Ionis PharmaceuticalsIONS
13F holders, Q3 2024 (September 30)354holders −3
49new positions
49sold out
7famous investors
$40.09avg. 13F price*
At the end of Q3 2024, 354 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, down 3 from Q2 2024. 49 opened new positions and 49 sold out. The largest holders were FMR LLC ($900.5M), Vanguard Group Inc. ($603.1M) and T. Rowe Price Investment Management, Inc. ($567.6M). 7 famous investors held it, including Cathie Wood (0.5% of ARK Investment Management's portfolio), Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2024 → Q3 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 49 | $101.0M |
| Exits | 49 | $128.4M |
All 13F filers, Q2 2024 → Q3 2024: 23,000,580 shares bought and 9,745,087 shares sold, net +13,255,493 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 354 holders
| FMR LLC | 0.05% | Add +2.7% | 22,479,529 | $900.5M |
| Vanguard Group Inc. | 0.01% | Add +8.7% | 15,055,758 | $603.1M |
| T. Rowe Price Investment Management, Inc. | 0.34% | Add +12.1% | 14,168,116 | $567.6M |
| BlackRock, Inc. | 0.01% | — | 10,813,023 | $433.2M |
| Wellington Management Group LLP | 0.06% | Add +33.0% | 8,735,787 | $350.0M |
| Bellevue Group AG | 5.11% | Reduce -4.7% | 7,874,400 | $315.4M |
| Capital World Investors | 0.05% | Add +247.6% | 7,828,372 | $313.6M |
| State Street Corp. | 0.01% | Add +15.7% | 4,850,137 | $194.3M |
| T. Rowe Price Associates Inc. | 0.02% | Add +7.0% | 4,210,172 | $168.7M |
| Tweedy, Browne Co LLC | 6.60% | No change | 3,454,676 | $138.4M |
| Geode Capital Management, LLC | 0.01% | Add +7.4% | 2,668,358 | $106.9M |
| Orbimed Advisors LLC | 1.70% | Reduce -2.0% | 2,324,447 | $93.1M |
| Artisan Partners Limited Partnership | 0.13% | Add +34.1% | 2,240,455 | $89.8M |
| Deep Track Capital, LP | 2.81% | Add +10.0% | 2,200,000 | $88.1M |
| Norges Bank | 0.01% | Add +98.9% | 2,027,161 | $81.2M |
| Marshall Wace, LLP | 0.10% | Add +1008.8% | 1,920,464 | $76.9M |
| Macquarie Group Ltd. | 0.08% | Reduce -0.2% | 1,869,806 | $74.9M |
| Clearbridge Investments, LLC | 0.05% | Reduce -21.2% | 1,702,393 | $68.2M |
| BVF Inc. | 1.70% | Reduce -54.4% | 1,451,879 | $58.2M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +8.7% | 1,443,020 | $57.8M |
| ARK Investment Management | 0.51% | Add +1.7% | 1,384,269 | $55.5M |
| Two Sigma Advisers, LP | 0.13% | Add +3.5% | 1,332,411 | $53.4M |
| Pictet Asset Management Holding SA | 0.06% | Reduce -45.9% | 1,303,501 | $52.7M |
| Morgan Stanley | 0.00% | Add +29.4% | 1,310,451 | $52.5M |
| TD Asset Management Inc | 0.04% | Add +14.7% | 1,092,990 | $44.6M |
| Candriam S.C.A. | 0.22% | No change | 948,266 | $38.0M |
| Two Sigma Investments, LP | 0.09% | Reduce -10.6% | 919,077 | $36.8M |
| Invesco Ltd. | 0.01% | Reduce -16.4% | 810,301 | $32.5M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.08% | Reduce -0.1% | 779,721 | $31.2M |
| Hudson Bay Capital Management LP | 0.25% | Add +109.5% | 766,900 | $30.7M |
| Logos Global Management LP | 3.37% | Add +150.0% | 750,000 | $30.0M |
| Northern Trust Corp. | 0.00% | Add +3.5% | 742,904 | $29.8M |
