Ionis PharmaceuticalsIONS
13F holders, Q1 2024 (March 31)361holders
7famous investors
$43.40avg. 13F price*
At the end of Q1 2024, 361 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings. The largest holders were FMR LLC ($947.7M), Vanguard Group Inc. ($582.2M) and T. Rowe Price Investment Management, Inc. ($577.3M). 7 famous investors held it, including Cathie Wood (0.4% of ARK Investment Management's portfolio), Steve Cohen (0.0% of Point72 Asset Management's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 47 | $82.3M |
| Exits | 49 | $69.8M |
Ownership 361 holders
| FMR LLC | 0.06% | Add +1.6% | 21,862,735 | $947.7M |
| Vanguard Group Inc. | 0.01% | Reduce -5.4% | 13,430,456 | $582.2M |
| T. Rowe Price Investment Management, Inc. | 0.35% | Add +0.9% | 13,317,112 | $577.3M |
| BlackRock Inc. | 0.01% | Add +7.9% | 9,771,891 | $423.6M |
| Bellevue Group AG | 5.49% | Reduce -4.8% | 8,299,514 | $359.8M |
| Wellington Management Group LLP | 0.04% | Add +23.4% | 5,695,699 | $246.9M |
| Clearbridge Investments, LLC | 0.15% | Reduce -5.1% | 4,466,191 | $193.6M |
| State Street Corp. | 0.01% | Add +3.7% | 4,155,664 | $180.1M |
| Pictet Asset Management Holding SA | 0.18% | Add +6.3% | 3,739,757 | $163.2M |
| T. Rowe Price Associates Inc. | 0.02% | Reduce -17.2% | 3,522,203 | $152.7M |
| Tweedy, Browne Co LLC | 7.03% | No change | 3,454,676 | $149.8M |
| Macquarie Group Ltd. | 0.16% | Add +3.6% | 3,200,578 | $138.7M |
| BVF Inc. | 2.89% | No change | 2,428,613 | $105.3M |
| Geode Capital Management, LLC | 0.01% | Add +3.9% | 2,364,256 | $102.5M |
| Orbimed Advisors LLC | 1.60% | Reduce -2.5% | 2,013,033 | $87.3M |
| ARK Investment Management | 0.42% | Reduce -26.5% | 1,399,852 | $60.7M |
| Deep Track Capital, LP | 1.71% | Add +10.0% | 1,373,475 | $59.5M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +2.0% | 1,301,368 | $56.4M |
| Norges Bank | 0.01% | Add +5.5% | 1,236,998 | $53.6M |
| Morgan Stanley | 0.00% | Add +6.7% | 1,163,598 | $50.4M |
| Two Sigma Investments, LP | 0.12% | Add +35.2% | 1,083,879 | $47.0M |
| Two Sigma Advisers, LP | 0.10% | Add +33.9% | 1,040,111 | $45.1M |
| Adage Capital Partners Gp, L.L.C. | 0.08% | Reduce -27.8% | 1,000,000 | $43.4M |
| Candriam S.C.A. | 0.26% | Add +45.0% | 911,897 | $39.5M |
| TD Asset Management Inc | 0.04% | Reduce -6.1% | 898,362 | $38.9M |
| Capital World Investors | 0.01% | No change | 839,463 | $36.4M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.09% | Add +129.2% | 778,593 | $33.8M |
| Squarepoint Ops LLC | 0.13% | Add +1158.7% | 745,173 | $32.3M |
| Farallon Capital Management, L.L.C. | 0.19% | Reduce -52.8% | 734,000 | $31.8M |
| Royal Bank of Canada | 0.01% | Reduce -5.4% | 732,237 | $31.7M |
| Northern Trust Corp. | 0.01% | Add +0.6% | 692,247 | $30.0M |
| JPMorgan Chase & Co. | 0.00% | Reduce -33.0% | 630,979 | $27.4M |
| Bank of America Corp. | 0.00% | Add +33.2% | 606,298 | $26.3M |
| Wells Fargo & Company | 0.01% | Reduce -1.7% | 584,158 | $25.3M |
| Bank of New York Mellon Corp | 0.00% | Reduce -9.0% | 583,589 | $25.3M |
| Millennium Management | 0.02% | Reduce -34.5% | 583,179 | $25.3M |
