LLC | 0.01% | Add +2.1% | 18,550 | $746K |
| New York State Teachers Retirement System | 0.00% | New | 18,299 | $736K |
| Duncan Williams Asset Management, LLC | 0.19% | No change | 17,005 | $684K |
| KLP Kapitalforvaltning As | 0.00% | No change | 16,200 | $652K |
| Summit Trail Advisors, LLC | 0.01% | Add +15.7% | 16,023 | $645K |
| GTS Securities LLC | 0.02% | New | 15,604 | $628K |
| Vident Advisory, LLC | 0.01% | Reduce -3.0% | 15,079 | $607K |
| Birchview Capital, LP | 0.32% | No change | 14,000 | $563K |
| denkapparat Operations GmbH | 0.22% | New | 13,334 | $536K |
| Dynasty Wealth Management, LLC | 0.00% | Add +44.4% | 13,321 | $536K |
| Bayesian Capital Management, LP | 0.64% | New | 13,104 | $527K |
| Blackstone Inc. | 0.00% | New | 12,712 | $511K |
| AE Wealth Management LLC | 0.00% | New | 12,316 | $495K |
| Sei Investments Co. | 0.00% | Reduce -80.5% | 11,747 | $473K |
| Mutual of America Capital Management LLC | 0.01% | New | 11,728 | $472K |
| Cwm, LLC | 0.00% | Reduce -72.8% | 11,403 | $459K |
| Franklin Resources Inc. | 0.00% | Add +0.7% | 11,380 | $458K |
| M&T Bank Corp | 0.00% | Reduce -23.7% | 11,049 | $444K |
| Landing Point Financial Group, LLC | 0.21% | New | 10,755 | $433K |
| Erste Asset Management GmbH | 0.00% | No change | 25,300 | $432K |
| Mercer Global Advisors Inc. | 0.00% | Reduce -39.6% | 10,663 | $429K |
| Shay Capital LLC | 0.06% | New | 10,347 | $416K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +1613.5% | 10,281 | $414K |
| Teacher Retirement System of Texas | 0.00% | Reduce -12.9% | 9,776 | $393K |
| Creative Planning | 0.00% | Reduce -42.1% | 9,521 | $383K |
| MML Investors Services, LLC | 0.00% | New | 9,504 | $382K |
| Wedmont Private Capital | 0.01% | Reduce -26.3% | 8,762 | $357K |
| Wells Fargo & Company | 0.00% | Reduce -91.7% | 8,592 | $346K |
| Y-Intercept (Hong Kong) Ltd | 0.01% | Reduce -73.0% | 8,536 | $343K |
| Laurel Oak Wealth Management, LLC | 0.06% | No change | 8,465 | $341K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 8,362 | $336K |
| BCK Capital Management LP | 1.40% | New | 8,000 | $322K |
| FORA Capital, LLC | 0.02% | New | 7,572 | $305K |
| Fifth Lane Capital, LP | 0.37% | New | 7,500 | $302K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -76.1% | 7,208 | $291K |
| AlphaGrep UK Ltd | 0.08% | Reduce -14.4% | 7,120 | $286K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -92.7% | 6,977 | $281K |
| ProShare Advisors LLC | 0.00% | New | 6,809 | $274K |
| Beese Fulmer Investment Management, Inc. | 0.02% | New | 6,748 | $271K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +8.5% | 6,668 | $268K |
| MetLife Investment Management, LLC | 0.00% | Reduce -4.7% | 6,633 | $267K |
| Walleye Trading LLC | 0.01% | Reduce -48.0% | 6,602 | $266K |
| Quantbot Technologies LP | 0.01% | Add +17.1% | 6,567 | $264K |
| DNB Asset Management AS | 0.00% | New | 6,184 | $249K |
| Yakira Capital Management, Inc. | 0.07% | New | 6,000 | $241K |
| Farallon Capital Management, L.L.C. | 0.00% | New | 6,000 | $241K |
| HSBC Holdings PLC | 0.00% | New | 5,944 | $239K |
| Marex Group Ltd | 0.00% | Reduce -74.3% | 5,919 | $238K |
| Orion Porfolio Solutions, LLC | 0.00% | New | 5,899 | $237K |
| Mach-1 Financial Group, LLC | 0.08% | New | 5,672 | $228K |
| Vise Technologies, Inc. | 0.00% | No change | 9,012 | $226K |
| Utah Retirement Systems | 0.00% | New | 5,600 | $225K |
| FMR LLC | 0.00% | Reduce -82.7% | 5,563 | $224K |
| Stelac Advisory Services LLC | 0.04% | No change | 5,520 | $222K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +27.3% | 12,788 | $219K |
| Swiss Life Asset Management Ltd | 0.00% | Reduce -50.3% | 5,384 | $217K |
| T. Rowe Price Investment Management, Inc. | 0.00% | Add +161.5% | 5,162 | $208K |
| Quantessence Capital LLC | 1.00% | New | 5,121 | $206K |
| Ensign Peak Advisors, Inc | 0.00% | No change | 4,747 | $191K |
| Walleye Capital LLC | 0.00% | Reduce -16.8% | 3,290 | $132K |
| GF Fund Management Co. LTD. | 0.00% | Add +14.3% | 2,841 | $114K |
| Hantz Financial Services, Inc. | 0.00% | New | 2,836 | $114K |
| Simplex Trading, LLC | 0.00% | Reduce -89.9% | 2,735 | $110K |
| Osaic Holdings, Inc. | 0.00% | Reduce -4.2% | 2,615 | $105K |