| Royal Bank of Canada | 0.01% | Reduce -1.2% | 670,149 | $26.8M |
| Jacobs Levy Equity Management, Inc. | 0.10% | Add +13.6% | 650,779 | $26.1M |
| Barclays PLC | 0.01% | Add +3.5% | 637,032 | $25.5M |
| Bank of New York Mellon Corp | 0.00% | Add +2.3% | 610,893 | $24.5M |
| J. Goldman & Co LP | 1.06% | Add +3382.0% | 609,416 | $24.4M |
| Man Group plc | 0.07% | Reduce -5.9% | 596,263 | $23.9M |
| Pinnacle Associates Ltd. | 0.39% | Add +1.2% | 458,979 | $23.2M |
| JPMorgan Chase & Co. | 0.00% | Reduce -4.2% | 568,906 | $22.8M |
| Bank of America Corp. | 0.00% | Add +10.5% | 568,660 | $22.8M |
| AXA S.A. | 0.07% | Add +20.7% | 561,243 | $22.5M |
| EcoR1 Capital, LLC | 0.69% | New | 500,000 | $20.0M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | Reduce -37.5% | 500,000 | $20.0M |
| Eversept Partners, LP | 1.45% | Add +3.2% | 471,355 | $18.9M |
| Nomura Holdings Inc. | 0.14% | Reduce -9.6% | 453,069 | $18.1M |
| Millennium Management | 0.02% | Add +235.9% | 430,723 | $17.3M |
| Tocqueville Asset Management L.P. | 0.26% | Add +80.8% | 406,870 | $16.3M |
| First Trust Advisors LP | 0.02% | Add +2384.3% | 402,300 | $16.1M |
| Citadel Advisors | 0.02% | Reduce -36.0% | 401,151 | $16.1M |
| Ghisallo Capital Management LLC | 0.87% | New | 400,000 | $16.0M |
| Ameriprise Financial Inc. | 0.00% | Add +4425.7% | 397,898 | $15.9M |
| Voloridge Investment Management, LLC | 0.06% | New | 380,641 | $15.2M |
| Schonfeld Strategic Advisors LLC | 0.12% | Reduce -49.9% | 362,888 | $14.5M |
| Wells Fargo & Company | 0.00% | Reduce -6.7% | 342,154 | $13.7M |
| Groupama Asset Managment | 0.35% | Add +9.5% | 416,060 | $13.4M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +12.4% | 308,947 | $12.4M |
| Nuveen Asset Management, LLC | 0.00% | Reduce -25.7% | 304,779 | $12.2M |
| Aberdeen Group plc | 0.02% | Add +22.8% | 303,274 | $12.1M |
| C WorldWide Group Holding A/S | 0.12% | No change | 300,000 | $12.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -10.8% | 285,697 | $11.4M |
| Swiss National Bank | 0.01% | Reduce -0.5% | 256,600 | $10.3M |
| Great Point Partners LLC | 3.08% | Reduce -22.7% | 255,000 | $10.2M |
| Privium Fund Management B.V. | 2.50% | Add +1.4% | 250,744 | $10.0M |
| Siren, L.L.C. | 0.50% | — | 250,000 | $10.0M |
| Corient Private Wealth LP | 0.01% | Reduce -11.6% | 237,076 | $9.5M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -28.2% | 235,710 | $9.4M |
| Twinbeech Capital LP | 0.18% | New | 235,477 | $9.4M |
| Driehaus Capital Management LLC | 0.08% | New | 229,969 | $9.2M |
| Baker Bros. Advisors LP | 0.09% | New | 223,470 | $9.0M |
| Orion Investment Co | 3.40% | Reduce -0.0% | 218,525 | $8.8M |
| Bank of Montreal | 0.00% | Reduce -3.0% | 213,883 | $8.7M |
| California Public Employees Retirement System | 0.01% | Add +7.8% | 211,756 | $8.5M |
| Sector Gamma As | 2.56% | Add +24.0% | 210,842 | $8.4M |
| Rafferty Asset Management, LLC | 0.03% | Add +17.7% | 198,759 | $8.0M |
| New York State Common Retirement Fund | 0.01% | Reduce -7.9% | 198,759 | $8.0M |
| Rhumbline Advisers | 0.01% | Add +10.6% | 196,942 | $7.9M |