| Barclays PLC | 0.01% | Reduce -10.4% | 577,387 | $25.0M |
| Jacobs Levy Equity Management, Inc. | 0.11% | Add +12.2% | 571,763 | $24.8M |
| Nomura Holdings Inc. | 0.17% | Reduce -3.8% | 470,837 | $20.4M |
| AXA S.A. | 0.06% | Add +0.0% | 464,815 | $20.1M |
| Pinnacle Associates Ltd. | 0.31% | Add +0.2% | 459,758 | $19.9M |
| Invesco Ltd. | 0.00% | Add +115.1% | 442,887 | $19.2M |
| Nuveen Asset Management, LLC | 0.01% | Add +30.6% | 423,030 | $18.3M |
| First Turn Management, LLC | 2.73% | Add +18.2% | 421,487 | $18.3M |
| Artisan Partners Limited Partnership | 0.03% | New | 416,729 | $18.1M |
| Groupama Asset Managment | 0.31% | Reduce -27.8% | 257,868 | $17.0M |
| Eversept Partners, LP | 1.22% | Add +15.9% | 376,438 | $16.3M |
| Hudson Bay Capital Management LP | 0.15% | Add +131.4% | 335,500 | $14.5M |
| C WorldWide Group Holding A/S | 0.15% | No change | 300,000 | $13.0M |
| Baillie Gifford & Co. | 0.01% | Reduce -0.9% | 295,683 | $12.8M |
| Cutter Capital Management, LP | 4.84% | New | 289,366 | $12.5M |
| Liontrust Investment Partners LLP | 0.17% | Add +1.6% | 288,544 | $12.5M |
| Point72 Asset Management | 0.04% | Reduce -70.4% | 286,602 | $12.4M |
| Verition Fund Management LLC | 0.13% | Add +100.2% | 285,947 | $12.4M |
| Cubist Systematic Strategies, LLC | 0.14% | Add +39.3% | 277,791 | $12.0M |
| Assenagon Asset Management S.A. | 0.03% | Add +47.1% | 271,263 | $11.8M |
| Zimmer Partners, LP | 0.25% | New | 270,300 | $11.7M |
| Corient Private Wealth LP | 0.02% | Reduce -0.0% | 267,291 | $11.6M |
| Swiss National Bank | 0.01% | Add +0.2% | 254,900 | $11.0M |
| Man Group plc | 0.03% | Add +222.7% | 253,221 | $11.0M |
| Kennedy Capital Management LLC | 0.22% | Add +9.2% | 249,527 | $10.8M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -6.0% | 245,067 | $10.6M |
| Bank of Montreal | 0.00% | Reduce -0.3% | 222,818 | $10.5M |
| Stifel Financial Corp. | 0.01% | Reduce -1.4% | 242,459 | $10.5M |
| J. Goldman & Co LP | 0.45% | New | 231,424 | $10.0M |
| Privium Fund Management B.V. | 2.87% | Add +4.4% | 226,993 | $9.8M |
| Citigroup Inc. | 0.01% | Add +122.4% | 222,943 | $9.7M |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | Reduce -12.8% | 220,261 | $9.5M |
| Amova Asset Management Americas, Inc. | 0.09% | Reduce -12.8% | 220,261 | $9.5M |
| Aberdeen Group plc | 0.02% | Add +60.8% | 219,421 | $9.5M |
| ExodusPoint Capital Management, LP | 0.12% | Add +819.3% | 215,893 | $9.4M |
| Rafferty Asset Management, LLC | 0.03% | Add +13.1% | 208,469 | $9.0M |
| California Public Employees Retirement System | 0.01% | Reduce -2.6% | 203,945 | $8.8M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -47.5% | 200,380 | $8.7M |
| Altrinsic Global Advisors LLC | 0.38% | Reduce -6.8% | 194,864 | $8.4M |
| BNP Paribas Financial Markets | 0.01% | Reduce -45.2% | 194,359 | $8.4M |
| Sicart Associates LLC | 3.08% | Reduce -0.1% | 193,993 | $8.4M |
| Jefferies Financial Group Inc. | 0.18% | Reduce -4.6% | 193,080 | $8.4M |
| Voloridge Investment Management, LLC | 0.03% | Reduce -27.6% | 191,367 | $8.3M |
| Alliancebernstein L.P. | 0.00% | Reduce -25.7% | 191,155 | $8.3M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | No change | 186,327 | $8.1M |
