Protagonist TherapeuticsPTGX

13F holders, Q2 2025 (June 30)
273holders −2
50new positions
47sold out
5famous investors
$55.29avg. 13F price*

At the end of Q2 2025, 273 institutions reported holding Protagonist Therapeutics Inc. (PTGX) in their 13F filings, down 2 from Q1 2025. 50 opened new positions and 47 sold out. The largest holders were BlackRock, Inc. ($532.3M), Farallon Capital Management, L.L.C. ($341.1M) and RTW Investments, LP ($318.1M). 5 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Joel Greenblatt (0.0% of Gotham Asset Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).

Company
Protagonist Therapeutics Inc.
CUSIP
74366E102
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400 Q1 2024: 184Q1 2024Q2 2024: 188Q2 2024Q3 2024: 240Q3 2024Q4 2024: 241Q4 2024Q1 2025: 275Q1 2025Q2 2025: 273Q2 2025Q3 2025: 275Q3 2025Q4 2025: 316Q4 2025Q1 2026: 320Q1 2026Q2 2026: 343Q2 2026

Total Exit/New Position Q1 2025 → Q2 2025

InstitutionsTotal Value
New Positions50$141.9M
Exits47$89.7M

All 13F filers, Q1 2025 → Q2 2025: 11,336,027 shares bought and 5,263,035 shares sold, net +6,072,992 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 273 holders

BlackRock, Inc. 0.01% Reduce -1.1% 9,630,341 $532.3M
Farallon Capital Management, L.L.C. 1.56% Add +1.1% 6,172,006 $341.1M
RTW Investments, LP 4.53% Add +0.6% 5,756,277 $318.1M
Vanguard Group Inc. 0.00% Add +1.9% 4,358,595 $240.9M
Deep Track Capital, LP 5.77% Add +8.2% 3,245,899 $179.4M
BVF Inc. 6.34% Add +24.7% 3,211,041 $177.5M
State Street Corp. 0.01% Add +18.5% 3,207,543 $177.3M
UBS Group AG 0.03% Add +608.8% 2,501,251 $138.2M
Johnson & Johnson 40.83% No change 2,449,183 $136.4M
Geode Capital Management, LLC 0.01% Add +1.4% 1,444,230 $79.8M
Adage Capital Partners Gp, L.L.C. 0.10% Add +218.0% 1,092,262 $60.4M
Commodore Capital LP 4.19% New 1,075,000 $59.4M
Perceptive Advisors LLC 2.23% Reduce -1.5% 1,074,448 $59.4M
Wellington Management Group LLP 0.01% Add +5.1% 1,037,738 $57.4M
ADAR1 Capital Management, LLC 8.60% Add +0.9% 948,069 $52.4M
Woodline Partners LP 0.28% Add +5.5% 946,884 $52.3M
T. Rowe Price Associates Inc. 0.01% Reduce -29.1% 936,703 $51.8M
Morgan Stanley 0.00% Add +74.8% 868,963 $48.0M
Bank of America Corp. 0.00% Add +80.6% 851,832 $47.1M
Jefferies Financial Group Inc. 0.79% Add +30.4% 824,019 $45.5M
American Century Companies Inc. 0.02% Add +18.7% 813,995 $45.0M
Goldman Sachs Group Inc. 0.01% Add +39.9% 777,307 $43.0M
Driehaus Capital Management LLC 0.34% Add +222.3% 757,710 $41.9M
Pictet Asset Management Holding SA 0.04% Add +154.4% 751,977 $41.6M
Lynx1 Capital Management LP 11.70% No change 733,014 $40.5M
Invesco Ltd. 0.01% Reduce -16.1% 721,680 $39.9M
Northern Trust Corp. 0.00% Reduce -3.8% 615,066 $34.0M
Charles Schwab Investment Management Inc. 0.01% Add +3.2% 575,364 $31.8M