| Amova Asset Management Americas, Inc. | 0.09% | Reduce -1.6% | 196,114 | $7.9M |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | Reduce -1.6% | 196,114 | $7.9M |
| Rhenman & Partners Asset Management AB | 0.63% | Add +50.0% | 195,000 | $7.8M |
| Sicart Associates LLC | 2.69% | No change | 191,523 | $7.7M |
| Renaissance Technologies | 0.01% | Reduce -23.6% | 190,514 | $7.6M |
| Sei Investments Co. | 0.01% | Add +43.5% | 189,837 | $7.6M |
| Altrinsic Global Advisors LLC | 0.31% | Reduce -2.7% | 182,734 | $7.3M |
| Stifel Financial Corp. | 0.01% | Reduce -15.6% | 182,505 | $7.3M |
| Jane Street Group, LLC | 0.01% | Reduce -1.5% | 176,560 | $7.1M |
| BNP Paribas Financial Markets | 0.01% | Reduce -5.7% | 175,328 | $7.0M |
| Alyeska Investment Group, L.P. | 0.03% | New | 168,951 | $6.8M |
| UBS Group AG | 0.00% | Add +10.0% | 167,880 | $6.7M |
| Kennedy Capital Management LLC | 0.14% | Reduce -36.3% | 162,076 | $6.5M |
| Legal & General Group Plc | 0.00% | Add +6.5% | 157,287 | $6.3M |
| Sonora Investment Management Group, LLC | 0.46% | Add +1.6% | 153,175 | $6.1M |
| BLB&B Advisors, LLC | 0.31% | Reduce -1.0% | 152,250 | $6.1M |
| State Board of Administration of Florida Retirement System | 0.01% | No change | 151,055 | $6.1M |
| Tang Capital Management LLC | 0.43% | No change | 150,000 | $6.0M |
| D. E. Shaw & Co. | 0.01% | Reduce -23.9% | 145,091 | $5.8M |
| Peregrine Capital Management LLC | 0.16% | Reduce -0.3% | 131,630 | $5.3M |
| Trexquant Investment LP | 0.07% | Add +334.9% | 130,858 | $5.2M |
| Swedbank AB | 0.01% | No change | 129,373 | $5.2M |
| Russell Investments Group, Ltd. | 0.01% | Reduce -3.2% | 128,469 | $5.1M |
| Squarepoint Ops LLC | 0.02% | Reduce -70.8% | 127,341 | $5.1M |
| California State Teachers Retirement System | 0.01% | Reduce -2.4% | 126,180 | $5.1M |
| Walleye Capital LLC | 0.06% | Add +26.8% | 124,116 | $5.0M |
| Amundi | 0.00% | Reduce -0.9% | 128,299 | $4.8M |
| Nicola Wealth Management LTD. | 0.37% | Add +17.6% | 87,000 | $4.7M |
| Eisler Capital (US) LLC | 0.87% | Add +622.6% | 117,565 | $4.7M |
| Cutter Capital Management, LP | 1.15% | Reduce -39.3% | 97,300 | $3.9M |
| Voya Investment Management LLC | 0.00% | Add +0.7% | 95,821 | $3.8M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 93,807 | $3.8M |
| Dimensional Fund Advisors LP | 0.00% | Add +6.3% | 94,332 | $3.8M |
| Prudential Financial Inc. | 0.01% | Add +472.7% | 90,017 | $3.6M |
| State of Wisconsin Investment Board | 0.01% | Reduce -1.8% | 86,166 | $3.5M |
| Granite Investment Partners, LLC | 0.15% | Reduce -24.8% | 85,793 | $3.4M |
| Atle Fund Management AB | 1.56% | Add +103.2% | 82,691 | $3.3M |
| Engineers Gate Manager LP | 0.06% | Add +383.3% | 78,874 | $3.2M |
| Commerce Bank | 0.02% | Add +1.6% | 77,553 | $3.1M |
| DAVENPORT & Co LLC | 0.02% | Reduce -6.3% | 75,598 | $3.0M |
| Deutsche Bank AG | 0.00% | Add +723.1% | 74,874 | $3.0M |
| Liontrust Investment Partners LLP | 0.04% | No change | 59,644 | $2.8M |
| Citigroup Inc. | 0.00% | Reduce -8.3% | 70,295 | $2.8M |
| Ensign Peak Advisors, Inc | 0.00% | Add +2.4% | 69,880 | $2.8M |