| Credit Suisse AG/ | 0.01% | Reduce -3.8% | 182,509 | $7.9M |
| Renaissance Technologies | 0.01% | Add +59.9% | 179,714 | $7.8M |
| Rhumbline Advisers | 0.01% | Reduce -10.0% | 179,419 | $7.8M |
| First Trust Advisors LP | 0.01% | Reduce -84.0% | 175,858 | $7.6M |
| Sector Gamma As | 2.14% | Add +21.0% | 175,507 | $7.6M |
| UBS Group AG | 0.00% | Add +7.5% | 171,763 | $7.4M |
| Schonfeld Strategic Advisors LLC | 0.06% | Reduce -45.5% | 170,860 | $7.4M |
| D. E. Shaw & Co. | 0.01% | Add +34.7% | 160,482 | $7.0M |
| Tocqueville Asset Management L.P. | 0.11% | Reduce -0.3% | 159,380 | $6.9M |
| Russell Investments Group, Ltd. | 0.01% | Reduce -2.8% | 153,415 | $6.7M |
| Sonora Investment Management Group, LLC | 0.52% | Add +1.0% | 150,814 | $6.5M |
| Tang Capital Management LLC | 0.68% | Reduce -25.0% | 150,000 | $6.5M |
| Legal & General Group Plc | 0.00% | Reduce -3.8% | 149,488 | $6.5M |
| BLB&B Advisors, LLC | 0.36% | Reduce -0.7% | 146,100 | $6.3M |
| Swedbank AB | 0.01% | Add +1.2% | 142,641 | $6.2M |
| Parkman Healthcare Partners LLC | 0.75% | Reduce -33.1% | 141,499 | $6.1M |
| Susquehanna International Group, LLP | 0.01% | Add +156.9% | 139,061 | $6.0M |
| Senator Investment Group LP | 0.27% | No change | 135,000 | $5.9M |
| New York State Common Retirement Fund | 0.01% | Add +26.0% | 132,710 | $5.8M |
| Amundi | 0.00% | Reduce -48.4% | 140,776 | $5.7M |
| California State Teachers Retirement System | 0.01% | Reduce -4.8% | 131,818 | $5.7M |
| Susquehanna Portfolio Strategies, LLC | 0.13% | Reduce -22.8% | 130,986 | $5.7M |
| Avidity Partners Management LP | 0.20% | New | 130,000 | $5.6M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -2.6% | 129,972 | $5.6M |
| State Board of Administration of Florida Retirement System | 0.01% | Add +2.7% | 155,145 | $5.5M |
| Superstring Capital Management LP | 3.47% | Reduce -36.2% | 120,896 | $5.2M |
| Peregrine Capital Management LLC | 0.15% | Add +10.0% | 118,598 | $5.1M |
| Jane Street Group, LLC | 0.01% | Reduce -23.4% | 118,132 | $5.1M |
| Granite Investment Partners, LLC | 0.19% | Reduce -3.2% | 116,144 | $5.0M |
| Schroder Investment Management Group | 0.01% | Add +169.0% | 115,658 | $5.0M |
| Raymond James & Associates | 0.00% | Reduce -38.7% | 112,554 | $4.9M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -12.7% | 109,303 | $4.7M |
| DekaBank Deutsche Girozentrale | 0.01% | Add +2.4% | 93,807 | $4.2M |
| Campbell & CO Investment Adviser LLC | 0.35% | New | 94,772 | $4.1M |
| State of Wisconsin Investment Board | 0.01% | Reduce -11.3% | 91,815 | $4.0M |
| Van Eck Associates Corp. | 0.01% | Add +38.4% | 91,101 | $4.0M |
| Walleye Capital LLC | 0.05% | New | 89,130 | $3.9M |
| Trexquant Investment LP | 0.07% | Reduce -24.5% | 85,352 | $3.7M |
| DAVENPORT & Co LLC | 0.02% | Reduce -2.8% | 83,928 | $3.6M |
| Commerce Bank | 0.02% | Add +23.0% | 82,433 | $3.6M |
| State of New Jersey Common Pension Fund D | 0.01% | No change | 81,847 | $3.5M |
| Sei Investments Co. | 0.01% | Add +13.8% | 79,887 | $3.5M |
| LPL Financial LLC | 0.00% | Reduce -8.7% | 79,722 | $3.5M |