FMR LLC 0.00% Add +12.6% 538,432 $29.8M
Holocene Advisors, LP 0.07% New 530,326 $29.3M
Janus Henderson Group PLC 0.01% Add +1982.7% 446,828 $24.7M
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% Add +17.5% 446,026 $24.7M
JPMorgan Chase & Co. 0.00% Reduce -5.0% 445,692 $24.6M
Toronto Dominion Bank 0.05% No change 445,440 $24.6M
683 Capital Management, LLC 2.64% Reduce -11.0% 445,000 $24.6M
Affinity Asset Advisors, LLC 3.75% Add +10.0% 440,000 $24.3M
Jupiter Asset Management Ltd. 0.19% Add +141.4% 405,644 $22.4M
Mangrove Partners Im, LLC 2.39% No change 395,383 $21.9M
Bank of New York Mellon Corp 0.00% Add +3.0% 388,082 $21.4M
Principal Financial Group Inc. 0.01% Reduce -4.9% 330,134 $18.2M
Raymond James Financial Inc. 0.01% Add +4.4% 311,986 $17.2M
Voya Investment Management LLC 0.02% Add +369.8% 280,354 $15.5M
Eversept Partners, LP 1.54% Reduce -49.3% 277,316 $15.3M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% Add +16.6% 243,373 $13.5M
Barclays PLC 0.00% Add +90.3% 212,112 $11.7M
Public Sector Pension Investment Board 0.05% Add +11.8% 211,281 $11.7M
Dimensional Fund Advisors LP 0.00% Add +48.1% 180,050 $10.0M
Renaissance Technologies 0.01% Reduce -46.5% 173,134 $9.6M
Rhumbline Advisers 0.01% Add +6.8% 173,028 $9.6M
Moody Aldrich Partners LLC 1.82% Add +4.3% 170,570 $9.4M
Ameriprise Financial Inc. 0.00% Add +23.0% 168,371 $9.3M
Legal & General Group Plc 0.00% Add +12.2% 166,181 $9.2M
Panagora Asset Management Inc. 0.04% Reduce -0.8% 148,790 $8.2M
Great Lakes Advisors, LLC 0.06% Reduce -8.5% 139,391 $7.7M
Nan Fung Trinity (hk) Ltd. 0.89% New 135,050 $7.5M
Kennedy Capital Management LLC 0.18% Reduce -1.9% 134,890 $7.5M
Nuveen, LLC 0.00% Reduce -15.2% 129,511 $7.2M
Segall Bryant & Hamill, LLC 0.09% New 120,159 $6.6M
TD Asset Management Inc 0.01% Reduce -31.5% 116,332 $6.4M
Capitolis Liquid Global Markets LLC 0.05% New 116,100 $6.4M
First Trust Advisors LP 0.01% Add +39.4% 113,907 $6.3M
Deutsche Bank AG 0.00% Add +69.2% 111,164 $6.1M
Opaleye Management Inc. 1.20% No change 105,000 $5.8M
Manufacturers Life Insurance Company, The 0.00% Reduce -21.6% 94,801 $5.2M
Swiss National Bank 0.00% Add +7.9% 93,800 $5.2M
Neuberger Berman Group LLC 0.00% New 93,582 $5.2M
Assenagon Asset Management S.A. 0.01% Add +104.8% 91,875 $5.1M
Victory Capital Management Inc. 0.00% Reduce -11.2% 90,932 $5.0M
Skandinaviska Enskilda Banken AB (publ) 0.02% Reduce -66.8% 82,750 $4.6M
Franklin Resources Inc. 0.00% Add +4.5% 82,579 $4.6M
EFG Asset Management (North America) Corp. 0.64% Add +14.9% 81,726 $4.5M
Checkpoint Capital L.P. 2.09% Reduce -53.6% 81,311 $4.5M
Rafferty Asset Management, LLC 0.01% Add +82.0% 80,543 $4.5M
Knott David M Jr 2.00% Add +5.3% 80,000 $4.4M
Northwestern Mutual Wealth Management Co. 0.00% No change 78,894 $4.4M