| Treasurer of the State of North Carolina | 0.01% | Add +8.3% | 68,363 | $2.7M |
| Neuberger Berman Group LLC | 0.00% | Add +353.3% | 64,874 | $2.6M |
| Sphera Funds Management LTD. | 0.42% | Reduce -54.5% | 63,821 | $2.6M |
| HBK Investments L P | 0.05% | New | 60,000 | $2.4M |
| Skandinaviska Enskilda Banken AB (publ) | 0.01% | No change | 59,626 | $2.4M |
| NEOS Investment Management LLC | 0.07% | Add +31.5% | 59,244 | $2.4M |
| Janus Henderson Group PLC | 0.00% | No change | 58,977 | $2.4M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -24.0% | 58,814 | $2.4M |
| Schroder Investment Management Group | 0.00% | No change | 56,222 | $2.3M |
| Susquehanna International Group, LLP | 0.00% | Reduce -40.3% | 57,239 | $2.3M |
| Public Employees Retirement System of Ohio | 0.01% | Add +2.8% | 56,825 | $2.3M |
| Teacher Retirement System of Texas | 0.01% | Add +7.9% | 56,699 | $2.3M |
| Van Eck Associates Corp. | 0.00% | Add +17.4% | 59,006 | $2.3M |
| Tudor Investment Corporation | 0.02% | Add +308.3% | 53,479 | $2.1M |
| Jefferies Financial Group Inc. | 0.04% | Reduce -15.1% | 52,781 | $2.1M |
| Erste Asset Management GmbH | 0.03% | No change | 51,300 | $2.1M |
| Alliancebernstein L.P. | 0.00% | Add +1.7% | 52,162 | $2.1M |
| State of New Jersey Common Pension Fund D | 0.01% | Reduce -6.5% | 51,775 | $2.1M |
| Blair William & Co. | 0.01% | Add +84.7% | 46,651 | $1.9M |
| Algert Global LLC | 0.05% | Reduce -39.7% | 45,430 | $1.8M |
| Private Advisor Group, LLC | 0.01% | Reduce -5.7% | 43,787 | $1.8M |
| Handelsbanken Fonder AB | 0.01% | Add +26.8% | 43,011 | $1.7M |
| LPL Financial LLC | 0.00% | Reduce -17.1% | 42,620 | $1.7M |
| NJ State Employees Deferred Compensation Plan | 0.20% | No change | 42,000 | $1.7M |
| CANADA LIFE ASSURANCE Co | 0.00% | Reduce -12.5% | 39,835 | $1.6M |
| Baillie Gifford & Co. | 0.00% | Reduce -84.8% | 39,581 | $1.6M |
| DCF Advisers, LLC | 0.83% | Add +71.7% | 39,500 | $1.6M |
| Arizona State Retirement System | 0.01% | Add +3.0% | 37,827 | $1.5M |
| Profund Advisors LLC | 0.06% | Add +25.4% | 37,596 | $1.5M |
| Guggenheim Capital LLC | 0.01% | Add +5.0% | 37,159 | $1.5M |
| Capital Counsel LLC | 0.06% | No change | 37,080 | $1.5M |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.04% | Reduce -13.2% | 36,957 | $1.5M |
| Polar Asset Management Partners Inc. | 0.05% | New | 35,400 | $1.4M |
| Grandfield & Dodd, LLC | 0.08% | Add +2.2% | 34,813 | $1.4M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -0.8% | 30,922 | $1.2M |
| Capital Fund Management S.A. | 0.01% | New | 30,691 | $1.2M |
| Artia Global Partners LP | 0.35% | Reduce -51.2% | 30,479 | $1.2M |
| Brevan Howard Capital Management LP | 0.06% | Add +30.4% | 28,479 | $1.1M |
| Creative Planning | 0.00% | Add +5.7% | 28,382 | $1.1M |
| China Universal Asset Management Co., Ltd. | 0.12% | Add +64.0% | 28,121 | $1.1M |
| Pathstone Holdings, LLC | 0.01% | Add +22.5% | 27,807 | $1.1M |
| Caption Management, LLC | 0.11% | Reduce -83.4% | 26,600 | $1.1M |
| Landscape Capital Management, L.L.C. | 0.10% | New | 25,435 | $1.0M |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 24,083 | $965K |