| Citadel Advisors | 0.00% | Reduce -69.1% | 78,030 | $3.4M |
| Nicola Wealth Management LTD. | 0.32% | No change | 56,000 | $3.3M |
| Parkwood LLC | 0.32% | Reduce -34.4% | 71,259 | $3.1M |
| HRT Financial LP | 0.02% | New | 66,503 | $2.9M |
| Atle Fund Management AB | 1.68% | Add +163.1% | 63,791 | $2.8M |
| Treasurer of the State of North Carolina | 0.01% | Add +0.7% | 63,582 | $2.8M |
| Janus Henderson Group PLC | 0.00% | Add +0.0% | 59,717 | $2.6M |
| Skandinaviska Enskilda Banken AB (publ) | 0.01% | No change | 59,626 | $2.6M |
| Public Employees Retirement System of Ohio | 0.01% | Reduce -8.6% | 54,493 | $2.4M |
| Voya Investment Management LLC | 0.00% | Reduce -29.5% | 54,196 | $2.3M |
| Ensign Peak Advisors, Inc | 0.00% | Add +15.1% | 53,320 | $2.3M |
| Erste Asset Management GmbH | 0.03% | No change | 51,300 | $2.3M |
| Private Advisor Group, LLC | 0.01% | Reduce -1.7% | 47,976 | $2.1M |
| Twinbeech Capital LP | 0.04% | Add +56.0% | 46,364 | $2.0M |
| Susquehanna Fundamental Investments, LLC | 0.09% | New | 45,574 | $2.0M |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.06% | Add +48.2% | 42,412 | $1.8M |
| NJ State Employees Deferred Compensation Plan | 0.23% | No change | 42,000 | $1.8M |
| CANADA LIFE ASSURANCE Co | 0.00% | Add +2.7% | 41,880 | $1.8M |
| Capital Counsel LLC | 0.08% | Reduce -1.3% | 39,580 | $1.7M |
| Comerica Bank | 0.01% | Reduce -0.3% | 39,491 | $1.7M |
| Engineers Gate Manager LP | 0.04% | Add +33.6% | 38,592 | $1.7M |
| Nicholas Investment Partners, LP | 0.19% | Add +25.4% | 38,186 | $1.7M |
| NEOS Investment Management LLC | 0.10% | Add +318.9% | 37,303 | $1.6M |
| Guggenheim Capital LLC | 0.01% | Add +8.1% | 35,850 | $1.6M |
| Arizona State Retirement System | 0.01% | Reduce -1.6% | 35,487 | $1.5M |
| Handelsbanken Fonder AB | 0.01% | Add +25.6% | 33,911 | $1.5M |
| Grandfield & Dodd, LLC | 0.09% | Add +2.0% | 33,774 | $1.5M |
| Profund Advisors LLC | 0.05% | Add +8.6% | 31,570 | $1.4M |
| Graham Capital Management, L.P. | 0.07% | Add +143.8% | 30,541 | $1.3M |
| Lighthouse Investment Partners, LLC | 0.08% | New | 30,379 | $1.3M |
| Algert Global LLC | 0.05% | Add +73.7% | 30,242 | $1.3M |
| STRS Ohio | 0.01% | Add +20.9% | 29,965 | $1.3M |
| Teza Capital Management LLC | 0.17% | Add +207.6% | 29,936 | $1.3M |
| Principal Financial Group Inc. | 0.00% | Reduce -4.2% | 29,824 | $1.3M |
| Teacher Retirement System of Texas | 0.01% | Reduce -3.7% | 28,736 | $1.2M |
| Point72 (DIFC) Ltd | 0.10% | — | 28,491 | $1.2M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -4.4% | 28,144 | $1.2M |
| China Universal Asset Management Co., Ltd. | 0.15% | Add +68.9% | 28,027 | $1.2M |
| Blair William & Co. | 0.00% | Add +67.4% | 27,838 | $1.2M |
| Lisanti Capital Growth, LLC | 0.29% | Reduce -55.4% | 27,835 | $1.2M |
| Creative Planning | 0.00% | Add +6.7% | 27,005 | $1.2M |
| Janney Montgomery Scott LLC | 0.00% | Reduce -5.2% | 26,893 | $1.2M |
| Pearl River Capital, LLC | 0.18% | New | 25,959 | $1.1M |
| Teachers Retirement System of the State of Kentucky | 0.01% | Add +70.6% | 24,083 | $1.0M |
| Natixis Advisors, LLC | 0.00% | Add +33.0% | 23,028 | $998K |