Citigroup Inc. 0.00% Reduce -36.0% 77,951 $4.3M
Prudential Financial Inc. 0.01% Add +32.6% 77,408 $4.3M
Schonfeld Strategic Advisors LLC 0.03% Reduce -73.2% 77,068 $4.3M
Diadema Partners LP 2.62% New 76,185 $4.2M
Royal Bank of Canada 0.00% Add +650.0% 74,734 $4.1M
Informed Momentum Co LLC 0.60% Add +4.0% 71,971 $4.0M
Susquehanna International Group, LLP 0.01% Reduce -62.9% 71,241 $3.9M
Global IMC LLC 1.00% Reduce -0.0% 69,726 $3.9M
Qube Research & Technologies Ltd 0.01% Reduce -79.9% 68,983 $3.8M
Alliancebernstein L.P. 0.00% No change 67,900 $3.8M
Parkman Healthcare Partners LLC 0.39% New 61,596 $3.4M
Boxer Capital Management, LLC 1.67% New 60,000 $3.3M
HighVista Strategies LLC 1.18% Reduce -26.3% 57,851 $3.2M
New York State Teachers Retirement System 0.01% Add +18.9% 55,713 $3.1M
Silvercrest Asset Management Group LLC 0.02% No change 54,723 $3.0M
Axiom Investors LLC 0.02% Add +28.2% 51,233 $2.8M
California State Teachers Retirement System 0.00% Add +22.3% 51,195 $2.8M
CANADA LIFE ASSURANCE Co 0.00% Reduce -1.4% 50,242 $2.8M
Capital Fund Management S.A. 0.03% New 49,805 $2.8M
Birchview Capital, LP 2.63% Reduce 0.0% 48,000 $2.7M
Exchange Traded Concepts, LLC 0.03% Add +73.0% 47,391 $2.6M
Thrivent Financial for Lutherans 0.01% Add +4.1% 45,576 $2.5M
Sei Investments Co. 0.00% Add +19.7% 44,932 $2.5M
Natixis 0.01% New 42,040 $2.3M
Aquatic Capital Management LLC 0.05% Add +178.0% 42,000 $2.3M
Wells Fargo & Company 0.00% Add +4.7% 41,687 $2.3M
State of New Jersey Common Pension Fund D 0.01% Reduce -23.6% 41,025 $2.3M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% Add +864.8% 40,484 $2.2M
Alps Advisors Inc. 0.01% Reduce -24.1% 40,220 $2.2M
Gotham Asset Management 0.01% Add +61.6% 37,287 $2.1M
State of Alaska, Department of Revenue 0.02% Add +11.8% 36,906 $2.0M
Trexquant Investment LP 0.02% Reduce -65.4% 36,018 $2.0M
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Reduce -4.2% 35,841 $2.0M
J. Goldman & Co LP 0.06% Reduce -45.1% 35,828 $2.0M
MetLife Investment Management, LLC 0.01% Reduce -0.1% 34,770 $1.9M
Man Group plc 0.00% Reduce -73.5% 34,013 $1.9M
Intech Investment Management LLC 0.02% Add +9.6% 33,953 $1.9M
State of Wisconsin Investment Board 0.00% Reduce -38.6% 32,988 $1.8M
Massachusetts Financial Services Co. 0.00% Add +1.3% 32,123 $1.8M
Hussman Strategic Advisors, Inc. 0.40% Reduce -40.0% 31,500 $1.7M
Creative Planning 0.00% Add +74.3% 30,204 $1.7M
Louisiana State Employees Retirement System 0.03% Add +3.2% 29,000 $1.6M
Illinois Municipal Retirement Fund 0.02% Add +41.3% 27,569 $1.5M
Citadel Advisors 0.00% Reduce -82.3% 27,201 $1.5M
Brevan Howard Capital Management LP 0.02% Add +67.5% 26,994 $1.5M
State of Tennessee, Department of Treasury 0.01% Reduce -1.9% 25,990 $1.4M
Envestnet Asset Management Inc. 0.00% Add +43.2% 23,878 $1.3M