| Castle Hook Partners LP | 0.03% | New | 23,940 | $959K |
| Mariner, LLC | 0.00% | Add +5.8% | 23,127 | $928K |
| Lazard Asset Management LLC | 0.00% | Add +140.9% | 22,923 | $917K |
| Raymond James & Associates | 0.00% | Reduce -4.5% | 22,524 | $902K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -5.4% | 21,453 | $859K |
| Natixis Advisors, LLC | 0.00% | Reduce -9.9% | 21,080 | $844K |
| Nicollet Investment Management, Inc. | 0.28% | Add +1.5% | 20,402 | $817K |
| Y-Intercept (Hong Kong) Ltd | 0.05% | New | 20,141 | $807K |
| Monashee Investment Management LLC | 0.09% | New | 20,000 | $801K |
| Xponance LLC | 0.01% | Add +5.0% | 19,021 | $762K |
| Tidal Investments LLC | 0.01% | Reduce -0.2% | 18,908 | $757K |
| Victory Capital Management Inc. | 0.00% | Add +5.9% | 18,350 | $735K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Reduce -59.9% | 17,741 | $711K |
| Seven Eight Capital, LP | 0.06% | New | 17,394 | $697K |
| Capula Management Ltd | 0.01% | New | 17,365 | $696K |
| NBT Bank, N.A. | 0.05% | No change | 17,050 | $683K |
| XTX Topco Ltd | 0.05% | New | 16,805 | $673K |
| Bleakley Financial Group, LLC | 0.02% | Add +2.1% | 16,678 | $668K |
| Osaic Holdings, Inc. | 0.00% | Add +11.4% | 16,372 | $656K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 15,589 | $624K |
| Raymond James Financial Services Advisors, Inc. | 0.00% | Reduce -5.0% | 14,570 | $584K |
| Tanaka Capital Management Inc. | 1.34% | No change | 14,512 | $581K |
| Chartwell Investment Partners, LLC | 0.02% | No change | 13,759 | $551K |
| North Star Asset Management Inc. | 0.02% | No change | 13,640 | $546K |
| PEAK6 Investments LLC | 0.03% | Reduce -10.0% | 13,500 | $541K |
| Westmount Partners, LLC | 0.16% | No change | 13,462 | $539K |
| PDT Partners, LLC | 0.05% | Reduce -0.2% | 13,400 | $537K |
| Assenagon Asset Management S.A. | 0.00% | Reduce -45.1% | 13,298 | $533K |
| Principal Financial Group Inc. | 0.00% | Reduce -24.9% | 13,112 | $525K |
| Martingale Asset Management L P | 0.01% | Add +0.0% | 12,809 | $513K |
| Stratos Wealth Partners, LTD. | 0.01% | Reduce -0.0% | 12,788 | $512K |
| E Fund Management Co., Ltd. | 0.03% | Add +24.4% | 12,752 | $511K |
| Brown Advisory Inc. | 0.00% | Add +16.2% | 12,746 | $511K |
| Twin Tree Management, LP | 0.01% | Add +19.7% | 12,428 | $498K |
| SpiderRock Advisors, LLC | 0.01% | Add +0.1% | 12,036 | $482K |
| Horizon Kinetics Asset Management LLC | 0.01% | Reduce -4.2% | 11,952 | $479K |
| Wolverine Trading, LLC | 0.01% | Reduce -45.6% | 11,611 | $474K |
| Aigen Investment Management, LP | 0.09% | New | 11,612 | $465K |
| Plancorp, LLC | 0.02% | No change | 11,286 | $452K |
| Janney Montgomery Scott LLC | 0.00% | Reduce -35.6% | 11,294 | $452K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +0.5% | 11,263 | $451K |
| Canada Pension Plan Investment Board | 0.00% | New | 11,200 | $449K |
| Bridgefront Capital, LLC | 0.17% | Add +101.4% | 11,196 | $449K |
| Midwest Professional Planners, LTD. | 0.14% | Add +9.5% | 11,106 | $445K |
| Susquehanna Portfolio Strategies, LLC | 0.03% | Reduce -74.7% | 10,894 | $436K |