| Commonwealth Equity Services, LLC | 0.00% | Add +2.4% | 21,974 | $953K |
| Cetera Investment Advisers | 0.00% | New | 21,758 | $943K |
| Pathstone Holdings, LLC | 0.00% | Add +78.9% | 21,253 | $921K |
| Mariner, LLC | 0.00% | Add +0.5% | 20,784 | $901K |
| Nicollet Investment Management, Inc. | 0.33% | Add +109.9% | 20,521 | $890K |
| Tidal Investments LLC | 0.02% | New | 20,405 | $885K |
| Edgestream Partners, L.P. | 0.04% | New | 17,646 | $765K |
| Victory Capital Management Inc. | 0.00% | Reduce -36.5% | 17,637 | $765K |
| NBT Bank, N.A. | 0.05% | No change | 17,050 | $739K |
| Aigen Investment Management, LP | 0.16% | Reduce -77.3% | 16,747 | $726K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 16,574 | $718K |
| Bleakley Financial Group, LLC | 0.02% | Add +32.6% | 16,229 | $704K |
| Simplicity Wealth,LLC | 0.02% | New | 16,229 | $704K |
| Xponance LLC | 0.01% | Reduce -2.9% | 16,209 | $703K |
| Jump Financial, LLC | 0.02% | Reduce -74.6% | 15,693 | $680K |
| Ameriprise Financial Inc. | 0.00% | Reduce -38.8% | 15,673 | $679K |
| Marshall Wace, LLP | 0.00% | Reduce -88.4% | 15,443 | $669K |
| Osaic Holdings, Inc. | 0.00% | Reduce -22.6% | 14,626 | $634K |
| Tanaka Capital Management Inc. | 1.56% | No change | 14,612 | $633K |
| Entropy Technologies, LP | 0.07% | New | 14,542 | $630K |
| Neuberger Berman Group LLC | 0.00% | Add +1.7% | 14,234 | $617K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | New | 15,081 | $613K |
| Westmount Partners, LLC | 0.22% | No change | 13,872 | $601K |
| North Star Asset Management Inc. | 0.03% | Reduce -0.1% | 13,640 | $591K |
| Raymond James Financial Services Advisors, Inc. | 0.00% | Reduce -1.0% | 13,508 | $586K |
| American Century Companies Inc. | 0.00% | Add +1.2% | 13,378 | $580K |
| Martingale Asset Management L P | 0.01% | Add +0.0% | 13,315 | $577K |
| Bank Julius Baer & Co. Ltd, Zurich | 0.00% | Reduce -25.3% | 14,230 | $571K |
| Horizon Kinetics Asset Management LLC | 0.01% | No change | 12,476 | $541K |
| Wolverine Trading, LLC | 0.01% | Add +26.9% | 12,047 | $522K |
| US Bancorp \de | 0.00% | Reduce -0.1% | 11,927 | $517K |
| Chartwell Investment Partners, LLC | 0.02% | Reduce -9.4% | 11,756 | $510K |
| Aquatic Capital Management LLC | 0.02% | Add +82.8% | 11,700 | $507K |
| Plancorp, LLC | 0.02% | No change | 11,155 | $484K |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 11,146 | $483K |
| Two Sigma Securities, LLC | 0.02% | Reduce -27.8% | 11,122 | $482K |
| Brown Advisory Inc. | 0.00% | Reduce -3.7% | 11,122 | $482K |
| PEAK6 Investments LLC | 0.02% | Add +22.2% | 11,000 | $477K |
| Montanova Capital, LLC | 0.02% | New | 10,800 | $468K |
| Corton Capital Inc. | 0.17% | Reduce -7.4% | 10,631 | $461K |
| Maryland State Retirement & Pension System | 0.01% | No change | 10,950 | $451K |
| Capula Management Ltd | 0.01% | New | 10,217 | $443K |
| ProShare Advisors LLC | 0.00% | Add +11.4% | 10,216 | $443K |
| Sherbrooke Park Advisers LLC | 0.09% | Add +49.0% | 10,119 | $439K |
| Sectoral Asset Management Inc. | 0.17% | Add +55.9% | 10,100 | $438K |
| Cypress Capital, LLC | 0.12% | New | 10,000 | $434K |
| Bard Financial Services, Inc. | 0.05% | Reduce -29.4% | 9,950 | $431K |