Tidal Investments LLC 0.01% Add +22.5% 23,777 $1.3M
Yousif Capital Management, LLC 0.01% Add +4.8% 23,404 $1.3M
Ensign Peak Advisors, Inc 0.00% Reduce -14.4% 23,136 $1.3M
Artia Global Partners LP 0.33% Reduce -93.1% 22,951 $1.3M
Horizon Investments, LLC 0.02% New 22,470 $1.2M
Mackenzie Financial Corp. 0.00% Reduce -1.1% 22,457 $1.2M
Allianz Asset Management GmbH 0.00% Add +248.4% 22,300 $1.2M
Glenmede Investment Management, LP 0.01% — 21,434 $1.2M
Comerica Bank 0.00% Add +5.2% 21,291 $1.2M
Fieldview Capital Management, LLC 0.17% New 20,381 $1.1M
STRS Ohio 0.00% Add +3.2% 19,600 $1.1M
New York State Common Retirement Fund 0.00% No change 19,582 $1.1M
Bellevue Group AG 0.02% Add +10.5% 19,472 $1.1M
Guggenheim Capital LLC 0.01% Add +1.6% 19,208 $1.1M
Profund Advisors LLC 0.04% Add +65.0% 19,074 $1.1M
VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% Add +8.0% 19,000 $1.1M
China Universal Asset Management Co., Ltd. 0.10% Add +0.7% 18,908 $1.0M
Teachers Retirement System of the State of Kentucky 0.01% Reduce -7.3% 18,732 $1.0M
Maryland State Retirement & Pension System 0.02% Add +4.7% 18,216 $1.0M
Arrowstreet Capital, Limited Partnership 0.00% New 17,856 $987K
Amalgamated Bank 0.01% Add +3.6% 17,543 $970K
Persistent Asset Partners Ltd 0.85% New 17,520 $968K
WINTON GROUP Ltd 0.05% Reduce -16.2% 17,433 $964K
AQR Capital Management 0.00% Reduce -56.6% 17,409 $962K
Handelsbanken Fonder AB 0.00% Add +18.1% 17,000 $940K
Stempoint Capital LP 0.30% Reduce -65.9% 16,770 $927K
State Board of Administration of Florida Retirement System 0.00% No change 16,303 $901K
Polen Capital Management LLC 0.00% New 15,999 $884K
Commonwealth of Pennsylvania Public School Empls Retrmt SYS 0.00% Add +11.6% 15,913 $880K
DekaBank Deutsche Girozentrale 0.00% No change 15,800 $879K
Moran Wealth Management, LLC 0.03% Reduce -0.8% 15,761 $871K
Mariner, LLC 0.00% Reduce -5.6% 15,701 $868K
ProShare Advisors LLC 0.00% Reduce -8.3% 15,376 $850K
Millennium Management 0.00% Reduce -88.7% 15,191 $840K
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% Add +8.9% 14,523 $803K
Precision Wealth Strategies, LLC 0.26% New 14,339 $793K
Arizona State Retirement System 0.00% Add +11.9% 14,326 $792K
Oregon Public Employees Retirement Fund 0.01% Add +3.6% 14,200 $785K
Erste Asset Management GmbH 0.01% No change 13,500 $752K
Police & Firemen's Retirement System of New Jersey 0.01% Add +4.1% 13,456 $744K
Natixis Advisors, LLC 0.00% New 13,442 $743K
Teacher Retirement System of Texas 0.00% Add +9.8% 13,205 $730K
Algert Global LLC 0.02% Reduce -30.1% 13,055 $722K
Harvest Investment Services, LLC 0.16% Reduce -18.1% 13,029 $720K
Royce & Associates LP 0.01% No change 12,255 $677K
Franklin Street Advisors Inc. 0.04% No change 11,300 $625K
KLP Kapitalforvaltning As 0.00% Add +19.5% 10,400 $575K