| Montanova Capital, LLC | 0.02% | No change | 10,800 | $433K |
| Teza Capital Management LLC | 0.05% | Reduce -57.9% | 10,600 | $425K |
| Advent Capital Management | 0.68% | New | 10,000 | $401K |
| Cypress Capital, LLC | 0.10% | No change | 10,000 | $401K |
| Troluce Capital Advisors LLC | 0.07% | New | 10,000 | $401K |
| Amalgamated Bank | 0.00% | Add +3.1% | 9,957 | $399K |
| Annis Gardner Whiting Capital Advisors, LLC | 0.11% | Add +5.8% | 9,936 | $398K |
| PNC Financial Services Group, Inc. | 0.00% | Add +5.7% | 9,893 | $396K |
| Franklin Resources Inc. | 0.00% | Add +1.3% | 10,155 | $392K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -3.1% | 9,738 | $390K |
| &partners | 0.01% | New | 9,606 | $385K |
| Fifth Third Bancorp | 0.00% | Add +1.2% | 9,572 | $383K |
| Sectoral Asset Management Inc. | 0.22% | Reduce -2.3% | 9,440 | $378K |
| MetLife Investment Management, LLC | 0.00% | Add +5.8% | 9,363 | $375K |
| Two Sigma Securities, LLC | 0.03% | Reduce -88.8% | 8,940 | $358K |
| M&T Bank Corp | 0.00% | Add +0.8% | 8,896 | $357K |
| Ariadne Wealth Management, LP | 0.19% | New | 9,147 | $352K |
| ProShare Advisors LLC | 0.00% | Reduce -4.1% | 8,640 | $346K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Add +10.2% | 8,404 | $337K |
| Utah Retirement Systems | 0.00% | Add +6.3% | 8,400 | $337K |
| Clearstead Advisors, LLC | 0.01% | No change | 8,285 | $332K |
| Maryland State Retirement & Pension System | 0.01% | Reduce -24.4% | 8,284 | $332K |
| International Assets Investment Management, LLC | 0.03% | Reduce -15.4% | 8,207 | $329K |
| Virtus Advisers, LLC | 0.15% | No change | 8,009 | $321K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +23.1% | 7,825 | $320K |
| Sanctuary Advisors, LLC | 0.00% | Reduce -43.6% | 9,277 | $316K |
| Comerica Bank | 0.00% | Reduce -64.5% | 7,615 | $305K |
| SG Americas Securities, LLC | 0.00% | New | 7,419 | $297K |
| Truist Financial Corp. | 0.00% | Reduce -8.2% | 7,348 | $294K |
| Simplex Trading, LLC | 0.01% | Reduce -89.0% | 6,944 | $278K |
| Jones Financial Companies LLLP | 0.00% | Add +97.7% | 6,724 | $275K |
| Castle Rock Wealth Management, LLC | 0.06% | No change | 6,972 | $264K |
| Acadian Asset Management LLC | 0.00% | New | 6,328 | $253K |
| American Century Companies Inc. | 0.00% | Reduce -53.2% | 6,293 | $252K |
| Gotham Asset Management | 0.00% | No change | 6,262 | $251K |
| Advisors Asset Management, Inc. | 0.00% | Add +21.0% | 6,140 | $246K |
| US Bancorp \de | 0.00% | Reduce -48.1% | 5,730 | $230K |
| Focus Partners Wealth | 0.00% | New | 5,696 | $228K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Reduce -8.1% | 5,585 | $224K |
| HighTower Advisors, LLC | 0.00% | Reduce -1.3% | 5,559 | $223K |
| Vontobel Holding Ltd. | 0.00% | Reduce -31.1% | 5,502 | $220K |
| Harbor Advisors LLC | 0.04% | New | 5,500 | $220K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +21.3% | 5,288 | $216K |
| O'shaughnessy Asset Management, LLC | 0.00% | New | 5,273 | $204K |
| FORA Capital, LLC | 0.02% | New | 5,081 | $204K |
| GTS Securities LLC | 0.00% | Reduce -91.7% | 5,056 | $203K |