| Oppenheimer Asset Management Inc. | 0.01% | Reduce -6.8% | 9,826 | $426K |
| E Fund Management Co., Ltd. | 0.03% | Reduce -0.4% | 9,825 | $426K |
| Franklin Resources Inc. | 0.00% | Reduce -28.4% | 9,809 | $425K |
| Midwest Professional Planners, LTD. | 0.15% | Add +14.1% | 9,716 | $421K |
| Fifth Third Bancorp | 0.00% | Add +3.8% | 9,633 | $418K |
| Truist Financial Corp. | 0.00% | Reduce -4.7% | 9,499 | $412K |
| Walleye Trading LLC | 0.01% | Add +6225.7% | 9,362 | $406K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -15.6% | 9,312 | $404K |
| Amalgamated Bank | 0.00% | Reduce -68.3% | 9,203 | $399K |
| PNC Financial Services Group, Inc. | 0.00% | Add +5.3% | 8,819 | $382K |
| Deutsche Bank AG | 0.00% | Reduce -76.0% | 8,588 | $372K |
| XTX Topco Ltd | 0.05% | New | 8,585 | $372K |
| Simplex Trading, LLC | 0.01% | Reduce -10.6% | 8,530 | $369K |
| Centiva Capital, LP | 0.02% | New | 8,474 | $367K |
| Gsa Capital Partners LLP | 0.03% | Reduce -28.7% | 8,325 | $361K |
| Torno Capital, LLC | 0.07% | Add +220.0% | 8,000 | $347K |
| Utah Retirement Systems | 0.00% | No change | 7,900 | $342K |
| Stephens Inc. | 0.01% | Reduce -1.3% | 7,853 | $340K |
| MetLife Investment Management, LLC | 0.00% | Add +0.3% | 7,841 | $340K |
| Lazard Asset Management LLC | 0.00% | Add +18.3% | 7,855 | $339K |
| International Assets Investment Management, LLC | 0.03% | New | 7,607 | $334K |
| Virtus Advisers, LLC | 0.18% | Add +16.8% | 7,648 | $332K |
| SG Americas Securities, LLC | 0.00% | Add +23.7% | 7,582 | $329K |
| Twin Tree Management, LP | 0.01% | New | 7,563 | $328K |
| Vontobel Holding Ltd. | 0.00% | Reduce -8.7% | 7,497 | $325K |
| Vanguard Personalized Indexing Management, LLC | 0.01% | Reduce -11.7% | 7,363 | $319K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.08% | New | 6,986 | $303K |
| Castle Rock Wealth Management, LLC | 0.08% | No change | 6,972 | $300K |
| Gotham Asset Management | 0.00% | Reduce -2.9% | 6,786 | $294K |
| Regions Financial Corp. | 0.00% | Add +66.1% | 6,785 | $294K |
| Baird Financial Group, Inc. | 0.00% | Add +0.1% | 6,696 | $290K |
| Wrapmanager Inc. | 0.08% | Reduce -9.9% | 6,668 | $289K |
| Diversified Trust Co. | 0.01% | New | 6,015 | $261K |
| Acadian Asset Management LLC | 0.00% | New | 5,891 | $255K |
| M&T Bank Corp | 0.00% | Add +12.7% | 5,848 | $254K |
| Massachusetts Financial Services Co. | 0.00% | Reduce -0.2% | 5,580 | $242K |
| Perkins Capital Management Inc. | 0.20% | No change | 5,550 | $241K |
| Kestra Advisory Services, LLC | 0.00% | Add +10.1% | 5,550 | $241K |
| Handelsinvest Investeringsforvaltning | 0.11% | Reduce -34.2% | 5,287 | $229K |
| Buckingham Strategic Wealth, LLC | 0.00% | Add +1.6% | 5,251 | $228K |
| Level Four Advisory Services, LLC | 0.01% | Add +2.2% | 4,396 | $222K |
| HighTower Advisors, LLC | 0.00% | Reduce -54.1% | 5,085 | $221K |
| Beaird Harris Wealth Management, LLC | 0.02% | No change | 5,000 | $217K |
| Brevan Howard Capital Management LP | 0.02% | New | 4,924 | $213K |
| Paloma Partners Management Co | 0.04% | New | 4,909 | $213K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +44.7% | 4,863 | $211K |