Bantamac Capital, LLC 0.20% New 10,226 $565K
Cache Advisors, LLC 0.15% No change 10,143 $561K
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Add +10.8% 10,073 $557K
HighTower Advisors, LLC 0.00% Add +53.1% 9,980 $552K
Cerity Partners LLC 0.00% Add +5.2% 9,722 $537K
Bank of Montreal 0.00% Add +7.2% 9,578 $533K
Simplex Trading, LLC 0.01% Reduce -63.5% 9,452 $522K
Aviva PLC 0.00% Reduce -28.5% 9,435 $521K
BNP Paribas Financial Markets 0.00% Reduce -35.5% 9,139 $505K
E Fund Management Co., Ltd. 0.02% Add +117.3% 8,990 $497K
Cambria Investment Management, L.P. 0.03% Reduce -2.7% 8,757 $484K
Pathstone Holdings, LLC 0.00% New 8,195 $453K
Mutual of America Capital Management LLC 0.00% Reduce -8.3% 7,962 $440K
Palumbo Wealth Management LLC 0.13% New 7,530 $416K
Nomura Holdings Inc. 0.00% New 7,416 $410K
XTX Topco Ltd 0.02% Reduce -48.6% 7,332 $405K
Inspire Investing, LLC 0.04% Reduce -66.6% 7,284 $403K
New Vernon Capital Holdings II LLC 0.19% No change 7,198 $398K
Cibc World Markets Corp. 0.00% Reduce -45.6% 7,173 $396K
Capstone Investment Advisors, LLC 0.00% New 6,987 $386K
Advantage Alpha Capital Partners LP 0.10% Reduce -19.3% 6,972 $385K
Orion Porfolio Solutions, LLC 0.00% Reduce -1.9% 6,600 $365K
Burney Co./ 0.01% Reduce -96.9% 6,318 $349K
Bryce Point Capital, LLC 0.29% New 6,200 $343K
King Wealth Management Group 0.05% No change 6,000 $332K
Mitsubishi UFJ Trust & Banking Corp 0.00% New 5,975 $330K
Ameritas Investment Partners, Inc. 0.01% No change 5,912 $327K
Net Worth Advisory Group 0.07% New 5,822 $322K
Kestra Advisory Services, LLC 0.00% Add +11.2% 5,763 $319K
Tower Research Capital LLC (TRC) 0.01% Add +2211.3% 5,339 $295K
US Bancorp \de 0.00% Add +42.9% 5,223 $289K
Cornerstone Investment Partners, LLC 0.01% Add +0.1% 4,980 $275K
Graham Capital Management, L.P. 0.01% New 4,979 $275K
LPL Financial LLC 0.00% Reduce -1.4% 4,818 $266K
Advisors Asset Management, Inc. 0.00% Add +0.1% 4,724 $261K
Bridgefront Capital, LLC 0.07% New 4,545 $251K
Xponance LLC 0.00% Add +0.9% 4,506 $249K
HSBC Holdings PLC 0.00% Reduce -48.7% 4,340 $242K
Crossmark Global Holdings, Inc. 0.00% New 4,065 $225K
State of Wyoming 0.03% Add +173.5% 3,985 $220K
Nisa Investment Advisors, LLC 0.00% Add +37.8% 3,903 $216K
Velan Capital Investment Management LP 0.20% New 3,700 $204K
Wexford Capital LP 0.05% New 3,315 $183K
Lanark Financial, Inc. 0.01% New 2,565 $141K
PNC Financial Services Group, Inc. 0.00% Add +21.2% 2,414 $133K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +16.6% 2,394 $132K
SG Americas Securities, LLC 0.00% New 1,924 $106K
Covestor Ltd 0.06% Reduce -16.4% 1,745 $97K
Virtus Investment Advisers, LLC 0.03% Reduce -58.9% 1,670 $92K
KBC Group NV 0.00% Reduce -24.8% 1,574 $87K
GF Fund Management Co. LTD. 0.00% No change 1,526 $84K