| Sandia Investment Management LP | 0.33% | New | 5,000 | $200K |
| Torno Capital, LLC | 0.26% | New | 5,000 | $200K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -91.4% | 4,301 | $172K |
| KBC Group NV | 0.00% | Add +12.4% | 3,808 | $153K |
| Walleye Trading LLC | 0.00% | New | 3,613 | $145K |
| CI Investments Inc. | 0.00% | Reduce -7.5% | 3,380 | $135K |
| Sterling Capital Management LLC | 0.00% | — | 3,045 | $122K |
| Corebridge Financial, Inc. | 0.00% | Add +4.2% | 2,876 | $115K |
| AlphaQuest LLC | 0.01% | Add +94.8% | 2,674 | $107K |
| CIBC Private Wealth Group LLC | 0.00% | Add +14.1% | 2,425 | $97K |
| Danske Bank A/S | 0.00% | Add +425.0% | 2,100 | $84K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +226.7% | 2,055 | $82K |
| NewEdge Advisors, LLC | 0.00% | Reduce -15.3% | 1,820 | $73K |
| Cwm, LLC | 0.00% | Reduce -21.5% | 1,741 | $70K |
| Twin Lakes Capital Management, LLC | 0.04% | No change | 1,500 | $60K |
| Quantbot Technologies LP | 0.00% | New | 1,267 | $51K |
| IFP Advisors, Inc | 0.00% | Add +14.6% | 1,226 | $49K |
| Horizon Investments, LLC | 0.00% | Reduce -26.3% | 1,101 | $44K |
| Itau Unibanco Holding S.A. | 0.00% | Add +40.9% | 1,081 | $43K |
| Fourpath Capital Management, LLC | 0.01% | New | 1,049 | $42K |
| Parallel Advisors, LLC | 0.00% | Add +62.7% | 1,028 | $41K |
| Sunbelt Securities, Inc. | 0.00% | No change | 1,014 | $41K |
| Earned Wealth Advisors, LLC | 0.01% | New | 1,000 | $40K |
| Harbour Investments, Inc. | 0.00% | No change | 900 | $36K |
| Quadrant Capital Group LLC | 0.00% | Add +1.2% | 870 | $35K |
| Manchester Capital Management LLC | 0.00% | Add +21.6% | 845 | $34K |
| Allworth Financial LP | 0.00% | Add +2.6% | 830 | $33K |
| ADAR1 Capital Management, LLC | 0.00% | Reduce -53.3% | 700 | $28K |
| GAMMA Investing LLC | 0.00% | Add +83.9% | 664 | $27K |
| Farther Finance Advisors, LLC | 0.00% | Add +10.3% | 621 | $25K |
| Archer Investment Corp | 0.01% | No change | 600 | $24K |
| Laurel Wealth Advisors LLC | 0.00% | No change | 600 | $24K |
| Daiwa Securities Group Inc. | 0.00% | No change | 541 | $22K |
| Mather Group, Llc. | 0.00% | Reduce -43.4% | 516 | $21K |
| Riverview Trust Co | 0.02% | Add +2.3% | 487 | $20K |
| Global Trust Asset Management, LLC | 0.01% | No change | 474 | $19K |
| Elequin Capital, LP | 0.04% | New | 437 | $18K |
| Smartleaf Asset Management LLC | 0.00% | Add +623.7% | 427 | $17K |
| Ascentis Wealth Management, LLC | 0.01% | — | 400 | $16K |
| AlphaMark Advisors, LLC | 0.01% | Reduce -35.3% | 369 | $15K |
| Lindbrook Capital, LLC | 0.00% | Reduce -6.2% | 365 | $15K |
| Signaturefd, LLC | 0.00% | Add +7.3% | 365 | $15K |
| Blue Trust, Inc. | 0.00% | Add +167.3% | 286 | $14K |
| Huntington National Bank | 0.00% | Add +0.6% | 324 | $13K |
| Parkside Financial Bank & Trust | 0.00% | Add +45.7% | 290 | $12K |
| Storebrand Asset Management As | 0.00% | No change | 271 | $11K |
| Claris Advisors, LLC / Mo / | 0.00% | New | 250 | $10K |
| Riggs Asset Managment Co. Inc. | 0.00% | No change | 250 | $10K |
| Covestor Ltd | 0.01% | Add +2.9% | 250 | $10K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 238 | $10K |