| Vident Advisory, LLC | 0.00% | Reduce -2.7% | 4,796 | $208K |
| Prospera Financial Services Inc | 0.01% | Reduce -1.7% | 4,617 | $200K |
| Quantbot Technologies LP | 0.01% | Reduce -66.3% | 4,284 | $186K |
| CI Investments Inc. | 0.00% | Reduce -29.0% | 3,967 | $172K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Add +4.0% | 3,842 | $167K |
| Advisors Asset Management, Inc. | 0.00% | Add +948.8% | 3,178 | $138K |
| KBC Group NV | 0.00% | Add +17.8% | 3,145 | $136K |
| ADAR1 Capital Management, LLC | 0.03% | New | 2,900 | $126K |
| Icon Wealth Advisors, LLC | 0.01% | Reduce -5.8% | 2,391 | $104K |
| Horizon Investments, LLC | 0.00% | Add +21.8% | 2,347 | $102K |
| AlphaQuest LLC | 0.02% | Add +229600.0% | 2,297 | $100K |
| Cwm, LLC | 0.00% | Add +1.4% | 2,228 | $97K |
| American International Group, Inc. | 0.00% | Reduce -1.3% | 2,208 | $96K |
| CIBC Private Wealth Group LLC | 0.00% | New | 2,168 | $95K |
| NewEdge Advisors, LLC | 0.00% | Reduce -3.0% | 2,025 | $88K |
| Natixis | 0.00% | Reduce -31.9% | 1,961 | $85K |
| Twin Lakes Capital Management, LLC | 0.04% | No change | 1,500 | $65K |
| Avior Wealth Management, LLC | 0.00% | New | 1,104 | $48K |
| IFP Advisors, Inc | 0.00% | No change | 1,070 | $46K |
| Sunbelt Securities, Inc. | 0.00% | New | 1,014 | $44K |
| Pacer Advisors, Inc. | 0.00% | New | 971 | $42K |
| Harbour Investments, Inc. | 0.00% | No change | 900 | $39K |
| Archer Investment Corp | 0.01% | No change | 850 | $37K |
| Allworth Financial LP | 0.00% | Add +2.6% | 796 | $35K |
| Mather Group, Llc. | 0.00% | New | 671 | $34K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +50.3% | 723 | $31K |
| Institutional & Family Asset Management, LLC | 0.00% | Reduce -5.2% | 691 | $30K |
| Global X Japan Co., Ltd. | 0.01% | Reduce -6.6% | 669 | $29K |
| GAMMA Investing LLC | 0.01% | Add +22.4% | 612 | $27K |
| Laurel Wealth Advisors LLC | 0.00% | No change | 600 | $26K |
| Farther Finance Advisors, LLC | 0.00% | No change | 569 | $25K |
| Quadrant Capital Group LLC | 0.00% | Reduce -14.5% | 574 | $25K |
| Parallel Advisors, LLC | 0.00% | Add +1.2% | 572 | $25K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -7.8% | 541 | $23K |
| Pingora Partners LLC | 0.02% | No change | 500 | $22K |
| Riverview Trust Co | 0.02% | New | 476 | $21K |
| Elequin Capital, LP | 0.01% | New | 474 | $21K |
| Global Trust Asset Management, LLC | 0.01% | No change | 474 | $21K |
| Clearstead Advisors, LLC | 0.00% | No change | 495 | $19K |
| AlphaMark Advisors, LLC | 0.01% | Reduce -20.0% | 400 | $17K |
| Banque Cantonale Vaudoise | 0.00% | No change | 400 | $17K |
| Private Trust Co. NA | 0.00% | Add +3.0% | 378 | $16K |
| Huntington National Bank | 0.00% | Add +25.6% | 363 | $16K |
| Signaturefd, LLC | 0.00% | Reduce -29.1% | 355 | $15K |
| Whittier Trust Co. of Nevada Inc. | 0.00% | No change | 341 | $15K |
| Lindbrook Capital, LLC | 0.00% | Reduce -20.1% | 314 | $14K |
| Riggs Asset Managment Co. Inc. | 0.00% | Add +12.8% | 282 | $12K |
| Storebrand Asset Management As | 0.00% | No change | 271 | $12K |
| Washington Trust Advisors, Inc. | 0.00% | No change | 258 | $11K |