Smartleaf Asset Management LLC 0.01% Add +3.8% 1,257 $70K
Osaic Holdings, Inc. 0.00% Add +79.5% 1,185 $65K
GAMMA Investing LLC 0.00% Reduce -10.5% 1,077 $60K
Truvestments Capital LLC 0.01% Add +131.3% 650 $36K
Cwm, LLC 0.00% Add +201.5% 609 $34K
Bessemer Group Inc. 0.00% Add +171.0% 504 $28K
FNY Investment Advisers, LLC 0.01% New 500 $27K
Brooklyn Investment Group 0.00% Reduce -65.2% 487 $27K
Global Retirement Partners, LLC 0.00% — 316 $17K
Assetmark, Inc. 0.00% Reduce -1.7% 290 $16K
EverSource Wealth Advisors, LLC 0.00% Add +153.9% 226 $12K
Rise Advisors, LLC 0.00% No change 224 $12K
Daiwa Securities Group Inc. 0.00% No change 215 $12K
Fifth Third Bancorp 0.00% Reduce -25.2% 211 $12K
UMB Bank, n.a. 0.00% Add +25.9% 199 $11K
Twin Peaks Wealth Advisors, LLC 0.00% New 171 $9K
Signaturefd, LLC 0.00% Add +58.5% 149 $8K
Hantz Financial Services, Inc. 0.00% Add +7050.0% 143 $8K
Sterling Capital Management LLC 0.00% Add +127.0% 143 $8K
Russell Investments Group, Ltd. 0.00% Reduce -96.2% 129 $7K
MassMutual Private Wealth & Trust, FSB 0.00% Add +164.4% 119 $7K
Allworth Financial LP 0.00% Add +290.0% 117 $6K
Rothschild Investment LLC 0.00% Add +15.8% 110 $6K
Clearstead Advisors, LLC 0.00% No change 110 $6K
Danske Bank A/S 0.00% No change 100 $6K
Parallel Advisors, LLC 0.00% Add +259.3% 97 $5K
Farther Finance Advisors, LLC 0.00% Reduce -76.1% 93 $5K
MAI Capital Management 0.00% New 86 $5K
Bell Investment Advisors, Inc 0.00% Add +161.3% 81 $4K
Brown Brothers Harriman & Co. 0.00% New 81 $4K
WPG Advisers, LLC 0.00% Add +875.0% 78 $4K
Annis Gardner Whiting Capital Advisors, LLC 0.00% New 76 $4K
Riggs Asset Managment Co. Inc. 0.00% New 71 $4K
Raffa Wealth Management, LLC 0.00% New 60 $3K
Geneos Wealth Management Inc. 0.00% Add +291.7% 47 $3K
Parkside Financial Bank & Trust 0.00% Add +32.4% 45 $2K
Caitong International Asset Management Co., Ltd 0.00% Reduce -98.5% 41 $2K
Huntington National Bank 0.00% New 39 $2K
Principal Securities, Inc. 0.00% Add +200.0% 36 $2K
Wolff Wiese Magana LLC 0.00% No change 35 $2K
Farmers & Merchants Investments Inc. 0.00% No change 35 $2K
Versant Capital Management, Inc 0.00% New 29 $2K
Kestra Investment Management, LLC 0.00% No change 27 $1K
Larson Financial Group LLC 0.00% Reduce -79.4% 26 $1K
Bare Financial Services, Inc 0.00% New 23 $1K
Whipplewood Advisors, LLC 0.00% New 22 $1K
Clearstead Trust, LLC 0.00% New 21 $1K
Jones Financial Companies LLLP 0.00% New 20 $1K
Picton Mahoney Asset Management 0.00% No change 25 $1K
Physician Wealth Advisors, Inc. 0.00% New 9 $498
Abound Wealth Management 0.00% No change 4 $222
Kilter Group LLC 0.00% New 4 $222
DecisionPoint Financial, LLC 0.00% New 4 $201

"% of holder's portfolio" is PTGX's weight in each manager's 13F, not the share of Protagonist Therapeutics Inc. the manager owns.