| STRS Ohio | 0.00% | Reduce -0.1% | 2,579 | $104K |
| KBC Group NV | 0.00% | No change | 2,313 | $93K |
| Parallel Advisors, LLC | 0.00% | Add +11.9% | 1,893 | $76K |
| Longfellow Investment Management Co. LLC | 0.02% | New | 1,860 | $75K |
| US Bancorp \de | 0.00% | Reduce -54.6% | 1,380 | $56K |
| State of Wyoming | 0.01% | New | 1,288 | $52K |
| Jones Financial Companies LLLP | 0.00% | Add +46.5% | 2,984 | $51K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +282.8% | 1,221 | $49K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -53.1% | 1,219 | $49K |
| Allworth Financial LP | 0.00% | Add +13.2% | 1,143 | $46K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | Add +30.9% | 1,100 | $44K |
| Versant Capital Management, Inc | 0.00% | Add +83.8% | 1,053 | $42K |
| Signaturefd, LLC | 0.00% | Reduce -35.9% | 954 | $38K |
| GAMMA Investing LLC | 0.00% | Add +66.2% | 796 | $32K |
| Sterling Capital Management LLC | 0.00% | No change | 772 | $31K |
| Leonteq Securities AG | 0.00% | Reduce -25.0% | 671 | $27K |
| Sound Income Strategies, LLC | 0.00% | No change | 621 | $25K |
| Archer Investment Corp | 0.00% | No change | 500 | $20K |
| IFP Advisors, Inc | 0.00% | Reduce -52.0% | 471 | $19K |
| SMA Capital LLC | 0.01% | New | 294 | $12K |
| SBI Securities Co., Ltd. | 0.00% | Add +87.6% | 257 | $10K |
| Nisa Investment Advisors, LLC | 0.00% | Add +404.0% | 252 | $10K |
| Larson Financial Group LLC | 0.00% | Reduce -46.4% | 250 | $10K |
| Covestor Ltd | 0.01% | Reduce -45.6% | 228 | $9K |
| Quent Capital, LLC | 0.00% | Add +46.6% | 217 | $9K |
| TFC Financial Management, Inc. | 0.00% | No change | 212 | $9K |
| HM Payson & Co. | 0.00% | New | 200 | $8K |
| UMB Bank, n.a. | 0.00% | Add +1516.7% | 194 | $8K |
| Pinnacle Wealth Planning Services, Inc. | 0.00% | Reduce -81.0% | 192 | $8K |
| Evelyn Partners Investment Management LLP | 0.00% | No change | 150 | $6K |
| Parkside Financial Bank & Trust | 0.00% | Add +260.6% | 119 | $5K |
| MAI Capital Management | 0.00% | New | 111 | $4K |
| Advisory Services Network, LLC | 0.00% | New | 105 | $4K |
| Financial Gravity Asset Management, Inc. | 0.00% | No change | 100 | $4K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | No change | 97 | $4K |
| Farther Finance Advisors, LLC | 0.00% | Reduce -74.1% | 95 | $4K |
| Brown Brothers Harriman & Co. | 0.00% | No change | 95 | $4K |
| Quadrant Capital Group LLC | 0.00% | Reduce -89.0% | 91 | $4K |
| SHP Wealth Management | 0.00% | New | 77 | $3K |
| Essential Partners LLC | 0.00% | Reduce -98.7% | 69 | $3K |
| Harbour Investments, Inc. | 0.00% | New | 67 | $3K |
| Sachetta, LLC | 0.00% | No change | 60 | $2K |
| TD Private Client Wealth LLC | 0.00% | No change | 56 | $2K |
| Farmers & Merchants Investments Inc. | 0.00% | New | 50 | $2K |
| Capital Analysts, LLC | 0.00% | No change | 57 | $2K |
| Smartleaf Asset Management LLC | 0.00% | Add +78.3% | 107 | $2K |
| NBT Bank, N.A. | 0.00% | New | 45 | $2K |
| Manchester Capital Management LLC | 0.00% | No change | 28 | $1K |
| Twin Peaks Wealth Advisors, LLC | 0.00% | New | 24 | $966 |
| Horizon Investments, LLC | 0.00% | New | 24 | $966 |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -100.0% | 23 | $925 |
| Clearstead Trust, LLC | 0.00% | Reduce -48.6% | 18 | $725 |
| Cedar Mountain Advisors, LLC | 0.00% | New | 18 | $724 |
| True Wealth Design, LLC | 0.00% | Reduce -91.5% | 16 | $644 |
| Root Financial Partners, LLC | 0.00% | New | 12 | $483 |
| Keating Financial Advisory Services, Inc. | 0.00% | New | 11 | $443 |
| MV Capital Management, Inc. | 0.00% | Reduce -33.3% | 6 | $242 |
| WPG Advisers, LLC | 0.00% | No change | 5 | $201 |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 0.00% | No change | 4 | $161 |
| Dunhill Financial, LLC | 0.00% | No change | 2 | $84 |
| Hughes Financial Services, LLC | 0.00% | Reduce -98.6% | 1 | $40 |
| Innovative Asset Advisors Group, LLC | 0.00% | — | 1 | $40 |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 1 | $0 |
| Clear Street Group Inc. | 0.00% | New | 350,000 | $0 |
"% of holder's portfolio" is APLS's weight in each manager's 13F, not the share of Apellis Pharmaceuticals Inc. the manager owns.