| Allspring Global Investments Holdings, LLC | 0.00% | Add +42.8% | 237 | $9K |
| Global X Japan Co., Ltd. | 0.00% | Reduce -10.3% | 235 | $9K |
| Whittier Trust Co. | 0.00% | No change | 214 | $9K |
| AllSquare Wealth Management LLC | 0.00% | No change | 198 | $8K |
| Exchange Traded Concepts, LLC | 0.00% | New | 195 | $8K |
| Whittier Trust Co. of Nevada Inc. | 0.00% | Reduce -28.0% | 157 | $6K |
| Pacifica Partners Inc. | 0.00% | No change | 150 | $6K |
| Abich Financial Wealth Management LLC | 0.01% | Add +191.1% | 131 | $5K |
| Dunhill Financial, LLC | 0.00% | No change | 130 | $5K |
| LRI Investments, LLC | 0.00% | Reduce -27.3% | 136 | $5K |
| Spire Wealth Management | 0.00% | No change | 125 | $5K |
| GPS Wealth Strategies Group, LLC | 0.00% | No change | 119 | $5K |
| First Horizon Advisors, Inc. | 0.00% | New | 112 | $4K |
| Wolff Wiese Magana LLC | 0.00% | New | 110 | $4K |
| Arax Advisory Partners | 0.00% | No change | 104 | $4K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Add +77.6% | 103 | $4K |
| Global Retirement Partners, LLC | 0.00% | Add +3.1% | 101 | $4K |
| Creekmur Asset Management LLC | 0.00% | No change | 100 | $4K |
| Sachetta, LLC | 0.00% | No change | 98 | $4K |
| Wilmington Savings Fund Society, FSB | 0.00% | New | 92 | $4K |
| Brooklyn Investment Group | 0.00% | New | 84 | $3K |
| Washington Trust Advisors, Inc. | 0.00% | Reduce -25.2% | 83 | $3K |
| Dynamic Wealth Strategies, LLC | 0.00% | No change | 80 | $3K |
| Hemington Wealth Management | 0.00% | New | 84 | $3K |
| Semmax Financial Advisors Inc. | 0.00% | No change | 79 | $3K |
| Quent Capital, LLC | 0.00% | No change | 74 | $3K |
| Raleigh Capital Management Inc. | 0.00% | No change | 72 | $3K |
| Bell Investment Advisors, Inc | 0.00% | No change | 71 | $3K |
| Bogart Wealth, LLC | 0.00% | Reduce -16.5% | 71 | $3K |
| Versant Capital Management, Inc | 0.00% | Add +14.6% | 63 | $3K |
| Leonteq Securities AG | 0.00% | New | 63 | $3K |
| Blume Capital Management, Inc. | 0.00% | No change | 55 | $2K |
| Clear Investment Research, LLC | 0.00% | New | 51 | $2K |
| Private Trust Co. NA | 0.00% | Reduce -42.2% | 48 | $2K |
| Sandy Spring Bank | 0.00% | No change | 34 | $1K |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $1K |
| CoreCap Advisors, LLC | 0.00% | New | 26 | $1K |
| TFC Financial Management, Inc. | 0.00% | No change | 21 | $842 |
| Front Row Advisors LLC | 0.00% | No change | 20 | $801 |
| Thurston, Springer, Miller, Herd & Titak, Inc. | 0.00% | No change | 20 | $801 |
| Rosenberg Matthew Hamilton | 0.00% | No change | 20 | $801 |
| Key Financial Inc | 0.00% | No change | 19 | $761 |
| Larson Financial Group LLC | 0.00% | No change | 18 | $721 |
| Voisard Asset Management Group, Inc. | 0.00% | New | 10 | $401 |
| Private Wealth Management Group, LLC | 0.00% | No change | 10 | $401 |
| Principal Securities, Inc. | 0.00% | Reduce -69.2% | 4 | $160 |
| MV Capital Management, Inc. | 0.00% | New | 2 | $81 |
| AdvisorNet Financial, Inc | 0.00% | New | 1 | $40 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.