| Covestor Ltd | 0.01% | Reduce -0.4% | 242 | $11K |
| Whittier Trust Co. | 0.00% | Reduce -50.0% | 231 | $10K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -30.3% | 237 | $10K |
| Leonteq Securities AG | 0.00% | New | 212 | $9K |
| SYSTM Wealth Solutions LLC | 0.00% | No change | 204 | $9K |
| LifeSteps Financial, Inc. | 0.01% | New | 200 | $9K |
| Catalyst Funds Management Pty Ltd | 0.00% | — | 200 | $9K |
| AllSquare Wealth Management LLC | 0.01% | No change | 198 | $9K |
| GPS Wealth Strategies Group, LLC | 0.00% | Reduce -7.1% | 184 | $8K |
| Pacifica Partners Inc. | 0.00% | No change | 150 | $7K |
| Sachetta, LLC | 0.00% | No change | 115 | $6K |
| Spire Wealth Management | 0.00% | No change | 125 | $5K |
| Creekmur Asset Management LLC | 0.00% | No change | 100 | $4K |
| Global Retirement Partners, LLC | 0.00% | Add +3.3% | 94 | $4K |
| Bogart Wealth, LLC | 0.00% | No change | 85 | $4K |
| Exchange Traded Concepts, LLC | 0.00% | New | 82 | $4K |
| Orion Capital Management LLC | 0.00% | Add +110.5% | 80 | $3K |
| EntryPoint Capital, LLC | 0.00% | Reduce -91.3% | 76 | $3K |
| National Bank of Canada | 0.00% | New | 80 | $3K |
| Raleigh Capital Management Inc. | 0.00% | No change | 72 | $3K |
| Bell Investment Advisors, Inc | 0.00% | No change | 71 | $3K |
| Semmax Financial Advisors Inc. | 0.00% | Reduce -3.7% | 79 | $3K |
| Dynamic Wealth Strategies, LLC | 0.00% | No change | 80 | $3K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | No change | 67 | $3K |
| Parkside Financial Bank & Trust | 0.00% | No change | 62 | $3K |
| Versant Capital Management, Inc | 0.00% | No change | 59 | $3K |
| Blume Capital Management, Inc. | 0.00% | No change | 55 | $2K |
| Quent Capital, LLC | 0.00% | Add +161.9% | 55 | $2K |
| Bessemer Group Inc. | 0.00% | No change | 52 | $2K |
| Cornerstone Planning Group LLC | 0.00% | Reduce -58.7% | 45 | $2K |
| Sandy Spring Bank | 0.00% | New | 34 | $1K |
| Kelly Financial Services LLC | 0.00% | No change | 30 | $1K |
| CVA Family Office, LLC | 0.00% | No change | 30 | $1K |
| First Pacific Financial | 0.00% | Add +45.0% | 29 | $1K |
| Raffa Wealth Management, LLC | 0.00% | No change | 28 | $1K |
| Smartleaf Asset Management LLC | 0.00% | New | 26 | $1K |
| CoreCap Advisors, LLC | 0.00% | New | 26 | $1K |
| Arax Advisory Partners | 0.00% | Reduce -70.2% | 25 | $1K |
| Rosenberg Matthew Hamilton | 0.00% | No change | 20 | $879 |
| Front Row Advisors LLC | 0.00% | No change | 20 | $867 |
| Key Financial Inc | 0.00% | No change | 19 | $824 |
| Concourse Financial Group Securities, Inc. | 0.00% | No change | 19 | $823 |
| Allspring Global Investments Holdings, LLC | 0.00% | Reduce -97.1% | 16 | $693 |
| Retirement Group, LLC | 0.00% | No change | 11 | $477 |
| Private Wealth Management Group, LLC | 0.00% | No change | 10 | $434 |
| Bokf, NA | 0.00% | New | 7 | $308 |
| Manchester Capital Management LLC | 0.00% | No change | 5 | $217 |
| Abich Financial Wealth Management LLC | 0.00% | New | 4 | $173 |
| Assetmark, Inc. | 0.00% | Reduce -85.7% | 1 | $43 |
| Capital Advisors, Ltd. LLC | 0.00% | New | 7 | $0 |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.